CN102357105A - Combination with effect of enhancing immunity and application thereof - Google Patents
Combination with effect of enhancing immunity and application thereof Download PDFInfo
- Publication number
- CN102357105A CN102357105A CN2011102945882A CN201110294588A CN102357105A CN 102357105 A CN102357105 A CN 102357105A CN 2011102945882 A CN2011102945882 A CN 2011102945882A CN 201110294588 A CN201110294588 A CN 201110294588A CN 102357105 A CN102357105 A CN 102357105A
- Authority
- CN
- China
- Prior art keywords
- immunity
- medicine
- compositions
- food
- spirulina
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a combination with an effect of enhancing immunity and application thereof. The combination comprises spirulina, stachyose and beta-glucan and can be used for preparing foods or medicines capable of enhancing the immunity, remarkably improve the immunity of human body, relieve fatigue, improve acid physique and regularize internal secretion.
Description
Technical field
The invention belongs to field of health care products, be specifically related to a kind of compositions and application thereof with immunological enhancement.
Background technology
Immunity is the defense mechanism of human body self; Be divided into nonspecific immunity and specific immunity; Be human body identification and the foreign body (virus, antibacterial etc.) of eliminating external intrusion, handle the ability of self cell and identification and the processing vivo mutations cell and the virus infected cell of old and feeble, damage, death, degeneration.Modern immunology thinks that immunity is human body identification and the physiological reaction of getting rid of " dissident ".What carry out this function in the human body is immune system, and the human immune system divides liquid immunity (immunoglobulin), two big types in cellular immunization (B cell, T cell).The B cell can generate various antibody, and the T cell can directly kill, engulf various pathogen.
Immunity degradation is exactly the level and the function reduction of B cell and T cell in the human body, makes the human immune system can not normally bring into play protective effect, very easily causes infection such as antibacterial, virus, fungus, thus hypoimmunity the most directly to show be exactly liable to illness.Because it is often ill; Increased the weight of the consumption of human body each item body; So generally have a delicate constitution, performance such as malnutrition, lethargy, fatigue and weak, appetite depression, sleep disorder; And disease is difficult to thorough healing, repeatability, regular sick easily, and for example show effect repeatedly repeatedly, asthma is shown effect repeatedly, bronchitis shows effect repeatedly, pneumonia is shown effect repeatedly flu, suffer from diarrhoea and show effect repeatedly by outbreak, tonsillitis.If things go on like this can cause health and intelligence development bad, also be prone to bring out major disease.
The reason that causes immunity degradation mainly comprises: malnutrition is unbalance, overwork, do not have enough sleep, do not like motion, unhealthy emotion, environmental pollution, virus infraction, alimentary toxicosis, chronic disease, health are aging, body obesity, medicine cause etc.To the above reason that causes immunity degradation, the method for at present main enhancing immunity has: the one, and regulation and control are careful in one's diet; The 2nd, the motion enhancing immunity; The 3rd, note daily life, guarantee well sleep; The 4th, regulate the phychology balance, keep emotional; The 5th, take the medicine or the health product of enhance immunity.
Current society, nervous work rhythm and heavy life stress make most of people strengthen self body immunity more often having to select to take Medicines and Health Product.Have the Medicines and Health Product of immunological enhancement in the market, of a great variety, the selection of multiple enhancing human body immunity ability is provided for people.
For the immunodeficiency treatment of specific immunity disease and malignant tumor, generally adopt medicines such as Nucleotide and Casein Injection, levamisole, polyinosini, thymosin, gamma globulin, interferon, transfer factor, placental lipo-glucosaminoglycan.Though these chemical compounds or biological product have been brought into play the positive therapeutic effect, still there is certain toxicity.
For the low treatment of non-specific immunity, mostly is effects of playing raise immunity through the combination collocation of different Chinese crude drug extracts, for example disclosed a kind of Chinese medicine preparation with immunostimulant among the one Chinese patent application CN1324656A.But; There are problems such as prescription Chinese crude drug kind is numerous and diverse, complicated process of preparation in this type of immunostimulant preparation, because the place of production of medical material is different, the diversity of its effective ingredient is very big simultaneously; Cause product on the stability that guarantees its effect, to have certain problem; There is the compatibility of medical material to use again to belong to because of people's determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, the traditional Chinese medical science system controlled of typing opinion due to illness, thereby makes that the crowd of being suitable for is limited, and suitablely take for a long time.
