CN102274456B - Pharmaceutical composition and preparation method thereof - Google Patents
Pharmaceutical composition and preparation method thereof Download PDFInfo
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- CN102274456B CN102274456B CN2011102062583A CN201110206258A CN102274456B CN 102274456 B CN102274456 B CN 102274456B CN 2011102062583 A CN2011102062583 A CN 2011102062583A CN 201110206258 A CN201110206258 A CN 201110206258A CN 102274456 B CN102274456 B CN 102274456B
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 67
- 238000002360 preparation method Methods 0.000 title claims abstract description 66
- 150000001875 compounds Chemical class 0.000 claims abstract description 47
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 47
- 239000007788 liquid Substances 0.000 claims abstract description 35
- 201000010153 skin papilloma Diseases 0.000 claims abstract description 35
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 31
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 31
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 239000003814 drug Substances 0.000 claims description 59
- 229940079593 drug Drugs 0.000 claims description 55
- 239000000203 mixture Substances 0.000 claims description 53
- 241000243684 Lumbricus Species 0.000 claims description 51
- 102000004190 Enzymes Human genes 0.000 claims description 45
- 108090000790 Enzymes Proteins 0.000 claims description 45
- 238000009472 formulation Methods 0.000 claims description 45
- 238000003756 stirring Methods 0.000 claims description 37
- 208000000260 Warts Diseases 0.000 claims description 34
- 241000934136 Verruca Species 0.000 claims description 33
- 206010000496 acne Diseases 0.000 claims description 28
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 26
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 17
- 239000000463 material Substances 0.000 claims description 15
- 230000001476 alcoholic effect Effects 0.000 claims description 14
- 239000002893 slag Substances 0.000 claims description 14
- 238000002791 soaking Methods 0.000 claims description 14
- 239000002671 adjuvant Substances 0.000 claims description 9
- 238000007796 conventional method Methods 0.000 claims description 9
- 239000003860 topical agent Substances 0.000 claims description 9
- 240000006394 Sorghum bicolor Species 0.000 claims description 6
- 235000007230 Sorghum bicolor Nutrition 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 6
- 239000002674 ointment Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 4
- 239000002966 varnish Substances 0.000 claims description 4
- 239000000499 gel Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 abstract description 9
- 244000124209 Crocus sativus Species 0.000 abstract description 3
- 235000015655 Crocus sativus Nutrition 0.000 abstract description 3
- 241000411851 herbal medicine Species 0.000 abstract 3
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 abstract 2
- 241000207925 Leonurus Species 0.000 abstract 2
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 abstract 2
- 238000002386 leaching Methods 0.000 abstract 2
- 235000013974 saffron Nutrition 0.000 abstract 2
- 239000004248 saffron Substances 0.000 abstract 2
- 208000020154 Acnes Diseases 0.000 abstract 1
- 230000009920 chelation Effects 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 229910000831 Steel Inorganic materials 0.000 description 8
- 239000010959 steel Substances 0.000 description 8
- 239000011521 glass Substances 0.000 description 6
- 239000000546 pharmaceutical excipient Substances 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 5
- 244000025254 Cannabis sativa Species 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 241000700605 Viruses Species 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 235000007650 Aralia spinosa Nutrition 0.000 description 1
- 241001407408 Berberis fortunei Species 0.000 description 1
- 206010011732 Cyst Diseases 0.000 description 1
- 206010016936 Folliculitis Diseases 0.000 description 1
- 240000003271 Leonurus japonicus Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 241000949456 Zanthoxylum Species 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 235000003373 curcuma longa Nutrition 0.000 description 1
- 239000001215 curcuma longa l. root Substances 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 150000002333 glycines Chemical class 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 210000000835 hypertrophic cicatrix Anatomy 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000037075 skin appearance Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a pharmaceutical composition and a preparation method thereof, and the pharmaceutical composition is prepared by the following raw materials in parts by weight: 4-5 parts of Chinese herbal medicine lumbokinase and peptide compound preparation, 2-4 parts of saffron, 1-1.5 parts of notoginseng and 1-1.5 parts of motherwort herb. The Chinese herbal medicine lumbokinase and peptide compound preparation is taken as a carrier for being compatible with saffron leaching liquor and the leaching liquor of the notoginseng and the motherwort herb, and the pharmaceutical composition is obtained by natural chelation of different Chinese herbal medicine liquid agents. The pharmaceutical composition can effectively treat acnes, flat warts and other skin diseases and has the characteristics of high cure rate and low recurrence rate.
Description
Technical field
The present invention relates to a kind of new pharmaceutical composition.This pharmaceutical composition is that the disclosed Chinese crude drug Lumbricus of the Chinese patent take publication number as CN101972449A enzyme, peptide compound formulation are the basis, the pharmaceutical composition that obtains with other Chinese crude drug compatibility.The present invention also comprises the method for pharmaceutical compositions and the purposes of this medicine composite for curing acne and verruca plana, belongs to field of pharmaceutical technology.
Background technology
Acne is one of modal sick kind of department of dermatologry, is again comedo, face Blisters or acne, folliculitis, except the child, has approximately 80%～90% people to suffer from primary disease or once suffered from primary disease (comprising light disease) among the crowd.Different because of the reaction of individuality, the extent of damage that acne causes also has difference, and its clinical performance is also different.Slight acne only appear in some people, serious cyst appears in some people, and this illness is obstinate and be difficult to cure, if especially suffer from not in time treatment of pustule, tuberosity, abscess, acne cystica person, can leave over lower recess or hypertrophic cicatrix, affect skin appearance.Gently have heavily but acne has, reason is complicated, and relapse rate is higher, and inappropriate medication can increase the weight of on the contrary, thereby causes the patients ' psychological problem.
Verruca plana is commonly called as " verruca plana, repair son ", is common skin vegetations, and normal sending out is syringe needle to the large flat pimple of Semen Glycines in adolescence's face, the back of the hand and forearm, and the course of disease is slow, but self infects.Verruca plana often is beading along scratch and arranges.If pruritus increases the weight of, the number of wart can sudden fast rush, color is red, heave, infectivity more, must and early treatment.Verruca plana is due to the virus, medical circle is without the medicine that directly kills verruca plana virus at present, the method for the treatment of verruca plana all adopts and improves the human body function of exempting from service and suppress, eliminate verruca plana, therefore this also be at home, the external basic reason very low to the cure rate of verruca plana, only about 25%, the mean treatment time needs about 3 months according to the cure rate of statistics verruca plana.
Although modern medicine has been obtained significant progress, yet still lack cure rate height, the Acne treatment that relapse rate is low, the medicine of verruca plana at present.Mostly the existing clinical treatment method that is used for acne and verruca plana is to adopt skin surface to smear antiinflammatory, sterilization, antipruritic ointment, and its therapeutic effect is all not bery desirable, and has certain toxic and side effects.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition and preparation method thereof.The present invention is the dermatopathy such as Acne treatment, verruca plana effectively, has the characteristics such as the property of healing is high, relapse rate is low, have no side effect.
Purpose of the present invention can realize by following technical proposal: a kind of pharmaceutical composition, this pharmaceutical composition are to be made according to weight portion by following raw material: 1～1.5 part of Chinese crude drug Lumbricus enzyme, 4～5 parts of peptide compound formulations, 2～4 parts of Stigma Crocis, 1～1.5 part of Radix Notoginseng and Herba Leonuri.
In the above-mentioned pharmaceutical composition, this pharmaceutical composition is to be made according to mass parts by following raw material: 1 part of Chinese crude drug Lumbricus enzyme, 4 parts of peptide compound formulations, 4 parts of Stigma Crocis, 1 part of Radix Notoginseng and Herba Leonuri.
In the aforesaid pharmaceutical composition, described pharmaceutical composition is external preparation.
In the aforesaid pharmaceutical composition, described external preparation is spray, varnish, ointment or gel.
In the aforesaid pharmaceutical composition, this pharmaceutical composition is used for the treatment of acne or verruca plana.
In the aforesaid pharmaceutical composition, Chinese crude drug Stigma Croci agents area: the top of the colored section of clean dried and stigma.
In the aforesaid pharmaceutical composition, Chinese crude drug Radix Notoginseng and Herba Leonuri agents area: the above Herb of Herba Leonuri grass roots of the full root of the Radix Notoginseng of clean dried, the front harvesting cleaning of blooming.
The preparation method of aforesaid pharmaceutical composition with filtering Radix Notoginseng, the Herba Leonuri lixiviating solution mix and blend that obtains after Chinese crude drug Lumbricus enzyme, peptide compound formulation and Radix Notoginseng and the Herba Leonuri lixiviate, obtains the X preparation; With filtering the Stigma Croci lixiviating solution mix and blend that obtains after Chinese crude drug Lumbricus enzyme, peptide compound formulation and the Stigma Croci lixiviate, obtain the Y preparation again; At last the X preparation is mixed with the Y preparation, add again conventional adjuvant or excipient, make topical agent through conventional technique.
