CN102327251A - Preparation method of hard capsule shell containing levan - Google Patents
Preparation method of hard capsule shell containing levan Download PDFInfo
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- CN102327251A CN102327251A CN201110170403A CN201110170403A CN102327251A CN 102327251 A CN102327251 A CN 102327251A CN 201110170403 A CN201110170403 A CN 201110170403A CN 201110170403 A CN201110170403 A CN 201110170403A CN 102327251 A CN102327251 A CN 102327251A
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Abstract
The invention relates to a preparation method of a hard capsule shell containing levan. The preparation method comprises the following steps: (1) preparing the following raw materials in parts by weight: 100 parts of levan, 1-1.5 parts of gels, 0.2-0.5 part of plasticizers, 0.01-0.1 part of emulsifiers, 0.5-1 part of cosolvents and 400 parts of water; (2) adding water in proportion, adding the levan and other raw materials except water into a stirrer in proportion, adjusting the stirring speed to 60-120r/min (revolutions per minute) after feeding the materials, and uniformly mixing and completely dissolving the raw materials; (3) starting a heating switch to raise the temperature in the stirrer to 60-95 DEG C, maintaining the temperature for 1-3 hours and carrying out vacuumizing to remove bubbles; (4) discharging gum solution, namely discharging the processed raw material mixed solution from the pipeline, filtering the mixed solution with a 100-300-mesh filter bag, putting the filtered gum solution into a heat insulation container to be insulated at 45-70 DEG C and standing for 3-10 hours; and (5) sending the prepared gum solution to a capsule making machine for making capsules conventionally, thus obtaining the hard capsule shell containing levan. The preparation method has the advantages of simple process and very obvious effect.
Description
Technical field
The present invention relates to a kind of method for preparing of pharmaceutic adjuvant hard capsule case, particularly a kind of method for preparing that contains the hard capsule case of levan.
Background technology
Levan levan (Lay ten thousand) is a kind of extracellular polysaccharide with extensive use, is a kind of of levan, wrap in the chondritic by residue of fructose and form, and the polysaccharide that the D-fructose that links to each other with β-2,6 glycosidic bond constitutes, molecular formula is (C
18H
32O
16) n.Levan (levan) can be separated in the cell debris from commodity production.Pharmaceutically, levan (levan) can be used as subcutaneous injection and uses cholesterol, the succedaneum of antitumor, immunomodulator, anti-inflammatory drug and blood plasma.On food, be used as two fructofuranoses, fructose, oligofructose, also can be used as the succedaneum of emulsifying agent, encapsulation agent, pigment and flavouring agent and fat.
Levan (levan) is different with other polysaccharide, has in strong viscosity, dense arrangement, the water not characteristics such as swelling, and resistance oxygen effect is splendid, is fit to very much active component and is prone to oxidized medicine.Levan has certain temperature stability, and water retention property is good, and the film that it forms has good pliability.Oligofructose can be described as bifidus factor again, can be utilized so can be described as bifidus factor by the bacillus bifidus of big enteral, can improve the intestinal microecology environment, strengthens the pipe intestinal digesting absorption function, effectively gets rid of vivotoxin, the resistance against diseases of enhancing body.
The colloid that is usually used in hard capsule case at present is a gelatin; Because gelatin exists the shortcoming that is difficult to overcome; For example be prone to aging, disintegration time is long, for protectiveness difference and the well-known safety problem and the problem of religion of Chinese medicine preparation, these shortcomings make that all the competitiveness of gelatin goods on market is more and more littler.
Therefore, provide a kind of preparation simple, obvious results contains the method for preparing of the hard capsule case of levan, is the big problem that this field scientific research and development personnel need research and solve.
Summary of the invention
The objective of the invention is to overcome above-mentioned weak point, provide a kind of preparation simple, obvious results contains the method for preparing of the hard capsule case of levan.