Summary of the invention
Therefore, the objective of the invention is, a kind of compositions with immunological enhancement is provided.
Another object of the present invention is that the purposes of above-mentioned composition is provided.
The objective of the invention is to realize through following technical scheme.On the one hand, the present invention provides a kind of compositions with immunological enhancement, and said compositions comprises: spirulina, stachyose and yeast beta-dextran.
Preferably, said compositions comprises: spirulina 100-400 weight portion, stachyose 60-250 weight portion, and yeast beta-dextran 15-65 weight portion.
Preferably, said compositions comprises: spirulina 250 weight portions, stachyose 150 weight portions, and yeast beta-dextran 40 weight portions.
On the other hand, the present invention provides above-mentioned composition to be used for the application of food, health product or the medicine of immunostimulant in preparation.
In addition, the present invention also provides a kind of food, health product or medicine with immunological enhancement, wherein comprises above-mentioned compositions.
Preferably, said food, health product or medicine are tablet or capsule.
Preferably, said food, health product or medicine also comprise food, health product or medicine acceptable auxiliary.
In addition, the present invention also provides the method for preparing of said food, health product or medicine, and with spirulina, stachyose and yeast beta-dextran mix the back granulates with said adjuvant, again tabletting or filling capsule.
Compositions with immunological enhancement provided by the invention, with spirulina, three kinds of components compatibilities of stachyose and yeast beta-dextran use, and significantly enhancing human immune, fatigue alleviating are improved acidic physique, endocrine regulation.Spirulina in the compositions can significantly improve body immunity, improves non-specific cellular immune function of body and specific humoral immunity function.Stachyose in the compositions and yeast beta-dextran can fundamentally be safeguarded the micro ecology of gastrointestinal tract balance, make gastric mucosa obtain nutrition and reparation; Simultaneously, stachyose and yeast beta-dextran can promote the nutritional labeling in the spirulina promptly to decompose the entering gastrointestinal tract, thus guarantee in the spirulina nutritional labeling by human body more fast, absorb more efficiently.
Intestinal is the maximum immune organ of human body, and 70% immune function of human body produces the antibody of human body 80% from intestinal, human body intestinal canal have for human body digest and assimilate, the function of immunity defence.Nearly half the human immunocyte is arranged attached to intestinal, the nutritional labeling that intestinal absorbs from food also is the material base that the human immune system normally maintains.Unsound intestinal not only normal function significantly weakens, but also can secrete poisonous and harmful substance infringement human immune system.The present invention is through setting up healthy intestinal immune environment, and equilibrium provides the necessary nutrient substance of human immune system basis, from reaching the effect of enhances human body immunity in essence.
The specific embodiment
The concrete embodiment of following reference explains the present invention.It will be appreciated by those skilled in the art that these embodiment only are used to explain the present invention, the scope that it does not limit the present invention in any way.
Embodiment 1
Present embodiment provides the pharmacological evaluation of the immunological enhancement of the present composition.
1) material and method
(1) sample: a kind of compositions (by 250 weight portion spirulinas, 150 weight parts water threoses and 40 weight portion yeast beta-dextrans are mixed to be got) of the present invention with immunological enhancement.According to the oral recommended amounts of human body is 2200mg/d, becomes body weight for humans 60kg to calculate, and amounts to dosage 36.7mg/kgbw.
(2) laboratory animal and grouping:
190 of cleaning level Kunming mouses, body weight is 18～22g, available from unming Medical College's Experimental Animal Center.Mice is divided into five groups at random.Immunity I organizes, and carries out the mensuration of dirty body ratio; Immunity II group is carried out the humoral immune function experiment; Immunity III group is carried out carbon and is cleaned up experiment; Immunity IV group is carried out the delayed allergy experiment; Immunity V group is carried out the antibody-producting cell test experience.