In the preparation method of above-mentioned pharmaceutical composition, the method comprises following concrete steps:
A, get Radix Notoginseng and Herba Leonuri and be positioned over slowly to stir to leave standstill after 15～30 minutes in the edible ethanol that alcoholic strength is 40 °～45 ° Sorghum vulgare Pers. Wine or 70 ° and soaked 15～30 days; Soak after 15～30 days, the material after soaking is removed slag after 300 order filter screens filter, obtain lixiviating solution A liquid;
B, get 80% Chinese crude drug Lumbricus enzyme, peptide compound formulation, add A liquid, be positioned in the lump and stir 20～40 minutes in the container, left standstill after the stirring 3～6 days, get the X preparation;
C, get Stigma Croci and be positioned over slowly to stir to leave standstill after 15～30 minutes in the edible ethanol that alcoholic strength is 40 °～45 ° jowar wine or 70 ° and soaked 7～14 days; Soak after 7～14 days, the material after soaking is removed slag after 300 order filter screens filter, obtain lixiviating solution B liquid;
D, get remaining 20% Chinese crude drug Lumbricus enzyme, peptide compound formulation, add B liquid, be positioned in the lump and stir 20～40 minutes in the container, left standstill after the stirring 7～10 days, get the Y preparation;
E, X preparation and Y preparation are mixed, add again conventional adjuvant or excipient, make topical agent through conventional technique.
In the preparation method of aforesaid pharmaceutical composition, the method comprises following concrete steps:
A, get Radix Notoginseng 0.1kg and Herba Leonuri 0.1kg and be positioned over slowly to stir to leave standstill after 15～30 minutes in the edible ethanol that the 1kg alcoholic strength is 40 °～45 ° Sorghum vulgare Pers. Wine or 70 ° and soaked 15～30 days; Soak after 15～30 days, the material after soaking is removed slag after 300 order filter screens filter, obtain lixiviating solution A liquid;
B, get 80% Chinese crude drug Lumbricus enzyme, peptide compound formulation, add A liquid, be positioned in the lump and stir 20～40 minutes in the container, left standstill after the stirring 3～6 days, get the X preparation;
C, get the 0.4kg Stigma Croci and be positioned over slowly to stir to leave standstill after 15～30 minutes in the edible ethanol that alcoholic strength is 40 °～45 ° 2kg jowar wine or 70 ° and soaked 7～14 days; Soak after 7～14 days, the material after soaking is removed slag after 300 order filter screens filter, obtain lixiviating solution B liquid;
D, get remaining 20% Chinese crude drug Lumbricus enzyme, peptide compound formulation, add B liquid, be positioned in the lump and stir 20～40 minutes in the container, left standstill after the stirring 7～10 days, get the Y preparation;
E, X preparation and Y preparation are mixed, add again conventional adjuvant or excipient, make topical agent through conventional technique.
Compared with prior art, the present invention is take Chinese crude drug Lumbricus enzyme, peptide compound formulation as carrier, with Stigma Croci leachate and Radix Notoginseng, Herba Leonuri leachate compatibility, and the pharmaceutical composition that the natural chelating by different Chinese crude drug liquors obtains.In order to verify the therapeutic effect of pharmaceutical composition of the present invention, the applicant has carried out corresponding experimental study, and result of the test shows the effectively dermatopathy such as Acne treatment, verruca plana of the present invention, and has the advantages that healing property is high, relapse rate is low.The test main contents are as follows: through patients with acne 86 people's trial edition invention pharmaceutical compositions, 72 examples of recovery from illness account for 83% in 15 days; 9 examples of recovery from illness account for 10% in 30 days; 5 examples of DeGrain account for 5%; And cured person has no recurrence, and to sum up pharmaceutical composition of the present invention has reached 93% for the cure rate of acne, has ideal cure rate.Through verruca plana patient 73 people's trial edition invention pharmaceutical compositions, 65 examples that verruca plana comes off fully in 7 days account for 89%; 5 examples that verruca plana comes off in 30 days account for 6%; 3 examples of DeGrain account for 4%, and cured person also has no recurrence, and to sum up pharmaceutical composition of the present invention has reached 95% for the cure rate of verruca plana, has ideal cure rate.
