CN102258644A - Antihypertensive medicinal composition and production method thereof - Google Patents
Antihypertensive medicinal composition and production method thereof Download PDFInfo
- Publication number
- CN102258644A CN102258644A CN 201110190325 CN201110190325A CN102258644A CN 102258644 A CN102258644 A CN 102258644A CN 201110190325 CN201110190325 CN 201110190325 CN 201110190325 A CN201110190325 A CN 201110190325A CN 102258644 A CN102258644 A CN 102258644A
- Authority
- CN
- China
- Prior art keywords
- parts
- ramulus uncariae
- uncariae cum
- cum uncis
- pollen typhae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the field of medicines and discloses a Chinese medicine which has the effects of clearing heat, detoxifying, tonifying qi and yin, promoting blood circulation and removing stasis and can be used for treating hypertension. The Chinese medicine is prepared from the following components in part by weight: 10 to 30 grams of astragalus, 5 to 15 parts of phellodendron, 5 to 20 parts of eucommia bark, 1 to 15 parts of coptis chinensis, 10 to 30 parts of uncaria, 5 to 15 parts of pollen typhae and 1 to 15 parts of pseudo-ginseng root. Clinic study indicates the medicine has antihypertensive effect and has remarkable treatment effect on symptoms caused by hypertension such as dizziness, dysphoria, headache, stuffiness, palpitation, numb limbs and debilitation.
Description
Technical field
The present invention relates to a kind of drug regimen and production method thereof, the invention belongs to drug world with antihypertensive function.
Background technology
Change along with process of industrialization and people life style, the sickness rate of hypertension (essential hypertension.EH) raises gradually, complication increases gradually, recent statistics result, China hyperpietic has reached 2.0 hundred million, and the mortality rate of the cardiovascular and cerebrovascular disease that is caused by hypertension has been discharged to first of all disease death rates.Hypertension is as a cardiovascular diseases's important risk factor, and to be seriality independent relevant with coronary heart disease, apoplexy, congestive heart failure and renal function injury.Along with the transformation of human diseases spectrum, be to increase day by day in cardiovascular diseases's sickness rate worldwide of representative with hypertension, coronary atherosclerotic heart disease (coronary heart disease) etc.China cardiovascular diseases's risk factor is the situation that rises appreciably, and the prevalence of hypertension, dyslipidemia, obesity, diabetes is all increasing, the task abnormity arduousness of the anti-angiocardiopathy of China.As not taking intervening measure timely and effectively, cardiovascular diseases's number of patients will roll up in 10 years in Chinese future, show that hypertension is not only a health problem of a mass character, and become a great public health problem.Therefore the hypertensive problem of preventing and treating has become the common important topic of paying close attention to of whole world medical circle, and the various countries scholar develops the hypertensive method of new treatment by different approach.Therefore developing the hypertensive medicine of a kind of effective treatment has very big realistic meaning for the human beings'health cause.
Summary of the invention
The present invention has set up by the Radix Astragali, the Cortex Eucommiae, Rhizoma Coptidis, Ramulus Uncariae Cum Uncis, Cortex Phellodendri, Pollen Typhae, Radix Notoginseng through for many years clinical verification, totally 7 flavor herbal prescriptions.The purpose of this invention is to provide a kind of Chinese medicine preparation with heat-clearing and toxic substances removing, QI invigorating, the effect of invigorating blood circulation, be used for the treatment of hypertension, particularly dizzy, irritated, the headache that is caused by hypertension, chest distress and palpitation symptoms, numb hand and foot, symptom such as weak have good curative effect; Another object of the present invention provides the production method of this drug regimen.