(3) experimental situation condition:
The conventional environment system, 20～24 ℃ of temperature, humidity 52～58%.
(4) dosage is selected and the sample processing:
According to the oral recommended amounts of human body, the basic, normal, high dosage of sample is respectively 183.5mg/kgbw, 367mg/kgbw, 1101mg/kgbw (be equivalent to respectively human body RD 5,10,30 times).Materials 183.5mg, 367mg, 1101mg adding distil water to 200ml, be made into basic, normal, high dosage desired concn.Irritate stomach every day 1 time, irritate the long-pending 14.7mg/10gbw of being of body of stomach, matched group is given isopyknic solvent, continuously 30d.
(5) key instrument and reagent
Animal platform balance, analytical balance, centrifuge, 722 spectrophotometers, constant water bath box, microscope, microsyringe, Na
2Co
3Solution, sheep red blood cell (SRBC) (SRBC), india ink etc.
(6) experimental technique
Carry out about the function of enhancing immunity inspection method in the reference " health food check and assessment technique standard " (2003 editions), and experimental result is carried out statistical analysis with Excel/SPSS software.
2) experimental result
(1) mensuration of body weight and internal organs/body weight ratio:
To the continuous gastric infusion of each dose groups of mice 30 days, once a day, observe the variation of body weight, mice is put to death in the back of weighing, and takes out spleen and thymus, on electronic analytical balance, weighs, and calculates dirty body ratio, and the result sees table 1 and table 2.
The influence of table 1 pair mice body weight
Annotate: each organizes P＞0.05
Visible by table 1, mid-term, experiment mice body weight in latter stage and experimental session weight of mice matched group are tested just, tested to each dose groups relatively, and difference does not have significance (P＞0.05).
The influence of table 2 pair mouse immune organ internal organs/body weight ratio
Visible by table 2, per os gives the sample 30 days of mice various dose, and mouse spleen/body weight ratio and thymus/body weight ratio are had appreciable impact (P＜0.05).
(2) humoral immune function experiment
With 40 of mices, be divided into 4 groups at random, gastric infusion; Once a day; Successive administration 15 days after administration the 9th day only carries out immunity to each group ip in mice 0.5% chicken RBC normal saline 0.2ml/, in immunity back 7 days; Eye socket passages through which vital energy circulates treating the preponderant disease instead of the secondary disease blood is made immunogenic hemolysin algoscopy by chicken RBC and is surveyed the hemolysin content of respectively organizing mice.Experimental result is made t and detected, and is as shown in table 3.
The influence
of table 3 pair mice hemolysin content
Annotate: * refers to compare * P＜0.05, * * P＜0.01 with matched group
Visible by table 3, the content that all can significantly increase the mice hemolysin of high, medium and low three dosage of sample compares P＜0.05～0.01 with matched group, shows that sample has the effect that increases mouse humoral immune.
(3) carbon clearance method (to the influence of non-specific immunity)
With 40 of mices, be divided into 4 groups at random, gastric infusion; Once a day, successive administration 30 days, after administration the 30th day; Through the india ink of mouse tail vein injection with 4 times of normal saline dilutions, every 10g body weight injection 0.1ml, timing immediately after prepared Chinese ink injects; In injecting prepared Chinese ink the 2nd, 10min, get blood 20ul through angular vein respectively, join 2mlNa
2CO
3Shake in the solution all.With Na
2CO
3Solution is made blank, with 722 type spectrophotometers at 60nm wavelength colorimetric photometry density value (OD value).Calculate phagocytic index K and the activate the phagocytic capacity of respectively organizing mice, experimental result is made t and is detected, and sees table 4.
The influence of table 4 pair mouse monokaryon phagocytic function
Annotate: * refers to compare * P＜0.05, * * P＜0.01 with matched group
Visible by table 4, high, medium and low three dose groups all can significantly increase cytophagous phagocytic index of mice and activate the phagocytic capacity, compare P＜0.05～0.01 with matched group, show the effect that sample has increases the mice non-specific immunity.
