CN102293685A - Animal skin cutting knife and application thereof - Google Patents
Animal skin cutting knife and application thereof Download PDFInfo
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- CN102293685A CN102293685A CN2011102269502A CN201110226950A CN102293685A CN 102293685 A CN102293685 A CN 102293685A CN 2011102269502 A CN2011102269502 A CN 2011102269502A CN 201110226950 A CN201110226950 A CN 201110226950A CN 102293685 A CN102293685 A CN 102293685A
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- animal skin
- knife rest
- cutting tool
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- skin cutting
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Abstract
The invention relates to an animal skin cutting knife, which comprises a knife frame, wherein a knife blade is fixed at both ends of the knife frame, and balance and thickness regulators are also arranged on the knife frame. The knife has the advantages that the thickness of the cut skin can be freely regulated, different layers of the animal skin are cut, in addition, the structure is simple, the design is reasonable, and the preparation cost is very low. The cut skin can be used for an in-vitro evaluation micro needle transdermal medication system. Because no proper knife for cutting the animal skin exists in the prior art, the animal skin cutting knife fills the blank that the in-vitro evaluation aiming at the transdermal medication system needs the separation of the skin stratum corneum.
Description
Technical field
The present invention relates to technical field of mechanical cutting tool manufacture, relate in particular to a kind of animal skin cutting tool and application thereof.
Background technology
Along with science and technology development, transdermal drug delivery system is developed into microneedle cutaneous by traditional drug delivery system, the advantage of micropin medicine-feeding technology maximum is that it can sting saturating biggest obstacle---epidermis and the horny layer thereof that hinders drug absorption under the prerequisite that does not injure corium and nerve.Owing to do not contact nerve, micropin does not create a painful feeling to piercing through of epidermis, even also be that the reversible deformation of skin is greater than wound for the Wicresoft of epidermis, but micropin is removed back reinstatement in a few hours, and water soluble drug, comprise protein polypeptide, then the pin hole that can sting out by micropin and entering in the body effectively.
But owing to contain especially subcutaneous layer of fat of thicker subcutaneous tissue, this skin is difficult to be adapted to be used for estimating the in vitro study that is similar to the micropin transdermal at external traditional animal skin.Because microneedle cutaneous system is exactly at horny layer, promptly as long as micropin can pierce through horny layer and just can be used for estimating its administering effect.Therefore, how isolating the horny layer of skin, is the problem that the in-vitro evaluation of such drug-supplying system is at present needed solution badly.
Summary of the invention
The present invention provides a kind of animal skin cutting tool and application thereof that animal skin can be divided into different-thickness for the problem that solves above-mentioned prior art existence.
Purpose of the present invention is achieved through the following technical solutions:
A kind of animal skin cutting tool comprises:
One knife rest;
One blade is fixed in described knife rest two ends;
Also comprise balance and thickness adjusting apparatus on the described knife rest.
Preferably, described knife rest is 1/4 sphere-like.
Preferably, described blade is sawtooth pattern, linear type or annular saw flute profile, and the blade two ends are fixed on the knife rest by screw, or with knife rest clamping, welding.
Preferably, described balance and thickness adjusting apparatus are some set screw or the micro actuator of being located at the knife rest bottom.
Preferably, described cutter also comprises a base, described knife rest be positioned on this base and on base any direction move.
Preferably, described base is tabular.
Preferably, also be provided with one on the described base and be used for fixing zoodermic fixed station, this fixed station comprises the height adjustable pressing plate of base plate and base plate top.
Preferably, described base plate is the groove shape, and base plate is fixed or is welded on by set screw on the base, and pressing plate flexibly connects by screw and brace, and brace is fixedlyed connected with base or base plate.
The application of animal skin cutting tool, described cutter is used for animal skin is divided into different-thickness.
Compared with prior art, the present invention has following beneficial effect:
The present invention is applied to the curative effect that field of medicaments animal isolated experiment is estimated transdermal drug delivery system, at this class medicine-feeding technology, provides a kind of animal skin cutting tool and application thereof.
