CN202199159U - Crystalizing tank for vincamine - Google Patents
Crystalizing tank for vincamine Download PDFInfo
- Publication number
- CN202199159U CN202199159U CN2011203275525U CN201120327552U CN202199159U CN 202199159 U CN202199159 U CN 202199159U CN 2011203275525 U CN2011203275525 U CN 2011203275525U CN 201120327552 U CN201120327552 U CN 201120327552U CN 202199159 U CN202199159 U CN 202199159U
- Authority
- CN
- China
- Prior art keywords
- tank
- tank body
- discharge port
- pervone
- crystallizing tank
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 title claims abstract description 22
- RXPRRQLKFXBCSJ-UHFFFAOYSA-N dl-Vincamin Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)CC(O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-UHFFFAOYSA-N 0.000 title abstract 3
- 229960002726 vincamine Drugs 0.000 title abstract 3
- 238000003756 stirring Methods 0.000 claims abstract description 7
- 239000000498 cooling water Substances 0.000 claims abstract description 6
- 239000002826 coolant Substances 0.000 claims description 4
- 238000010907 mechanical stirring Methods 0.000 claims description 3
- 230000000903 blocking effect Effects 0.000 abstract description 4
- 239000002245 particle Substances 0.000 abstract description 3
- 238000002425 crystallisation Methods 0.000 description 11
- 230000008025 crystallization Effects 0.000 description 11
- 238000005516 engineering process Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000007664 blowing Methods 0.000 description 2
- 230000003727 cerebral blood flow Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000012452 mother liquor Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- JSLDLCGKZDUQSH-RTBUJCADSA-N 19-epivindolinine Natural products O=C(OC)[C@H]1[C@@]23[C@H](C)[C@]4([C@@H]5N(CC=C4)CC[C@]25c2c(N3)cccc2)C1 JSLDLCGKZDUQSH-RTBUJCADSA-N 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 206010065559 Cerebral arteriosclerosis Diseases 0.000 description 1
- 206010008088 Cerebral artery embolism Diseases 0.000 description 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 206010008132 Cerebral thrombosis Diseases 0.000 description 1
- 201000001429 Intracranial Thrombosis Diseases 0.000 description 1
- 240000001090 Papaver somniferum Species 0.000 description 1
- KILNDJCLJBOWAN-UHFFFAOYSA-N Tabersonine Natural products CCC12CC(=C3N(C)c4cc(OC)ccc4C35CCN(CC=C1)C25)C(=O)OC KILNDJCLJBOWAN-UHFFFAOYSA-N 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- PBKVEOSEPXMKDN-LZHUFOCISA-N chembl2311030 Chemical compound CS(O)(=O)=O.CS(O)(=O)=O.CS(O)(=O)=O.CS(O)(=O)=O.C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)N4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)C(C)C)C(C)C)=C3C2=CNC3=C1.C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)N4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)C(C)CC)C(C)C)=C3C2=CNC3=C1.C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)N4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)CC(C)C)C(C)C)=C3C2=CNC3=C1.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](C(N21)=O)(NC(=O)[C@H]1CN(C)[C@H]2[C@@H](C=3C=CC=C4NC=C(C=34)C2)C1)C(C)C)C1=CC=CC=C1 PBKVEOSEPXMKDN-LZHUFOCISA-N 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 201000005851 intracranial arteriosclerosis Diseases 0.000 description 1
- 201000010849 intracranial embolism Diseases 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 235000006502 papoula Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- FNGGIPWAZSFKCN-ACRUOGEOSA-N tabersonine Chemical compound N1C2=CC=CC=C2[C@]2([C@H]34)C1=C(C(=O)OC)C[C@]3(CC)C=CCN4CC2 FNGGIPWAZSFKCN-ACRUOGEOSA-N 0.000 description 1
- FNGGIPWAZSFKCN-UHFFFAOYSA-N xi-tabersonine Natural products N1C2=CC=CC=C2C2(C34)C1=C(C(=O)OC)CC3(CC)C=CCN4CC2 FNGGIPWAZSFKCN-UHFFFAOYSA-N 0.000 description 1
Images
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- Mixers Of The Rotary Stirring Type (AREA)
Abstract
The utility model relates to a crystalizing tank for vincamine, which comprises a tank holder, a tank arranged on the tank holder and a stirring device. The tank comprises a tank body and a tank cover hermetically connected with the tank body, a discharge outlet is arranged at the bottom of the tank body, a discharge valve is arranged at the discharge outlet, a feed inlet is arranged on the tank cover, a jacket with a cooling water inlet and a cooling water outlet is arranged on the periphery of the tank body, the discharge valve comprises a disc and a filter plate, and the disc is used for blocking the discharge outlet. The crystalizing tank for vincamine is characterized in that the thickness of the discharge outlet is equal to that of the bottom of the tank and the upper surface of the disc used for blocking the discharge outlet and the inner surface of the bottom of the tank form a continuously curved surface. Since the upper surface of the disc used for blocking the discharge outlet and the inner surface of the bottom of the tank body form the continuously curved surface, dead angle in stirring is avoided, and fine crystalline particles uniform in diameter can be generated finally.