For realizing that the technical scheme that above-mentioned purpose the present invention is adopted is:
A kind of method for preparing that contains the hard capsule case of levan is characterized in that implementation step is following:
(1) is equipped with following raw material by weight: 100 parts of levan levan (Lay ten thousand), gel 1-1.5 part, plasticizer 0.2-0.5 part, emulsifying agent 0.01-0.1 part, cosolvent 0.5-1 part, 400 parts in water;
(2) in proportion water is added the heating stirrer of vacuum-pumping; Blender turns round with 40-80 rev/min speed; Levan and other raw material beyond dewatering are added in the agitator in proportion, after feeding intake speed of agitator is transferred to 60-120 rev/min, raw materials mix evenly and is fully dissolved;
(3) open heater switch, temperature in the agitator is risen to 60-95 ℃, kept 1-3 hour, evacuation is eliminated bubble;
(4) put glue, be about to the raw materials mix liquid that step (3) handles well and from pipeline, emit, and use 100 orders-300 purpose filter bag to filter, filtering glue (raw materials mix liquid) is placed cool-bag 45-70 ℃, left standstill 3-10 hour;
(5) glue that makes is sent into system capsule machine by routine system capsule, promptly obtain containing the hard capsule case of levan levan.
Said gel be starch, gellan gum, xanthan gum, cellulose gum wherein more than one.
Said plasticizer be sorbitol, Polyethylene Glycol, potassium chloride wherein more than one.
Said emulsifying agent be sucrose ester, sodium lauryl sulphate, Sodium Hydroxymethyl Stalcs wherein more than one.
Said cosolvent is calcium carboxymethylcellulose, gather sorbic acid fat, low replace hydroxy methocel wherein more than one.
Levan of the present invention (levan) is to be that 1,000,000 macromole levan is a main component with molecular weight, adds above-mentioned various excipient and is prepared from.
Main component characteristic and composition principle: because levan (levan) has in strong viscosity, dense arrangement, the water not characteristics such as swelling; Resistance oxygen effect is splendid; Be fit to very much active component and be prone to oxidized medicine; Because it is slightly not enough aspect capsule intensity, can improve its intensity with other prescription to compatibility, makes the medicine in its more effective protection capsule.
The invention has the beneficial effects as follows: the present invention provides a kind of can substitute the active polysaccharide that gelatin is used for hard capsule case, and the preparation technology of this hard capsule case also is provided simultaneously.The safety of levan (levan) and the functional gelatin of all winning far away, thus levan (levan) be a kind of novel, medicine is had the good protection effect, have the excipient substance of intestines and stomach health-care function; Its preparation technology is simple, obvious application effect.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows for characteristic:
Embodiment 1 (every part by 10 grams)
A kind of method for preparing that contains the hard capsule case of levan levan (Lay ten thousand), implementation step is following:
(1) at first, prepare following raw material: levan (levan) 1000 grams (molecular weight is 1,000,000 macromole levan), gellan gum 10 grams, potassium chloride 5 grams, sodium lauryl sulphate 0.8 gram, calcium carboxymethylcellulose 6 grams, water 4000 grams;
(2) with 4000 gram water add can the heating stirrer of evacuation in, mixing speed is 45 rev/mins, with levan (levan) 1000 grams; Gellan gum 10 grams, potassium chloride 5 grams, sodium lauryl sulphate 0.8 gram; Calcium carboxymethylcellulose 6 grams; Put into respectively in the agitator, rotating speed is adjusted to 80 rev/mins, each raw materials mix evenly and is fully dissolved;
(3) open heater switch, temperature is risen to 65 ℃, kept 1.5 hours, and evacuation is eliminated bubble;
(4) put glue, be about to the glue (raw materials mix liquid) that step (3) handles well and from pipeline, emit, and, filtering glue is placed 65 ℃ of insulations of cool-bag, left standstill 3 hours with the filtration of 250 order filter bags;
(5) glue that makes is sent into system capsule machine system capsule, promptly obtain containing the hard capsule case of levan (levan).
The gel that comprises among the present invention, plasticizer, emulsifying agent, cosolvent, wherein:
Gel be starch, gellan gum, xanthan gum, cellulose gum wherein one or more;
Plasticizer be sorbitol, Polyethylene Glycol, potassium chloride wherein one or more;
Emulsifying agent be sucrose ester, sodium lauryl sulphate, Sodium Hydroxymethyl Stalcs wherein one or more;
Cosolvent is calcium carboxymethylcellulose, gather sorbic acid fat, low replace hydroxy methocel wherein one or more.
