CN102329442A - Low-protein-content medical natural rubber material and preparation method thereof - Google Patents
Low-protein-content medical natural rubber material and preparation method thereof Download PDFInfo
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- CN102329442A CN102329442A CN 201110245731 CN201110245731A CN102329442A CN 102329442 A CN102329442 A CN 102329442A CN 201110245731 CN201110245731 CN 201110245731 CN 201110245731 A CN201110245731 A CN 201110245731A CN 102329442 A CN102329442 A CN 102329442A
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Abstract
The invention discloses a low-protein-content medical natural rubber material and a preparation method thereof, wherein the low-protein-content medical natural rubber material is prepared from the following components in part by weight: 100 parts of natural latex, 1-2 parts of non-ionic surfactant, 0.05-0.1 part of viscosity modulator, 0.1-0.2 part of stabilizer and 0.1-0.3 part of alkali protease. The nitrogen content of the natural rubber material prepared by using the method disclosed by the invention is less than 0.03% (note: protein content = nitrogen content*6.25); and when the rubber product is used, the incidence rate of protein allergies is greatly reduced.
Description
Technical field
The present invention relates to the rubber preparation field, be specifically related to medical tree elastomer material of a kind of lower protein content and preparation method thereof.
Background technology
Tree elastomer has excellent comprehensive performances such as easy gel, good film-forming property, high, the easy sulfuration of wet gel strength, intensity height.On medical, be widely used, comprise disposable medical gloves, syringe rubber plug, catheter etc.But tree elastomer protein allergy symptom is appearring over nearly 20 years.The tree elastomer staple is suitable-1, and the 4-TR 301 also contains natural tranquilizers such as protein, phosphatide, also contains resin, sugar, inorganic salt and vegeto-alkali in addition.Some people is when directly touching some protein of tree elastomer, and antibody, these antibody that health can produce a kind of IgE (immunoglobulin E) can be directed attacking sensibiligen.IgE just can combine with mastocyte and basophilic leukocyte like this.When sensibiligen got into immunity system once more, it just can fasten the IgE on the mastocyte.Then, mastocyte breaks thereupon, and discharges I4EA.I4EA then can produce with health and interact, and stimulates positions such as nose, eyes and throat.I4EA makes health produce allergic symptom can make the inner membrance swelling in the nose, and makes nose produce too much mucus; And it also possibly stimulate eyes.Therefore, remove nasal congestion, have a running nose, sneeze and symptom such as eyes itch outside, also can make skin itch, rubescent, play fash or urticaria, serious bronchial allergy outbreak, the laryngeal edema of having.Also have the only a few severe patient to suffer a shock, even life is on the hazard.
Summary of the invention
In view of above-mentioned weak point; The object of the present invention is to provide medical tree elastomer material of a kind of lower protein content and preparation method thereof; Adopt the natural rubber material nitrogen content of the present invention's preparation to be lower than 0.03%, make to cause that the probability of protein allergy reduces greatly.
In order to achieve the above object, the present invention has adopted following technical scheme: a kind of medical tree elastomer material of lower protein content, to count by weight ratio, and this natural rubber material is processed by following composition:
100 parts of natural emulsions
Non-ionics 1-2 part
Viscosity adjusting control agent 0.05-0.1 part
Stablizer 0.1-0.2 part
Sumizyme MP 0.1-0.3 part
Above-mentioned non-ionics is an iso-octyl phenoxy polyethoxyethanols.
The aforementioned stable agent is a sodium laurylsulfonate.
Above-mentioned viscosity-controlling agent is an oxammonium sulfate.
