CN102319264B - Processing method capable of sufficiently maintaining activity of cartialgenous - Google Patents
Processing method capable of sufficiently maintaining activity of cartialgenous Download PDFInfo
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- CN102319264B CN102319264B CN2011102212453A CN201110221245A CN102319264B CN 102319264 B CN102319264 B CN 102319264B CN 2011102212453 A CN2011102212453 A CN 2011102212453A CN 201110221245 A CN201110221245 A CN 201110221245A CN 102319264 B CN102319264 B CN 102319264B
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- cartialgenous
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- cervi pantotrichum
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- 239000007788 liquid Substances 0.000 claims abstract description 3
- 238000004108 freeze drying Methods 0.000 claims description 15
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- 230000023555 blood coagulation Effects 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 238000001556 precipitation Methods 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 2
- 238000007710 freezing Methods 0.000 claims description 2
- 230000008014 freezing Effects 0.000 claims description 2
- 239000008280 blood Substances 0.000 abstract description 3
- 239000000047 product Substances 0.000 abstract description 3
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- 102000019197 Superoxide Dismutase Human genes 0.000 description 18
- 108010012715 Superoxide dismutase Proteins 0.000 description 18
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 6
- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 102000010909 Monoamine Oxidase Human genes 0.000 description 3
- 108010062431 Monoamine oxidase Proteins 0.000 description 3
- 229930003427 Vitamin E Natural products 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000000084 colloidal system Substances 0.000 description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 3
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 3
- 229960003180 glutathione Drugs 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 235000019165 vitamin E Nutrition 0.000 description 3
- 239000011709 vitamin E Substances 0.000 description 3
- 229940046009 vitamin E Drugs 0.000 description 3
- RYCNUMLMNKHWPZ-SNVBAGLBSA-N 1-acetyl-sn-glycero-3-phosphocholine Chemical compound CC(=O)OC[C@@H](O)COP([O-])(=O)OCC[N+](C)(C)C RYCNUMLMNKHWPZ-SNVBAGLBSA-N 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical group [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000010941 cobalt Substances 0.000 description 2
- 229910017052 cobalt Inorganic materials 0.000 description 2
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 235000003969 glutathione Nutrition 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 2
- 108010075016 Ceruloplasmin Proteins 0.000 description 1
- 102100023321 Ceruloplasmin Human genes 0.000 description 1
- 241000282994 Cervidae Species 0.000 description 1
- 241000283026 Cervus elaphus Species 0.000 description 1
- 241000283007 Cervus nippon Species 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- 208000019914 Mental Fatigue Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 238000006701 autoxidation reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
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- 230000032677 cell aging Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000013495 cobalt Nutrition 0.000 description 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
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- -1 lipid peroxide Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
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- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
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- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 229940079877 pyrogallol Drugs 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 108010048734 sclerotin Proteins 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 230000036299 sexual function Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
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- 235000019158 vitamin B6 Nutrition 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a processing method capable of sufficiently maintaining activity of cartialgenous. The method comprises the following steps: quickly dicing newly cut cartialgenous before blood in the cartialgenous is coagulated; crushing; centrifuging at high speed; removing precipitate; and lyophilizing the liquid to obtain light brown powder. According to the processing method, loss of nutrition and functional activity of the cartialgenous in the processing process is prevented, the cartialgenous can be placed for a long time with excellent appearance and is not easy to deteriorate, and the daily dose of a cartialgenous product is reduced.
Description
Technical field
The invention belongs to and contain raw-material medicinal preparation field, be specifically related to a kind of processing method that can fully keep new fresh pilose antler active.
Background technology
Cornu Cervi Pantotrichum is China tradition rare Chinese medicine, is the young horn of the unossified close living fine hair of stag of animal in deer family Cervus nippon Temminck or Cervus elaphus linnaeus.Have that shape kidney yang, benefiting essence-blood, bone and muscle strengthening, accent punching are appointed, the effect of holder sore.Be used for the diseases such as insufficiency of kidney-YANG, blood and essence asthenia, Mental fatigue, fear of cold, soreness of the waist and knees.
Contain a large amount of superoxide dismutase (SOD), cells produce element (HGH) in the Cornu Cervi Pantotrichum.Contain a large amount of LYSO-PHOSPHATIDYLCHOLINE LYSOPC in the Sanguis Cornu Cervi Pantotrichum, lipid sphyngomyelin and hypoxanthine, vitamin E etc.
Superoxide dismutase (SOD), glutathion peroxidase (GSH), dehydrogenase impel O
2 -Change into O
2, and glutathion changes in the oxidation shape process and absorbs H by going back original shape
2O
2O
2 -, and make H
2O
2Be reduced into water, and under the effect of vitamin E, keep the reproducibility of cell membrane, delaying cell aging improves tissue organ function, strengthens metabolism, reduces the content of the lipid peroxide (LPO) of the histoorgans such as liver, brain.