Cutter of the present invention can be regulated the thickness of cutting apart skin arbitrarily, be partitioned into zoodermic different layers, as horny layer, horny layer and skin corium or horny layer and corium and subcutaneous non-fat deposit as the skin layer of the 40-2000 micron of not fatty layer etc., and simple in structure, reasonable in design, preparation cost is very cheap.The skin of cutting can be used for the microneedle cutaneous system of in-vitro evaluation, owing to also be not fit to cut apart at present the cutter that animal skin is used, the present invention has filled up the blank of isolating keratodermatitis at the in-vitro evaluation needs of such transdermal drug delivery system.
Description of drawings
Fig. 1 is the structural representation of the embodiment of the invention one;
Fig. 2 is the structural representation of the embodiment of the invention two.
The specific embodiment
Describe the present invention in detail below in conjunction with accompanying drawing.
Embodiment one
As shown in Figure 1, a kind of animal skin cutting tool comprises: a knife rest 1, and knife rest 1 is 1/4 sphere-like, is welded or be spirally connected by some steel bars to form; Be fixed with a blade 2 at the two ends of knife rest 1 diametrical position, blade 2 preferred sawtooth patterns, linear type or annular saw flute profile, blade 2 two ends are fixed on the knife rest 1 by screw, or with knife rest 1 clamping, welding, the blade edge of a knife is toward the outer side, and is parallel with horizontal line; Also be provided with balance and thickness adjusting apparatus in knife rest 1 bottom, this balance and thickness adjusting apparatus are three set screw 3(or the micro actuator that is divided into knife rest 1 bottom).
Embodiment two
As the preferred embodiments of the present invention, as shown in Figure 2, a kind of animal skin cutting tool, comprise that knife rest 1, blade 2 and balance and thickness adjusting apparatus are set screw 3, this cutter also comprises tabular pedestal 4, as the sheet material of rectangle corrosion resistant plate or other other shapes of material, knife rest 1 places on this base 4 and can move with any direction on base 4.
Preferably, also be provided with one on the base 4 and be used for fixing zoodermic fixed station, this fixed station comprises the height adjustable pressing plate 52 of base plate 51 and base plate top.Base plate 51 is a square indentations, base plate 51 is fixed or is welded on the base 4 by set screw, pressing plate 52 is square corrosion resistant plate (or sheet material of other other shapes of material), flexibly connects by screw and brace 53, and brace 53 is fixedlyed connected with base 4 or base plate 51.
Cutter of the present invention is used for animal skin is divided into different-thickness.During use, what at first will need to cut is placed on the fixed station through refrigerated animal skin tissue, regulate the spacing of pressing plate and base plate, animal skin tissue is fixed, then knife rest is placed on the base, the set screw (or micro actuator) of regulating the knife rest bottom makes the knife rest balance, and with fixed station on the zoodermic thickness that needs to cut at same horizontal plane, follow rest makes the edge of a knife aim at animal skin and cuts then.
The present invention is applied to the curative effect that field of medicaments animal isolated experiment is estimated transdermal drug delivery system, at this class medicine-feeding technology, provides a kind of animal skin cutting tool and application thereof.
Cutter of the present invention can be regulated the thickness of cutting apart skin arbitrarily, be partitioned into zoodermic different layers, as horny layer, horny layer and skin corium or horny layer and corium and subcutaneous non-fat deposit as the skin layer of the 40-2000 micron of not fatty layer etc., and simple in structure, reasonable in design, preparation cost is very cheap.The skin of cutting can be used for the microneedle cutaneous system of in-vitro evaluation, owing to also be not fit to cut apart at present the cutter that animal skin is used, the present invention has filled up the blank of isolating keratodermatitis at the in-vitro evaluation needs of such transdermal drug delivery system.
More than disclosed only be several specific embodiments of the application, but the application is not limited thereto, any those skilled in the art can think variation, all should drop in the application's the protection domain.
Claims (9)
1. an animal skin cutting tool is characterized in that, comprising:
One knife rest;
One blade is fixed in described knife rest two ends;
Also comprise balance and thickness adjusting apparatus on the described knife rest.
2. animal skin cutting tool as claimed in claim 1 is characterized in that, described knife rest is 1/4 sphere-like.
3. animal skin cutting tool as claimed in claim 1 is characterized in that, described blade is sawtooth pattern, linear type or annular saw flute profile, and the blade two ends are fixed on the knife rest by screw, or with knife rest clamping, welding.
