CN102350083B - Crystallizing tank used for vincamine - Google Patents
Crystallizing tank used for vincamine Download PDFInfo
- Publication number
- CN102350083B CN102350083B CN 201110258054 CN201110258054A CN102350083B CN 102350083 B CN102350083 B CN 102350083B CN 201110258054 CN201110258054 CN 201110258054 CN 201110258054 A CN201110258054 A CN 201110258054A CN 102350083 B CN102350083 B CN 102350083B
- Authority
- CN
- China
- Prior art keywords
- tank
- tank body
- discharge port
- discharge hole
- blocking
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 title claims abstract description 24
- RXPRRQLKFXBCSJ-UHFFFAOYSA-N dl-Vincamin Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)CC(O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-UHFFFAOYSA-N 0.000 title claims abstract description 9
- 229960002726 vincamine Drugs 0.000 title claims abstract description 9
- 230000000903 blocking effect Effects 0.000 claims abstract description 10
- 238000003756 stirring Methods 0.000 claims abstract description 8
- 239000000498 cooling water Substances 0.000 claims abstract description 6
- 239000002826 coolant Substances 0.000 claims description 4
- 238000010907 mechanical stirring Methods 0.000 claims description 3
- 238000002425 crystallisation Methods 0.000 abstract description 12
- 230000008025 crystallization Effects 0.000 abstract description 12
- 239000002245 particle Substances 0.000 abstract description 3
- 238000007789 sealing Methods 0.000 abstract 1
- 238000007599 discharging Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 230000003727 cerebral blood flow Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000012452 mother liquor Substances 0.000 description 2
- JSLDLCGKZDUQSH-RTBUJCADSA-N 19-epivindolinine Natural products O=C(OC)[C@H]1[C@@]23[C@H](C)[C@]4([C@@H]5N(CC=C4)CC[C@]25c2c(N3)cccc2)C1 JSLDLCGKZDUQSH-RTBUJCADSA-N 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 206010065559 Cerebral arteriosclerosis Diseases 0.000 description 1
- 206010008088 Cerebral artery embolism Diseases 0.000 description 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 206010008132 Cerebral thrombosis Diseases 0.000 description 1
- 201000001429 Intracranial Thrombosis Diseases 0.000 description 1
- 240000001090 Papaver somniferum Species 0.000 description 1
- KILNDJCLJBOWAN-UHFFFAOYSA-N Tabersonine Natural products CCC12CC(=C3N(C)c4cc(OC)ccc4C35CCN(CC=C1)C25)C(=O)OC KILNDJCLJBOWAN-UHFFFAOYSA-N 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- PBKVEOSEPXMKDN-LZHUFOCISA-N chembl2311030 Chemical compound CS(O)(=O)=O.CS(O)(=O)=O.CS(O)(=O)=O.CS(O)(=O)=O.C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)N4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)C(C)C)C(C)C)=C3C2=CNC3=C1.C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)N4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)C(C)CC)C(C)C)=C3C2=CNC3=C1.C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)N4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)CC(C)C)C(C)C)=C3C2=CNC3=C1.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](C(N21)=O)(NC(=O)[C@H]1CN(C)[C@H]2[C@@H](C=3C=CC=C4NC=C(C=34)C2)C1)C(C)C)C1=CC=CC=C1 PBKVEOSEPXMKDN-LZHUFOCISA-N 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 201000005851 intracranial arteriosclerosis Diseases 0.000 description 1
- 201000010849 intracranial embolism Diseases 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 235000006502 papoula Nutrition 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- FNGGIPWAZSFKCN-ACRUOGEOSA-N tabersonine Chemical compound N1C2=CC=CC=C2[C@]2([C@H]34)C1=C(C(=O)OC)C[C@]3(CC)C=CCN4CC2 FNGGIPWAZSFKCN-ACRUOGEOSA-N 0.000 description 1
- FNGGIPWAZSFKCN-UHFFFAOYSA-N xi-tabersonine Natural products N1C2=CC=CC=C2C2(C34)C1=C(C(=O)OC)CC3(CC)C=CCN4CC2 FNGGIPWAZSFKCN-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Mixers Of The Rotary Stirring Type (AREA)
- Accessories For Mixers (AREA)
Abstract
The invention relates to a crystallizing tank used for vincamine, comprising a tank rack, a tank and a stirring device, wherein the tank and the stirring device are arranged on the tank rack; the tank comprises a tank body and a tank cover connected with the tank body in a sealing mode; the bottom of the tank body is provided with a discharge hole; a dump valve is arranged on the discharge hole; the tank cover is provided with a feeding hole; the circumstance of the tank body is also provided with a jacket with a cooling water inlet and a cooling water outlet; and the discharge valve comprises a valve plate and a filter plate for blocking the discharge hole. Especially, the thickness of the discharge hole is same with that of the bottom of the tank body; and the valve plate is used for blocking an annular continuous arc-shaped surface formed by parts of upper surface of the discharge hole and the inner surface of the bottom of the tank. The crystallizing tank is characterized in that the valve plate of the discharge valve is used for blocking the annular continuous arc-shaped surface formed by parts of upper surface of the discharge hole and the inner surface of the bottom of the tank without any stirring dead corner, and fine-grain crystallization with even particle diameter can be obtained.