LYSO-PHOSPHATIDYLCHOLINE LYSOPC in the Sanguis Cornu Cervi Pantotrichum, lipid sphyngomyelin and hypoxanthine suppress monoamine oxidase, MAO (MAO-B) activity, reduce free radical and form.Vitamin E energy Cell protection film in the Sanguis Cornu Cervi Pantotrichum, ferrum, cobalt and several amino acids are blood cell composition, and copper forms Ceruloplasmin in body, promote absorption and the transportation of ferrum, and cobalt, vitamin B6, vitamin B12 can excite bone marrow hematogenesis.In addition, the testis trunk in the Sanguis Cornu Cervi Pantotrichum can not only improve the body sexual function, and the protection secondary sexual characteristics can also in the presence of several amino acids, promote the deposition of protein, strong skeleton, firm tooth.Inorganic elements copper, zinc, manganese and magnesium are the nucleuses of superoxide dismutase (SOD), have to promote the synthetic of SOD, and can activate the SOD Enzyme Production and intensify.
Tradition Cornu Cervi Pantotrichum processing method is that summer Qiu Erji saw is got Cornu Cervi Pantotrichum, dries in the shade or dries.Cornu Cervi Pantotrichum after the processing is difficult for transportation, storage and apt to deteriorate, effective ingredient scatters and disappears.
Summary of the invention
To the objective of the invention is in order addressing the above problem, a kind of processing method that can fully keep new fresh pilose antler active to be provided, the method may further comprise the steps:
Get the Cornu Cervi Pantotrichum that newly cuts off, rapidly stripping and slicing before the blood clotting in Cornu Cervi Pantotrichum is pulverized, and is centrifugal with two-forty again, discards precipitation, gets the liquid freezing drying, obtains the powder of light brown.
To be broken to particle diameter be the following powder of 0.01mm to preferred powder in the inventive method.Described two-forty is centrifugal to be can be in centrifuge with centrifugal under 5000～10000 rev/mins of rotating speeds, and centrifugation time is 10～30 minutes.Preferably freeze drying condition in the method: cryodesiccation chamber's pressure can be 25～30Pa, and thickness of feed layer is 18～20mm, and temperature is-40 ℃, and this centrifugal and lyophilisation condition can prevent further that effective ingredient scatters and disappears.
The Pulveratum Cornu Cervi Pantotrichum that obtains by the inventive method can be made into the acceptable various preparations of pharmacy.As: be pressed into the conventional formulations such as tablet, direct fill capsule or the agent of adding adjuvant granulation.
Beneficial effect of the present invention compared with the prior art: adopt the inventive method, the a large amount of cutin sclerotin compositions in the Cornu Cervi Pantotrichum medical material have been removed, fully kept original superoxide dismutase (SOD) in the Cornu Cervi Pantotrichum, cells produce element functional components such as (HGH), when having increased the activity of Cornu Cervi Pantotrichum product, greatly reduce the taking dose of Cornu Cervi Pantotrichum, reduced to everyone 0.2g every day from everyone 2g every day.
Adopt Cornu Cervi Pantotrichum mass ratio that processing method of the present invention and traditional method obtain:
Laboratory sample:
Commercially available pilose antler piece (available from Nanjing medical material company); Pulveratum Cornu Cervi Pantotrichum: get Sanguis Cornu Cervi Pantotrichum and newly cut Cornu Cervi Pantotrichum before solidifying, the Pulveratum Cornu Cervi Pantotrichum for preparing according to the embodiment of the invention 1 method; Bright Cornu Cervi Pantotrichum: newly cut Cornu Cervi Pantotrichum before Sanguis Cornu Cervi Pantotrichum is condensed.
Content assaying method: in the 06th phase in 2000 " Chinese Journal of Health Laboratory Technology ", the method for " it is active that the pyrogallol Autoxidation Method is measured SOD " is got respectively bright Cornu Cervi Pantotrichum, pilose antler piece and Pulveratum Cornu Cervi Pantotrichum 10g, and the SOD that measures wherein is active.SOD activity and the outward appearance of the Cornu Cervi Pantotrichum that 3 kinds of sample determinations are obtained compare, and concrete outcome sees Table 1:
Table 1
The result: take the Pulveratum Cornu Cervi Pantotrichum SOD activity value (U/g) of the inventive method preparation as more than 1000, effect was preserved 6 months under 4 ℃ of conditions without destruction, and outward appearance is unchanged; And not detected the SOD activity in the pilose antler piece, bright Cornu Cervi Pantotrichum placement became the dark reddish purple color in the cross section after 6 months, and is rotten.Therefore, processing method of the present invention has prevented Cornu Cervi Pantotrichum nutrition and functional activity loss in the course of processing, the long-term placement, and outward appearance is good, and is not perishable, and reduced the day dose of velvet product.
