CN102274387A - Garlic and sophora flavescens injection and preparation method thereof - Google Patents
Garlic and sophora flavescens injection and preparation method thereof Download PDFInfo
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- CN102274387A CN102274387A CN2011102329645A CN201110232964A CN102274387A CN 102274387 A CN102274387 A CN 102274387A CN 2011102329645 A CN2011102329645 A CN 2011102329645A CN 201110232964 A CN201110232964 A CN 201110232964A CN 102274387 A CN102274387 A CN 102274387A
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- bulbus allii
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Abstract
The invention discloses garlic and sophora flavescens injection and preparation method thereof. The garlic and sophora flavescens injection comprises the following raw material in part by weight: 800 to 1,200 parts of garlic and 800 to 1,200 parts of sophora flavescens. The process control of the garlic and sophora flavescens injection prepared by the method is simple, the bioavailability is high, the medicine effect is remarkable, the treatment effect is quick and the cost is low.
Description
Technical field
The present invention relates to field of medicaments, be specially Bulbus Allii lightyellow sophora root injection that is used for the treatment of yellow and white dysentery of piglet and preparation method thereof.
Background technology
Yellow and white dysentery of piglet is being collectively referred to as of yellow scour of piglet and Hakuri, produces the acute Intestinum Sus domestica road transmission disease that toxin causes by Escherichia coli in intestinal.Yellow scours is mainly in 7 ages in days with interior suckling pig, and 1～3 age in days is the most common, and the above piglets of 7 ages in days falls ill few.Its disease symptom is discharged yellow or lark water sample loose stool with diarrhoea, and morbidity is anxious, dehydration rapidly, and weak, death is feature, and sickness rate is common more than 90%, and mortality rate can be up to more than 80%, but sickness rate reduction gradually with the increase of age in days.Hakuri generally betides 7～30 age in days piglet diarrhea, and the piglet about 1～2 age in days very easily causes enteritis and septicemia.Be feature from color or ash from the stench feces of color thickness with dysentery, discharge breast clinically, cuing open inspection is feature with enteritis, and it is little good or dead to be easy to cause piglet growth to grow, and sickness rate is generally 10～30%, and mortality rate is 10%.Yellow and white dysentery of piglet is a kind of big disease that has a strong impact on piglet growth, has caused serious economy loss to pig industry for a long time.
At present, the veterinary drug of treatment yellow and white dysentery of piglet is a lot, but the overwhelming majority is a chemical drugs, easily in the poultry body, have residual after the use, produce toxic and side effects and more and more serious to the healthy phenomenon of people's the healthy potential safety hazard that exists, particularly antibacterials residual directly harm people in livestock products by livestock products food.
Summary of the invention
Technical problem solved by the invention is to provide a kind of Bulbus Allii lightyellow sophora root injection and preparation method thereof,
To solve the problem in the background technology.
Technical problem solved by the invention realizes by the following technical solutions:
1. the composition of Bulbus Allii lightyellow sophora root injection is counted by weight, and raw material is composed as follows: 800～1200 parts in Bulbus Allii, 800～1200 parts of Radix Sophorae Flavescentiss;
2. by following processing step and technological parameter preparation:
(1) gets 800～1200 parts in Bulbus Allii, rub, add an amount of distilled water distilling under reduced pressure, collect distillate 160～240ml;
(2) get 800～1200 parts of Radix Sophorae Flavescentiss, decoct with water twice, collecting decoction, filter, it is 1.20～1.25(60 ℃ of survey that filtrate decompression is concentrated into relative density), room temperature is placed, stir and add ethanol, make to contain alcohol amount and reach 70%, fully stir, left standstill 24 hours, divide and get supernatant, filtration, filtrate recycling ethanol gets fluid extract to there not being the alcohol flavor;
(3) (1) gained distillate and (2) gained fluid extract are merged, add each 5ml of tween 80 and benzyl alcohol, stir, add injection water to 800～1200ml, regulate pH value to 5.6～6.4, fine straining, embedding, sterilization, promptly.
In the present invention, the optimum weight proportioning is as follows: 1000 parts in Bulbus Allii, 1000 parts of Radix Sophorae Flavescentiss.
In the present invention, it is best collecting distillate 200ml in the processing step (1), and adding the injection water in the processing step (3) is best to 1000ml, and it is best regulating pH value to 6.
The present invention is pale brown color or fallow clear liquid; Clearing away heat-damp and promoting diuresis is arranged, and the antidiarrheal dysentery relieving is used for the treatment of yellow and white dysentery of piglet, every 1kg body weight intramuscular injection 0.2～0.25ml the present invention.
