CN102356163A - 采用非编码rna表达分析的方法 - Google Patents

采用非编码rna表达分析的方法 Download PDF

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Publication number
CN102356163A
CN102356163A CN2010800129012A CN201080012901A CN102356163A CN 102356163 A CN102356163 A CN 102356163A CN 2010800129012 A CN2010800129012 A CN 2010800129012A CN 201080012901 A CN201080012901 A CN 201080012901A CN 102356163 A CN102356163 A CN 102356163A
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China
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expression
intervention
interventions
coding
coding rnas
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CN2010800129012A
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English (en)
Chinese (zh)
Inventor
J·P·埃斯蒂贝罗
J·F·戈登
C·R·希利尔
V·奥布赖恩
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Sistemic Scotland Ltd
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Sistemic Scotland Ltd
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Priority claimed from GB0900809A external-priority patent/GB0900809D0/en
Priority claimed from GB0917708A external-priority patent/GB0917708D0/en
Application filed by Sistemic Scotland Ltd filed Critical Sistemic Scotland Ltd
Publication of CN102356163A publication Critical patent/CN102356163A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/142—Toxicological screening, e.g. expression profiles which identify toxicity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Wood Science & Technology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
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  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN2010800129012A 2009-01-19 2010-01-19 采用非编码rna表达分析的方法 Pending CN102356163A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0900809.5 2009-01-19
GB0900809A GB0900809D0 (en) 2009-01-19 2009-01-19 Methods employing non-coding RNA expression assays
GB0917708.0 2009-10-09
GB0917708A GB0917708D0 (en) 2009-10-09 2009-10-09 Methods employing non-coding rna expression assays
PCT/GB2010/000076 WO2010082039A1 (en) 2009-01-19 2010-01-19 Methods employing non-coding rna expression assays

Publications (1)

Publication Number Publication Date
CN102356163A true CN102356163A (zh) 2012-02-15

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CN2010800129012A Pending CN102356163A (zh) 2009-01-19 2010-01-19 采用非编码rna表达分析的方法

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Country Link
US (3) US9074241B2 (https=)
EP (2) EP2387617B1 (https=)
JP (1) JP2012514994A (https=)
KR (1) KR20110138341A (https=)
CN (1) CN102356163A (https=)
AU (1) AU2010205493A1 (https=)
CA (1) CA2787218A1 (https=)
IL (1) IL214154A (https=)
SG (2) SG173042A1 (https=)
WO (1) WO2010082039A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108319814A (zh) * 2018-01-29 2018-07-24 中国科学院生物物理研究所 基于染色体空间相互作用预测长非编码rna生物学功能的方法
CN113593700A (zh) * 2021-08-06 2021-11-02 江苏师范大学 分析肺癌进展的方法、装置、设备、介质及程序产品

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201014049D0 (en) * 2010-08-23 2010-10-06 Sistemic Uk Cell characterisation
CN111899788B (zh) * 2020-07-06 2023-08-18 李霞 一种非编码rna调控疾病风险靶通路的识别方法及系统

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050266552A1 (en) * 2003-12-05 2005-12-01 Doench John G Reagents and methods for identification of RNAi pathway genes and chemical modulators of RNAi

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9914913A (pt) * 1998-10-27 2001-10-16 Rosetta Inpharmatics Inc Processos para analisar uma amostra biológica, para agrupar perfis de resposta biológica, para analisar uma rede n-dimensional de dados, para remover um ou mais artefatos de um perfil biológico medido, e, rede de sondas de polinucleotìdeos
CA2562390C (en) * 2004-04-07 2014-12-02 Exiqon A/S Novel methods for quantification of micrornas and small interfering rnas
US20100310583A1 (en) 2007-01-31 2010-12-09 Immune Disease Institute Let-7 microrna and mimetics thereof as therapeutics for cancer
AU2008231393A1 (en) 2007-03-27 2008-10-02 Rosetta Genomics Ltd. Gene expression signature for classification of cancers
US20090099034A1 (en) 2007-06-07 2009-04-16 Wisconsin Alumni Research Foundation Reagents and Methods for miRNA Expression Analysis and Identification of Cancer Biomarkers
US8367318B2 (en) * 2007-07-23 2013-02-05 Dharmacon, Inc. Screening of micro-RNA cluster inhibitor pools
CA2676113C (en) * 2007-07-25 2014-07-08 University Of Louisville Research Foundation, Inc. Exosome-associated microrna as a diagnostic marker
CN101918594A (zh) * 2007-11-30 2010-12-15 俄亥俄州立大学研究基金会 肺癌中外周血中的微rna表达特征谱和靶向

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050266552A1 (en) * 2003-12-05 2005-12-01 Doench John G Reagents and methods for identification of RNAi pathway genes and chemical modulators of RNAi

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HAN-HUA LIU等: "Microarray-based analysis of stress-regulated microRNAs in Arabidopsis thaliana", 《RNA》 *
KRUTZFELDT J等: "Silencing of microRNAs in vivo with antagomirs", 《NATURE》 *
STERGHIOS A MOSCHOS1 ET AL: "《Expression profiling in vivo demonstrates rapid changes in lung》", 《BMC GENOMICS》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108319814A (zh) * 2018-01-29 2018-07-24 中国科学院生物物理研究所 基于染色体空间相互作用预测长非编码rna生物学功能的方法
CN113593700A (zh) * 2021-08-06 2021-11-02 江苏师范大学 分析肺癌进展的方法、装置、设备、介质及程序产品
CN113593700B (zh) * 2021-08-06 2024-02-27 江苏师范大学 分析肺癌进展的方法、装置、设备、介质及程序产品

Also Published As

Publication number Publication date
EP2387617B1 (en) 2014-10-29
US20160002722A1 (en) 2016-01-07
EP2387617A1 (en) 2011-11-23
US20170058346A1 (en) 2017-03-02
EP2492357B1 (en) 2015-09-23
IL214154A0 (en) 2011-08-31
WO2010082039A1 (en) 2010-07-22
EP2492357A1 (en) 2012-08-29
JP2012514994A (ja) 2012-07-05
IL214154A (en) 2016-10-31
KR20110138341A (ko) 2011-12-27
US9074241B2 (en) 2015-07-07
SG173042A1 (en) 2011-08-29
AU2010205493A1 (en) 2011-09-08
CA2787218A1 (en) 2010-07-22
US20110312524A1 (en) 2011-12-22
SG196843A1 (en) 2014-02-13

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Application publication date: 20120215