Description
Technical field
< b TranNum=" 73 ">the utility model relates to a kind of crystallizing tank, and particularly a kind of pervone is used crystallizing tank.</b>
Background technology
< b TranNum=" 76 ">pervone belongs to ivory alkene structure alkaloids, has very strong physiologically active.Early stage external concentrated its hypotensive activity of research, owing to can penetrate blood-brain barrier, the back finds aspect hemangiectasis, the increase cerebral blood flow (CBF) good effect is being arranged, and heart, blood vessel and blood pressure etc. are not had influence.Be treatment cerebral ischemia one line medicine at present, clinical indication is applicable to cerebrovascular disorder, cerebral embolism, cerebral thrombosis and hemorrhage sequelae etc.Curative effect to cerebral arteriosclerosis is stronger than hydergine and opium poppy alkali.At present, pervone can be through the semi-synthesizing technology preparation, and for example the open CN 102108082A of Chinese invention patent is disclosed is raw material with the tabersonine, and through catalytic hydrogenation, peroxidating, rearrangement and crystallization recrystallization make the method for pervone.In the prior art, the final step crystallization recrystallization that pervone prepares in the process all is in traditional crystallizing tank, to carry out.</b>
< b TranNum=" 78 ">traditional crystallizing tank is known; Comprise a jar frame as the one of which, be located at tank body on jar frame, be arranged on tank body outer chuck, agitating device; Wherein agitating device adopts mechanical agitation usually, agitator that specifically comprise fire-proof motor, decelerator, links to each other with decelerator etc.According to the requirement of the applied object of crystallizing tank, agitator can be for comprising rotary propeller type, turbine type, slurry formula, and anchor formula etc. are at interior various forms.For the ease of discharging; Usually be provided with discharge port in the bottom of crystallizing tank, and be provided with baiting valve in the discharge port position, baiting valve has the flashboard that the discharge port of tank body is blocked; Open the flashboard of baiting valve; Just can crystal and mother liquor be discharged tank body,, generally also be provided with filter plate on the baiting valve crystal is held back wherein for isolation of crystalline and mother liquor.The characteristics that existing crystallizing tank also has are; Under discharge port to having an extension; Also just in fact formed a blowing passage at the discharge port place, the part at least of the flashboard of baiting valve is blocked the lower end of this passage, and a such blowing passage has constituted the stirring dead angle inevitably; The product that gathers easily for this crystallization of pervone itself; Such stirring dead angle has just directly caused crystalline product the crystallization bulk to occur, and can't obtain the particulate crystallization of homogeneous, has had a strong impact on the quality of product.</b>
Summary of the invention
< b TranNum=" 81 ">the utility model technical problem to be solved is the deficiency that overcomes prior art, provides a kind of pervone that obtains the particulate crystallization of homogeneous to use crystallizing tank.</b>
For solving the problems of the technologies described above, the utility model is taked following technical scheme:
< b TranNum=" 85 ">a kind of pervone is used crystallizing tank, and it comprises a jar frame, is arranged on tank body and agitating device on jar frame, and said tank body comprises can body and the cover that is tightly connected with can body; The bottom of said can body offers discharge port; And be provided with baiting valve in the discharge port position, cover is provided with charging aperture, also is provided with the chuck with cooling water inlet and coolant outlet in the can body periphery; Said baiting valve comprises flashboard and the filter plate that is used to block discharge port; Particularly, the thickness at the thickness of described discharge port and the end of tank body is identical, and the inner surface at the end of upper surface and tank body that valve plate is used to block the part of discharge port constitutes continuous curved surfaces.</b>
< b TranNum=" 87 ">are according to the further embodiment of the utility model: described agitating device is a mechanical stirring device, and it specifically comprises fire-proof motor, decelerator and anchor agitator.</b>
< b TranNum=" 89 ">preferably, crystallizing tank comprises that also the tetrafluoro of the stirring anchor periphery that is arranged on anchor agitator scrapes wall, and tetrafluoro is scraped wall and is close on the said inner tank wall.Scrape the setting of wall, can prevent on the still inwall, to form crystallization material film, on the one hand, prevent that the existence of expecting film from hindering heat transfer, on the other hand, reduce in the crystallization process product losses.</b>