Drug regimen of the present invention is made up of following component (weight portion):
The Radix Astragali 10～30, Cortex Phellodendri 5～15, the Cortex Eucommiae 5～20, Rhizoma Coptidis 1～15, Ramulus Uncariae Cum Uncis 10～30, Pollen Typhae 5～15, Radix Notoginseng 1～15
The present invention preferably makes up:
15 parts of the Radixs Astragali, 10 parts of Cortex Phellodendris, 10 parts of the Cortexs Eucommiae, 8 parts of Rhizoma Coptidis, 12 parts of Ramulus Uncariae Cum Uncis, 10 parts of Pollen Typhaes, 5 parts of Radix Notoginseng
For above drug regimen is prepared as Chinese patent medicine, can finish by the following method:
1. the Radix Astragali, the Cortex Eucommiae, Rhizoma Coptidis, Ramulus Uncariae Cum Uncis, Cortex Phellodendri, Pollen Typhae, Radix Notoginseng decoct with water, and Ramulus Uncariae Cum Uncis leaves the back at water and adds.Water cooking liquid concentrates, and precipitate with ethanol is got supernatant; 2. the precipitate with ethanol supernatant concentration is to thick paste, vacuum drying, and dried cream breaks into fine powder, mixing; 3. add adjuvant, make required dosage form, as tablet, pill, capsule etc.
The specific embodiment
The following example is used to illustrate the present invention, is not any restriction to protection domain of the present invention.
Embodiment one
Prescription: the Radix Astragali 1000, Cortex Phellodendri 666, the Cortex Eucommiae 666, Rhizoma Coptidis 533, Ramulus Uncariae Cum Uncis 800, Pollen Typhae 666, Radix Notoginseng 333.
1. the Radix Astragali, the Cortex Eucommiae, Rhizoma Coptidis, Ramulus Uncariae Cum Uncis, Cortex Phellodendri, Pollen Typhae, Radix Notoginseng decoct with water 2 times, and Ramulus Uncariae Cum Uncis leaves the back at water and adds.10 times of amounts 1.5 hours, were measured 1 hour for 8 times for the second time for the first time.Decocting liquid filters, collecting decoction, and being evaporated to relative density is 1.10～1.20 (80 ℃), 95% ethanol that adds 2 times of amounts is done the precipitate with ethanol processing, leaves standstill the leaching supernatant 24 hours.
2. precipitate with ethanol supernatant decompression recycling ethanol is concentrated into thick paste, and thick paste moves to pallet, and 60～80 ℃ of vacuum dryings become dried cream, and dried cream breaks into fine powder, whole mistake 160 mesh sieves;
3. add appropriate amount of starch, granulate, be pressed into 1000 with 85% ethanol water.
4. usage and dosage: every day 3 times, each 4～6.
Embodiment two
Prescription: the Radix Astragali 1000, Cortex Phellodendri 800, the Cortex Eucommiae 400, Rhizoma Coptidis 1066, Ramulus Uncariae Cum Uncis 400, Pollen Typhae 666, Radix Notoginseng 533.
1. the Radix Astragali, the Cortex Eucommiae, Rhizoma Coptidis, Ramulus Uncariae Cum Uncis, Cortex Phellodendri, Pollen Typhae, Radix Notoginseng decoct with water 2 times, and Ramulus Uncariae Cum Uncis leaves the back at water and adds.10 times of amounts 1.5 hours, were measured 1 hour for 8 times for the second time for the first time.Decocting liquid filters, collecting decoction, and being evaporated to relative density is 1.10～1.20 (80 ℃), 95% ethanol that adds 2 times of amounts is done the precipitate with ethanol processing, leaves standstill the leaching supernatant 24 hours.
2. precipitate with ethanol supernatant decompression recycling ethanol is concentrated into thick paste, and thick paste moves to pallet, and 60～80 ℃ of vacuum dryings become dried cream, and dried cream breaks into fine powder, whole mistake 160 mesh sieves;
3. add appropriate amount of starch, make binding agent with Mel, general ball gets 6000 balls.
4. usage and dosage: every day 3 times, each 8 balls.
Embodiment three
Prescription: Radix Astragali 45g, Cortex Phellodendri 35g, Cortex Eucommiae 20g, Rhizoma Coptidis 16g, Ramulus Uncariae Cum Uncis 15g, Pollen Typhae 15g, Radix Notoginseng 10g.
