CN102327184A - Hydrogel coating process - Google Patents
Hydrogel coating process Download PDFInfo
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- CN102327184A CN102327184A CN201110161592A CN201110161592A CN102327184A CN 102327184 A CN102327184 A CN 102327184A CN 201110161592 A CN201110161592 A CN 201110161592A CN 201110161592 A CN201110161592 A CN 201110161592A CN 102327184 A CN102327184 A CN 102327184A
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- hydrogel
- coating process
- hydrogel coating
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Abstract
The invention discloses a hydrogel coating process which is characterized by comprising the step of: coating a hydrogel layer on a heat-resisting substrate by adopting a hydrogel coating device, wherein hydrogel is firstly subjected to defoaming through a vacuum oven and then coated on the heat-resisting substrate, and the heat-resisting substrate subjected to sizing treatment and the hydrogel are subjected to steam treatment. The hydrogel coating process has a simple preparation process, is suitable for industrial and automatic production, and can be used as an industrial preparation method of multiple traumatic dressings without using gasoline and other organic solvents, thus loss of volatile components in Chinese medicinal herbs in a production process is avoided, medicine effects are ensured, and pollution of the gasoline to the environment is avoided. According to the hydrogel coating process, the property of the hydrogel can be effectively ensured, the adhesive force of the hydrogel and the heat-resisting substrate, sterile safety and water-bearing property of the hydrogel are better ensured.
Description
Technical field
The invention belongs to the preparation technology that the medical aquogel wound is applied ointment or plaster, concrete relate to the coating preparation technology that a kind of hydrogel wound is applied ointment or plaster.
Background technology
Science and unified kind of hydrogel coating process according in recent years is characterized in that said hydrogel coating process comprises:
Adopt a gel coated equipment on a resistant substrates, to be coated with hydrogel layer, the resistant substrates after coating is carried out the deaeration processing through a vacuum drying oven, and resistant substrates and hydrogel after handling through typing carry out steam treatment again.Meter report, the demand in global wound market is increasing, surgical operation class wound particularly, its total number of persons has been broken through 100,000,000 person-times of every year, and is the trend that increases year by year.Because wound that contingency caused and lacerated wound are about 2,000 ten thousand person-times of every year, burn and scald quantity is about 1,000 ten thousand person-times of every year; Because of ulcer property wound that chronic disease, diabetes, the aging of population caused has then surpassed 3,000 ten thousand person-times of every year.
Surgical operation is because of the demand of treatment and being in fashion of endoscopic surgery; Significantly reduced because the risk that operation is caused; But but being better wound, the thing followed looks after and the scar after the operation prevention; Occurred carrying out wound at present and looked after, eliminated cicatrix simultaneously so as to shortening wound healing time by various advanced dressing.
Traditional dressing is to be made up of natural plant fibre or animal hairs material, and like gauze, cotton pad, Pilus Caprae seu Ovis, all kinds of oil gauzes etc., this type dressing is temporary cladding material, all needs in the regular hour, to change.The research of existing wound dressing makes and lets people for the understanding of wound dressing science day by day, and research shows: preferable wound dressing can keep the good cell growth healing environment of site of injury, can control and absorb exudate; Ventilative, wet thoroughly, can stop the antibacterial intrusion; Can closely stick in wound face; Can carry and establish, discharge medicine; Should have favorable tissue and blood compatibility in addition, not stick together and desquamation taking off from wound face when getting; Also should have preferable mechanical performance and tensile strength, easy to use.For example on October 29th, 2008, disclosed one Chinese patent application 200810122438.1 provided the method for preparing of dressing on a kind of medical aquogel bed in the prior art; For example on January 12nd, 2005, disclosed publication number was called the patent application of " containing aquogel type wound dressing of aqueous emulsion of polyurethane and preparation method thereof " for the CN1562382A name again; It is the medical dressing of matrix that hydrogel all is provided; But the medicine carrying property of above-mentioned dressing is limited, and adhesive can't thoroughly be eliminated.