Embodiment 2
(1) at first, prepare following raw material: levan (levan) 1000 grams (molecular weight is 1,000,000 macromole levan), xanthan gum 12 grams, sorbitol 3 grams, sucrose ester 0.6 gram, calcium carboxymethylcellulose 6 grams, water 4000 grams;
(2) with 4000 gram water add can the heating stirrer of evacuation in, mixing speed is 50 rev/mins, with levan (levan) 1000 grams; Xanthan gum 12 grams, sorbitol 3 grams, sucrose ester 0.6 gram; Calcium carboxymethylcellulose 6 grams; Put into respectively in the agitator, rotating speed is adjusted to 90 rev/mins, each raw materials mix evenly and is fully dissolved;
(3) open heater switch, temperature is risen to 70 ℃, kept 2 hours, and evacuation is eliminated bubble;
(4) put glue, be about to the glue (raw materials mix liquid) that step (3) handles well and from pipeline, emit, and, filtering glue is placed 65 ℃ of insulations of cool-bag, left standstill 3.5 hours with the filtration of 300 order filter bags;
(5) glue that makes is sent into system capsule machine system capsule, promptly obtain containing the hard capsule case of levan (levan).
Other is with embodiment 1.
Embodiment 3
(1) at first, prepare following raw material: levan (levan) 1000 grams (molecular weight is 1,000,000 macromole levan), cellulose gum 15 grams, Polyethylene Glycol 4 grams, sucrose ester 0.8 gram gathers sorbic acid fat 8 grams, water 4000 grams;
(2) with 4000 gram water add can the heating stirrer of evacuation in, mixing speed is 55 rev/mins, with levan (levan) 1000 grams; Cellulose gum 15 grams, Polyethylene Glycol 4 grams, sucrose ester 0.8 gram; Gather sorbic acid fat 8 grams; Put into respectively in the agitator, rotating speed is adjusted to 100 rev/mins, each raw materials mix evenly and is fully dissolved;
(3) open heater switch, temperature is risen to 80 ℃, kept 2 hours, and evacuation is eliminated bubble;
(4) put glue, be about to the glue (raw materials mix liquid) that step (3) handles well and from pipeline, emit, and, filtering glue is placed 55 ℃ of insulations of cool-bag, left standstill 5 hours with the filtration of 200 order filter bags;
(5) glue that makes is sent into system capsule machine system capsule, promptly obtain containing the hard capsule case of levan (levan).
Other is with embodiment 1.
Embodiment 4
(1) at first, prepare following raw material: levan (levan) 1000 grams (molecular weight is 1,000,000 macromole levan), cellulose gum 15 grams, Polyethylene Glycol 4 grams, carboxymethyl starch sodium 0.7 gram, low Carboxymethyl cellulose sodium 6 grams that replace, water 4000 grams.
(2) with 4000 gram water add can the heating stirrer of evacuation in, mixing speed is 75 rev/mins, with levan (levan) 1000 grams; Cellulose gum 15 grams, Polyethylene Glycol 4 grams, carboxymethyl starch sodium 0.7 gram; Low Carboxymethyl cellulose sodium 6 grams that replace; Put into respectively in the agitator, rotating speed is adjusted to 120 rev/mins, each raw materials mix evenly and is fully dissolved.
(3) open heater switch, temperature is risen to 90 ℃, kept 2.5 hours, and evacuation is eliminated bubble.
(4) put glue, be about to the glue (raw materials mix liquid) that step (3) handles well and from pipeline, emit, and, filtering glue is placed 45 ℃ of insulations of cool-bag, left standstill 9 hours with the filtration of 150 order filter bags.
(5) glue that makes is sent into system capsule machine system capsule, promptly obtain containing the hard capsule case of levan (levan).
Other is with embodiment 1.
Effect: the safety of levan (levan) and the functional gelatin of all winning far away, so levan (levan) be a kind of novel, medicine is had the good protection effect, have the excipient substance of intestines and stomach health-care function.