1. the Radix Astragali, the Cortex Eucommiae, Rhizoma Coptidis, Ramulus Uncariae Cum Uncis, Cortex Phellodendri, Pollen Typhae, Radix Notoginseng decoct with water 2 times, and Ramulus Uncariae Cum Uncis leaves the back at water and adds.10 times of amounts 1.5 hours, were measured 1 hour for 8 times for the second time for the first time.Decocting liquid filters, collecting decoction, and being evaporated to relative density is 1.10～1.20 (80 ℃), 95% ethanol that adds 2 times of amounts is done the precipitate with ethanol processing, leaves standstill the leaching supernatant 24 hours.
2. precipitate with ethanol supernatant decompression recycling ethanol is concentrated into thick paste, and thick paste moves to pallet, and 60～80 ℃ of vacuum dryings become dried cream, and dried cream breaks into fine powder, whole mistake 160 mesh sieves;
3. dried cream is beaten powder, adds appropriate amount of starch, granulates.
4. pour into capsule, get 27.
5. usage and dosage: every day 3 times, each 3.
Embodiment four
Prescription: Radix Astragali 1500g, Cortex Phellodendri 800g, Cortex Eucommiae 800g, Rhizoma Coptidis 600g, Ramulus Uncariae Cum Uncis 1000g, Pollen Typhae 1000g, Radix Notoginseng 600g.
1. the Radix Astragali, the Cortex Eucommiae, Rhizoma Coptidis, Ramulus Uncariae Cum Uncis, Cortex Phellodendri, Pollen Typhae, Radix Notoginseng decoct with water 2 times, and Ramulus Uncariae Cum Uncis leaves the back at water and adds.10 times of amounts 1.5 hours, were measured 1 hour for 8 times for the second time for the first time.Decocting liquid filters, collecting decoction, and being evaporated to relative density is 1.10～1.20 (80 ℃), 95% ethanol that adds 2 times of amounts is done the precipitate with ethanol processing, leaves standstill the leaching supernatant 24 hours.
2. precipitate with ethanol supernatant decompression recycling ethanol is not distinguished the flavor of to there being alcohol, and concentrating under reduced pressure is that 60 ℃ of survey relative densities are the clear paste of 1.20-1.25.
3. clear paste adds suitable adjuvant, makes mixture, and embedding becomes 600.
4. usage and dosage: every day 3 times, each 1.
Clinical practice
Drug regimen of the present invention is used for many years clinically, has antihypertensive effect, particularly dizzy, irritated, the headache that caused by hypertension, chest distress and palpitation symptoms, numb hand and foot, symptom such as weak is had good efficacy; Used case shows, during this medicine can be controlled, low hyperpietic's blood pressure, and dizzy, irritated, the headache that improves effectively that hypertension causes, chest distress and palpitation symptoms, numb hand and foot, symptom such as weak; For the severe hypertension patient, share with Western medicine, can reduce the use amount of Western medicine, effectively reduce Western medicine and cause toxic and side effects.
Claims (4)
1. one kind has antihypertensive pharmaceutical composition, it is characterized in that: the crude drug proportion of composing is (in a weight portion): the Radix Astragali 10～30, Cortex Phellodendri 5～15, the Cortex Eucommiae 5～20, Rhizoma Coptidis 1～15, Ramulus Uncariae Cum Uncis 10～30, Pollen Typhae 5～15, Radix Notoginseng 1～15.
2. according to claim 1 have an antihypertensive pharmaceutical composition, it is characterized in that described crude drug proportion of composing comprises (in weight portion): the Radix Astragali 15, Cortex Phellodendri 10, the Cortex Eucommiae 10, Rhizoma Coptidis 8, Ramulus Uncariae Cum Uncis 12, Pollen Typhae 10, Radix Notoginseng 5.
3. as the described preparation of drug combination method of right 1-2, it is characterized in that:
1. the Radix Astragali, the Cortex Eucommiae, Rhizoma Coptidis, Ramulus Uncariae Cum Uncis, Cortex Phellodendri, Pollen Typhae, Radix Notoginseng decoct with water, and Ramulus Uncariae Cum Uncis leaves the back at water and adds.Decocting liquid concentrates, and precipitate with ethanol is got supernatant; 2. the precipitate with ethanol supernatant concentration is to thick paste, vacuum drying, and dried cream breaks into fine powder, mixing; 3. add adjuvant, make required dosage form, as tablet, pill, capsule etc.