Chinese crude drug Lumbricus enzyme of the present invention, peptide compound formulation are that publication number is CN101972449A, denomination of invention is the disclosed Chinese crude drug Lumbricus of Chinese patent enzyme, the peptide compound formulation of " Chinese crude drug Lumbricus enzyme, peptide compound formulation and preparation method thereof ", all can be used for the present invention at Chinese crude drug Lumbricus enzyme, the peptide compound formulation of above-mentioned patent disclosure.Chinese crude drug Lumbricus enzyme, peptide compound formulation and preparation method thereof have been complete open in the Chinese patent of CN101972449A at publication number, can select such as Chinese crude drug Lumbricus enzyme, the concrete preparation method of peptide compound formulation but are not limited to the following methods preparation:
(1) Lumbricus that will live is cleaned with clean water, removes the foreign material that the Lumbricus body surface adheres to, and filters excessive moisture;
(2) be positioned in the rustless steel container after the Lumbricus of cleaning is weighed, by the weighing scale of Lumbricus, add the Mahonia fortunei (Lindl.) Fedde powder of its weight 3～6%, then add the distilled water of 1.5～3 times of Lumbricus weight, stir 30～60 minutes, filter to get A liquid;
(3) again by the Lumbricus weighing scale, add the Turmeric Root of its weight 2～4%, add 1～2 times distilled water, stirred 20～30 minutes, filter to get B liquid;
(4) repeat to add the Pricklyash peel of its weight 1～3% by the Lumbricus weighing scale, add 1～2 times distilled water, stirred 30～50 minutes, filter to get C liquid;
(5) A, B and three liquid mixing of C are got mixed liquor, mixed liquor is positioned in the rustless steel container water-bath sterilization filters removal of contamination after 90～120 minutes, get D liquid;
(6) D liquid is packed into leave standstill in the container of sealing and get supernatant after 10～40 days and be enzyme, peptide compound formulation.
Meanwhile, the croceous Latin formal name used at school of indication of the present invention is Crocus sativus; The Latin formal name used at school of Radix Notoginseng is Panax Notoginseng (Burk.) F.H.Chen; The Latin formal name used at school of Herba Leonuri is Leonurus heterophyllus Sweet.
The specific embodiment
Embodiment 1: a kind of pharmaceutical composition, this pharmaceutical composition are to be made according to mass parts by following raw material: Chinese crude drug Lumbricus enzyme, peptide compound formulation 0.5kg, Stigma Croci 0.2kg, Radix Notoginseng 0.15kg and Herba Leonuri 0.15kg make.Described pharmaceutical composition is external preparation, and described external preparation can be varnish.This pharmaceutical composition is used for the treatment of acne or verruca plana.
The preparation method of above-mentioned pharmaceutical composition is as follows:
The method comprises following concrete steps:
A, getting Radix Notoginseng and Herba Leonuri, to be positioned over the 1kg alcoholic strength be slowly to stir to leave standstill after 30 minutes in 40 ° the Sorghum vulgare Pers. Wine to soak 30 days, and the full root of Radix Notoginseng of Chinese crude drug Radix Notoginseng and the preferred clean dried of Herba Leonuri agents area, the front clean above Herb of Herba Leonuri grass roots of plucking blooms; Soak after 30 days, the material after soaking is removed slag after 300 order filter screens filter, obtain lixiviating solution A liquid;
B, get 80% Chinese crude drug Lumbricus enzyme, peptide compound formulation, namely get Chinese crude drug Lumbricus enzyme, the peptide compound formulation of 0.4kg, add A liquid, be positioned in the lump in glass or the rustless steel container and stirred 40 minutes, left standstill after the stirring 6 days, get the X preparation;
C, getting the 0.4kg Stigma Croci, to be positioned over the 2kg alcoholic strength be slowly to stir in 40 ° the jowar wine to leave standstill after 30 minutes to soak top and the stigma of the colored section of the preferred clean dried of Chinese crude drug Stigma Croci agents area 14 days; Soak after 14 days, the material after soaking is removed slag after 300 order filter screens filter, obtain lixiviating solution B liquid;
D, get remaining 20% Chinese crude drug Lumbricus enzyme, peptide compound formulation, namely get Chinese crude drug Lumbricus enzyme, the peptide compound formulation of remaining 0.1kg, add B liquid, be positioned in the lump in glass or the rustless steel container and stirred 40 minutes, left standstill after the stirring 7 days, get the Y preparation;
E, X preparation and Y preparation are mixed, add again conventional adjuvant or excipient, make varnish through conventional technique.