Description
Technical field
the present invention relates to a kind of crystallizing tank, particularly a kind of Crystalizing tank for vincamine.
Background technology
pervone belongs to ivory alkene structure alkaloids, has very strong physiologically active.External concentrating studied its hypotensive activity in early days, and owing to penetrating blood-brain barrier, rear discovery is having good effect aspect hemangiectasis, increase cerebral blood flow (CBF), and on nothing impacts such as heart, blood vessel and blood pressures.Be treatment cerebral ischemia first-line drug at present, clinical indication is applicable to cerebrovascular disorder, cerebral embolism, cerebral thrombosis and hemorrhage sequelae etc.Curative effect to cerebral arteriosclerosis is stronger than hydergine and opium poppy alkali.At present, can prepare by semi-synthesizing technology by pervone, and for example open CN 102108082A is disclosed take tabersonine as raw material for Chinese invention patent, through catalytic hydrogenation, peroxidating, resets and crystallization is recrystallized and makes the method for pervone.In prior art, the final step crystallization recrystallization in the pervone preparation process is all to carry out in traditional crystallizing tank.
traditional crystallizing tank is known, it generally comprises the tank frame, be located at tank body on the tank frame, be arranged on tank body outer chuck, agitating device, wherein agitating device adopts mechanical agitation usually, agitator that specifically comprise fire-proof motor, decelerator, with decelerator, is connected etc.According to the requirement of the applied object of crystallizing tank, agitator can be for comprising rotary propeller type, turbine type, slurry formula, and anchor formula etc. are at interior various forms.For the ease of discharging, usually be provided with discharge port in the bottom of crystallizing tank, and be provided with baiting valve in the discharge port position, baiting valve has the flashboard that the discharge port of tank body is blocked, open the flashboard of baiting valve, just crystal and mother liquor can be discharged to tank body, wherein for isolation of crystalline and mother liquor, generally also be provided with filter plate on baiting valve crystal is held back.The characteristics that existing crystallizing tank also has are, under the self-discharging mouth to thering is an extension, also just in fact at the discharge port place, formed a discharging channel, at least partly the lower end of this passage being blocked of the flashboard of baiting valve, such a discharging channel has inevitably formed the stirring dead angle, the product easily gathered for this crystallization of pervone itself, such stirring dead angle has just directly caused crystalline product the crystallization bulk to occur, and can't obtain the particulate crystallization of homogeneous, had a strong impact on the quality of product.
Summary of the invention
technical problem to be solved by this invention is to overcome the deficiencies in the prior art, and a kind of Crystalizing tank for vincamine that obtains the particulate crystallization of homogeneous is provided.
for solving the problems of the technologies described above, the present invention takes following technical scheme:
a kind of Crystalizing tank for vincamine, it comprises the tank frame, be arranged on tank body and agitating device on the tank frame, described tank body comprises can body and the cover be tightly connected with can body, the bottom of described can body offers discharge port, and be provided with baiting valve in the discharge port position, cover is provided with charging aperture, also be provided with the chuck with cooling water inlet and coolant outlet in the can body periphery, described baiting valve comprises flashboard and the filter plate for blocking discharge port, particularly, the thickness of described discharge port is identical with the thickness at the end of tank body, valve plate forms continuous curved surfaces for the inner surface at the end of the upper surface of part of blocking discharge port and tank body.