It is to be substrate with crosslinked or partial cross-linked water-soluble high-molecular compound or hydroaropic substance that the hydrogel wound is applied ointment or plaster; Close the gel mixture that forms through refining with ingredient; Coat and form on the backing of non-woven fabrics; Its hydrogel water-soluble base applied range is good with water solublity, fat-soluble medicine intermiscibility; The drug loading of hydrogel is big, is fit to very much Chinese medicine multicomponent, heavy dose of medication characteristics; Principal agent stability is not had influence, have no side effect; Dosage is accurate, and absorption area is fixed, so blood drug level is stable; The breathability of hydrogel, skin adherence, heat insulating ability all are superior to traditional emplastrum, thereby have and use comfortablely, can take off repeatedly and pull and stick, do not take off after pollution clothes, noresidue, the use and pull advantages such as not having pain.In addition, hydrogel contains usually and surpasses 50% moisture, and good water-retaining property is arranged, and is prone to make keratodermatitis softening, helps the Transdermal absorption of medicine.
Still not exclusively ripe in the prior art to the original preparation technology who applies ointment or plaster in the hydrogel, can't satisfy industrialized mass production.
Summary of the invention
It is simple to the invention provides a kind of preparation technology; The hydrogel coating process that is fit to industrialization, automated production; It can be used as multiple traumatic industrialized process for preparing of applying ointment or plaster, and does not use gasoline and other organic solvents in the process, has both avoided volatile ingredient loss in process of production in the Chinese medicine; Guarantee drug effect, avoided the pollution of gasoline again environment.It can effectively guarantee the performance of hydrogel own and make the adhesive force of hydrogel and resistant substrates, the aseptic safety and the property of water-bearing of hydrogel all obtain preferable assurance.
The technical scheme that the present invention adopted is following:
A kind of hydrogel coating process is characterized in that said hydrogel coating process comprises:
Adopt a gel coated equipment on a resistant substrates, to be coated with hydrogel layer, the resistant substrates after coating is carried out the deaeration processing through a vacuum drying oven, and the hydrogel after handling through deaeration carries out steam treatment with resistant substrates again.
In one embodiment, said hydrogel coating process further comprises: at first hydrogel materials is stirred, softens, and then carry out the coating on the resistant substrates.
In one embodiment, said resistant substrates is a thermoset macromolecule material.
In another embodiment, the setting temperature in the said vacuum drying oven remains on 20-30 degree centigrade, and pressure remains in 1～10Torr, makes the hydrogel raw material carry out deaeration.
In another embodiment, said steam treatment is that the steam with pressure is handled base material and hydrogel after the coating in a vapor chamber.
In the embodiment, said coating process further comprises again: the hydrogel surface after the steam treatment is covered a stripping film.
This hydrogel coating process adopts mechanical coating apparatus and technology, and immediately to the processing of finalizing the design of resistant substrates and hydrogel coating layer after the coating, effectively raises the adhesion between hydrogel and coated substrate.This pretreatment can be adopted polyurethane that surface modification is carried out on the resistant substrates surface and form, and can reasonably regulate the water content of hydrogel, makes it can have preferable result of use.
Beneficial effect of the present invention is; Preparation technology is simple for this hydrogel coating process, is fit to industrialization, automated production, and it can be used as multiple traumatic industrialized process for preparing of applying ointment or plaster; Do not use gasoline and other organic solvents in the process; Both avoided volatile ingredient loss in process of production in the Chinese medicine, guaranteed drug effect, avoided the pollution of gasoline again environment.It can effectively guarantee the performance of hydrogel own and make the adhesive force of hydrogel and resistant substrates, the aseptic safety and the property of water-bearing of hydrogel all obtain preferable assurance.
Below in conjunction with the accompanying drawing and the specific embodiment the present invention is done further elaboration.
Description of drawings
Fig. 1 is the step block diagram of the specific embodiment of the invention.