Authentication method of the present invention is as follows:
(1) get this product 10ml, add chloroform 25ml, add strong ammonia solution and regulate pH value to 9.5, reflux 1 hour is put coldly, gets chloroform liquid evaporate to dryness, and residue adds ethanol 2ml makes dissolving, as test sample liquid.Other gets the oxymatrine reference substance, adds ethanol and makes the solution that every 1ml contains 1mg, in contrast product solution.According to thin layer chromatography (appendix XX page or leaf) test, draw each 5 μ l of above-mentioned two kinds of solution, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, with benzene-acetone-ethyl acetate-dense ammonia (2: 3: 4: 0.2) be developing solvent, launch, take out, dry.Spray is with rare bismuth potassium iodide test solution.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
(2) get this product 20ml, put in the round-bottomed flask, add water 150ml and bead number, shake up, according to determination of volatile oil method (appendix XX page or leaf) operation, add water from the determinator upper end and make and be full of the scale part, and overflow is gone into till the flask, heating extraction 40 minutes, put coldly, will measure liquid in pipe and put into separatory funnel, wash condensing tube at twice and measure pipe with ether 30ml, the cleaning mixture gradation adds in the separatory funnel, shaking out merges ether solution, volatilizes, residue adds n-hexane 1ml makes dissolving, as need testing solution.Other gets the garlicin reference substance, and it is an amount of to add n-hexane, makes the solution that every 1ml contains 0.2mg, in contrast product solution.According to thin layer chromatography (appendix XX page or leaf) test, draw reference substance solution 5 μ l, need testing solution 10 μ l, put respectively on same silica gel g thin-layer plate, with n-hexane-ethyl acetate (8: 2) is developing solvent, launches, and takes out, dry, put in the iodine cylinder and develop the color to clear spot.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show identical brown speckle.
Beneficial effect:
The technology controlling and process that the present invention makes the Bulbus Allii lightyellow sophora root injection is simple, the bioavailability height, and good drug efficacy, curative effect is fast, and cost is low.
The specific embodiment
Best embodiment of the present invention divides other scheme according to integral body, implements respectively, below by embodiment the present invention is specifically described:
Bulbus Allii 1000g, Radix Sophorae Flavescentis 1000g.Preparation process is as follows:
(1) gets Bulbus Allii 1000g, rub, add an amount of distilled water distilling under reduced pressure, collect distillate 200ml;
(2) get Radix Sophorae Flavescentis 1000g, decoct with water twice, collecting decoction, filter, it is 1.20～1.25(60 ℃ of survey that filtrate decompression is concentrated into relative density), room temperature is placed, stir and add ethanol, make to contain alcohol amount and reach 70%, fully stir, left standstill 24 hours, divide and get supernatant, filtration, filtrate recycling ethanol gets fluid extract to there not being the alcohol flavor;
(3) (1) gained distillate and (2) gained fluid extract are merged, add each 5ml of tween 80 and benzyl alcohol, stir, add the injection water, regulate pH value to 6.0 to 1000ml, fine straining, embedding, sterilization, promptly.
More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that describes in the foregoing description and the description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof
Claims (6)
1. the composition of Bulbus Allii lightyellow sophora root injection is counted by weight, it is characterized in that, raw material is composed as follows: 800～1200 parts in Bulbus Allii, 800～1200 parts of Radix Sophorae Flavescentiss.
2. Bulbus Allii lightyellow sophora root injection according to claim 1 is characterized in that, the optimum weight proportioning is as follows: 1000 parts in Bulbus Allii, 1000 parts of Radix Sophorae Flavescentiss.
3. the preparation method of Bulbus Allii lightyellow sophora root injection is characterized in that, counts by weight, presses following processing step:
Get 800～1200 parts in Bulbus Allii, rub, add an amount of distilled water distilling under reduced pressure, collect distillate 160～240ml;
(2) get 800～1200 parts of Radix Sophorae Flavescentiss, decoct with water twice, collecting decoction, filter, it is 1.20～1.25(60 ℃ of survey that filtrate decompression is concentrated into relative density), room temperature is placed, stir and add ethanol, make to contain alcohol amount and reach 70%, fully stir, left standstill 24 hours, divide and get supernatant, filtration, filtrate recycling ethanol gets fluid extract to there not being the alcohol flavor;
(3) (1) gained distillate and (2) gained fluid extract are merged, add each 5ml of tween 80 and benzyl alcohol, stir, add injection water to 800～1200ml, regulate pH value to 5.6～6.4, fine straining, embedding, sterilization, promptly.
4. Bulbus Allii lightyellow sophora root injection preparation method according to claim 3 is characterized in that, the best distillate 200ml that collects.
5. Bulbus Allii lightyellow sophora root injection preparation method according to claim 3 is characterized in that, the best adds the injection water to 1000ml.
6. Bulbus Allii lightyellow sophora root injection preparation method according to claim 3 is characterized in that optimum adjustment pH value to 6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102329645A CN102274387A (en) | 2011-08-13 | 2011-08-13 | Garlic and sophora flavescens injection and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102329645A CN102274387A (en) | 2011-08-13 | 2011-08-13 | Garlic and sophora flavescens injection and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102274387A true CN102274387A (en) | 2011-12-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011102329645A Pending CN102274387A (en) | 2011-08-13 | 2011-08-13 | Garlic and sophora flavescens injection and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102961563A (en) * | 2012-12-11 | 2013-03-13 | 青岛农业大学 | Pharmaceutical composition for treating livestock and poultry dysentery and preparation method thereof |
-
2011
- 2011-08-13 CN CN2011102329645A patent/CN102274387A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 刘权: "介绍几种中药注射剂的临床应用", 《新医药学杂志》 * |
| 张申为等: "大蒜素的提取及其注射液的制备", 《西安联合大学学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102961563A (en) * | 2012-12-11 | 2013-03-13 | 青岛农业大学 | Pharmaceutical composition for treating livestock and poultry dysentery and preparation method thereof |
| CN102961563B (en) * | 2012-12-11 | 2015-02-18 | 青岛农业大学 | Pharmaceutical composition for treating livestock and poultry dysentery and preparation method thereof |
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Application publication date: 20111214 |