JP2015231476A - Needle-like body pad - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a needle-like body pad capable of effectively feeding a medicament to a target skin layer by a simple and inexpensive method.SOLUTION: A needle-like body pad P including a plurality of needle-like parts 12 on one surface of a base part 11 as a base plate, includes a reinforcing layer 5 on a surface in a side where the needle-like parts 12 of the base part 11 are formed, where the base part 11 and the needle-like parts 12 are formed using a medical resin as a material. The reinforcing layer 5 is formed into such a shape as to reduce a gap between tips of the needle-like parts 12 and the root parts of the needle-like parts 12, and is disposed around the needle-like parts 12, with it stuck to a surface forming the needle-like parts 12 out of the base part 11.

Description

  The present invention relates to a structure of a needle-like body pad used for administration of a drug into the skin.

It is widely established that drugs such as vaccines are administered into the body by injection. Although injection is a highly safe administration method, many of them are severely painful because a needle is punctured deep into the body for drug administration to subcutaneous tissues. In developing countries in particular, there is a high possibility of infection or needle stick accidents due to reuse of injection needles.
Therefore, as a method for administering a drug in place of injection, attention has been paid to a method in which a drug is directly permeated into the skin by perforating the skin using an array composed of a large number of microscopic needles.

According to this method, by controlling the length of the needle-like body so as not to reach the nerve cells in the dermis layer, it is possible to suppress pain felt by the patient at the time of puncturing the skin. In addition, it is possible to easily administer a drug intradermally without using a special medication device (see, for example, Patent Documents 1 and 2).
In addition, when the vaccine is administered intradermally using needles, the amount of vaccine used should be reduced compared to subcutaneous injection for administration into the skin where antigen presenting cells are abundant. Is possible.

The shape of the needle-like body is required to have a sufficient thinness and a tip angle for piercing the skin and a sufficient length for allowing the drug solution to penetrate into the skin.
For this reason, the diameter of the acicular body is preferably within a range of several μm or more and several hundred μm or less. The length of the acicular body is preferably a length that can penetrate the stratum corneum, which is the outermost layer of the skin, and does not reach the nerve layer, specifically, a range of several tens μm to several hundreds μm. The inside is preferable.

The material constituting the needle-shaped body is required not to adversely affect the human body even if the needle-shaped body is broken and remains in the body. As such a material, for example, a resin material having biocompatibility such as medical silicone, maltose, polylactic acid, and dextran is considered promising (see, for example, Patent Document 3).
In the case of producing a needle-like body using the resin material as described above, in order to produce a fine structure such as a needle-like body at a low cost and in large quantities using such a resin material, for example, Transfer molding methods typified by injection molding, imprinting, casting and the like are effective.

However, in any method, in order to perform molding, a mold in which a desired shape is inverted is necessary, and an aspect ratio (height or depth of the structure with respect to the diameter of the structure body) is required. In order to form a structure having a high ratio), a complicated manufacturing process is required.
In addition, the biocompatible resin material (biocompatible resin material) as described above is more expensive than a general resin material, so that the biocompatible resin does not impair the function of the needle-like body. Reducing the amount of material used is one of the effective methods for cost reduction.

JP 2006-345993 A JP 2006-341089 A Japanese Patent Laid-Open No. 2005-21677

As a method for reducing the amount of the biocompatible resin material used, for example, there is a method of thinning the base material portion that supports the needle-like body. However, this method has a problem that the strength of the entire needle-like body is lowered and it is difficult to effectively puncture.
The present invention is intended to solve such problems, and provides a needle-like pad that can effectively supply a drug to a target skin layer by a simple and inexpensive method. For the purpose.

In order to achieve the above object, one aspect of the present invention is a needle-like body pad including a needle-like portion on one surface of a substrate,
A reinforcing layer is provided on the surface of the substrate on which the needle-like portion is formed.
One embodiment of the present invention is the acicular pad, wherein the reinforcing layer includes a through hole through which the acicular portion passes.
Another embodiment of the present invention is the acicular pad, wherein the reinforcing layer is curved in the thickness direction of the substrate in a side view.