Above-mentioned detailed description of this method for preparing that contains the hard capsule case of levan being carried out with reference to embodiment; Be illustrative rather than determinate; Can be according to limited range several embodiment that give an example out; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (5)
1. method for preparing that contains the hard capsule case of levan is characterized in that implementation step is following:
(1) is equipped with following raw material: 100 parts of levan levan, gel 1-1.5 part, plasticizer 0.2-0.5 part, emulsifying agent 0.01-0.1 part, cosolvent 0.5-1 part, 400 parts in water by weight;
(2) in proportion water is added the heating stirrer of vacuum-pumping; Blender turns round with 40-80 rev/min speed; Levan and other raw material beyond dewatering are added in the agitator in proportion, after feeding intake speed of agitator is transferred to 60-120 rev/min, raw materials mix evenly and is fully dissolved;
(3) open heater switch, temperature in the agitator is risen to 60-95 ℃, kept 1-3 hour, evacuation is eliminated bubble;
(4) put glue, be about to the raw materials mix liquid that step (3) handles well and from pipeline, emit, and use 100 orders-300 purpose filter bag to filter, filtering glue is placed cool-bag 45-70 ℃, left standstill 3-10 hour;
(5) glue that makes is sent into system capsule machine by routine system capsule, promptly obtain containing the hard capsule case of levan levan.
2. the method for preparing that contains the hard capsule case of levan according to claim 1, it is characterized in that said gel be starch, gellan gum, xanthan gum, cellulose gum wherein more than one.
3. the method for preparing that contains the hard capsule case of levan according to claim 1, it is characterized in that said plasticizer be sorbitol, Polyethylene Glycol, potassium chloride wherein more than one.
4. the method for preparing that contains the hard capsule case of levan according to claim 1, it is characterized in that said emulsifying agent be sucrose ester, sodium lauryl sulphate, Sodium Hydroxymethyl Stalcs wherein more than one.
5. the method for preparing that contains the hard capsule case of levan according to claim 1, it is characterized in that said cosolvent be calcium carboxymethylcellulose, gather sorbic acid fat, low replace hydroxy methocel wherein more than one.
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| CN201110170403A CN102327251A (en) | 2011-06-23 | 2011-06-23 | Preparation method of hard capsule shell containing levan |
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| CN201110170403A CN102327251A (en) | 2011-06-23 | 2011-06-23 | Preparation method of hard capsule shell containing levan |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102743359A (en) * | 2012-07-12 | 2012-10-24 | 青岛益青药用胶囊有限公司 | Cellulose or polysaccharide plant pearly-luster hollow capsule and method for preparing same |
| CN102743358A (en) * | 2012-06-19 | 2012-10-24 | 中国科学院烟台海岸带研究所 | Hollow capsule and its preparation method and application |
| CN105168118A (en) * | 2015-09-30 | 2015-12-23 | 安徽丰乐香料有限责任公司 | Preparation method of natural menthol or peppermint oil hydrogel |
| CN105878030A (en) * | 2016-05-31 | 2016-08-24 | 江苏力凡胶囊有限公司 | Glue release device |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101579326A (en) * | 2008-05-13 | 2009-11-18 | 金斐嘉 | Pulullan polysaccharide empty hard capsule and preparation method thereof |
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2011
- 2011-06-23 CN CN201110170403A patent/CN102327251A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101579326A (en) * | 2008-05-13 | 2009-11-18 | 金斐嘉 | Pulullan polysaccharide empty hard capsule and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 李兴军: "果聚糖的合成与利用", 《中国食物与营养》, no. 2, 31 December 2010 (2010-12-31), pages 23 - 26 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102743358A (en) * | 2012-06-19 | 2012-10-24 | 中国科学院烟台海岸带研究所 | Hollow capsule and its preparation method and application |
| CN102743359A (en) * | 2012-07-12 | 2012-10-24 | 青岛益青药用胶囊有限公司 | Cellulose or polysaccharide plant pearly-luster hollow capsule and method for preparing same |
| CN105168118A (en) * | 2015-09-30 | 2015-12-23 | 安徽丰乐香料有限责任公司 | Preparation method of natural menthol or peppermint oil hydrogel |
| CN105878030A (en) * | 2016-05-31 | 2016-08-24 | 江苏力凡胶囊有限公司 | Glue release device |
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Application publication date: 20120125 |