Chinese crude drug Lumbricus enzyme of the present invention, peptide compound formulation are that publication number is CN101972449A, denomination of invention is the disclosed Chinese crude drug Lumbricus of Chinese patent enzyme, the peptide compound formulation of " Chinese crude drug Lumbricus enzyme, peptide compound formulation and preparation method thereof ", all can be used for the present invention at Chinese crude drug Lumbricus enzyme, the peptide compound formulation of above-mentioned patent disclosure.Because Chinese crude drug Lumbricus enzyme, peptide compound formulation and preparation method thereof have been complete open in the Chinese patent of CN101972449A at publication number, therefore repeat no more in this patent embodiment, lower with.
Pharmaceutical composition of the present invention is used for the treatment of the dermatopathies such as acne and verruca plana, the using method of this pharmaceutical composition: 1, clean affected part; 2, this topical agent is applied to affected part; Be coated with 2～3 times in 1st when 3, being used for the treatment of acne, be coated with 3～5 times in 1st when being used for the treatment of verruca plana, once be coated with in right amount and get final product; 4, visible obvious therapeutic effect in 5～7 days; 5, in the use procedure without special taboo.
Embodiment 2: a kind of pharmaceutical composition, this pharmaceutical composition are to be made according to mass parts by following raw material: Chinese crude drug Lumbricus enzyme, peptide compound formulation 0.4kg, Stigma Croci 0.3kg, Radix Notoginseng 0.1kg and Herba Leonuri 0.1kg make.Described pharmaceutical composition is external preparation, and described external preparation is spray.This pharmaceutical composition is used for the treatment of acne or verruca plana.
The preparation method of above-mentioned pharmaceutical composition is as follows:
The method comprises following concrete steps:
A, getting Radix Notoginseng and Herba Leonuri, to be positioned over the 1kg alcoholic strength be slowly to stir to leave standstill after 15 minutes in 70 ° the edible ethanol to soak 20 days, and the full root of Radix Notoginseng of Chinese crude drug Radix Notoginseng and the preferred clean dried of Herba Leonuri agents area, the front clean above Herb of Herba Leonuri grass roots of plucking blooms; Soak after 20 days, the material after soaking is removed slag after 300 order filter screens filter, obtain lixiviating solution A liquid;
B, get 80% Chinese crude drug Lumbricus enzyme, peptide compound formulation, namely get Chinese crude drug Lumbricus enzyme, the peptide compound formulation of 0.32kg, add A liquid, be positioned in the lump in glass or the rustless steel container and stirred 20 minutes, left standstill after the stirring 3 days, get the X preparation;
C, getting the 0.4kg Stigma Croci, to be positioned over the 2kg alcoholic strength be slowly to stir in 70 ° the edible ethanol to leave standstill after 20 minutes to soak top and the stigma of the colored section of the preferred clean dried of Chinese crude drug Stigma Croci agents area 10 days; Soak after 10 days, the material after soaking is removed slag after 300 order filter screens filter, obtain lixiviating solution B liquid;
D, get remaining 20% Chinese crude drug Lumbricus enzyme, peptide compound formulation, namely get Chinese crude drug Lumbricus enzyme, the peptide compound formulation of remaining 0.08kg, add B liquid, be positioned in the lump in glass or the rustless steel container and stirred 20 minutes, left standstill after the stirring 7 days, get the Y preparation;
E, X preparation and Y preparation are mixed, add again conventional adjuvant or excipient, make spray through conventional technique.
Pharmaceutical composition of the present invention is used for the treatment of the dermatopathies such as acne and verruca plana, the using method of this pharmaceutical composition: 1, clean affected part; 2, this topical agent is sprayed on affected part; One spray is 2～3 times when 3, being used for the treatment of acne, and one spray is 3～5 times when being used for the treatment of verruca plana, once is coated with in right amount to get final product; 4, visible obvious therapeutic effect in 5～7 days; 5, in the use procedure without special taboo.