Another embodiment of the present invention is a needle-like body pad in which a back surface reinforcing layer is provided on a surface of the base material opposite to a surface on which the needle-like portion is formed.
Moreover, one aspect of the present invention includes a reinforcing layer installation recess for installing the reinforcing layer on the surface of the base on which the needle-like part is formed,
The acicular pad is characterized in that the reinforcing layer is installed in the reinforcing layer installation recess.
Another embodiment of the present invention is the acicular pad, wherein the reinforcing layer is formed of a porous material.

  According to one embodiment of the present invention, by selecting a material having high mechanical strength as the material constituting the reinforcing layer, the base material portion can be made thin, and the biocompatible resin material that is a material with a high unit price It becomes possible to reduce the amount of use.

It is a figure which shows the structure of the acicular body pad of 1st embodiment of this invention. It is a figure which shows the manufacturing method of the acicular body pad of 1st embodiment of this invention. It is a figure which shows the modification of this invention. It is a figure which shows the modification of this invention. It is a figure which shows the modification of this invention. It is a figure which shows the modification of this invention. It is a figure which shows the modification of this invention. It is a figure which shows the modification of this invention. It is a figure which shows the modification of this invention. It is a figure which shows the modification of this invention. It is a figure which shows the modification of this invention. It is a figure which shows the modification of this invention. It is a figure which shows the modification of this invention. It is a figure which shows the modification of this invention. It is a figure which shows the modification of this invention. It is a figure which shows the modification of this invention. It is a figure which shows the modification of this invention.

Embodiments of the present invention will be described below with reference to the drawings.
(First embodiment)
Hereinafter, a first embodiment of the present invention will be described with reference to the drawings.
(Constitution)
As shown in FIG. 1, the needle-like body pad P (microneedle array) includes a base portion 11 (substrate), a needle-like portion 12, and a reinforcing layer 5. In FIG. 1, only the reinforcing layer 5 is shown in cross section.
The base portion 11 is formed in a flat plate shape using a medical resin such as PGA (Polyglycic acid) as a material.

In the first embodiment, a case where the thickness of the base portion 11 is set to 100 μm will be described as an example.
The needle-like portion 12 is formed integrally with the base portion 11 using a medical resin as a material, and a plurality of needle-like portions 12 are formed on at least one surface of the base portion 11.
The plurality of needle-like portions 12 are arranged in a square lattice shape.

  In the first embodiment, as an example, a case will be described in which the plurality of needle-like portions 12 are configured by 16 needle-like bodies of 4 rows × 4 rows. In the first embodiment, as an example, a case where the pitch between adjacent needle-like parts 12 is 800 μm and the outer shape of the chip is a 5 mm square will be described. In the first embodiment, as an example, a case where the height of the needle-like part 12 is 800 μm and the maximum value of the diameter of the needle-like part 12 is 300 μm will be described.

As a manufacturing method of the needle-like part 12, it is possible to use machining such as grinding and cutting for the base part 11 (material of the base part 11), for example.
The shape of the needle-like part 12 is a needle-like body. The shape of the needle-like part 12 is not particularly limited as long as it is a needle-like body, and may be, for example, a cone or a pyramid. A plurality of needle-like parts 12 may be arranged on the surface of the base part 11.

The medical resin used as the material of the base portion 11 and the needle-like portion 12 is not particularly limited. However, when a thermoplastic medical resin is used, the base portion 11 and the needle-like shape can be obtained by appropriately controlling the temperature rise and fall. The part 12 can be produced quickly.
The reinforcing layer 5 reduces the gap between the tip (needle tip) of the needle-like part 12 and the root part of the needle-like part 12, and adheres to the surface of the base part 11 where the needle-like part 12 is formed. And disposed around the needle-like portion 12. Specifically, the reinforcing layer 5 is bonded to the surface of the base portion 11 where the needle-like portion 12 is formed so as to cover the outer peripheral portion of the needle-like portion 12 and a part between the needle-like portions 12. Yes.