(4) delayed allergy (DTH) (the sufficient sole of the foot thickens method)
With 40 of mices, be divided into 4 groups at random, gastric infusion; Once a day; In irritating stomach the 30th day, inject 2% sheep red blood cell (SRBC) (SRBC) 0.2mF to mouse peritoneal and only carry out sensitization, after immunity the 4th day the left back toe ring of the every Mus subcutaneous injection 20%SRBC of portion (20ul/ only) attack.And before attacking, measured the same position of the left back sufficient intestinal of every Mus thickness in back 24 hours with attacking, and calculating the forward and backward difference of attack, each dose groups result and solvent control group relatively and carry out variance analysis are seen table 5.
The influence of table 5 pair mice delayed allergy (DTH)
Visible by table 5, per os gives the mice various dose a kind of functional food with immunological enhancement 30 days, middle and high dosage can increase the mice swelling degree of the paw, with the matched group comparing difference significance (P＜0.05) is arranged.
(5) antibody-producting cell detects (Jerne improves slide method)
With 30 of mices, be divided into 3 groups at random, gastric infusion once a day, in irritating stomach the 30th day, begins test.Hematocrit sheep red blood cell (SRBC) (SRBC) is made into the cell suspension of 2% (v/v) with normal saline, every mouse peritoneal injection 0.2ml.Mice that immunity is back 4 days is put to death, and gets spleen and tears to shreds gently, use Hank ' s liquid to process cell suspension, and 200 eye mesh screens filter, wash, centrifugal 2 times, at last with cell suspension in 5ml Hank ' s liquid.With mixing with Hank ' the s liquid of 7.4,2 times of concentration of pH of equivalent after the culture medium heating for dissolving of top layer; The packing small test tube; Every pipe 0.5ml; In pipe, add 10%SRBC 50ul (v/v), 20ul splenocyte suspension again, be poured on the slide of brushing the thin layer agarose behind the mixing rapidly, treat after agarose solidifies flat button of slide to be placed on the slide frame with the preparation of SA liquid; Put into the CO2 gas incubator incubation 1.5 hours, the complement (1: 10) that will use SA liquid to dilute joins the interior incubation that continues of slide groove and counts the hemolysis plaque number after 1.5 hours.Experimental result is seen table 6.
The influence
of table 6 pair mouse antibodies cellulation number
Can be known that by table 6 the mouse antibodies cellulation number of spirulina high dose group and high dose group of the present invention is apparently higher than the blank group, difference has significance (P＜0.05).In addition; Under the spirulina same dose; Compositions of the present invention also obviously is superior to independent spirulina, and this is because added stachyose and yeast beta-dextran in the compositions of the present invention, can improve digestive function through regulating archenteric flora; Thereby promote absorption, thereby have stronger immunological enhancement spirulina.
3) conclusion
Visible by above result; Per os gives the sample 30 days of mice 183.5mg/kgbw, 367mg/kgbw, 1101mg/kgbw dosage; Can increase mice delayed allergy ability; Can increase mice haemolysis and count content, cytophagous phagocytic index of mice and activate the phagocytic capacity, spleen/body weight ratio, thymus/body weight ratio and matched group comparing difference have significance, show that compositions provided by the invention has significant raise immunity.
Embodiment 2The immunopotentiating composition tablet
Present embodiment is prepared into tablet with immunopotentiating composition, and concrete prescription and preparation method thereof as follows.
Prescription:
Active component: spirulina 250 grams, stachyose 150 grams, β yeast dextran 40 grams;
Adjuvant: polyacrylic resin IV number 11 grams, micropowder silica gel 15 grams, microcrystalline Cellulose 75 grams, magnesium stearate 4 grams.
Method for preparing:
Be dissolved in 75% ethanol with polyacrylic resin IV number, it is subsequent use to process wetting agent; With spirulina, stachyose, β yeast dextran, micropowder silica gel, microcrystalline Cellulose mix homogeneously, add wetting agent system soft material, cross 16 mesh sieves and granulate; 60 ℃ of dryings after 16 mesh sieve granulate, add the magnesium stearate mixing; Tabletting promptly gets, and makes 1000 in tablet altogether.
Embodiment 3The immunopotentiating composition capsule
Present embodiment is prepared into capsule with immunopotentiating composition, and concrete prescription and preparation method thereof as follows.