Embodiment 3: a kind of pharmaceutical composition, this pharmaceutical composition are to be made according to mass parts by following raw material: Chinese crude drug Lumbricus enzyme, peptide compound formulation 0.4kg, Stigma Croci 0.4kg, Radix Notoginseng 0.1kg and Herba Leonuri 0.1kg make.Described pharmaceutical composition is external preparation, and described external preparation can be ointment.This pharmaceutical composition is used for the treatment of acne or verruca plana.
The preparation method of above-mentioned pharmaceutical composition is as follows:
The method comprises following concrete steps:
A, getting Radix Notoginseng and Herba Leonuri, to be positioned over the 1kg alcoholic strength be slowly to stir to leave standstill after 30 minutes in 40 ° the edible ethanol of Sorghum vulgare Pers. Wine to soak 30 days, and the full root of Radix Notoginseng of Chinese crude drug Radix Notoginseng and the preferred clean dried of Herba Leonuri agents area, the front clean above Herb of Herba Leonuri grass roots of plucking blooms; Soak after 30 days, the material after soaking is removed slag after 300 order filter screens filter, obtain lixiviating solution A liquid;
B, get 80% Chinese crude drug Lumbricus enzyme, peptide compound formulation, namely get Chinese crude drug Lumbricus enzyme, the peptide compound formulation of 0.32kg, add A liquid, be positioned in the lump in glass or the rustless steel container and stirred 30 minutes, left standstill after the stirring 3 days, get the X preparation;
C, getting the 0.4kg Stigma Croci, to be positioned over the 2kg alcoholic strength be slowly to stir in 40 ° the jowar wine to leave standstill after 30 minutes to soak top and the stigma of the colored section of the preferred clean dried of Chinese crude drug Stigma Croci agents area 7 days; Soak after 7 days, the material after soaking is removed slag after 300 order filter screens filter, obtain lixiviating solution B liquid;
D, get remaining 20% Chinese crude drug Lumbricus enzyme, peptide compound formulation, namely get Chinese crude drug Lumbricus enzyme, the peptide compound formulation of remaining 0.08kg, add B liquid, be positioned in the lump in glass or the rustless steel container and stirred 30 minutes, left standstill after the stirring 7 days, get the Y preparation;
E, X preparation and Y preparation are mixed, add again conventional adjuvant or excipient, make ointment through conventional technique.
Pharmaceutical composition of the present invention is used for the treatment of the dermatopathies such as acne and verruca plana, the using method of this pharmaceutical composition: 1, clean affected part; 2, this topical agent is spread on affected part; Applied 2～3 times in 1st when 3, being used for the treatment of acne, one spray coating is 3～5 times when being used for the treatment of verruca plana, once is coated with in right amount to get final product; 4, visible obvious therapeutic effect in 5～7 days; 5, in the use procedure without special taboo.
Through the pharmaceutical composition of patients with acne 86 people's trial edition embodiment, 72 examples of recovery from illness account for 83% in 15 days; 9 examples of recovery from illness account for 10% in 30 days; 5 examples of DeGrain account for 5%; And cured person has no recurrence, and to sum up pharmaceutical composition of the present invention has reached 93% for the cure rate of acne, has ideal cure rate.Through verruca plana patient 73 people's trial edition invention pharmaceutical compositions, 65 examples that verruca plana comes off fully in 7 days account for 89%; 5 examples that verruca plana comes off in 30 days account for 6%; 3 examples of DeGrain account for 4%, and cured person also has no recurrence, and to sum up pharmaceutical composition of the present invention has reached 95% for the cure rate of verruca plana, has ideal cure rate.
Claims (7)
1. pharmaceutical composition, it is characterized in that: this pharmaceutical composition is to be made according to weight portion by following raw material: 1～1.5 part of Chinese crude drug Lumbricus enzyme, 4～5 parts of peptide compound formulations, 2～4 parts of Stigma Crocis, 1～1.5 part of Radix Notoginseng and Herba Leonuri.
2. pharmaceutical composition according to claim 1, it is characterized in that: this pharmaceutical composition is to be made according to mass parts by following raw material: 1 part of Chinese crude drug Lumbricus enzyme, 4 parts of peptide compound formulations, 4 parts of Stigma Crocis, 1 part of Radix Notoginseng and Herba Leonuri.
3. pharmaceutical composition according to claim 1, it is characterized in that: described pharmaceutical composition is external preparation.
4. pharmaceutical composition according to claim 3, it is characterized in that: described external preparation is spray, varnish, ointment or gel.
5. pharmaceutical composition according to claim 1, it is characterized in that: this pharmaceutical composition is used for the treatment of acne or verruca plana.