< b TranNum=" 91 ">according to the utility model, and described crystallizing tank also comprises the visor hand hole that is arranged on the cover, explosion-proofly looks lamp and lead to the respirator in the tank body.</b>
Because the enforcement of above technical scheme, the utility model compared with prior art has following advantage:
The crystallizing tank of < b TranNum=" 95 ">the utility model; The inner surface at the end of upper surface and tank body that being used to of the valve plate of baiting valve blocked the part of discharge port constitutes continuous curved surfaces; Do not have any stirring dead angle, thereby can access the particulate crystallization of uniform particle diameter.</b>
Description of drawings
< b TranNum=" 98 ">are done further detailed explanation below in conjunction with accompanying drawing and concrete embodiment to the utility model.</b>
Fig. 1 is for looking sketch map according to the pervone of the utility model with the master of crystallizing tank;
< b TranNum=" 102 ">wherein: 1, jar frame; 2, tank body; 20, can body; 200, discharge port; 21, cover; 210, charging aperture; 3, agitating device; 30, fire-proof motor; 31, decelerator; 32, anchor agitator; 4, baiting valve; 40, valve plate; 41, filter plate; 5, chuck; 50, cooling water inlet; 51, coolant outlet; 7, visor hand hole; 8, the explosion-proof lamp of looking; 9, respirator; 10, feed pipe; 12, tetrafluoro is scraped wall.</b>
The specific embodiment
< b TranNum=" 105 ">are as shown in Figure 1; Pervone according to present embodiment is used crystallizing tank, and it comprises jar frame 1, is arranged on tank body 2, agitating device 3 on jar frame 1, and wherein: tank body 2 comprises can body 20 and the cover 21 that is tightly connected with can body 20; The bottom of said can body 20 offers discharge port 200; And be provided with baiting valve 4 in discharge port 200 positions, cover 21 is provided with charging aperture 210, also is provided with the chuck 5 with cooling water inlet 50 and coolant outlet 51 in can body 20 peripheries.</b>
< b TranNum=" 107 ">agitating device 3 adopts conventional mechanical stirring device, and it mainly comprises fire-proof motor 30, decelerator 31, anchor agitator 32.Anchor agitator 32 is provided with tetrafluoro and scrapes wall 12, and tetrafluoro is scraped wall 12 and is close to the inwall of still body 20, can prevent to form on still body 20 inwalls material film.</b>
< b TranNum=" 109 ">baiting valve 4 also adopts conventional structure; It includes the flashboard 40 and filter plate 41 that is used to block discharge port 200; But different with prior art is in the utility model, not have the extension between discharge port 200 and the flashboard 40; The upper surface of blocking discharge port 200 of flashboard 20 has constituted (the not demonstration among the figure of continuous curved surfaces with the inner surface at the end of kettle 2; But can be easy to imagination and understanding), making does not have the dead angle fully in whole tank body.So, effectively avoid the generation of crystallization bulk and obtained the pervone particulate crystallization of uniform particle diameter.</b>
More than the utility model has been done detailed description; Its purpose is to let the personage that is familiar with this art can understand the content of the utility model and implements; Can not limit the protection domain of the utility model with this; All equivalences of doing according to the spirit of the utility model change or modify, and all should be encompassed in the protection domain of the utility model
Claims (4)
1. a pervone is used crystallizing tank; It comprises a jar frame (1), is arranged on tank body (2) and agitating device (3) on the said jar of frame (1); Said tank body (2) comprises can body (20) and the cover (21) that is tightly connected with can body (20); The bottom of said can body (20) offers discharge port (200); And be provided with baiting valve (4) in said discharge port (200) position; Said cover (21) is provided with charging aperture (210), also is provided with the chuck (5) with cooling water inlet (50) and coolant outlet (51) in said can body (20) periphery, and said baiting valve (4) comprises flashboard (40) and the filter plate (41) that is used to block said discharge port (200); It is characterized in that: the thickness at the thickness of described discharge port (200) and the end of tank body (2) is identical, and the inner surface at the end of upper surface and described tank body (2) that being used to of described valve plate (40) blocked the part of described discharge port (200) constitutes continuous curved surfaces.