A kind of medical tree elastomer preparation methods of lower protein content may further comprise the steps:
(1) takes by weighing above-mentioned raw materials by above-mentioned formula ratio;
(2) in natural emulsion, add non-ionics, viscosity adjusting control agent, stablizer then, make its stabilization (stabilization just be meant and add above-mentioned each auxiliary agent after, the latex viscosity of flow-like increases originally, becomes the material of similar gels shape);
(3) we extract ten halves with step (2) gained material, are numbered 1,2,3 respectively ... 11,12.Add the equivalent Sumizyme MP respectively; After then they being placed 3 hours, 6 hours, 12 hours or 24 hours one by one in the baking oven of 20 ℃, 40 ℃ or 60 ℃; Again the gained sizing material is put in the whizzer of 10000r/min and handled 3-5min, obtain the tree elastomer of 12 parts of lower protein contents.Tree elastomer to these 12 parts of lower protein contents adopts micro-nitrogen determination to carry out the nitrogen content test respectively at last, also adopts micro-nitrogen determination to carry out the nitrogen content test to existing natural rubber material simultaneously, and test result is seen table 1.
Table 1 adopts the data sheet of micro-nitrogen determination to nitrogen content test in untreated existing natural rubber material and the sizing material of the present invention (1 ~ 12).
| Test group | Temperature of reaction (℃) | Reaction times (h) | Nitrogen content (%) MV | Protein contnt (%) MV |
| Tree elastomer | — | — | 0.643 | 4.019 |
| 1 | 20 | 3 | 0.182 | 1.137 |
| 2 | 20 | 6 | 0.196 | 1.224 |
| 3 | 20 | 12 | 0.137 | 0.858 |
| 4 | 20 | 24 | 0.120 | 0.747 |
| 5 | 40 | 3 | 0.132 | 0.825 |
| 6 | 40 | 6 | 0.102 | 0.637 |
| 7 | 40 | 12 | 0.066 | 0.412 |
| 8 | 40 | 24 | 0.065 | 0.407 |
| 9 | 60 | 3 | 0.027 | 0.169 |
| 10 | 60 | 6 | 0.050 | 0.314 |
| 11 | 60 | 12 | 0.097 | 0.607 |
| 12 | 60 | 24 | 0.067 | 0.418 |
Annotate: protein contnt=nitrogen content * 6.25
Can find out from last table; Reaction conditions is that 60 ℃, 3h one histone matter content are minimum; Reason is that temperature is when being 60 ℃; Alkaline protease activity activates fully, and within a short period of time, Sumizyme MP just can be complete with proteins react in the tree elastomer, thereby just can obtain deproteinated effect preferably within a short period of time.So the reaction conditions that preparation process condition of the present invention is chosen is to place 3 hours in 60 ℃ the baking oven.
Beneficial effect of the present invention is: the natural rubber material nitrogen content that the present invention makes is lower than 0.03% and (annotates: protein contnt=nitrogen content * 6.25), make that when using this rubber item protein allergy symptom probability takes place to be reduced greatly.
Embodiment
Embodiment 1
(Thailand three trees natural emulsion THL, trade mark RSS-3) adds 1kg iso-octyl phenoxy polyethoxyethanols, 0.05kg oxammonium sulfate at the 100kg natural emulsion; 0.1kg sodium laurylsulfonate; Make its stabilization (let the natural emulsion viscosity increase, become the material of similar gels shape), add the 0.1kg Sumizyme MP then; In 60 ℃ baking oven, place after 3 hours, take out sizing material; At last the gained sizing material is put in the whizzer of 10000r/min centrifugal treating and handle 3-5min, promptly obtain the natural rubber material of lower protein content.
Embodiment 2
(Thailand three trees natural emulsion THL, trade mark RSS-3) adds 1.5kg iso-octyl phenoxy polyethoxyethanols, 0.08kg oxammonium sulfate at the 100kg natural emulsion; 0.15kg sodium laurylsulfonate; Make its stabilization (let the natural emulsion viscosity increase, become the material of similar gels shape), add the 0.2kg Sumizyme MP then; In 60 ℃ baking oven, place after 3 hours, take out sizing material; At last the gained sizing material is put in the whizzer of 10000r/min centrifugal treating and handle 3-5min, promptly obtain the natural rubber material of lower protein content.