4. according to claim 3 have an antihypertensive medicine, and it is characterized in that: dosage form is a peroral dosage form, as tablet, pill, capsule, oral liquid, granule etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110190325 CN102258644A (en) | 2011-07-08 | 2011-07-08 | Antihypertensive medicinal composition and production method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110190325 CN102258644A (en) | 2011-07-08 | 2011-07-08 | Antihypertensive medicinal composition and production method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102258644A true CN102258644A (en) | 2011-11-30 |
Family
ID=45005610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110190325 Pending CN102258644A (en) | 2011-07-08 | 2011-07-08 | Antihypertensive medicinal composition and production method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102258644A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103285220A (en) * | 2013-05-17 | 2013-09-11 | 周波 | Traditional Chinese medicine for treating hypertension |
| CN106074910A (en) * | 2016-08-12 | 2016-11-09 | 广西中医药大学附属瑞康医院 | A kind of Anti-hypertension Chinese medicine formulation preparation method |
-
2011
- 2011-07-08 CN CN 201110190325 patent/CN102258644A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 《中西医结合心脑血管病杂志》 20070831 岳桂华 益气活血解毒法对高血压血管内皮保护的临床观察 733-734 第5卷, 第8期 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103285220A (en) * | 2013-05-17 | 2013-09-11 | 周波 | Traditional Chinese medicine for treating hypertension |
| CN103285220B (en) * | 2013-05-17 | 2015-04-01 | 周博 | Traditional Chinese medicine for treating hypertension |
| CN106074910A (en) * | 2016-08-12 | 2016-11-09 | 广西中医药大学附属瑞康医院 | A kind of Anti-hypertension Chinese medicine formulation preparation method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101264205A (en) | Chinese medicinal composition for treating gout and preparation thereof | |
| CN102973719A (en) | Traditional Chinese medicine health-care food with bowel relaxing function and preparation method thereof | |
| CN101485870A (en) | Medicament for promoting digestion and expelling intestinal parasites | |
| CN101347605B (en) | Chinese medicinal composition for treating gout and preparation method and application thereof | |
| CN101757281B (en) | Traditional Chinese medicine composition for treating gastrointestinal disease and preparation method thereof | |
| CN102258644A (en) | Antihypertensive medicinal composition and production method thereof | |
| CN100500183C (en) | Preparation of Chinese medicinal mixture for treating gynecologic menstrual disease | |
| CN102641364A (en) | Drug for treating constipation and preparation method thereof | |
| CN102430008B (en) | Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof | |
| CN102430009B (en) | Traditional Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof | |
| CN103585495B (en) | Capsule for treating diabetic kidney damage | |
| CN101862364A (en) | Preparation method of traditional Chinese medicinal extract of Chinese angelica and red flower and series preparations thereof | |
| CN105194355A (en) | Traditional Chinese medicine preparation for treating primary hypertension | |
| CN110870894A (en) | Traditional Chinese medicine composition for treating diarrhea | |
| CN108743885A (en) | A kind of Chinese medicine and preparation method thereof for treating Diabetic Macrovascular Complications | |
| CN104306649A (en) | Medicament for treating herpes zoster | |
| CN102266540B (en) | Chinese medicament for treating constipation | |
| CN100443103C (en) | Pharmaceutical composition for treating diabetes complication and preparation process thereof | |
| CN102133316B (en) | Chinese medicine pill for treating anorectal diseases | |
| CN102641413A (en) | Medicine for treating acute enteritis and preparing method thereof | |
| CN102416088B (en) | Chinese medicinal composition for treating gastrointestinal diseases and preparation method thereof | |
| CN102430075B (en) | Traditional Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof | |
| CN101468144B (en) | Chinese medicine compound preparation for treating ventricular premature beat | |
| CN105288410A (en) | Traditional Chinese medicine composition for treating diabetic nephropathy and application of traditional Chinese medicine composition | |
| CN104739940A (en) | Traditional Chinese medicine for treating rheumatic bone diseases and preparation method of Chinese patent medicine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20111130 |