" % " of the present invention is the quality percentage composition.
The specific embodiment
By the following examples the present invention is further elaborated.
Embodiment 1
Get the Cornu Cervi Pantotrichum that newly cuts off, rapidly stripping and slicing before the blood clotting in Cornu Cervi Pantotrichum, being placed on and being crushed to particle diameter in the colloid mill is the following powder of 0.01mm, adds in the tube centrifuge with 10000 rev/mins two-forty centrifugal 20 minutes again, discards precipitation, get the supernatant lyophilization, the lyophilization condition is: lyophilizing pressure is 26.6Pa, and thickness of feed layer is 18～20mm, and temperature is-40 ℃, get light brown powder after the lyophilization, directly pour into capsule.SOD determination of activity result is 1290U/g.
Embodiment 2
Get the Cornu Cervi Pantotrichum that newly cuts off, rapidly stripping and slicing before the blood clotting in Cornu Cervi Pantotrichum, being placed on and being crushed to particle diameter in the colloid mill is the following powder of 0.01mm, adds in the tube centrifuge with 5000 rev/mins two-forty centrifugal 30 minutes again, discards precipitation, get the supernatant lyophilization, the lyophilization condition is: lyophilizing pressure is 26.6Pa, and thickness of feed layer is 18～20mm, and temperature is-40 ℃, get light brown powder, direct compression after the lyophilization.SOD determination of activity result is 1220U/g.
Embodiment 3
Get the Cornu Cervi Pantotrichum that newly cuts off, rapidly stripping and slicing before the blood clotting in Cornu Cervi Pantotrichum, being placed on and being crushed to particle diameter in the colloid mill is the following powder of 0.01mm, added again in the tube centrifuge with 10000 rev/mins two-forty centrifugal 10 minutes, discard precipitation, get the supernatant lyophilization, the lyophilization condition is: cryodesiccation chamber's pressure is 26.6Pa, thickness of feed layer is 18～20mm, and freeze temperature is-40 ℃.Get light brown powder after the lyophilization, add the adjuvant granulation.SOD determination of activity result is 1260U/g.
Claims (2)
1. processing method that can fully keep pilose antler active is characterized in that the method may further comprise the steps:
Get the Cornu Cervi Pantotrichum that newly cuts off, rapidly stripping and slicing before the blood clotting in Cornu Cervi Pantotrichum, being crushed to particle diameter is the following powder of 0.01mm, in centrifuge with 5000～10000 rev/mins rotating speed centrifugal 10～30 minutes again, discard precipitation, get the liquid freezing drying, obtain light brown powder; Wherein, the lyophilization condition: cryodesiccation chamber's pressure is 25～30Pa, and thickness of feed layer is 18～20mm, and temperature is-40 ℃.
2. processing method according to claim 1 is characterized in that the powder that the method obtains makes the acceptable various preparations of pharmacy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102212453A CN102319264B (en) | 2011-08-04 | 2011-08-04 | Processing method capable of sufficiently maintaining activity of cartialgenous |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102212453A CN102319264B (en) | 2011-08-04 | 2011-08-04 | Processing method capable of sufficiently maintaining activity of cartialgenous |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102319264A CN102319264A (en) | 2012-01-18 |
| CN102319264B true CN102319264B (en) | 2013-03-27 |
Family
ID=45447191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011102212453A Active CN102319264B (en) | 2011-08-04 | 2011-08-04 | Processing method capable of sufficiently maintaining activity of cartialgenous |
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| Country | Link |
|---|---|
| CN (1) | CN102319264B (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1603344A (en) * | 2004-08-04 | 2005-04-06 | 王利忠 | Method for extracting insulin-like growth factor (IGF-1) from fresh antler |
-
2011
- 2011-08-04 CN CN2011102212453A patent/CN102319264B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1603344A (en) * | 2004-08-04 | 2005-04-06 | 王利忠 | Method for extracting insulin-like growth factor (IGF-1) from fresh antler |
Non-Patent Citations (3)
| Title |
|---|
| 唐树友 等."鹿茸粉加工工艺研究".《中国林副特产》.2007,(第1期),第22-23页. |
| 李秀娟 等."鹿茸加工方法与工艺进展".《内蒙古农业大学学报》.2008,第29卷(第3期),第201-204页. |
| 柯李晶 等."不同加工工艺鹿茸的蛋白成分和活性比较".《中药材》.2008,第31卷(第1期),第11-14页. |
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| CN102319264A (en) | 2012-01-18 |
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Denomination of invention: A processing method that can fully maintain the activity of deer antler Effective date of registration: 20231007 Granted publication date: 20130327 Pledgee: China Merchants Bank Co.,Ltd. Nanjing Branch Pledgor: NANJING ZHONGKE PHARMACEUTICAL Co.,Ltd. Registration number: Y2023980059703 |