CN102302467B - Test calculation method adopted for solving dissolution problem of traditional Chinese drug pill - Google Patents
Test calculation method adopted for solving dissolution problem of traditional Chinese drug pill Download PDFInfo
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Abstract
The invention relates to a test calculation method adopted for solving a dissolution problem of traditional Chinese drug pill. With the present invention, the following problems are effectively solved: pill dissolution, assurance of dissolution of active ingredients in the pill, and assurance of therapeutic effect. The technical scheme for solving the problems is: determining a formulation of the pill according to clinical requirements, wherein the formulation comprises a general preparation, a slow release preparation, a long-acting preparation and the like; analyzing whether traditional Chinese drug materials in the pill prescription have significant assistant functions and functional properties; preparing a model drug through calculating the ratios of the materials, then carrying out a dissolution experiment; calculating the dissolution and the dissolution parameters, establishing a non-linear mathematical model to obtain the related material parameters; processing the materials according to the material parameters, preparing the pill and verifying the material parameters; adjusting the parameters, calculating the material ratio of the pill. The method provided by the present invention is simple, and is easy to be used. With the method, the optimal formula of the drug composition is effectively solved, the dissolution of the pill and the efficacy of pill are ensured. Therefore, the method is a major innovation in the development of the traditional Chinese drug.
Description
Technical field
The invention belongs to Chinese medicine and natural medicinal formulations field, particularly a kind of experiment calculation method that is applicable to solve medicine pill stripping problem.
Background technology
1, dissolution and clinical efficacy are closely related
Dissolution is as control solid drugs quality and the important means of estimating bioavailability in the body, and direct relation clinical efficacy, therefore recorded as statutory standards by countries in the world.As in 1967 " American National formulary " 12 editions (NF XII) second added editions, introducing first the dissolution detection method of slow releasing tablet and capsule; " American Pharmacopeia " in 1970 18 editions (USP X VIII) recorded the solid preparation kind that 12 needs are done Dissolution Rate Testing; 1973 editions " British Pharmacopoeia " stipulated dissolution and the release inspection of digoxin, and introduces the dissolution test method in 1988 editions; 1981 " Pharmacopeia of Japan " the 10th edition records Dissolution Rate Testing first." Chinese pharmacopoeia two radicals by which characters are arranged in traditional Chinese dictionaries recorded 7 chemical drugss need doing dissolution test, and version had reached 276 kinds in 2005 version in 1985 in China.But because medicine pill is comprised of multiple components such as animal, plant and mineral, contain the complicated ingredients such as fiber-like, protide, polysaccharide; And the variation of Preparation equipment, the reasons such as preparation technology's disunity." Chinese pharmacopoeia one one (Chinese medicine part) was not included yet relevant method and need to be done the kind of detection, and this makes troubles for drug manufacture and development to version in 2010;
2, medicine pill dissolution problems affect clinical efficacy
Medicine pill has at least use in 3000 historical, is a kind of excellent tradition dosage form with the obvious advantage, traditional Chinese medical science diseases prevention, cure the disease and prevention and health care in have great strategic importance.Be only the LIUWEI DIHUANG WAN sale such as 2006 and reach 2,700,000,000, Chinese Medicine (186 phase/2006) describes and is " the flames of war are raging in LIUWEI DIHUANG WAN market ", drawn the conclusion of " perhaps capsule is difficult to shake the large man status, market of pill ".Pill has effect and relaxes lastingly, is more suitable for the needs of Chinese traditional treatment chronic disease, rehabilitation, and is also having one's own knack aspect the drug toxicity preparation attenuation.Simultaneously, compare with other dosage form, production cost is low, greatly energy savings, resource.But at present the research majority of medicine pill is more paid attention to the research of molding aspect, the dissolution study of direct relation curative effect is not deep enough.This heterogeneity with the complexity of Chinese medicine preparation composition, preparation technology is relevant.Totally 21 pieces in the document from nineteen ninety-2007 year that the author finds, the pill that relates to altogether 23 kinds wherein has 6 kinds and meets that " the regulation requirement of Chinese pharmacopoeia dissolution can't be determined for a kind, 16 kinds exceed prescribed limit, the stripping of pill index components in 45 minutes of 73% are namely arranged less than 75%.Can think that the dissolution of most of medicine pill is against regulation.The dissolution problem of pill has directly affected clinical efficacy, therefore the pill kind is year by year downward trend is arranged." in the Chinese patent medicine kind that Chinese pharmacopoeia is included, pill shared ratio nineteen ninety is to only have 30%, average per 5 years decline 4%-8%, (seeing Table 1) in 56%, 2010 year such as national standard.