The material of the reinforcing layer 5 is not particularly limited, but a metal material such as stainless steel or a resin material such as polyethylene may be used. In the first embodiment, as an example, a case where a medical polycarbonate is used as the material of the reinforcing layer 5 will be described.
Here, when the material of the reinforcing layer 5 is a metal material, the strength is higher than when the material of the reinforcing layer 5 is a resin material, and the base portion 11 formed of a medical resin is deformed into a desired shape. Adjustment to make it easy to adjust to a parallel shape.

On the other hand, when the material of the reinforcing layer 5 is a resin material, it is cheaper than the case where the material of the reinforcing layer 5 is a metal material, and the weight is light and does not contain non-combustible materials at the time of disposal. Handling becomes easy.
As an adhesive for adhering the reinforcing layer 5 to the base portion 11, for example, a medical adhesive such as a medical acrylic adhesive can be used as appropriate.
In the first embodiment, a case where the thickness of the reinforcing layer 5 is 300 μm will be described as an example. In the first embodiment, as an example, as the width of the reinforcing layer 5, the width of the portion bonded to the outer periphery of the needle-shaped portion 12 is 1050 μm, and the width of the portion bonded between the needle-shaped portions 12 is 300 μm. The case will be described.

(Manufacturing method of acicular pad)
Next, the manufacturing method of the needle-like body pad P is demonstrated using FIGS. 2-4, referring FIG.
The manufacturing method of the acicular pad P has a duplicate plate manufacturing process and a acicular pad manufacturing process.
-Replicated plate manufacturing process In the replicated plate manufacturing process, in order to fabricate a large amount of the same needle-shaped body, the original needle-shaped body pad 1 shown in FIG. As described above, the duplicate plate 2 having a concave portion obtained by inverting the shape of the needle-like portion 12 is produced.

The original needle pad 1 is formed using, for example, silicon.
Further, a step forming concave portion 1a is formed at a position corresponding to the surface of the original needle-like body pad 1 on which the needle-like portion 12 of the base portion 11 is formed. Thereby, as shown in FIG.2 (c), the duplicate plate 2 will have the level | step difference 7 which is the convex part which reversed the shape of the recessed part 1a for level | step difference formation. In the first embodiment, a case where the height of the step 7 is set to 100 μm will be described as an example.

Further, the duplicate plate 2 is formed using, for example, Ni (Nickel) or silicon.
-Needle-shaped body pad manufacturing process In the needle-shaped body pad manufacturing process, as shown in FIG.2 (d), the medical resin 3 is arrange | positioned on the recessed part of the replica plate 2 manufactured at the replica plate manufacturing process. Next, as shown in FIG. 2 (e), the medical resin 3 is melted and filled in the recesses of the duplicate plate 2. Thereby, the base part 11 and the needle-like part 12 are formed. The base portion 11 may be made thin. For example, the thickness of the base portion 11 can be reduced by limiting the amount of the medical resin 3 to be supplied or by reusing the surplus portion outside the frame. The cost increase may be suppressed while keeping the constant. In addition, since the base portion 11 can be easily deformed into a curved surface by making the base portion 11 thin, for example, by using the curved reinforcing layer 5, the needle-like body pad in which the base portion 11 is curved is used. P can be easily produced.

After the medical resin 3 filled in the concave portion of the duplicate plate 2 is cured, the cured medical resin 3 is peeled from the concave portion of the duplicate plate 2 as shown in FIG. The pad body 4 is produced. And the reinforcement layer 5 is adhere | attached on the surface in which the acicular part 12 was formed among the base parts 11 which the acicular body pad main body 4 has, and the acicular body pad P is manufactured (refer FIG. 1).
Here, when the cured medical resin 3 is peeled from the concave portion of the duplicate plate 2, the vacuum is applied from the back surface side of the surface on which the needle-like portion 12 is formed in the base portion 11 of the needle-like body pad body 4. The adhesive may be peeled off by adhering the adhesive to the back side. Moreover, you may peel from the replication plate 2 side using an ejector pin.

Further, by adhering the reinforcing layer 5 to the needle-shaped pad body 4, the reinforcing layers 5 having various shapes can be integrated with the needle-shaped pad body 4.
The above-described first embodiment is an example of the present invention, and the present invention is not limited to the above-described first embodiment, and the present invention may be applied to other forms than this embodiment. Various modifications can be made according to the design or the like as long as they do not depart from the technical idea. Furthermore, the above-described first embodiment includes inventions at various stages, and various inventions can be extracted by appropriately combining a plurality of disclosed constituent elements. For example, even if some structural requirements are deleted from all the structural requirements shown in the first embodiment described above, the problem described in the column of the problem to be solved by the invention can be solved, and is described in the effect of the invention. In the case where the effect obtained is obtained, a configuration from which this configuration requirement is deleted can be extracted as an invention.

(Effects of the first embodiment)
The acicular pad P of the first embodiment is provided with the reinforcing layer 5 on the surface of the base portion 11 on which the acicular portion 12 is formed, and selects a material having high mechanical strength as a material constituting the reinforcing layer 5. This makes it possible to reduce the thickness of the base 11 without reducing the strength of the entire needle-like body pad P, and to reduce the amount of biocompatible material that is a high-priced material. It becomes.

In addition, the needle-like body pad P of the first embodiment can reduce the amount of biocompatible material that is a high-priced material without using a biodegradable resin.
Furthermore, since the needle-like body pad P of the first embodiment can change the height of the needle-like portion 12 by changing the thickness of the reinforcing layer, skin (for example, heels) having a different thickness depending on the part. In this case, it is possible to form a needle-like body pad P that can accommodate about 2 mm for the epidermis and dermis, and about 0.6 mm for the heel.

Moreover, since the needle-like body pad P of the first embodiment can change the height of the needle-like portion 12 by changing the thickness of the reinforcing layer, the skin (for example, a newborn) whose thickness varies with age. Etc. is only about half the thickness of adults, and after adults tend to become thinner with age).
That is, the needle-like pad P of the first embodiment can be prepared from needle-like bodies of one size, and the needle-like body pads having various heights of needle-like portions can be manufactured. It is advantageous.

(Modification)
Hereinafter, modifications of the first embodiment will be described.
(1) For example, as shown in FIG. 3, the reinforcing layer 5 may be fitted into the needle-shaped pad body 4 in order to integrate the needle-shaped pad body 4 and the reinforcing layer 5. Further, for example, the reinforcing layer 5 may be fitted so as to surround the side surface portion of the needle-like portion 12. In this case, the needle pad body 4 and the reinforcing layer 5 can be firmly integrated without using a special adhesive by fitting. Note that FIG. 3 shows a cross section of only the reinforcing layer 5.

(2) For example, as shown in FIG. 4, the reinforcing layer 5 may have a shape surrounding all the needle-like parts 12. In this case, the reinforcing layer 5 surrounds the outer peripheral part of all the needle-like parts 12, so that the area of the reinforcing layer 5 is compared with the configuration in which the needle-like body pad body 4 and the reinforcing layer 5 are fitted together. And the integration process is reduced. Further, it can be easily applied to the needle-like body pad main body 4 having a short pitch between the needle-like portions 12. In FIG. 4, only the reinforcing layer 5 is shown in cross section.

(3) The reinforcing layer 5 may be provided with a strip-shaped opening, for example, as shown in FIG. In this case, it is possible to reduce the amount of material used for the reinforcing layer 5 and arrange the reinforcing layers 5 efficiently. Note that FIG. 5 shows a cross section of only the reinforcing layer 5.
(4) For example, as shown in FIG. 6, the reinforcing layer 5 may be configured to include a through hole 13 through which the needle-like portion 12 passes. In this case, since the reinforcing layer 5 can be formed as close as possible to the needle-like part 12 by reducing the through-hole 13, the height of the applicable needle-like part 12 is more strictly defined. Is possible. FIG. 6 shows a cross section of only the reinforcing layer 5.

(5) For example, as shown in FIG. 7, the reinforcing layer 5 may have a configuration in which only the needle-like portion 12 is opened. In this case, since the reinforcing layer 5 can be formed as close as possible to the needle-like portion 12 by reducing the opening, it is possible to more precisely define the applicable height of the needle-like portion 12. It becomes possible. That is, the reinforcing layer 5 may be provided on all portions other than the needle-like portion 12 in the surface of the base portion 11 on the side where the needle-like portion 12 is formed. In FIG. 7, only the reinforcing layer 5 is shown in cross section.

(6) As the reinforcing layer 5, for example, as shown in FIGS. 8 and 9, reinforcing layers 5 having various thicknesses may be used. In this case, for example, by increasing the thickness of the reinforcing layer 5, the needle-like portion 12 having a low height can be manufactured. 8 and 9, only the reinforcing layer 5 is shown in cross section.
Moreover, if the thickness of the reinforcing layer 5 is changed, the substantial height of the needle-like part 12 will fluctuate. For example, the needle-like part 12 having a height of 500 μm can be produced by providing the reinforcing layer 5 having a thickness of 300 μm to the needle-like part 12 having a height of 800 μm. It becomes possible.
Here, by providing the reinforcing layer 5 having a thickness of 500 μm with respect to the same acicular portion 12, the acicular portion 12 having a height of 300 μm can be produced, and the thickness of the reinforcing layer 5 is changed. It is possible to produce the needle-like part 12 having a plurality of heights by using the same needle-like part 12.

(7) The reinforcing layer 5 may be used by stacking a plurality of stages as shown in FIG. In this case, it can be used as the reinforcing layer 5 having various thicknesses. In addition, in FIG. 10, the cross section of only the reinforcement layer 5 is shown.
(8) As the reinforcing layer 5, for example, a curved reinforcing layer 5 may be used as shown in FIG. In this case, by using the curved reinforcing layer 5, the base portion 11 is curved following the curvature of the reinforcing layer 5, so that the needle-like body pad P that is curved as a whole can be manufactured. In addition, the degree and shape of the curve can be changed according to the shape of the reinforcing layer 5 and can be changed to various shapes such as a convex shape, a concave shape, and a saddle shape. That is, the reinforcing layer 5 may be curved in the thickness direction of the base portion 11 when viewed from the direction orthogonal to the thickness direction of the needle-like body pad P, that is, in a side view. In addition, in FIG. 11, the cross section of only the reinforcement layer 5 is shown.

(9) As the reinforcing layer 5, for example, as shown in FIG. 12, the back surface side reinforcing layer 15 may be provided on the back surface side of the surface of the base portion 11 where the needle-like portion 12 is formed. . In this case, for example, the height of the needle-like portion 12 is adjusted with the reinforcing layer 5 (the front-side reinforcing layer), and the entire bending is suppressed with the back-side reinforcing layer 15. Moreover, it becomes possible to produce the acicular body pad P provided with the acicular part 12 which has a complicated shape and various heights by giving the front and back reinforcing layers different actions. In addition, in FIG. 12, the cross section of only the reinforcement layer 5 is shown.

(10) As the reinforcing layer 5, for example, as shown in FIG. 13, a recess 16 for fitting into an applicator or the like may be provided in the back surface side reinforcing layer 15. In this case, when the puncture using the applicator is performed, the recess 16 is provided and the back surface side reinforcing layer 15 is grooved, so that it can be easily set. In FIG. 13, only the reinforcing layer 5 is shown in cross section.
(11) As the reinforcing layer 5, for example, as shown in FIGS. 14 and 15, reinforcing layers 5 having different thicknesses may be provided at a plurality of locations. In this case, the needle-like body pad P having a height distribution can be produced. 14 and 15 show a cross section of only the reinforcing layer 5.

(12) As shown in FIG. 16, the needle-like body pad body 4 is provided with a reinforcing layer which is a recess for installing the reinforcing layer 5 on the surface of the base portion 11 where the needle-like portion 12 is formed. It is good also as a structure which provided the recessed part 6. FIG. In this case, it is possible to reduce alignment when the reinforcing layer 5 is bonded to the base portion 11. Further, in order to form the reinforcing layer installation recess 6, for example, as shown in FIG. 17, an original plate side recess 6 a corresponding to the reinforcement layer installation recess 6 is formed on the original needle pad 1. It is only necessary to perform processing, and various shapes and locations can be selected. In FIG. 16, only the reinforcing layer 5 is shown in cross section. Also, in FIG. 17, FIGS. 17A to 17C show a duplicate plate manufacturing process, and FIGS. 17D to 17F show a needle pad manufacturing process.
(13) The reinforcing layer 5 may be formed from a porous material. In this case, it becomes possible to store the drug solution for release in the reinforcing layer 5 and collect tissue fluid from the reinforcing layer 5.

With reference to FIGS. 1 to 17 of the first embodiment described above, the needle-like pad P of the present invention will be described with reference to examples described below.
(Example 1)
First, a duplicate plate 2 that serves as a mold for the needle-like body pad P is prepared. In Example 1, Ni replica 2 was used. The duplicate plate 2 was produced by electroforming, and the original needle pad 1 was produced by a 5-axis processing machine. The material used was silicon. And after performing Ni electroforming with respect to the original needle-like body pad 1 and producing the duplicate plate 2, the original needle-like body pad 1 is removed by hot alkali.
Further, a step 7 is formed on the flat portion of the surface of the duplicate plate 2. This is provided so that the molten resin does not flow beyond the target location, and a structure corresponding to the target thickness of the base 11 can be selected as appropriate. In Example 1, the height of the step 7 was set to 100 μm.

Next, PGA, which is one of medical biodegradable resins, was placed on the duplicate plate 2 and heated to 250 ° C. to melt.
Further, the melted PGA was pressurized from above with a roller made of silicon rubber, and the PGA was pushed into the concave portion of the duplicate plate 2.
Then, after cooling from the front and back of the duplicate plate 2 and the temperature drops to near room temperature, vacuum tweezers are attached to the back surface of the surface of the base portion 11 where the needle-like portion 12 is formed, and perpendicular to the duplicate plate 2 I peeled it off. At this time, if it cannot be peeled off vertically, the tip of the needle-like part 12 is likely to be broken or bent.

Next, on the outer peripheral part of each needle-like part 12, a medical acrylic adhesive was thinly applied and a reinforcing layer 5 made of polycarbonate having a thickness of 300 [mu] m and processed into a "field" shape was adhered.
As a result, a needle-like pad P having a two-layer structure with a height of 500 μm and a base portion 11 thickness of 400 μm was obtained.
Next, the reinforcing layer 5 is bonded to the back surface side of the surface on which the needle-like part 12 of the base part 11 is formed using the PGA needle-like body pad body 4 having the same configuration as described above. The reinforcing layer 5 is obtained by cutting a polycarbonate having a thickness of 300 μm into a rectangle. The same adhesive as in the first embodiment was used.

As a result, a needle-like pad P having a two-layer structure with a height of 800 μm and a base portion 11 thickness of 400 μm was obtained.
At this time, the same reinforcing layer 5 used on the surface side of the base portion 11 on which the needle-like portion 12 is formed may be used on the back surface of the surface on which the needle-like portion 12 of the base portion 11 is formed. From the needle-shaped body pad main body 4 and the reinforcing layer 5, it is possible to produce two types of samples in which the thickness of the base portion 11 is 400 μm and the height of the needle-like portion 12 is different.

(Example 2)
Next, a case where a curved needle pad P is produced will be described.
First, the needle-like body pad main body 4 is produced by the same method as in the first embodiment. The needle-like part 12 is composed of PGA, the height of the needle-like part 12 is 800 μm, the base dimension of the needle-like part 12 is 300 μm, and a plurality of each needle-like part 12 is arranged in a square lattice shape, Sixteen needle-like parts 12 of 4 rows × 4 rows were configured. The pitch between adjacent needle-like parts 12 is 800 μm, and the outer shape of the chip is a 5 mm square. Further, the thickness of the base portion 11 is 100 μm.

Next, the curved reinforcing layer 5 is prepared. A 300 μm-thick polycarbonate processed into a square shape was pressed onto a stainless hemisphere with a radius of curvature of 20 mm heated to near the softening point for 30 seconds. As a result, a reinforcing layer 5 having a central portion raised by 150 μm as compared with the outer periphery was obtained.
Then, the needle pad body 4 is fixed to the reinforcing layer 5 with a medical adhesive, the height of the needle-like part 12 is 500 μm, the thickness of the base part 11 is 400 μm, and the center part is A needle-like body pad P having a convex two-layer structure raised about 150 μm compared to the outer periphery was obtained.

(Example 3)
In Example 3, a case where the reinforcing layer 5 is set on the needle-shaped body pad body 4 provided with the reinforcing layer installation recess 6 will be described.
First, an original plate side recess 6 a corresponding to the reinforcing layer installation recess 6 is formed on the original needle pad 1. A 5-axis processing machine was used for the production of the original-side recess 6a. The depth of the original-side concave portion 6a was 100 μm, the width of the original-side concave portion 6a was 300 μm between the adjacent needle-like portions 12, and 1050 μm at the outer peripheral portion. The acicular portion 12 had a height of 800 μm and a conical shape with a root size of 300 μm. Furthermore, each needle-like part 12 is arranged in an array of 4 rows × 4 rows, and the pitch is 800 μm.
Subsequent steps can be manufactured in the same manner as in Example 1.
As the reinforcing layer 5, a reinforcing layer 5 made of polycarbonate having a thickness of 300 μm was used.
As a result, a needle-like pad P having a two-layer structure with a height of 600 μm and a base portion 11 thickness of 400 μm was obtained.

  DESCRIPTION OF SYMBOLS 1 ... Original needle-shaped body pad, 1a ... Recessed step forming recess, 2 ... Duplicating plate, 3 ... Medical resin, 4 ... Needle-like body, 5 ... Reinforcing layer, 6 ... Reinforcing layer installation recessed portion, 6a ... Original plate side Recessed portion, 7 ... step, 8 ... back die pad, 9 ... insulating resin portion, 10 ... plated layer, 11 ... base portion, 12 ... needle portion, 13 ... through hole, 15 ... reinforcing side reinforcing layer, 16 ... dent, P ... Needle pad

Claims (6)

A needle-like body pad having a needle-like portion on one surface of the substrate,
An acicular pad, wherein a reinforcing layer is provided on a surface of the substrate on which the acicular portion is formed.   The said reinforcement layer is provided with the through-hole which the said acicular part penetrates, The acicular body pad described in Claim 1 characterized by the above-mentioned.   The acicular pad according to claim 1 or 2, wherein the reinforcing layer is curved in a thickness direction of the substrate in a side view.   The needle according to any one of claims 1 to 3, wherein a back surface reinforcing layer is provided on a surface of the base material opposite to the surface on which the needle-like portion is formed. A body pad. Provided on the surface of the base material on which the needle-like part is formed, a reinforcing layer installation recess for installing the reinforcing layer;
The acicular pad according to any one of claims 1 to 4, wherein the reinforcing layer is installed in the reinforcing layer installation recess.   The acicular pad according to any one of claims 1 to 5, wherein the reinforcing layer is made of a porous material.

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