Prescription:
Active component: spirulina 125 grams, stachyose 75 grams, β yeast dextran 20 grams;
Adjuvant: polyacrylic resin IV number 4 grams, micropowder silica gel 5 grams, microcrystalline Cellulose 25 grams, magnesium stearate 2 grams.
Method for preparing:
Be dissolved in 75% ethanol with polyacrylic resin IV number, it is subsequent use to process wetting agent; With spirulina, stachyose, β yeast dextran, micropowder silica gel, microcrystalline Cellulose mix homogeneously, add wetting agent system soft material, cross 20 mesh sieves and granulate; 60 ℃ of dryings after 20 mesh sieve granulate, add the magnesium stearate mixing; Filled capsules promptly gets, and makes 1000 of hard capsules altogether.
Claims (8)
1. the compositions with immunological enhancement is characterized in that, said compositions comprises: spirulina, stachyose and yeast beta-dextran.
2. compositions according to claim 1 is characterized in that, said compositions comprises: spirulina 100-400 weight portion, stachyose 60-250 weight portion, and yeast beta-dextran 15-65 weight portion.
3. compositions according to claim 1 and 2 is characterized in that, said compositions comprises: spirulina 250 weight portions, stachyose 150 weight portions, and yeast beta-dextran 40 weight portions.
4. each said compositions is used for the application of food, health product or the medicine of immunostimulant in the claim 1 to 3 in preparation.
5. food, health product or the medicine with immunological enhancement wherein comprises each described compositions in the claim 1 to 3.
6. food according to claim 5, health product or medicine is characterized in that, said food, health product or medicine are tablet or capsule.
7. food according to claim 6, health product or medicine is characterized in that, said food, health product or medicine also comprise food, health product or medicine acceptable auxiliary.
8. the method for preparing of food according to claim 7, health product or medicine is characterized in that, with spirulina, stachyose and yeast beta-dextran mix the back granulates with said adjuvant, again tabletting or filling capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110294588 CN102357105B (en) | 2011-09-30 | 2011-09-30 | Combination with effect of enhancing immunity and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110294588 CN102357105B (en) | 2011-09-30 | 2011-09-30 | Combination with effect of enhancing immunity and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102357105A true CN102357105A (en) | 2012-02-22 |
| CN102357105B CN102357105B (en) | 2013-06-19 |
Family
ID=45582522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110294588 Expired - Fee Related CN102357105B (en) | 2011-09-30 | 2011-09-30 | Combination with effect of enhancing immunity and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102357105B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102715236A (en) * | 2012-06-19 | 2012-10-10 | 重庆市天友乳业股份有限公司 | Functional milk and production method thereof |
| CN106552098A (en) * | 2015-09-25 | 2017-04-05 | 哈尔滨华藻生物科技开发有限公司 | A kind of spirulina endocrine regulation medicated wine and preparation method thereof |
| CN108077936A (en) * | 2017-11-16 | 2018-05-29 | 山西五台山沙棘制品有限公司 | A kind of Seabuckthorn Oil Spirulina soft capsule and preparation method thereof |
| CN111011609A (en) * | 2019-12-24 | 2020-04-17 | 仙乐健康科技(安徽)有限公司 | A composition for enhancing immunity of mammals |
| CN112493487A (en) * | 2020-11-27 | 2021-03-16 | 深圳市新靶向生物科技有限公司 | Composition for enhancing human immunity, preparation method thereof and health-care product |
| CN116869169A (en) * | 2023-09-07 | 2023-10-13 | 四川合泰新光生物科技有限公司 | Composition with function of relaxing bowels and preparation method and application thereof |
-
2011
- 2011-09-30 CN CN 201110294588 patent/CN102357105B/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 杨月欣: "我国营养和功能成分应用现状分析", 《中国食品学报》 * |
| 高杨等: "益生元的发展和应用", 《中国畜牧兽医学会动物微生态学分会第四届第九次学术研讨会论文集（上册）》 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102715236A (en) * | 2012-06-19 | 2012-10-10 | 重庆市天友乳业股份有限公司 | Functional milk and production method thereof |