Table 1 medicine pill kind is downward trend table (" one one of Chinese pharmacopoeia) year by year
| Source of data | Nineteen ninety pharmacopeia | Nineteen ninety-five pharmacopeia | Pharmacopeia in 2000 | Pharmacopeia in 2005 | Pharmacopeia in 2010 |
| Preparation variety | 275 | 422 | 466 | 588 | 1061 |
| The pill kind | 154 | 202 | 207 | 212 | 322 |
| The pill accounting | 56% | 48% | 44% | 36% | 30% |
Therefore solving pill dissolution problem is the key that solves the medicine pill clinical efficacy, also is the key issue that concerns this dosage form future destiny.But the report of the effective ways of experiment calculation dissolution so far there are no how.
Summary of the invention
For above-mentioned situation, for overcoming the defective of prior art, the present invention's purpose can effectively solve the pill dissolution with regard to providing a kind of experiment calculation method that is applicable to solve medicine pill stripping problem, guarantees the problem of pill effective ingredient stripping and curative effect.
The technical scheme that the present invention solves is to determine that according to clinical requirement pill is the dosage forms such as ordinary preparation (being conventional fugitive preparation), slow releasing preparation, durative action preparation; Which Chinese medicine material has significant auxiliary sexual function (auxiliary property) and functional character in the analysis pill prescription; Prepare model drug by calculating material proportion, carry out the dissolution experiment; Calculate dissolution and stripping parameter, draft nonlinear mathematical model, extract relevant parameter of materials; By the parameter of materials material handling, preparation pill, checking parameter of materials; Adjust parameter, calculate pill material ratio.That is to say the dosage form requirement of at first determining pill, namely be defined as conventional pill, quick-acting pill, long-acting pill (slow release) according to having or not of clinical needs and prescription toxic composition, universality according to " the auxiliary unification of medicine ", prescription Chinese medicine composition, material properties are analyzed, by result of the test to short molten/processing of classifying of the Chinese medicine of the molten effect of resistance, verify again after adjusting the material ratio, finally obtain the optimum proportion ratio.
The inventive method is simple, and easy to operate effectively solves the optimum formula of composition of medicine, and guarantee the dissolution of pill and guarantee the curative effect of pill, be the greatly innovation in the Chinese medicine development.
Description of drawings
Fig. 1 is flow chart of steps of the present invention.
Fig. 2 is the property of medicine and auxiliary property schematic diagram (wherein, the effective ingredient of A for confirming, the auxiliary property composition of the prepared slices of Chinese crude drugs of the present invention; The invalid components of B for confirming is without auxiliary property composition; C be unconfirmed whether effectively or adjunct ingredient).
The specific embodiment
Below in conjunction with flow chart of steps the specific embodiment of the present invention is elaborated.
The present invention is provided by process chart, is realized by following steps:
(1), determine the pill dosage form: the function according to prescription cures mainly, the target formulation of component dosage, clinical requirement, and pill is divided into ordinary preparation (being conventional fugitive preparation), slow releasing preparation, durative action preparation;
(2), analyze the component effect in the pill prescription, which component has complementary function, which component has functional character, lists the auxiliary sexual function classification of Chinese medicine from short molten, the molten aspect of resistance:
Chinese medicine is by auxiliary sexual function classification (giving an example)
| Classification of TCD | Chinese medicine for example | The major auxiliary burden performance | Use and application characteristic |
| Starch based | Rhizoma Dioscoreae, Radix Trichosanthis, Pachyrhizua angulatus | The auxiliary property of slow release (making slurry) | Durative action preparation, contain the toxicity component preparation |
| The auxiliary property of disintegrate (dry powder) | Reduce the pill dissolve scattered time limit | ||
| Dilute auxiliary property | Increase the preparation capacity | ||
| Absorb auxiliary property | The absorption of volatilization wet goods liquid medicine | ||
| Bind auxiliary property | Be conducive to molding | ||
| Fiber-like | Rhizoma Cimicifugae, Radix Bupleuri, Caulis Akebiae | Urge to release auxiliary property | Ordinary preparation, quick releasing formulation |
| Dilute auxiliary property | The same | ||
| Mineral substance | Halloysitum Rubrum, Talcum, Calamina | The auxiliary property of slow release | The same |
| Dilute auxiliary property | The same | ||
| Absorb auxiliary property | The same | ||
| Protide | Pheretima, Hirudo, Endothelium Corneum Gigeriae Galli | The auxiliary property of slow release (Denatured protein) | The same |
| Oils | Semen Armeniacae Amarum, Semen Persicae, Semen Pruni | The auxiliary property of slow release | The same |
| The solubility salt | Natrii Sulfas, Chalcanthitum, Melanteritum | The auxiliary property of slow release (having ready conditions) | The same |
| The auxiliary property of disintegrate | The same | ||
| Resin natural gum class | Olibanum, Myrrha, Styrax | The auxiliary property of slow release | The same |
Annotate: other adjuvant function is as binding auxiliary property, and-absorption of-increase the preparation capacity, absorb auxiliary property-volatilization wet goods liquid medicine that is conducive to molding, dilutes auxiliary property etc. are not at category of the present invention, therefore exclude wherein;
According to classification, prescription Chinese medicinal components (decoction pieces) is analyzed, define the component (pharmaceutical decocting piece) of remarkable adjuvant character;
(3), according to the classification of the auxiliary property of Chinese medicine, select the Chinese medicinal components that possesses respective secondary, and process, method is, the inapparent component of auxiliary property is directly carried out extracts active ingredients or micronization, the significant component of auxiliary property is prepared model drug by calculating material proportion, and carry out Dissolution Rate Testing, " two rated conditions of Chinese pharmacopoeia and assay method drew dissolution and dissolution time by version in 1985;
(4), obtain component stripping parameter, distribute according to Weibull and extract the stripping parameter, draft nonlinear mathematical model with Matlab software;
Stripping parameter T
50(time of composition stripping 50%) relational expression with medical material content is:
T
50=b
0*b
1^X；y=e^(b
0+b
1X)；y=b
0e^(b
1X)
b
0, b
1Be the nonlinear fitting coefficient
X: the content % of pill Chinese crude drug
Y: for accounting for the percentage amounts of preparation composition weight;
(5), prepare pill according to material component and compatibility amount, or material component is extracted or micronization, make pill;
(6), measure the pill dissolution, according to model drug checking stripping parameter; Adjust component ratio according to the result, be prepared into again pill, measure again dissolution, verify again, until finally reach best compatibility ratio.
Below in conjunction with concrete prescription the specific embodiment of the present invention is elaborated again.
Take Rhizoma Dioscoreae Rhizoma Cimicifugae ball as example, this Rhizoma Dioscoreae Rhizoma Cimicifugae ball is by Pheretima, Halloysitum Rubrum, Semen Armeniacae Amarum, Natrii Sulfas, Olibanum, Rhizoma Dioscoreae and Rhizoma Cimicifugae are made, has the spleen invigorating invigorating middle warmer, ascending up spleen-Qi and Yang, be used for deficiency-weakness of spleen-QI, the gastrointestinal dysfunction disease of sinking of QI of middle-JIAO, such as chronic abdominal pain, chronic diarrhea, chronic colitis etc., according to prescription element, be conventional formulation (ordinary preparation), " two rated conditions of Chinese pharmacopoeia and assay method drew dissolution according to version in 1985, the effective ingredient ferulic acid is planted agent's stripping in 45 minutes more than 70%, determine to have in the prescription material of auxiliary property effect, by the material of decoction pieces in the prescription is analyzed, draw the decoction pieces with the effect of auxiliary property and be classified as follows:
Rhizoma Dioscoreae-starch based; Rhizoma Cimicifugae-fiber-like; Halloysitum Rubrum-mineral substance; Pheretima-protide; Semen Armeniacae Amarum-oils; Natrii Sulfas-solubility salt; Olibanum-resin natural gum;
The preparation of model pill, according to prescription Chinese medicine ratio, (prescription Chinese medicine ratio can not be adjusted, but can pass through water boiling and extraction in 12 ratio adjustment with each material in uniform design, change the ratio of the raw material powder with adjuvant function), prepare 12 kinds of pills;
Extract the stripping parameter: " two ones of Chinese pharmacopoeia were measured the dissolution of 12 kinds of pills to stripping parameter defined terms and assay method, distribute according to Weibull and extract the stripping parameter, calculate stripping parameter T by version in 1985
70(time of composition stripping 70%), see the following form.
From upper table as seen, the dissolution of 1,2,3,4,5, No. 9 pill of experiment meets that " Chinese pharmacopoeia regulation, other is all against regulation.In production reality, can according to the complexity of pill molding, preparation, in 1,2,3,4,5, No. 9, select the optimum proportion ratio;
Stripping parameter T
70Nonlinear mathematical model match with proportion scale: often so lucky in production reality, may once test and can not obtain pill up to specification, then need by proportioning materials ratio and stripping parameter T
70Between the non-linear relation match, generally adopt the Matlab software data processing, obtain the algebraic relation formula of the two, by calculating, obtain reasonable proportion scale, this routine result of calculation is as follows:
T
70=207.367-629.736X
1+289.695X
4+415.280X
5-653.657X
7 R
2=0.9591
Y: be T
50(min)
X: the content % of pill Chinese crude drug
X
1: Pheretima; X
4: Natrii Sulfas; X
5: Olibanum; X
7: Rhizoma Cimicifugae
R
2Be regression coefficient square, its Zhi Jie more is nearly 1, shows that Ni closes Qu Xian more good
The result of this routine match is linear representation, and linear mathematical model is a kind of special case of non-linear number;
Adjust the material ratio: this example is chosen in the prescription 7 kinds of materials and is tested, dissolution there be above-mentioned 4 kinds of only having of appreciable impact, wherein Pheretima, Rhizoma Cimicifugae show the promotion stripping, and Natrii Sulfas, Olibanum are the retardance stripping, obtain the optimum proportion ratio by the ratio of adjusting 4 kinds of material raw material powders;
This example has the dissolution of 1,2,3,4,5, No. 9 pill to meet " pharmacopeia " regulation, and optional leeway is larger, therefore directly choose the charge ratio of No. 5 pills, adjusts pill prescription ratio;
Prepare pill, verify whether dissolution is up to specification, determines best proportioning materials ratio;
Get in No. 5 pill prescription ratios and to be ground into fine powder, the preparation pill;
Measure dissolution.The time of calculating stripping 70% is T
70=28.56 minutes, up to specification;
According to above-mentioned steps, the best compatibility that obtains at last Rhizoma Dioscoreae Rhizoma Cimicifugae ball is: Pheretima 11.22%, Halloysitum Rubrum 17.97%, Semen Armeniacae Amarum 6.92%, Natrii Sulfas 1.40%, Olibanum 7.54%, Rhizoma Dioscoreae 32.08% and Rhizoma Cimicifugae 22.87%, this prescription is tested through clinical 158 people, be used for the treatment of chronic abdominal pain, chronic spleen rushes down, the functional disorder of intestine diseases such as chronic colitis, effective percentage is up to more than 99%, than the Rhizoma Dioscoreae Rhizoma Cimicifugae ball effective percentage mean height of other component compatibility amount more than 10%, and dosage is little, safety, fully shown the reliable of the inventive method, safety, the suitability, because the test method of medicine all is known technology, no longer describe in detail in the description of the present invention.
Can find out by stating, its core of the present invention be each Chinese medicine as a kind of solid substance, have simultaneously two large attributes-property of medicine and auxiliary property, i.e. therapeutical effect and the adjuvant effect stripping of retardance composition (promote or), the two is the unification of content and form, is the unification of pharmacodynamics and pharmaceutics.By changing the decoction pieces material ratio that has remarkable auxiliary property in the medicine pill, can solve pill stripping problem.
In preparation during medicine pill, should remove as far as possible on the one hand in the medicine through confirming invalid composition, thereby farthest reduce the dose of pill; On the other hand, be able in order better to bring into play curative effect, suitably keep some without the invalid components of confirming or having confirmed, as long as these compositions possess the adjuvant effect that is suitable for this medicine drug effect performance.
One of characteristics of Chinese medicine are the compound recipe medications, each material medicine possesses different auxiliary property, can carry out as required choice and optimization: if we can carry out auxiliary Journal of Sex Research to 500 kinds of Chinese medicines commonly used, then can reach economize on resources (medical material), energy savings, reduction poisonous side effect of medicine, improve biological effectiveness, be conducive to develop new effective preparation, be conducive to embody Chinese medicine " harmony between man and nature " theory.
Medicine pill is by raw material of Chinese medicine powder or extracting section thing or adds certain adjuvant, is prepared from by certain technique.The fiber-like that pill itself contains, protein-based, polysaccharide, pectin, lymphatic temperament, resinae, waxiness class, fat, oils and fats etc. have to promote or the adjuvant effect of retardance effective ingredient stripping.Jointly having formed the entity (the medicine adjuvant is unified) of medicine, adjuvant with the contained effective ingredient of pill, is the entity of pharmaceutics, pharmacodynamics.
In addition, we carry out further investigated by the formulation characteristic to pill and research is found, medicine pill or full powder formulation, or the former powder of part adds the preparation that extractum, Mel etc. are made, but all have the Activities of Some Plants cell to exist.The plant cell diameter is generally 10-100 μ m, much smaller than the fine powder particle diameter (150 μ m-180 μ m) of preparation pill.Therefore, the plant cell majority is complete basically in pill.The cell membrane that the cell wall that complete plant cell skin is comprised of tough and tensile cellulose, lignin etc. reaches two structure of phospholipid surrounds, coating in the similar modern preparation or microcapsule, microsphere, stripping to effective ingredient has certain regulating and controlling effect, is the distinctive adjuvant of pill.Based on the above-mentioned fact, by part medicinal raw material in the pill prescription is carried out water or ethanol extraction, control the content of fiber-like wherein, protein-based, polysaccharide, pectin, lymphatic temperament, resinae, waxiness class etc., or by micropowder technique destruction plant cell, effective ingredient is exposed, accelerate the composition stripping, thus the dissolution of control pill.
Experiment one:To contain the more medical material Pheretima of protide composition as object of study, total flavones carries out the stripping experiment as index in the pill, and we have measured the dissolution of 12 kinds of pills, distributes according to Weibull and extracts the stripping parameter, use the SPSS software data processing, drafted nonlinear mathematical model.Stripping parameter T
50(time of composition stripping 50%) relational expression with medical material content is:
Y=b
0*b
1^X；y=e^(b
0+b
1X)；y=b
0e^(b
1X)
b
0, b
1Be the nonlinear fitting coefficient
Y: be T
50(min)
X: the content % of pill Chinese crude drug
Experiment two:Equally, take the more medical material Rhizoma Cimicifugae of cellulose constituents as object of study, draw following mathematical model:
Y=596 - 5984X+27489X
2 - 41704X
3 ,
Experiment shows: protein-based in the pill/fiber-like medical material content becomes negative correlation/positively related quantitative change relation with its dissolution, protein-based/fiber-like Chinese medicine has played the effect of blocker/promoter adjuvant in pill effective ingredient process in leaching.Regulate the dissolution of albumen quality class/controlled pill agent of fiber-like medical material content namely under certain condition,
［ 3,4 ］
Experiment three:The medicine material that affects the pill stripping is divided into seven classes, be starch based, fiber-like, mineral substance, animal proteinum class, oils, solubility salt, resin natural gum class etc., and select seven kinds of representative drugs Rhizoma Dioscoreaes, Rhizoma Cimicifugae, Halloysitum Rubrum, Pheretima, Semen Armeniacae Amarum, Natrii Sulfas, Olibanum as object of study, adopt multifactor multilevel Uniform Design method prescription, in the situation that strict control technological parameter prepares 12 batches of pills.Investigate by the dissolution to index components sodium ferulate (good water solubility) and rutin (poorly water-soluble), data have been set up the mathematical model relational expression between material and stripping parameter through software processes such as SPSS:
Y=0.740-0.132*X
2-0.628*X
3-1.289*X
4-1.503*X
5-0.295*X
6+0.575*X
7
Experiment shows: Rhizoma Cimicifugae promotes stripping; Semen Armeniacae Amarum, Natrii Sulfas, Olibanum, Rhizoma Dioscoreae, Halloysitum Rubrum suppress stripping, and inhibiting order is: Olibanum〉Natrii Sulfas〉Semen Armeniacae Amarum〉Rhizoma Dioscoreae〉Halloysitum Rubrum.Be the stripping that the fiber-like medical material can promote pill, and effect significantly; Solubility salt, resin natural gum class, starch based, oils and mineral substance suppress the stripping of pill, and the order of effect is: resin natural gum class〉the solubility salt〉oils〉starch based〉mineral substance.
The above-mentioned pill " the auxiliary general theory of medicine " that experimental results show that has also proved the stripping that can control pill by material ratio in the adjusting prescription, solves pill dissolution problem, thereby reaches the purpose of performance optimum curative effect.Therefore, the present invention compared with prior art has following outstanding characteristics and significant progressive:
1, rationally utilizes the natural spice resource of Chinese medicine, both can reach the clinical treatment purpose simultaneously, have important practical significance again.