according to further embodiment of the present invention: described agitating device is mechanical stirring device, and it specifically comprises fire-proof motor, decelerator and anchor agitator.
preferably, crystallizing tank also comprises that the tetrafluoro of the stirring anchor periphery that is arranged on anchor agitator scrapes wall, and tetrafluoro is scraped wall and is close on described inner tank wall.Scrape the setting of wall, can prevent from forming crystallization material film on the still inwall, on the one hand, prevent that the existence of expecting film from hindering heat transfer, on the other hand, reduce in crystallization process the loss of product.
according to the present invention, described crystallizing tank also comprises the visor hand hole that is arranged on cover, explosion-proofly looks lamp and lead to the respirator in tank body.
due to the enforcement of above technical scheme, the present invention compared with prior art has following advantage:
crystallizing tank of the present invention, the upper surface for the part of blocking discharge port of the valve plate of baiting valve and the inner surface at the end of tank body form continuous curved surfaces, without any stirring dead angle, thereby can access the particulate crystallization of uniform particle diameter.
The accompanying drawing explanation
below in conjunction with accompanying drawing and specific embodiment, the present invention will be further described in detail.
fig. 1 is for to look schematic diagram according to the master of Crystalizing tank for vincamine of the present invention;
wherein: 1, tank frame; 2, tank body; 20, can body; 200, discharge port; 21, cover; 210, charging aperture; 3, agitating device; 30, fire-proof motor; 31, decelerator; 32, anchor agitator; 4, baiting valve; 40, valve plate; 41, filter plate; 5, chuck; 50, cooling water inlet; 51, coolant outlet; 7, visor hand hole; 8, the explosion-proof lamp of looking; 9, respirator; 10, feed pipe; 12, tetrafluoro is scraped wall.
The specific embodiment
as shown in Figure 1, Crystalizing tank for vincamine according to the present embodiment, it comprises tank frame 1, is arranged on tank body 2, agitating device 3 on tank frame 1, wherein: tank body 2 comprises can body 20 and the cover 21 be tightly connected with can body 20, the bottom of described can body 20 offers discharge port 200, and be provided with baiting valve 4 in discharge port 200 positions, cover 21 is provided with charging aperture 210, also be provided with the chuck 5 with cooling water inlet 50 and coolant outlet 51 in can body 20 peripheries.
agitating device 3 adopts conventional mechanical stirring device, and it mainly comprises fire-proof motor 30, decelerator 31, anchor agitator 32.Be provided with tetrafluoro and scrape wall 12 on anchor agitator 32, tetrafluoro is scraped wall 12 and is close to the inwall of still body 20, can prevent from still body 20 inwalls forming the material film.
baiting valve 4 also adopts conventional structure, it includes flashboard 40 and filter plate 41 for blocking discharge port 200, but different from prior art is, in the present invention, do not have extension between discharge port 200 and flashboard 40, the upper surface of blocking discharge port 200 of flashboard 20 has formed continuous curved surfaces (do not show in figure, but can be easy to imagination and understand) together with the inner surface at the end of kettle 2, make in whole tank body, there is no dead angle fully.So, effectively avoided the generation of crystallization bulk and obtained the pervone particulate crystallization of uniform particle diameter.
above the present invention is described in detail; its purpose is to allow the personage who is familiar with this art can understand content of the present invention and be implemented; can not limit the scope of the invention with this; the equivalence that all Spirit Essences according to the present invention are done changes or modifies, and all should be encompassed in protection scope of the present invention.
