CN102256611B - 使用含缺损基因组片段的病毒的抗病毒保护 - Google Patents

使用含缺损基因组片段的病毒的抗病毒保护 Download PDF

Info

Publication number
CN102256611B
CN102256611B CN200980149732.4A CN200980149732A CN102256611B CN 102256611 B CN102256611 B CN 102256611B CN 200980149732 A CN200980149732 A CN 200980149732A CN 102256611 B CN102256611 B CN 102256611B
Authority
CN
China
Prior art keywords
virus
influenza
mice
viruses
interferon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN200980149732.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN102256611A (zh
Inventor
N·迪莫克
A·伊斯顿
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Warwick
Original Assignee
University of Warwick
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Warwick filed Critical University of Warwick
Publication of CN102256611A publication Critical patent/CN102256611A/zh
Application granted granted Critical
Publication of CN102256611B publication Critical patent/CN102256611B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16161—Methods of inactivation or attenuation
    • C12N2760/16162—Methods of inactivation or attenuation by genetic engineering

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN200980149732.4A 2008-12-12 2009-12-08 使用含缺损基因组片段的病毒的抗病毒保护 Active CN102256611B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0822672.2A GB0822672D0 (en) 2008-12-12 2008-12-12 Anti-viral protection with viruses containing a defective genome
GB0822672.2 2008-12-12
PCT/GB2009/051666 WO2010067109A1 (en) 2008-12-12 2009-12-08 Anti-viral protection with viruses containing defective genome segments

Publications (2)

Publication Number Publication Date
CN102256611A CN102256611A (zh) 2011-11-23
CN102256611B true CN102256611B (zh) 2014-05-21

Family

ID=40325992

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980149732.4A Active CN102256611B (zh) 2008-12-12 2009-12-08 使用含缺损基因组片段的病毒的抗病毒保护

Country Status (11)

Country Link
US (1) US8691215B2 (https=)
EP (1) EP2355834B1 (https=)
CN (1) CN102256611B (https=)
AU (1) AU2009326204B2 (https=)
CA (1) CA2746495C (https=)
DK (1) DK2355834T3 (https=)
ES (1) ES2423193T3 (https=)
GB (1) GB0822672D0 (https=)
IN (1) IN2011KN02819A (https=)
PL (1) PL2355834T3 (https=)
WO (1) WO2010067109A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2019685B1 (en) 2006-05-24 2014-11-12 The University Of Warwick Defective interfering virus
GB2522615A (en) * 2014-01-16 2015-08-05 Univ Warwick Assay and medicament
WO2019206285A1 (en) * 2018-04-26 2019-10-31 The University Of Hong Kong Nucleic acid molecules and dual-functional peptides having antiviral activity and delivery activity, compositions and methods thereof
GB202209861D0 (en) * 2022-07-05 2022-08-17 Univ Court Univ St Andrews Viral vectors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2437799A (en) * 2006-05-24 2007-11-07 Univ Warwick Defective interfering (DI) virus

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8715940B2 (en) 1999-04-06 2014-05-06 Wisconsin Alumni Research Foundation Method of making recombinant influenza virus
JP5147405B2 (ja) 2004-10-06 2013-02-20 メディミューン，エルエルシー 冷蔵温度安定型インフルエンザワクチン組成物
AU2005303817B8 (en) 2004-11-11 2010-09-30 Abbott Biologicals B.V. Defective influenza virus particles
EP2019685B1 (en) 2006-05-24 2014-11-12 The University Of Warwick Defective interfering virus

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2437799A (en) * 2006-05-24 2007-11-07 Univ Warwick Defective interfering (DI) virus
CN101454023A (zh) * 2006-05-24 2009-06-10 沃里克大学 干扰缺损病毒

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Susan D.Duhaut,et al.Heterologous Protection of Mice from a Lethal Human H1N1 Influenza A Virus Infection by H3N8 Equine Defective Interfering Virus: Comparison of Defective RNA Sequences Isolated from the DI Inoculum and Mouse Lung.《VIROLOGY》.1998,第248卷(第2期),第241-253页. *

Also Published As

Publication number Publication date
CN102256611A (zh) 2011-11-23
ES2423193T3 (es) 2013-09-18
US8691215B2 (en) 2014-04-08
US20110243896A1 (en) 2011-10-06
CA2746495C (en) 2018-04-17
AU2009326204A1 (en) 2011-06-23
CA2746495A1 (en) 2010-06-17
DK2355834T3 (da) 2013-07-29
EP2355834B1 (en) 2013-05-01
EP2355834A1 (en) 2011-08-17
WO2010067109A1 (en) 2010-06-17
GB0822672D0 (en) 2009-01-21
PL2355834T3 (pl) 2014-03-31
IN2011KN02819A (https=) 2015-07-10
AU2009326204B2 (en) 2014-01-09

Similar Documents

Publication Publication Date Title
Easton et al. A novel broad-spectrum treatment for respiratory virus infections: influenza-based defective interfering virus provides protection against pneumovirus infection in vivo
US10793834B2 (en) Live-attenuated virus and methods of production and use
KR20090007599A (ko) 인플루엔자 바이러스 백신
García‐Sastre et al. Lessons learned from reconstructing the 1918 influenza pandemic
Mann et al. Interfering vaccine (defective interfering influenza A virus) protects ferrets from influenza, and allows them to develop solid immunity to reinfection
CN102256611B (zh) 使用含缺损基因组片段的病毒的抗病毒保护
US9089516B2 (en) Method of preventing or treating influenza A viral infection using cloned DI influenza A viral particles
Scott et al. Defective interfering virus protects elderly mice from influenza
CN101454023B (zh) 干扰缺损病毒
KR101626798B1 (ko) 신규한 h3n2 혈청형의 인플루엔자 바이러스 및 이를 포함하는 백신 조성물
RU2563351C2 (ru) ШТАММ ВИРУСА ГРИППА А/17/Ануи/2013/61 (H7N9) ДЛЯ ПРОИЗВОДСТВА ЖИВОЙ ИНТРАНАЗАЛЬНОЙ ГРИППОЗНОЙ ВАКЦИНЫ
US10272149B2 (en) Modified bat influenza viruses and their uses
KR101582490B1 (ko) 인플루엔자 바이러스의 다중 아형에 대한 교차 면역반응을 형성하는 신규한 재조합 바이러스 백신
KR102370100B1 (ko) 이종 인플루엔자 a 바이러스에 대한 면역/치료반응을 형성하는 신규한 재조합 인플루엔자 바이러스 및 이를 포함하는 유전자 전달체 및 치료백신
Donabedian ATTENUATING GENES OF THE COLD-ADAPTED B/ANN ARBOR/1/66 INFLUENZA VIRUS (TEMPERATURE SENSITIVE, VIRULENCE)
Nasser Antiviral activity of influenza virus M1 zinc finger peptides
Ngunjiri Influenza virus noninfectious biologically active particle subpopulations: Detection, quantification, genetic complexity, function and their novel use as an in vitro screen for self-adjuvating live-attenuated influenza vaccines

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant