CN102288652A - Preparation method of siphon channel of rapid detection test strip - Google Patents
Preparation method of siphon channel of rapid detection test strip Download PDFInfo
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- CN102288652A CN102288652A CN2010102095652A CN201010209565A CN102288652A CN 102288652 A CN102288652 A CN 102288652A CN 2010102095652 A CN2010102095652 A CN 2010102095652A CN 201010209565 A CN201010209565 A CN 201010209565A CN 102288652 A CN102288652 A CN 102288652A
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- siphon
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- raceway groove
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Abstract
The invention discloses a preparation method for a siphon channel of a rapid detection test strip, which comprises the following steps: (1) coating or printing light-sensitive ink on the surface of a first substrate, and drying the light-sensitive ink to form a dry film, wherein the first substrate is made of plastic; (2) exposing and developing the dry film according to the pattern of the required siphon channel to obtain the pattern of the required siphon channel; (3) coating adhesive on the pattern of the siphon channel, and transferring the pattern on the first substrate onto a second substrate, wherein the second substrate is made of plastic or paper, the surface of the second substrate is printed with electrodes, the electrodes are separated to form a reaction area, and the pattern just corresponds to the position of the reaction area. By adopting the preparation method, the space of a reaction chamber can be adjusted conveniently, the requirements of rapid mass production can be satisfied, the preparation cost can be reduced greatly, and conditions can be provided for low-cost and high-efficiency preparation of the rapid detection test strip.
Description
Technical field
The present invention relates to the preparation method of siphon raceway groove on a kind of fast detecting strip.
Background technology
Show that according to the investigation of the World Health Organization (WHO) beginning of this century, the whole world has 1.71 hundred million diabetics, to the year two thousand thirty this numeral will be increased to 3.66 hundred million." Chinese cardiovascular report " investigation shows that over nearly 20 years, Chinese diabetes prevalence is multiple and increases, and nearly more than 2,000 ten thousand diabetics of China estimate to reach 6,000 ten thousand to China diabetic in 2025 at present.Selftest blood sugar is a kind of method that is used for measuring glucose sugar value in the blood.It is that the blood of a finger is placed on the blood sugar test paper, measures the sugar value by a blood sugar instrument then.This test can make the patient that diabetes are controlled to some extent, can show that treatment has to no effect.
At the reaction zone that has commercially available blood sugar strip product now channel structure is arranged all, can form reaction chamber like this after the raceway groove sealing, as the space of test reaction, channel structure has syphonic effect on the other hand, tested test solution can be directed to reaction zone on the one hand.
The structure of present this raceway groove is to utilize certain thickness double sticky tape to fit at the strip substrate surface, and manually manual assembly also can adopt artificial semi-automatic laminating type in conjunction with frock.Directly the figure of applying formation is fairly simple, and the reaction chamber space is difficult for adjusting, and can't reduce to be directed the volume of test fluid.The construction method of other raceway groove is, adhesive tape forms the punching of certain pattern after punch press is die-cut, and its opening can be adjusted, and the volume in corresponding test chamber space also can be controlled, and be beneficial to regulation and control, but cost is higher, operates more complicated.
Summary of the invention
Fundamental purpose of the present invention, be to provide a kind of preparation method of fast detecting strip siphon raceway groove, it can conveniently adjust the space of reaction chamber in the siphon raceway groove, satisfy quick requirement of mass production, can reduce preparation cost significantly, for the low cost of fast detecting strip, high-level efficiency preparation create conditions.
In order to reach above-mentioned purpose, solution of the present invention is:
A kind of preparation method of fast detecting strip siphon raceway groove comprises the steps:
(1) in the surface coated of first base material or printing photosensitive-ink, and treat to form dry film after the photosensitive-ink drying, described first base material is made by plastic material;
(2) figure according to required siphon raceway groove carries out exposure imaging to dry film, obtains the figure of required siphon raceway groove;
(3) on the figure of siphon raceway groove, apply adhesive, with the graph transfer printing on first base material to second base material; Described second base material is made by plastics or paper material, and its surface printing has electrode, is separated to form reaction zone between the electrode, and the position of the lucky corresponding reaction zone of figure.
In the above-mentioned steps (1), adopt positivity photosensitive-ink or negative photosensitive printing ink.
The detailed step of above-mentioned steps (2) is: (2a) according to the figure of required siphon raceway groove, according to the character of photosensitive-ink dry film is carried out shading treatment; (2b) dry film to first substrate surface carries out the ultraviolet exposure processing; (2c) dry film is carried out development treatment; (2d) dry processing through the dry film of development treatment and first base material that adheres to thereof, obtain the figure of required siphon raceway groove aforementioned.
Above-mentioned preparation method adopts negative photosensitive printing ink, and step (2a) is: according to the figure of required siphon raceway groove, shading treatment is carried out in the zone beyond corresponding figure; Step (2c) is: dry film is placed water-soluble dry film imaging liquid, carry out development treatment.
Above-mentioned preparation method adopts the positivity photosensitive-ink, and step (2a) is: according to the figure of required siphon raceway groove, carry out shading treatment in the zone of corresponding figure; Step (2c) is: dry film is carried out the impact of hydraulic pressure water, finish developing process.
When carrying out shading treatment in the above-mentioned steps (2a), adopt film shading mode, or on dry film, do not need exposed areas printing black out ink.
In the above-mentioned steps (3), the process of transfer printing is: first base material that will have the figure of adhesive spreads on second base material, makes figure corresponding with the reaction zone position of second substrate surface; Again will be softening towards the adhesive of second base material, between first and second base material, pressurize then, make adhesive adhere to second base material; Behind the reasonable time, first and second base material is separated, the figure of siphon raceway groove is the surface from the surface transfer of original first base material to second base material just.
In the above-mentioned steps (3), when having the figure of some siphon raceway grooves on second base material, also second base material is cut according to reaction zone.
After adopting such scheme, the present invention does not re-use double faced adhesive tape, but the technology of employing exposure imaging, the surface that photosensitive-ink is accumulated in first base material forms certain thickness, has stereoscopic sensation, and utilize the soluble under given conditions characteristic of zones of different after the photosensitive-ink exposure-processed, form the figure of siphon raceway groove, mode by transfer printing is transferred to reaction zone with it then, form the fast detecting strip, the space of reaction chamber in the flexibly changing siphon raceway groove in this process, preparation flow is simple simultaneously, quick requirement of mass production can be satisfied, thereby preparation cost can be reduced significantly.
Description of drawings
Fig. 1 is preparation flow figure of the present invention;
To be the present invention carry out synoptic diagram behind the exposure imaging to first base material that has photosensitive-ink to Fig. 2;
Fig. 3 is the synoptic diagram that applies adhesive on the figure of formed siphon raceway groove behind the exposure imaging;
Fig. 4 is with the graph transfer printing of the siphon raceway groove synoptic diagram to second base material.
Embodiment
As described in Figure 1, the invention provides a kind of preparation method of fast detecting strip siphon raceway groove, may further comprise the steps:
(1) in surface coated or printing one deck photosensitive-ink of first base material 102, promptly forms dry film after this photosensitive-ink drying; First base material 102 adopts plastic material herein, it can be the simple plastic material or the composite plastics material of surface coating, about 100 ℃ high temperature in energy tolerance printing or the coating film forming process, as polyester (PET), tygon plastic sheetings such as (PE), the width of first base material 101 can or be printed as film method according to the coating of concrete employing to be decided, can arrive about 2 meters, general application can be selected about 0.5 meter; And photosensitive-ink can be a positivity, also can be negative photosensitive printing ink, and the thickness after its coating can reach 200 μ m;
(2) figure according to required siphon raceway groove carries out exposure imaging to the formed dry film of photosensitive-ink in the abovementioned steps (1), obtains the figure 101 of required siphon raceway groove, can be with reference to shown in Figure 2; The step of exposure imaging is herein:
(2a), dry film is carried out shading treatment according to the figure of required siphon raceway groove; The zone of carrying out shading treatment herein need be according to the character of coating photosensitive-ink, if the positivity photosensitive-ink then needs carry out shading treatment in the zone of corresponding figure, and if use negative photosensitive printing ink, then needs carry out shading treatment in corresponding figure zone in addition; Can adopt film shading mode herein, or on dry film, not need exposed areas printing black out ink;
(2b) dry film to first base material, 102 surfaces carries out the ultraviolet exposure processing;
(2c) for negative photosensitive printing ink, when carrying out development treatment, dry film is placed water-soluble dry film imaging liquid (is the Carbon Dioxide sodium solution of 1-2% as concentration), carry out development treatment, reactive group and the imaging liquid reaction generation solable matter of unexposed portion and dissolve in this moment dry film, and the dry film of exposed portion is not by swelling;
And for the positivity photosensitive-ink, developing process can be finished by the impact of suitable hydraulic pressure water in the exposure back;
(2d) dry processing through the dry film of development treatment and first base material 102 that adheres to thereof, obtain the figure 101 of required siphon raceway groove aforementioned; When the thickness of photosensitive-ink on first base material 102 was enough, formed figure 101 had spatial structure, thus the double faced adhesive tape mode in the alternative existing structure;
(3) apply adhesive 103 on the figure 101 of the siphon raceway groove that after aforementioned dry film develops, forms; Reference simultaneously is shown in Figure 3, specifically is that adhesive 103 directly graphically is printed on the figure 101, and described adhesive 103 can adopt pressure sensitive adhesive or heat-sensitive glue, and thickness is 1-100 μ m;
(4) figure 101 with the siphon raceway groove is transferred on second base material 202 of fast detecting strip; Cooperate shown in Figure 4, described second base material 202 adopts the plastics or the paper material that can tolerate 100 ℃ of left and right sides high temperature, as polyester plastics or polycarbonate plastic etc., and require it not softening, indeformable in transfer process, the surface of this second base material 202 also is printed with electrode, and is separated to form reaction zone between the electrode; The concrete steps of transfer printing are: first base material 102 that has the figure 101 of adhesive 103 shown in Figure 3 is spread on second base material 202, make the reaction zone on figure 101 lucky corresponding second base materials 202, adopt the method for transfer printing to soften again towards the adhesive 103 of second base material 202, pressurization between first and second base material 102,202 then makes adhesive 103 can adhere to second base material 202; Behind the reasonable time, first and second base material 102,202 is separated, the figure 101 of siphon raceway groove is the surface of the method by transfer printing from the surface transfer of original first base material 102 to second base material 202 just; Because first base material 102 is made by plastic material, figure 101 adhesion that form with photosensitive-ink are lower, therefore are easy to realize the process of transfer printing.
It is pointed out that the siphon raceway groove for preparing according to this method, can be monomer, also can be that some siphon raceway grooves are arranged in order and form, when finished product comprises some siphon raceway grooves, can adopt the mode of cutting to separate, can enhance productivity greatly like this, reduce preparation cost.
Below how explanation utilizes fast detecting strip siphon raceway groove of the present invention to prepare the method for corresponding strip.With the blood sugar chemical examination is example, illustrate how to utilize fast detecting strip siphon raceway groove of the present invention the preparation method.Utilize the siphon raceway groove figure 101 of this method preparation, carry out chromatography, around reaction zone, form the space structure that has opening with the reaction zone that adopts the electrode surface of method of printing on second base material 202 to be separated out; After this base material 202 suitably cut, make it to be fit to be placed on the platform of micro-sampling instrument, the solution equal-volume that reagent such as glucose oxidase are formed drips at the reaction zone electrode surface.On the siphon raceway groove, cover cover plate and encapsulate, promptly can be made into the strip that can be used for the blood sugar fast detecting with water-wetted surface.The strip preparation process of other kind similarly.
Those skilled in the art only should be noted that among this instructions embodiment the formula explanation of giving an example of institute's materials used, as first base material 102 of siphon raceway groove graphic printing can adopt that other is heat-resisting, the simple or compound substance of surfacing, characteristic homogeneous; Plastic material also is not limited to polyester (PET), tygon (PE); The width of the figure 101 of siphon raceway groove and mutual distance can design according to actual needs; All heat-sensitive glues or pressure sensitive adhesive apply figure 101 and design according to concrete technology and material, and its printing is not limited to wire mark and intaglio printing.Wish that the preparation method that the present invention protected does not limit the use of in the preparation of blood sugar strip.
Above embodiment only for explanation technological thought of the present invention, can not limit protection scope of the present invention with this, every technological thought that proposes according to the present invention, and any change of being done on the technical scheme basis all falls within the protection domain of the present invention.
Claims (8)
1. the preparation method of a fast detecting strip siphon raceway groove is characterized in that comprising the steps:
(1) in the surface coated of first base material or printing photosensitive-ink, and treat to form dry film after the photosensitive-ink drying, described first base material is made by plastic material;
(2) figure according to required siphon raceway groove carries out exposure imaging to dry film, obtains the figure of required siphon raceway groove;
(3) on the figure of siphon raceway groove, apply adhesive, with the graph transfer printing on first base material to second base material; Described second base material is made by plastics or paper material, and its surface printing has electrode, is separated to form reaction zone between the electrode, and the position of the lucky corresponding reaction zone of figure.
2. the preparation method of fast detecting strip siphon raceway groove as claimed in claim 1 is characterized in that: in the described step (1), adopt positivity photosensitive-ink or negative photosensitive printing ink.
3. the preparation method of fast detecting strip siphon raceway groove as claimed in claim 2 is characterized in that: the detailed step of described step (2) is:
(2a), dry film is carried out shading treatment according to the character of photosensitive-ink according to the figure of required siphon raceway groove;
(2b) dry film to first substrate surface carries out the ultraviolet exposure processing;
(2c) dry film is carried out development treatment;
(2d) dry processing through the dry film of development treatment and first base material that adheres to thereof, obtain the figure of required siphon raceway groove aforementioned.
4. the preparation method of fast detecting strip siphon raceway groove as claimed in claim 3, it is characterized in that: described preparation method adopts negative photosensitive printing ink, step (2a) is: according to the figure of required siphon raceway groove, shading treatment is carried out in the zone beyond corresponding figure;
Step (2c) is: dry film is placed water-soluble dry film imaging liquid, carry out development treatment.
5. the preparation method of fast detecting strip siphon raceway groove as claimed in claim 3, it is characterized in that: described preparation method adopts the positivity photosensitive-ink, and step (2a) is: according to the figure of required siphon raceway groove, carry out shading treatment in the zone of corresponding figure;
Step (2c) is: dry film is carried out the impact of hydraulic pressure water, finish developing process.
6. the preparation method of fast detecting strip siphon raceway groove as claimed in claim 3 is characterized in that: when carrying out shading treatment in the described step (2a), adopt film shading mode, or do not need exposed areas printing black out ink on dry film.
7. the preparation method of fast detecting strip siphon raceway groove as claimed in claim 1, it is characterized in that: in the described step (3), the process of transfer printing is: first base material that will have the figure of adhesive spreads on second base material, makes figure corresponding with the reaction zone position of second substrate surface; Again will be softening towards the adhesive of second base material, between first and second base material, pressurize then, make adhesive adhere to second base material; Behind the reasonable time, first and second base material is separated, the figure of siphon raceway groove is the surface from the surface transfer of original first base material to second base material just.
8. the preparation method of fast detecting strip siphon raceway groove as claimed in claim 1 is characterized in that: in the described step (3), when having the figure of some siphon raceway grooves on second base material, also second base material is cut according to reaction zone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2010102095652A CN102288652A (en) | 2010-06-18 | 2010-06-18 | Preparation method of siphon channel of rapid detection test strip |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102095652A CN102288652A (en) | 2010-06-18 | 2010-06-18 | Preparation method of siphon channel of rapid detection test strip |
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| CN102288652A true CN102288652A (en) | 2011-12-21 |
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| CN2010102095652A Pending CN102288652A (en) | 2010-06-18 | 2010-06-18 | Preparation method of siphon channel of rapid detection test strip |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103364547A (en) * | 2012-04-01 | 2013-10-23 | 嘉善德智医疗器械科技有限公司 | Multi-parameter immunochromatographic assay test paper and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2342393Y (en) * | 1998-01-25 | 1999-10-06 | 林鸿学 | Light sensitive film transfer coating |
| CN1512175A (en) * | 2002-12-30 | 2004-07-14 | 长沙三诺生物传感技术有限公司 | Test strip for testing biochemical matter in blood and its producing method |
| TW200708730A (en) * | 2005-08-16 | 2007-03-01 | Gen Life Biotechnology Co Ltd | An electro-chemical immunization test piece and the formation thereof |
| CN101288028A (en) * | 2004-08-11 | 2008-10-15 | 陶氏康宁公司 | Photopolymerizable silicone materials forming semipermeable membranes for sensor applications |
-
2010
- 2010-06-18 CN CN2010102095652A patent/CN102288652A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2342393Y (en) * | 1998-01-25 | 1999-10-06 | 林鸿学 | Light sensitive film transfer coating |
| CN1512175A (en) * | 2002-12-30 | 2004-07-14 | 长沙三诺生物传感技术有限公司 | Test strip for testing biochemical matter in blood and its producing method |
| CN101288028A (en) * | 2004-08-11 | 2008-10-15 | 陶氏康宁公司 | Photopolymerizable silicone materials forming semipermeable membranes for sensor applications |
| TW200708730A (en) * | 2005-08-16 | 2007-03-01 | Gen Life Biotechnology Co Ltd | An electro-chemical immunization test piece and the formation thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103364547A (en) * | 2012-04-01 | 2013-10-23 | 嘉善德智医疗器械科技有限公司 | Multi-parameter immunochromatographic assay test paper and preparation method thereof |
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Application publication date: 20111221 |