CN102343066B - Medicinal composition for treating hyperosteogeny and preparation method thereof - Google Patents
Medicinal composition for treating hyperosteogeny and preparation method thereof Download PDFInfo
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- CN102343066B CN102343066B CN2010102411221A CN201010241122A CN102343066B CN 102343066 B CN102343066 B CN 102343066B CN 2010102411221 A CN2010102411221 A CN 2010102411221A CN 201010241122 A CN201010241122 A CN 201010241122A CN 102343066 B CN102343066 B CN 102343066B
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Abstract
The invention discloses a medicinal composition for treating hyperosteogeny. The medicinal composition comprises medicaments of long-noded pit viper, incised notopterygium rhizome, white mustard seed, asafoetida, toad venom, epimedium herb, dragon's blood, erycibe obtusifolia, turmeric, monkshood and the like. The medicinal composition is prepared into clinically acceptable black plaster, emplastrum, ointment, liniment, powder or spray by adding the conventional auxiliary materials according to the conventional process. The medicinal composition has the effects of dispelling wind-evil and clearing away cold, tonifying kidney and strengthening bone, activating blood circulation to dissipate blood stasis, relaxing tendons and activating collaterals, and softening hardness and eliminating swelling, and has an obvious curative effect on both pain and edema caused by various types of hyperosteogeny.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly a kind of pharmaceutical composition for the treatment of hyperosteogeny and preparation method thereof.
Background technology
Bone matrix hyperplasia, the traditional Chinese medical science are thought, belong to the impediment syndrome category, and be relevant with factors such as wound, strain, obstruction of collaterals by blood stasis, the damp that is affected by the cold; catch cold; contract a cold, phlegm resistance, caused by liver and kidney deficiency.Since insufficiency of vital energy and blood, caused by liver and kidney deficiency, wind-cold damp pathogen is invaded bone network or tumbling down sprain and contusion, trauma bone network, so that stagnation of QI-blood, and operation is lost smooth, stagnation of QI and blood may bring about pain." kidney controlling essence storage, main bone is given birth to marrow ", if then body is strong for the kidney essense abundance, skeleton profile and internal structure are normal, and can endure hardships and involve general trauma.And " liver storing blood, the sharp joint of main muscle Shugu ", then the muscle arteries and veins is powerful for the liver blood abundance, quiet all bones, the bone marrow of supplementing nutrition protected; Moving then retrain all bones, exempt to cause over-activity, prevent dislocation.If deficiency of kidney-essence, deficiency of liver-blood, then development of bone marrow is unusual, and more double muscles is not hard, flourish foster weary source, both unable protection bone marrow, the bone marrow of supplementing nutrition can not retrain all bones again, prevented dislocation.
Hyperosteogeny is a kind of ancient disease, is a kind of pertinacious disease that is difficult to cure.Hyperosteogeny and articular degeneration can cause is invaded joint instability, the narrow or fissure of displacement; Can stimulation, pressuring nerve and blood vessel, can rub, stimulate that synovium of joint oozes out, edema, fine hair hypertrophy thicken, unsmooth etc.; Perhaps cause bone system on every side fibrous tissue inflammatory edema, agglomerate adhesion or calcification etc.; Perhaps cause disc tissue bulging, outstanding, cartilage comes off, the bone trabecula fracture, subside, even B﹠J distortion, dislocation etc., thereby the clinical symptoms such as generation pain.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition for the treatment of hyperosteogeny and preparation method thereof.
The present invention is achieved through the following technical solutions:
The crude drug of pharmaceutical composition of the present invention consists of:
Agkistrodon 10-30 weight portion Rhizoma Et Radix Notopterygii 10-30 weight portion Semen Sinapis Albae 10-30 weight portion
Resina Ferulae 5-15 weight portion Venenum Bufonis 3-8 weight portion Herba Epimedii 10-30 weight portion
Sanguis Draxonis 10-30 weight portion Caulis Erycibes 10-30 weight portion Rhizoma Curcumae Longae 15-45 weight portion
Radix Aconiti 15-45 weight portion.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Agkistrodon 20 weight portion Rhizoma Et Radix Notopterygiis 20 weight portion Semen Sinapis Albaes 20 weight portions
Resina Ferulae 10 weight portion Venenum Bufoniss 5 weight portion Herba Epimedii 20 weight portions
Sanguis Draxonis 20 weight portion Caulis Erycibess 20 weight portion Rhizoma Curcumae Longaes 30 weight portions
Radix Aconiti 30 weight portions.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Agkistrodon 28 weight portion Rhizoma Et Radix Notopterygiis 12 weight portion Semen Sinapis Albaes 28 weight portions
Resina Ferulae 7 weight portion Venenum Bufoniss 7 weight portion Herba Epimedii 12 weight portions
Sanguis Draxonis 28 weight portion Caulis Erycibess 12 weight portion Rhizoma Curcumae Longaes 42 weight portions
Radix Aconiti 18 weight portions.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Agkistrodon 12 weight portion Rhizoma Et Radix Notopterygiis 28 weight portion Semen Sinapis Albaes 12 weight portions
Resina Ferulae 13 weight portion Venenum Bufoniss 4 weight portion Herba Epimedii 28 weight portions
Sanguis Draxonis 12 weight portion Caulis Erycibess 28 weight portions, Rhizoma Curcumae Longae 18 weight portions
Radix Aconiti 42 weight portions.
Get pharmaceutical composition crude drug of the present invention, make black plaster, emplastrum, ointment, liniment, powder or spray according to the conventional adjuvant that common process adds pharmaceutically.
Pharmaceutical composition of the present invention has expelling wind and cold, invigorating the kidney and strengthening the bones, and blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, the effect of softening hardness and disperse swelling, the pain, the edema that cause for various hyperosteogenys all have significant curative effect.
Following experimental example and embodiment are used for further specifying but are not limited to the present invention.
Experimental example:
1, clinical data
Clinical treatment hyperosteogeny case 300 examples of the present invention, male 130 examples wherein, women 170 examples the oldest 63 years old, minimum 22 years old, obtain promising result.
2, preparation method:
Prescription:
Agkistrodon 20kg Rhizoma Et Radix Notopterygii 20kg Semen Sinapis Albae 20kg
Resina Ferulae 10kg Venenum Bufonis 5kg Herba Epimedii 20kg
Sanguis Draxonis 20kg Caulis Erycibes 20kg, Rhizoma Curcumae Longae 30kg
Radix Aconiti 30kg;
Said medicine is made black plaster according to the conventional adjuvant that common process adds pharmaceutically, every plaster 26 grams.
Usage: heat a little, stick in the part, every plaster ten days as not healing, is had a rest and is pasted two days later again, and usage is the same.
Contraindication: usefulness is avoided in local skin ulcer or infection.
3, diagnostic criteria, criterion of therapeutical effect:
Diagnosis and treatment standard with reference to the Chinese medicine industry standard disease Standardization of diagnosis and curative effect ZY/T001.1-94 of People's Republic of China (PRC) file is fixed as follows:
Cure: arthralgia disappears, and it is normal that movable function recovers, and lab testing is normal
Produce effects: arthralgia, swelling alleviate, and movable function is clearly better.
Effectively: arthralgia and swelling make moderate progress.
Invalid: symptom is without improvement.
4, model case:
Case 1: patient: the woman, 44 years old, from Xiangyang, a workman.
First visit on February 12.
Symptom:
Unfavorable 8 months of cervicodynia, activity, aggravation in nearly 2 months, the right side aching of the shoulder and arm, food, middle finger numbness have the ant row to feel; Head layback or to the right during flex, have electric shock sample string picotement from the neck root to the right shoulder arm transmission; When carrying shoulder, receipts arm, elbow in the wrong, upper limb is aching and tired to be alleviated with numbness.Premorbid is without obvious trauma history.Incidence is gently bent left forward, and there are tenderness and radiating pain in transverse process point front lower place, cervical vertebra 6～7 right side; The intervertebral foramina compression test is positive, and the brachial plexus distraction test is positive; Finger is cool, and onyx is simple and unadorned, thin white fur of tongue, deep,thready and forceless pulse.X takes the photograph sheet prompting cervical vertebrae physiological lordosis radian and straightens, and neck 6～7 uncovertebral joints have the bony spur hypertrophy, and intervertebral foramina is slightly narrow and small.
Analyze:
Be diagnosed as cervical spondylotic radiculopathy.Card belongs to kidney yang deficiency, asthenia of essence and blood, and muscles and bones mistake is supported; In addition Cold-dampness, the vim and vigour discord, meridians lose in unobstructed.
Treatment:
Tonifying kidney-yin, benefiting essence-blood are held concurrently and are dredged governor vessel.
Give the Drug therapy of the embodiment of the invention 1, after 1 week, brace up, dizziness alleviates, and all diseases alleviate; Continuous took for 1 week, neck, shoulder, arm and numbness of the fingers obviously alleviate.March 20 began for the 2nd course for the treatment of, the two weeks of taking medicine, and the symptom complete obiteration, cervical vertebra moving is good, and x-ray is taken the photograph the sheet check and is shown that cervical vertebrae physiological curve recovers normal.August 10 visited, and resumed work, without any discomfort.
Case 2: name: right * sex: woman's age: 46 years old native place: people from Feidong County.
Came my institute's treatment on August 28th, 2008.
Symptom: be afraid of cold easy catching a cold.Diet is not good enough, day dizzy dim eyesight, insomnia and dreamful sleep is sent out and is waked from a dream with a start, the extremity pain, paralysis, the refreshing pain of lumbar vertebra hyperosteogeny compressing, when bending over to stand up pain very, waist arm thigh rear side difference pain, medical history 3 years.
Analyze: QI and blood is poor, and Liver and kidney is weak, liver governing tendons, and kidney governing bones, deficiency of the kidney marrow ravine profit bone makes hyperosteogeny.
Smelting is treated: the strengthening the spleen and stomach that fills blood, and tranquilizing mind, the smart marrow of mending of benefit, soothing the channels and quicking the network vessels is changed hypertrophy, treating both the principal and secondary aspects of a disease.
Give the Drug therapy of the embodiment of the invention 2, after the week, the dizziness and blurred vision transference cure, continual cure patient's two courses for the treatment of pain symptom of standing up obviously disappears, and 3 courses for the treatment of of follow-up after treatment, indices has recovered normal on inspection.
Case 3: name: Xiao * *, sex: woman's age: 46 years old native place: Wan'an County kiln hood town.
Came my institute's treatment on May 26th, 2008.
Symptom:
Diet is not good enough, day dizzy dim eyesight, insomnia and dreamful sleep is sent out and is waked from a dream with a start, the extremity pain, paralysis, the refreshing pain of lumbar vertebra hyperosteogeny compressing, when bending over to stand up pain very, waist arm thigh rear side difference pain, medical history 6 years.
Analyze: caused by liver and kidney deficiency, liver governing tendons, kidney governing bones, deficiency of the kidney marrow ravine profit bone makes hyperosteogeny.
Smelting is treated: liver and kidney tonifying, soothing the channels and quicking the network vessels is changed hypertrophy.
Give the Drug therapy of the embodiment of the invention 3 after the week, dizzy, insomnia and dreamful sleep obviously alleviate etc. symptom, and the extremity symptom alleviates to some extent.The various symptoms of continual cure patient's 4 courses for the treatment of all disappear.
Case 4: name: Dong * *; Sex: woman; Age: 41 years old; Address: students in Fangshan District of Beijing Shilou County township's farming.
First visit on July 24 in 2003
Symptom:
Lumbago companion left lower extremity fiber crops pain 3 years increased the weight of 6 months, companion left side lower limb pain, and numbness, existing waist limitation of activity can not walk on their own, and left side lower limb pain numbness is carrying out property and increases the weight of.The dark tenderness in vertebral body left side is radial, the waist percussion pain, and left side gluteus maximus tenderness, left vertical leg improves test (25 °).
Analyze: deficiency of kidney-essence, deficiency of liver-blood, muscles are not hard, flourish foster weary source.
Treatment: liver and kidney tonifying, the meridian dredging.
Give 2 week of Drug therapy of the embodiment of the invention 6, patient's readme above-mentioned symptom is clearly better, and 4 courses for the treatment of of continual cure, patient's waist and left lower extremity be without sense of discomfort, and movable all are normal.
5, therapeutic outcome:
| Group | The treatment number | Cure | Produce effects | Effectively | Invalid | Total effective rate |
| Treatment group | 300 | 114 | 123 | 45 | 28 | 94％ |
| Matched group | 300 | 86 | 102 | 46 | 66 | 78％ |
Annotate: treatment group is made plaster by oneself with us and is treated three courses for the treatment of (10 days each courses for the treatment of), and matched group is treated three courses for the treatment of with common plaster.
The present invention treats 300 routine patient's curative effect statistics: cure 114 examples, produce effects: 123 examples, and effective 45 examples, invalid 28 examples, total effective rate 94%, invalid: 28 examples account for 6%.
Following embodiment all can realize the described effect of above-mentioned experimental example
The specific embodiment
Embodiment 1: black plaster
Agkistrodon 20kg Rhizoma Et Radix Notopterygii 20kg Semen Sinapis Albae 20kg
Resina Ferulae 10kg Venenum Bufonis 5kg Herba Epimedii 20kg
Sanguis Draxonis 20kg Caulis Erycibes 20kg, Rhizoma Curcumae Longae 30kg
Radix Aconiti 30kg;
Said medicine is made black plaster according to the conventional adjuvant that common process adds pharmaceutically, every plaster 26 grams.
Usage: heat a little, stick in the part, every plaster ten days as not healing, is had a rest and is pasted two days later again, and usage is the same.
Contraindication: usefulness is avoided in local skin ulcer or infection.
Embodiment 2: ointment
Agkistrodon 28kg Rhizoma Et Radix Notopterygii 12kg Semen Sinapis Albae 28kg
Resina Ferulae 7kg Venenum Bufonis 7kg Herba Epimedii 12kg
Sanguis Draxonis 28kg Caulis Erycibes 12kg Rhizoma Curcumae Longae 42kg
Radix Aconiti 18kg;
Said medicine routinely technique adds conventional adjuvant and makes ointment.
Embodiment 3: liniment
Agkistrodon 12kg Rhizoma Et Radix Notopterygii 28kg Semen Sinapis Albae 12kg
Resina Ferulae 13kg Venenum Bufonis 4kg Herba Epimedii 28kg
Sanguis Draxonis 12kg Caulis Erycibes 28kg, Rhizoma Curcumae Longae 18kg
Radix Aconiti 42kg;
Said medicine routinely technique adds conventional adjuvant and makes liniment.
Embodiment 4: powder
Agkistrodon 28kg Rhizoma Et Radix Notopterygii 12kg Semen Sinapis Albae 28kg
Resina Ferulae 7kg Venenum Bufonis 7kg Herba Epimedii 12kg
Sanguis Draxonis 28kg Caulis Erycibes 12kg Rhizoma Curcumae Longae 42kg
Radix Aconiti 18kg;
Said medicine routinely technique adds conventional adjuvant and makes powder.
Embodiment 5: spray
Agkistrodon 20kg Rhizoma Et Radix Notopterygii 20kg Semen Sinapis Albae 20kg
Resina Ferulae 10kg Venenum Bufonis 5kg Herba Epimedii 20kg
Sanguis Draxonis 20kg Caulis Erycibes 20kg, Rhizoma Curcumae Longae 30kg
Radix Aconiti 30kg;
Said medicine routinely technique adds conventional adjuvant and makes spray.
Embodiment 6: emplastrum
Agkistrodon 12kg Rhizoma Et Radix Notopterygii 28kg Semen Sinapis Albae 12kg
Resina Ferulae 13kg Venenum Bufonis 4kg Herba Epimedii 28kg
Sanguis Draxonis 12kg Caulis Erycibes 28kg, Rhizoma Curcumae Longae 18kg
Radix Aconiti 42kg;
Said medicine is made black plaster according to the conventional adjuvant that common process adds pharmaceutically, every plaster 26 grams.
Usage: heat a little, stick in the part, every plaster ten days as not healing, is had a rest and is pasted two days later again, and usage is the same.
Contraindication: usefulness is avoided in local skin ulcer or infection.
Claims (8)
1. pharmaceutical composition for the treatment of hyperosteogeny is characterized in that the crude drug of this pharmaceutical composition consists of:
2. pharmaceutical composition for the treatment of hyperosteogeny is characterized in that the crude drug of this pharmaceutical composition consists of:
3. pharmaceutical composition for the treatment of hyperosteogeny is characterized in that the crude drug of this pharmaceutical composition consists of:
4. arbitrary described pharmaceutical composition according to claim 1-3, the compositions crude drug that it is characterized in that getting it filled adds conventional adjuvant and makes emplastrum, ointment, liniment, powder or spray according to common process.
5. such as the arbitrary described pharmaceutical composition of claim 1-3, the compositions crude drug that it is characterized in that getting it filled adds conventional adjuvant and makes black plaster according to common process.
6. such as the application of the arbitrary described pharmaceutical composition of claim 1-3 in the medicine of preparation treatment hyperosteogeny.
7. the application of pharmaceutical composition as claimed in claim 4 in the medicine of preparation treatment hyperosteogeny.
8. the application of pharmaceutical composition as claimed in claim 5 in the medicine of preparation treatment hyperosteogeny.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102411221A CN102343066B (en) | 2010-07-29 | 2010-07-29 | Medicinal composition for treating hyperosteogeny and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102411221A CN102343066B (en) | 2010-07-29 | 2010-07-29 | Medicinal composition for treating hyperosteogeny and preparation method thereof |
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| CN102343066A CN102343066A (en) | 2012-02-08 |
| CN102343066B true CN102343066B (en) | 2013-04-03 |
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| CN107184759A (en) * | 2017-05-31 | 2017-09-22 | 陈佃德 | A kind of plaster for treating pain of neck, shoulder, waist and leg |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101632737A (en) * | 2008-07-23 | 2010-01-27 | 吉林一正药业集团有限公司 | Medicament for relieving pain of human body and preparation method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101632737A (en) * | 2008-07-23 | 2010-01-27 | 吉林一正药业集团有限公司 | Medicament for relieving pain of human body and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 中医药治疗膝关节骨性关节炎概况;吕书政等;《吉林中医药》;20080930;第28卷(第9期);第332-333页 * |
| 吕书政等.中医药治疗膝关节骨性关节炎概况.《吉林中医药》.2008,第28卷(第9期),第698-699页. |
| 张怡燕，陈进春.中医药治疗类风湿关节炎的近况.《光明中医》.2010,第25卷(第2期),第332-333页. * |
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