4. animal skin cutting tool as claimed in claim 1 is characterized in that, described balance and thickness adjusting apparatus are some set screw or the micro actuator of being located at the knife rest bottom.
5. animal skin cutting tool as claimed in claim 1 is characterized in that described cutter also comprises a base, described knife rest be positioned on this base and on base any direction move.
6. animal skin cutting tool as claimed in claim 5 is characterized in that, described base is tabular.
7. animal skin cutting tool as claimed in claim 5 is characterized in that, also is provided with one on the described base and is used for fixing zoodermic fixed station, and this fixed station comprises the height adjustable pressing plate of base plate and base plate top.
8. animal skin cutting tool as claimed in claim 7 is characterized in that, described base plate is the groove shape, and base plate is fixed or is welded on by set screw on the base, and pressing plate flexibly connects by screw and brace, and brace is fixedlyed connected with base or base plate.
9. the application of an animal skin cutting tool as claimed in claim 1 is characterized in that, described cutter is used for animal skin is divided into different-thickness.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110226950.2A CN102293685B (en) | 2011-08-09 | 2011-08-09 | Animal skin cutting knife and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110226950.2A CN102293685B (en) | 2011-08-09 | 2011-08-09 | Animal skin cutting knife and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102293685A true CN102293685A (en) | 2011-12-28 |
| CN102293685B CN102293685B (en) | 2014-04-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110226950.2A Expired - Fee Related CN102293685B (en) | 2011-08-09 | 2011-08-09 | Animal skin cutting knife and application thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN102293685B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103750922A (en) * | 2013-12-31 | 2014-04-30 | 金仕生物科技（常熟）有限公司 | Artificial heart valve and valve leaflet manufacturing method |
| CN104027182A (en) * | 2014-06-23 | 2014-09-10 | 中国农业科学院特产研究所 | Combined tool for animal intracutaneous cutting |
| CN104376772A (en) * | 2014-11-03 | 2015-02-25 | 力帆实业(集团)股份有限公司 | Rough clay model machining tool |
| CN105361970A (en) * | 2015-09-28 | 2016-03-02 | 宁波出入境检验检疫局检验检疫技术中心 | Animal skin wound treatment device |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226315A (en) * | 1996-07-29 | 1999-08-18 | 莱卡显微系统努斯洛赫股份有限公司 | Disc-type slicer |
| US20090138027A1 (en) * | 2007-11-28 | 2009-05-28 | Dadson Manufacturing Corp. | Dermatome with ultrasonic cutting blade |
| CN101756628A (en) * | 2009-10-21 | 2010-06-30 | 刘博宇 | Novel fruit knife |
-
2011
- 2011-08-09 CN CN201110226950.2A patent/CN102293685B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226315A (en) * | 1996-07-29 | 1999-08-18 | 莱卡显微系统努斯洛赫股份有限公司 | Disc-type slicer |
| US20090138027A1 (en) * | 2007-11-28 | 2009-05-28 | Dadson Manufacturing Corp. | Dermatome with ultrasonic cutting blade |
| CN101756628A (en) * | 2009-10-21 | 2010-06-30 | 刘博宇 | Novel fruit knife |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103750922A (en) * | 2013-12-31 | 2014-04-30 | 金仕生物科技（常熟）有限公司 | Artificial heart valve and valve leaflet manufacturing method |
| US10149755B2 (en) | 2013-12-31 | 2018-12-11 | Kingstronbio (Changshu) Co., Ltd. | Method for preparing an artificial heart valve leaflet |
| CN104027182A (en) * | 2014-06-23 | 2014-09-10 | 中国农业科学院特产研究所 | Combined tool for animal intracutaneous cutting |
| CN104376772A (en) * | 2014-11-03 | 2015-02-25 | 力帆实业(集团)股份有限公司 | Rough clay model machining tool |
| CN105361970A (en) * | 2015-09-28 | 2016-03-02 | 宁波出入境检验检疫局检验检疫技术中心 | Animal skin wound treatment device |
| CN105361970B (en) * | 2015-09-28 | 2018-01-30 | 宁波出入境检验检疫局检验检疫技术中心 | Animal skin breakage processor |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102293685B (en) | 2014-04-30 |
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Granted publication date: 20140430 Termination date: 20160809 |
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