The specific embodiment
This hydrogel coating process mainly is to be used for the preparation that wound is applied ointment or plaster, and its hydrogel materials of selecting for use is the Polysaccharides hydrogel, carries effective ingredient in it.At first, this Polysaccharides hydrogel is pulverized filtration, mix with adhesive agent, wetting agent, filler, transdermal enhancer, softening agent and other additives etc. then like step S110; Then like step S120; With the hydrogel coating apparatus Polysaccharides hydrogel is coated on the heat-resisting thermosetting polymer vessel; Step S130 carries out deaeration to the resistant substrates after coating through a vacuum drying oven and handles for another example, and the deaeration temperature in the baking oven remains on 20-30 degree centigrade.Carry out step S140 again; Resistant substrates and hydrogel through after the typing processing carry out steam treatment again, and this steam can adopt press water steam, perhaps water at atmospheric pressure steam; Make the time of its pressure condition scalable steam treatment, make hydrogel recover its best moisture ratio.Last like step S150, the hydrogel surface after the steam treatment is covered a stripping film.
Claims (6)
1. hydrogel coating process; It is characterized in that said hydrogel coating process comprises: adopt a gel coated equipment on a resistant substrates, to be coated with hydrogel layer; Hydrogel carries out deaeration through vacuum drying oven earlier to be handled, and hydrogel after handling through deaeration and resistant substrates and hydrogel carry out high-temperature steam again to be handled.
2. hydrogel coating process according to claim 1 is characterized in that said hydrogel coating process further comprises: at first the Polysaccharides hydrogel materials is carried out stirring and dissolving, and then carry out the coating on the resistant substrates.
3. hydrogel coating process according to claim 1 is characterized in that said resistant substrates is heat-resisting thermoset macromolecule material.
4. hydrogel coating process according to claim 1 is characterized in that the deaeration temperature in the said baking oven remains on 20-30 degree centigrade.
5. hydrogel coating process according to claim 1 is characterized in that said steam treatment is that the steam with pressure is handled thermosetting polymer base material and hydrogel after the coating in a vapor chamber.
6. hydrogel coating process according to claim 1 is characterized in that said coating process further comprises: the hydrogel surface after the steam treatment is covered a stripping film.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110161592A CN102327184A (en) | 2011-06-16 | 2011-06-16 | Hydrogel coating process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110161592A CN102327184A (en) | 2011-06-16 | 2011-06-16 | Hydrogel coating process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102327184A true CN102327184A (en) | 2012-01-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110161592A Pending CN102327184A (en) | 2011-06-16 | 2011-06-16 | Hydrogel coating process |
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| CN (1) | CN102327184A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109758293A (en) * | 2019-03-11 | 2019-05-17 | 山东煜和堂药业有限公司 | Postpartum Warn uterus paste and application method and manufacture the equipment that material is organized in the postpartum Warn uterus paste |
| CN110167387A (en) * | 2017-09-25 | 2019-08-23 | 株式会社爱茉莉太平洋 | Utilize the beautifying skin film manufacturing device and its control method of hydrogel |
| CN115340630A (en) * | 2022-09-02 | 2022-11-15 | 东莞市中森新材料有限公司 | Gel with good heat dissipation effect and rapid cooling and manufacturing process |
-
2011
- 2011-06-16 CN CN201110161592A patent/CN102327184A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110167387A (en) * | 2017-09-25 | 2019-08-23 | 株式会社爱茉莉太平洋 | Utilize the beautifying skin film manufacturing device and its control method of hydrogel |
| CN110167387B (en) * | 2017-09-25 | 2022-05-03 | 株式会社爱茉莉太平洋 | Apparatus for manufacturing skin beauty mask using hydrogel and method for controlling the same |
| CN109758293A (en) * | 2019-03-11 | 2019-05-17 | 山东煜和堂药业有限公司 | Postpartum Warn uterus paste and application method and manufacture the equipment that material is organized in the postpartum Warn uterus paste |
| CN115340630A (en) * | 2022-09-02 | 2022-11-15 | 东莞市中森新材料有限公司 | Gel with good heat dissipation effect and rapid cooling and manufacturing process |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120125 |