Claims (1)
1. a Crystalizing tank for vincamine, it comprises tank frame (1), be arranged on tank body (2) and agitating device (3) on described tank frame (1), described tank body (2) comprises can body (20) and the cover (21) be tightly connected with can body (20), the bottom of described can body (20) offers discharge port (200), and be provided with baiting valve (4) in described discharge port (200) position, described cover (21) is provided with charging aperture (210), also be provided with the chuck (5) with cooling water inlet (50) and coolant outlet (51) in described can body (20) periphery, described baiting valve (4) comprises flashboard (40) and the filter plate (41) for blocking described discharge port (200), it is characterized in that: the thickness of described discharge port (200) is identical with the thickness at the end of tank body (2), the inner surface at the upper surface for the part of blocking described discharge port (200) of described flashboard (40) and the end of described tank body (2) forms continuous curved surfaces, described agitating device (3) is mechanical stirring device, it comprises fire-proof motor (30), decelerator (31) and anchor agitator (32), stirring anchor (320) periphery of described anchor agitator (32) is provided with tetrafluoro and scrapes wall (12), and described tetrafluoro is scraped wall (12) and is close on described tank body (2) inwall, visor hand hole (7) on described cover (21), explosion-proofly look lamp (8) and lead to the respirator (9) in described tank body (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110258054 CN102350083B (en) | 2011-09-02 | 2011-09-02 | Crystallizing tank used for vincamine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110258054 CN102350083B (en) | 2011-09-02 | 2011-09-02 | Crystallizing tank used for vincamine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102350083A CN102350083A (en) | 2012-02-15 |
| CN102350083B true CN102350083B (en) | 2013-01-09 |
Family
ID=45573794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110258054 Expired - Fee Related CN102350083B (en) | 2011-09-02 | 2011-09-02 | Crystallizing tank used for vincamine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102350083B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281775A (en) * | 2017-08-16 | 2017-10-24 | 广东海翔教育科技有限公司 | A kind of energy-conserving and environment-protective crystallizing tank |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2231123Y (en) * | 1995-08-11 | 1996-07-17 | 北京化工大学 | Crystal separater |
| JP2003236303A (en) * | 2002-02-13 | 2003-08-26 | Konica Corp | Concentrating crystallization apparatus |
| CN201410307Y (en) * | 2009-03-23 | 2010-02-24 | 烟台招金励福贵金属股份有限公司 | crystallization kettle |
-
2011
- 2011-09-02 CN CN 201110258054 patent/CN102350083B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2231123Y (en) * | 1995-08-11 | 1996-07-17 | 北京化工大学 | Crystal separater |
| JP2003236303A (en) * | 2002-02-13 | 2003-08-26 | Konica Corp | Concentrating crystallization apparatus |
| CN201410307Y (en) * | 2009-03-23 | 2010-02-24 | 烟台招金励福贵金属股份有限公司 | crystallization kettle |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102350083A (en) | 2012-02-15 |
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Effective date of registration: 20161012 Address after: Qingdao Road South Chemical Industrial Park Industry in Wuyang County of Luohe City, Henan province 462400 area Patentee after: WUYANG WEISEN BIOMEDICAL CO.,LTD. Address before: 3, building 7, building D, No. 215634, Guangdong Road, Zhangjiagang Free Trade Zone, Suzhou, Jiangsu Patentee before: JIANGSU SWELLXIN BIO-PHARM. Pty Ltd. |
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Denomination of invention: Crystallizing tank used for vincamine Effective date of registration: 20171026 Granted publication date: 20130109 Pledgee: Bank of China Limited by Share Ltd. Luohe branch Pledgor: WUYANG WEISEN BIOMEDICAL CO.,LTD. Registration number: 2017990000990 |
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Date of cancellation: 20181113 Granted publication date: 20130109 Pledgee: Bank of China Limited by Share Ltd. Luohe branch Pledgor: WUYANG WEISEN BIOMEDICAL CO.,LTD. Registration number: 2017990000990 |
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Denomination of invention: Crystallizing tank used for vincamine Effective date of registration: 20181120 Granted publication date: 20130109 Pledgee: Bank of China Limited by Share Ltd. Luohe branch Pledgor: WUYANG WEISEN BIOMEDICAL CO.,LTD. Registration number: 2018990001068 |
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Denomination of invention: Crystallizing tank used for vincamine Effective date of registration: 20191111 Granted publication date: 20130109 Pledgee: Bank of China Limited by Share Ltd. Luohe branch Pledgor: WUYANG WEISEN BIOMEDICAL CO.,LTD. Registration number: Y2019990000500 |
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Denomination of invention: A crystallizer for vinblastine Effective date of registration: 20201210 Granted publication date: 20130109 Pledgee: Bank of China Limited by Share Ltd. Luohe branch Pledgor: WUYANG WEISEN BIOMEDICAL Co.,Ltd. Registration number: Y2020980009103 |
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Denomination of invention: Crystallization tank for vinblastine Effective date of registration: 20211129 Granted publication date: 20130109 Pledgee: Bank of China Limited by Share Ltd. Luohe branch Pledgor: WUYANG WEISEN BIOMEDICAL CO.,LTD. Registration number: Y2021980013477 |
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