| CN106552098A (en) * | 2015-09-25 | 2017-04-05 | 哈尔滨华藻生物科技开发有限公司 | A kind of spirulina endocrine regulation medicated wine and preparation method thereof |
| CN108077936A (en) * | 2017-11-16 | 2018-05-29 | 山西五台山沙棘制品有限公司 | A kind of Seabuckthorn Oil Spirulina soft capsule and preparation method thereof |
| CN111011609A (en) * | 2019-12-24 | 2020-04-17 | 仙乐健康科技(安徽)有限公司 | A composition for enhancing immunity of mammals |
| CN112493487A (en) * | 2020-11-27 | 2021-03-16 | 深圳市新靶向生物科技有限公司 | Composition for enhancing human immunity, preparation method thereof and health-care product |
| CN112493487B (en) * | 2020-11-27 | 2022-10-25 | 深圳市新靶向生物科技有限公司 | Composition for enhancing human immunity, preparation method thereof and health-care product |
| CN116869169A (en) * | 2023-09-07 | 2023-10-13 | 四川合泰新光生物科技有限公司 | Composition with function of relaxing bowels and preparation method and application thereof |
| CN116869169B (en) * | 2023-09-07 | 2023-11-28 | 四川合泰新光生物科技有限公司 | Composition with function of relaxing bowels and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102357105B (en) | 2013-06-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102357105B (en) | Combination with effect of enhancing immunity and application thereof | |
| CN103800390A (en) | Health-care product with immunity-reinforcing and liver-protecting functions, preparation method and application thereof | |
| CN103800661B (en) | A kind of enhancing immunity, alleviating physical fatigue compositions and containing its preparation | |
| Yan et al. | Effects of polysaccharides from Cordyceps sinensis mycelium on physical fatigue in mice | |
| CN103169737B (en) | Composite of Antrodia camphorata entity and shell-broken ganoderma lucidum spore powder and application thereof in immune adjustment | |
| CN108065286A (en) | A kind of chewable tablets containing acerola concentrate powder, VC and taurine and preparation method thereof | |
| CN114246918A (en) | Traditional Chinese medicine composition for treating hashimoto thyroiditis and preparation method thereof | |
| CN103800352B (en) | Compound traditional Chinese medicinal effective component preparation for resisting alcoholic fatty liver disease and application thereof | |
| CN103768157A (en) | Veterinary antiviral traditional Chinese medicine Ziqi effervescent granules and preparation method thereof | |
| CN101322738A (en) | Preparation of red sandalwood extract for treating diabetic and uses thereof | |
| CN104286844B (en) | A kind of improve the food of immunity, health product or pharmaceutical composition | |
| CN106177227A (en) | A kind of compositions containing coenzyme Q10 strengthening body immunity | |
| CN106880784A (en) | It is a kind of with fatigue-relieving, the Chinese medicine composition of anti-aging and its application | |
| CN1506092A (en) | Elsholizia extract capsule for treating diarrhea and its prepn | |
| CN103007280B (en) | Piglet colibacillosis lyophilized serum immunoglobulin preparation and preparation process thereof | |
| CN1259082C (en) | Medicine for treating diseases of respiratory system | |
| CN1242791C (en) | Medicinal mixture and its preparation method | |
| CN104042790B (en) | A kind of pharmaceutical composition and its application for health care for the middle and old aged | |
| CN109170865A (en) | A kind of health care product and preparation method thereof adjusting immunity | |
| CN104740428B (en) | A kind of compound tonifying blood containing red skin of peanut pharmaceutical preparation and its application and detection method | |
| CN1067270C (en) | Nutritious health care medicine | |
| CN104758719B (en) | A kind of Chinese medicine composition, granule and preparation method for treating leukopenia | |
| CN1506093A (en) | Elsholizia extract prepn and its quality control method and new use | |
| Peng et al. | Zhishi Daozhi decoction alleviates constipation induced by a high-fat and high-protein diet via regulating intestinal mucosal microbiota and oxidative stress | |
| CN104491176B (en) | A kind of Chinese medicine for improving immunity after chemotherapy of tumors and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130619 Termination date: 20200930 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |