CN102341117B - 用于缓解神经突生长抑制的蛋白激酶a和/或酪蛋白激酶ii - Google Patents

用于缓解神经突生长抑制的蛋白激酶a和/或酪蛋白激酶ii Download PDF

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Publication number
CN102341117B
CN102341117B CN201080009932.2A CN201080009932A CN102341117B CN 102341117 B CN102341117 B CN 102341117B CN 201080009932 A CN201080009932 A CN 201080009932A CN 102341117 B CN102341117 B CN 102341117B
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nogo
ngr1
cells
neurite outgrowth
phosphorylation
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CN102341117A (zh
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武井义则
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Medical Research Council
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Medical Research Council
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C12N9/1211—Thymidine kinase (2.7.1.21)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201080009932.2A 2009-03-06 2010-03-05 用于缓解神经突生长抑制的蛋白激酶a和/或酪蛋白激酶ii Expired - Fee Related CN102341117B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0903913.2 2009-03-06
GBGB0903913.2A GB0903913D0 (en) 2009-03-06 2009-03-06 Compositions and methods
PCT/GB2010/000391 WO2010100428A2 (en) 2009-03-06 2010-03-05 Compositions and methods

Publications (2)

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CN102341117A CN102341117A (zh) 2012-02-01
CN102341117B true CN102341117B (zh) 2015-01-21

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CN201080009932.2A Expired - Fee Related CN102341117B (zh) 2009-03-06 2010-03-05 用于缓解神经突生长抑制的蛋白激酶a和/或酪蛋白激酶ii

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US (1) US9089565B2 (enExample)
EP (1) EP2403515B1 (enExample)
JP (1) JP5670921B2 (enExample)
CN (1) CN102341117B (enExample)
AU (1) AU2010219463A1 (enExample)
CA (1) CA2750911A1 (enExample)
DK (1) DK2403515T3 (enExample)
ES (1) ES2493619T3 (enExample)
GB (1) GB0903913D0 (enExample)
WO (1) WO2010100428A2 (enExample)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1849132A (zh) * 2003-09-10 2006-10-18 伦敦大学国王学院 调节神经元生长的化合物以及它们的用途

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AU3214099A (en) 1998-04-03 1999-10-25 Curagen Corporation Lyst protein complexes and lyst interacting proteins
US6903187B1 (en) * 2000-07-21 2005-06-07 Allergan, Inc. Leucine-based motif and clostridial neurotoxins
JP2005508631A (ja) * 2001-07-17 2005-04-07 インサイト・ゲノミックス・インコーポレイテッド 受容体および膜結合タンパク質
JP2003093056A (ja) 2001-09-26 2003-04-02 Japan Science & Technology Corp ｐ５３のＳｅｒ４６をリン酸化する酵素
JP2007526440A (ja) 2003-06-03 2007-09-13 バイエル・ヘルスケア・エルエルシー 携帯型医療診断装置
GB0314943D0 (en) * 2003-06-25 2003-07-30 Proteome Sciences Plc Screening methods
CA2549000A1 (en) * 2003-12-16 2005-06-30 Children's Medical Center Corporation Method for treating neurological disorders
US20050214288A1 (en) * 2004-03-26 2005-09-29 Human Genome Sciences, Inc. Antibodies against Nogo receptor
EP1789070B1 (en) 2004-08-03 2012-10-24 Biogen Idec MA Inc. Taj in neuronal function
US7414637B2 (en) * 2004-09-10 2008-08-19 Telmap Ltd. Placement of map labels
CA2684321A1 (en) 2007-03-21 2008-09-25 Effat Emamian Compositions comprising pkac fragments and uses thereof for inhibiting akt1, p70s6k or abl activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1849132A (zh) * 2003-09-10 2006-10-18 伦敦大学国王学院 调节神经元生长的化合物以及它们的用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Myelin-Associated Inhibitors of Axonal Regeneration in the Adult Mammalian CNS;Filbin,Marie T 等;《Neuroscience》;20030930;第4卷;摘要，第1页第2栏最后一段至第2页第2栏第3段，第3页第二栏第3-5段，第6页第1栏最后一段至第2栏第2段，第7页Box3部分，图3 *
Phosphorylation of Microtubule Proteins in Rat Brain at Different Developmental Stages:Comparison with That Found in Neuronal Cultures;Diaz-Nido,Javier 等;《Journal of Neurochemistry》;19900131;第54卷(第1期);第220页第二栏 *

Also Published As

Publication number Publication date
JP2012519676A (ja) 2012-08-30
EP2403515A2 (en) 2012-01-11
DK2403515T3 (da) 2014-08-11
CN102341117A (zh) 2012-02-01
ES2493619T3 (es) 2014-09-12
WO2010100428A3 (en) 2010-10-21
HK1166017A1 (en) 2012-10-19
US20110318326A1 (en) 2011-12-29
EP2403515B1 (en) 2014-05-21
GB0903913D0 (en) 2009-04-22
WO2010100428A2 (en) 2010-09-10
US9089565B2 (en) 2015-07-28
AU2010219463A1 (en) 2011-09-22
JP5670921B2 (ja) 2015-02-18
CA2750911A1 (en) 2010-09-10

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