6. according to claim 1 to the preparation method of 5 each described pharmaceutical compositions, it is characterized in that: with filtering Radix Notoginseng, the Herba Leonuri lixiviating solution mix and blend that obtains after Chinese crude drug Lumbricus enzyme, peptide compound formulation and Radix Notoginseng and the Herba Leonuri lixiviate, obtain the X preparation; With filtering the Stigma Croci lixiviating solution mix and blend that obtains after Chinese crude drug Lumbricus enzyme, peptide compound formulation and the Stigma Croci lixiviate, obtain the Y preparation again; At last the X preparation is mixed with the Y preparation, add again conventional adjuvant, make topical agent through conventional technique; The method comprises following concrete steps:
A, get Radix Notoginseng and Herba Leonuri and be positioned over slowly to stir to leave standstill after 15～30 minutes in the edible ethanol that alcoholic strength is 40 °～45 ° Sorghum vulgare Pers. Wine or 70 ° and soaked 15～30 days; Soak after 15～30 days, the material after soaking is removed slag after 300 order filter screens filter, obtain lixiviating solution A liquid;
B, get 80% Chinese crude drug Lumbricus enzyme, peptide compound formulation, add A liquid, be positioned in the lump and stir 20～40 minutes in the container, left standstill after the stirring 3～6 days, get the X preparation;
C, get Stigma Croci and be positioned over slowly to stir to leave standstill after 15～30 minutes in the edible ethanol that alcoholic strength is 40 °～45 ° jowar wine or 70 ° and soaked 7～14 days; Soak after 7～14 days, the material after soaking is removed slag after 300 order filter screens filter, obtain lixiviating solution B liquid;
D, get remaining 20% Chinese crude drug Lumbricus enzyme, peptide compound formulation, add B liquid, be positioned in the lump and stir 20～40 minutes in the container, left standstill after the stirring 7～10 days, get the Y preparation;
E, X preparation and Y preparation are mixed, add again conventional adjuvant, make topical agent through conventional technique.
7. the preparation method of pharmaceutical composition according to claim 6, it is characterized in that: the method comprises following concrete steps:
A, get Radix Notoginseng 0.1kg and Herba Leonuri 0.1kg and be positioned over slowly to stir to leave standstill after 15～30 minutes in the edible ethanol that the 1kg alcoholic strength is 40 °～45 ° Sorghum vulgare Pers. Wine or 70 ° and soaked 15～30 days; Soak after 15～30 days, the material after soaking is removed slag after 300 order filter screens filter, obtain lixiviating solution A liquid;
B, get Chinese crude drug Lumbricus enzyme, the peptide compound formulation of 0.32kg, add A liquid, be positioned in the lump and stir 20～40 minutes in the container, left standstill after the stirring 3～6 days, get the X preparation;
C, get the 0.4kg Stigma Croci and be positioned over slowly to stir to leave standstill after 15～30 minutes in the edible ethanol that alcoholic strength is 40 °～45 ° 2kg jowar wine or 70 ° and soaked 7～14 days; Soak after 7～14 days, the material after soaking is removed slag after 300 order filter screens filter, obtain lixiviating solution B liquid;
D, get 0.08kg Chinese crude drug Lumbricus enzyme, peptide compound formulation, add B liquid, be positioned in the lump and stir 20～40 minutes in the container, left standstill after the stirring 7～10 days, get the Y preparation;
E, X preparation and Y preparation are mixed, add again conventional adjuvant, make topical agent through conventional technique.
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| CN101214293A (en) * | 2008-01-17 | 2008-07-09 | 刘兆森 | Chinese medicine preparation for treating acne and acne scar and preparation thereof |
| CN101972449A (en) * | 2010-10-22 | 2011-02-16 | 杨孟臻 | Chinese medicinal material earthworm enzyme and peptide compound preparation and preparation method thereof |
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| CN101214293A (en) * | 2008-01-17 | 2008-07-09 | 刘兆森 | Chinese medicine preparation for treating acne and acne scar and preparation thereof |
| CN101972449A (en) * | 2010-10-22 | 2011-02-16 | 杨孟臻 | Chinese medicinal material earthworm enzyme and peptide compound preparation and preparation method thereof |
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| Title |
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| 熊丽辉等.痤疮的中医药治疗进展.《吉林中医药》.2006,第26卷(第04期),61-62. * |
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