2, by the effect of Chinese medicine material performance pharmaceutical adjunct
1) the clinical drug effect that is conducive to bring into play expection prepares slow releasing pill such as the retardation by spice, reduces toxicity, delays drug effect, for traditional Chinese medical science preventive treatment of disease, prevention and health care provide the medicine support thereby reach;
2) molding that is conducive to medicament such as viscosity, adsorptivity by spice, help the molding of pill, or increase the flexible plasticization of medicament etc.;
3) be conducive to the finishing smoothly such as the fluidizer that increases the medicated powder flowability, the effect such as lubricated, anti-stick of preparation process, being conducive to the preparation preparation process carries out smoothly;
4) stability that is conducive to improve preparation is as preventing the protective effect of the rotten antioxygen of oxidation of drug, painted, coating etc.;
5) raising that is conducive to patient compliance is conducive to patient's compliance such as the taste masking that improves the pharmaceutical preparation mouthfeel, sweet taste etc., improves clinical efficacy.
3, to the meaning of socio-economic development
1) (medical material) economizes on resources: make the former invalid Chinese medicine ingredients thought, become useful " adjuvant ", realize sustainable development;
2) energy savings, low-carbon (LC): reduce the consumption because of extracts active ingredients, concentrated, the dry run energy;
3) reduce poisonous side effect of medicine: improve the safety of medicament, guarantee drug safety;
4) improve biological effectiveness: improve the curative effect of medicament, be conducive to social diseases prevention, cure the disease, prevention and health care;
5) be conducive to develop new effective preparation: by research, the excavation of Chinese medicine adjuvant performance, promote new drug development.
Claims (1)
1. an experiment calculation method that is applicable to solve Chinese medicine pill Ji stripping problem is characterized in that, is realized by following steps:
(1), determine the pill dosage form: the function according to prescription cures mainly, the target formulation of component dosage, clinical requirement, and pill is divided into ordinary preparation, slow releasing preparation, durative action preparation;
(2), analyze the component effect in the pill prescription, which component has complementary function, which component has functional character, lists the auxiliary sexual function classification of Chinese medicine from short molten, the molten aspect of resistance:
According to classification, the prescription Chinese medicinal components is analyzed, determine the significant component of auxiliary property;
(3), according to the classification of the auxiliary property of Chinese medicine, select the Chinese medicinal components that possesses respective secondary, and process, method is, the inapparent component of auxiliary property is directly carried out extracts active ingredients or micronization, the significant component of auxiliary property is prepared model drug by calculating material proportion, and carry out Dissolution Rate Testing, " two rated conditions of Chinese pharmacopoeia and assay method drew dissolution and dissolution time by version in 1985;
(4), obtain component stripping parameter, distribute according to Weibull and extract the stripping parameter, draft nonlinear mathematical model with Matlab software;
The time T of composition stripping 50%
50With the relational expression of medical material content be:
y=b
0*b
1^X；y=e^(b
0+b
1X)；y=b
0e^(b
1X)
b
0, b
1Variation coefficient for nonlinear fitting
X: the content % of pill Chinese crude drug
Y: be the time of pill composition stripping 50%;
(5), prepare pill according to material component and compatibility amount, or material component is extracted or micronization, make pill;
(6), measure the pill dissolution, according to model drug checking stripping parameter; Adjust component ratio according to the result, be prepared into again pill, measure again dissolution, verify again, until finally reach best compatibility ratio.
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| Title |
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| 陈天朝.中药丸剂的缓释制剂特点探讨.《药学专论》.2009,第18卷(第6期),17-19. * |
| 陈天朝等.含蛋白质类中药与丸剂溶出度的量变关系研究.《中国实用医药》.2008,第3卷(第34期),16-18. * |
| 陈天朝等.纤维类中药对水丸溶出度影响的试验研究.《中国实验方剂学杂志》.2010,第16卷(第16期),21-23. * |
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Inventor after: Chen Tianchao Inventor after: Zha Daocheng Inventor after: Li Xuelin Inventor after: Liu Ruixin Inventor after: Kang Bingya Inventor after: Tang Jinfa Inventor before: Chen Tianchao Inventor before: Li Xuelin Inventor before: Liu Ruixin Inventor before: Kang Bingya Inventor before: Tang Jinfa |
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Free format text: CORRECT: INVENTOR; FROM: CHEN TIANCHAO LI XUELIN LIU RUIXIN KANG BINGYA TANG JINFA TO: CHEN TIANCHAO CHA DAOCHENG LI XUELIN LIU RUIXIN KANG BINGYA TANG JINFA |
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Granted publication date: 20130220 Termination date: 20210913 |
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