Embodiment 3
(Thailand three trees natural emulsion THL, trade mark RSS-3) adds 2kg iso-octyl phenoxy polyethoxyethanols, 0.1kg oxammonium sulfate at the 100kg natural emulsion; 0.2kg sodium laurylsulfonate; Make its stabilization (let the natural emulsion viscosity increase, become the material of similar gels shape), add the 0.3kg Sumizyme MP then; In 60 ℃ baking oven, place after 3 hours, take out sizing material; At last the gained sizing material is put in the whizzer of 10000r/min centrifugal treating and handle 3-5min, promptly obtain the natural rubber material of lower protein content.
Claims (5)
1. the medical tree elastomer material of a lower protein content is characterized in that: meter by weight ratio, and this natural rubber material is processed by following composition:
100 parts of natural emulsions
Non-ionics 1-2 part
Viscosity adjusting control agent 0.05-0.1 part
Stablizer 0.1-0.2 part
Sumizyme MP 0.1-0.3 part.
2. the medical tree elastomer material of a kind of lower protein content according to claim 1, it is characterized in that: described non-ionics is an iso-octyl phenoxy polyethoxyethanols.
3. the medical tree elastomer material of a kind of lower protein content according to claim 1, it is characterized in that: said viscosity-controlling agent is an oxammonium sulfate.
4. the medical tree elastomer material of a kind of lower protein content according to claim 1, it is characterized in that: said stablizer is a sodium laurylsulfonate.
5. the medical tree elastomer preparation methods of a lower protein content as claimed in claim 1, it is characterized in that: this preparation method may further comprise the steps:
(1) takes by weighing above-mentioned raw materials by above-mentioned formula ratio;
(2) in natural emulsion, add non-ionics, viscosity adjusting control agent and stablizer then, make its stabilization; (3) treat the natural rubber latex stabilization after, add Sumizyme MP then, in 60 ℃ baking oven, place after 3 hours, take out sizing material;
(4) step (3) gained sizing material is put in the whizzer of 10000r/min centrifugal treating and handle 3-5min, promptly obtain the natural rubber material of lower protein content.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110245731 CN102329442B (en) | 2011-08-25 | 2011-08-25 | Low-protein-content medical natural rubber material and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201110245731 CN102329442B (en) | 2011-08-25 | 2011-08-25 | Low-protein-content medical natural rubber material and preparation method thereof |
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| CN102329442A true CN102329442A (en) | 2012-01-25 |
| CN102329442B CN102329442B (en) | 2013-01-30 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103554566A (en) * | 2013-11-12 | 2014-02-05 | 镇江苏惠乳胶制品有限公司 | Medical gloves prepared from natural rubber and production method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1086520A (en) * | 1992-08-05 | 1994-05-11 | 花王株式会社 | Deproteinized natural rubber and produce its method |
| CN1246485A (en) * | 1999-09-03 | 2000-03-08 | 中国科学院昆明植物研究所 | Process for preparing protein-removed natural rubber |
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2011
- 2011-08-25 CN CN 201110245731 patent/CN102329442B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1086520A (en) * | 1992-08-05 | 1994-05-11 | 花王株式会社 | Deproteinized natural rubber and produce its method |
| CN1246485A (en) * | 1999-09-03 | 2000-03-08 | 中国科学院昆明植物研究所 | Process for preparing protein-removed natural rubber |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103554566A (en) * | 2013-11-12 | 2014-02-05 | 镇江苏惠乳胶制品有限公司 | Medical gloves prepared from natural rubber and production method thereof |
| CN103554566B (en) * | 2013-11-12 | 2015-09-16 | 镇江苏惠乳胶制品有限公司 | A kind of natural rubber medical gloves and preparation method thereof |
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| CN102329442B (en) | 2013-01-30 |
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