2. pervone according to claim 1 is used crystallizing tank, it is characterized in that: described agitating device (3) is a mechanical stirring device, and it comprises fire-proof motor (30), decelerator (31) and anchor agitator (32).
3. pervone according to claim 2 is used crystallizing tank; It is characterized in that: described crystallizing tank comprises that also the tetrafluoro of stirring anchor (320) periphery that is arranged on said anchor agitator (32) scrapes wall (12), and described tetrafluoro is scraped wall (12) and is close on said tank body (2) inwall.
4. pervone according to claim 1 is used crystallizing tank, it is characterized in that: described crystallizing tank also comprises the visor hand hole (7) that is arranged on the said cover (21), explosion-proofly looks lamp (8) and lead to the respirator (9) in the said tank body (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011203275525U CN202199159U (en) | 2011-09-02 | 2011-09-02 | Crystalizing tank for vincamine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011203275525U CN202199159U (en) | 2011-09-02 | 2011-09-02 | Crystalizing tank for vincamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202199159U true CN202199159U (en) | 2012-04-25 |
Family
ID=45963297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011203275525U Expired - Lifetime CN202199159U (en) | 2011-09-02 | 2011-09-02 | Crystalizing tank for vincamine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202199159U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115531908A (en) * | 2022-09-06 | 2022-12-30 | 广东邦普循环科技有限公司 | Device for extracting lithium carbonate from salt lake brine |
-
2011
- 2011-09-02 CN CN2011203275525U patent/CN202199159U/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115531908A (en) * | 2022-09-06 | 2022-12-30 | 广东邦普循环科技有限公司 | Device for extracting lithium carbonate from salt lake brine |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20161012 Address after: Qingdao Road South Chemical Industrial Park Industry in Wuyang County of Luohe City, Henan province 462400 area Patentee after: Wuyang lelexin Biological Medicine Co Ltd Address before: 3, building 7, building D, No. 215634, Guangdong Road, Zhangjiagang Free Trade Zone, Suzhou, Jiangsu Patentee before: Jiangsu Swithin Biological Medicine Engineering Research Center Co., Ltd. |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: Crystallizing tank used for vincamine Effective date of registration: 20171026 Granted publication date: 20120425 Pledgee: Bank of China Limited by Share Ltd Luohe branch Pledgor: Wuyang lelexin Biological Medicine Co Ltd Registration number: 2017990000990 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20181113 Granted publication date: 20120425 Pledgee: Bank of China Limited by Share Ltd Luohe branch Pledgor: Wuyang lelexin Biological Medicine Co Ltd Registration number: 2017990000990 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: Crystallizing tank used for vincamine Effective date of registration: 20181120 Granted publication date: 20120425 Pledgee: Bank of China Limited by Share Ltd Luohe branch Pledgor: Wuyang lelexin Biological Medicine Co Ltd Registration number: 2018990001068 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20191105 Granted publication date: 20120425 Pledgee: Bank of China Limited by Share Ltd Luohe branch Pledgor: Wuyang lelexin Biological Medicine Co Ltd Registration number: 2018990001068 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| CX01 | Expiry of patent term |
Granted publication date: 20120425 |
|
| CX01 | Expiry of patent term |