CN102256567A - 具有扩展焦深的眼内透镜 - Google Patents
具有扩展焦深的眼内透镜 Download PDFInfo
- Publication number
- CN102256567A CN102256567A CN2009801507237A CN200980150723A CN102256567A CN 102256567 A CN102256567 A CN 102256567A CN 2009801507237 A CN2009801507237 A CN 2009801507237A CN 200980150723 A CN200980150723 A CN 200980150723A CN 102256567 A CN102256567 A CN 102256567A
- Authority
- CN
- China
- Prior art keywords
- ophthalmic lens
- profile
- lens
- sinusoidal
- iol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1616—Pseudo-accommodative, e.g. multifocal or enabling monovision
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1616—Pseudo-accommodative, e.g. multifocal or enabling monovision
- A61F2/1618—Multifocal lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1637—Correcting aberrations caused by inhomogeneities; correcting intrinsic aberrations, e.g. of the cornea, of the surface of the natural lens, aspheric, cylindrical, toric lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1637—Correcting aberrations caused by inhomogeneities; correcting intrinsic aberrations, e.g. of the cornea, of the surface of the natural lens, aspheric, cylindrical, toric lenses
- A61F2/164—Aspheric lenses
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
- G02C7/041—Contact lenses for the eyes bifocal; multifocal
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C2202/00—Generic optical aspects applicable to one or more of the subgroups of G02C7/00
- G02C2202/20—Diffractive and Fresnel lenses or lens portions
Abstract
公开了一种眼科透镜,一种实施例包括具有关于光轴布置的前表面和后表面的光学器件,其中至少一个表面具有由基本轮廓和辅助轮廓的叠加表征的轮廓,该辅助轮廓包括从基本轮廓起的连续模式的表面偏差。该辅助轮廓是正弦轮廓而且可以进行幅值调制、频率调制或者进行幅值和频率调制。所述眼科透镜可以是IOL。
Description
技术领域
本发明总体上涉及眼科透镜,尤其涉及提供增强焦深的眼科透镜。
背景技术
眼内透镜通常是在白内障手术的过程中植入到患者眼中,以替代天然的晶状体。为了校正视觉疾病,例如白内障、近视、远视或者散光,采用多种眼科透镜。例如,眼内透镜(IOL)可以在白内障手术的过程中植入患者眼中,以补偿被摘除的晶状体的丧失的光焦度。然而,在许多情况下,植入的透镜可能不能在目标物距提供最佳的聚焦。
现代传统IOL光学器件的设计主要集中在两个结果:提供像差校正来提供清晰远距视力的光学器件,或者可以在提供远距视力的同时还提供近距视力需求的多焦光学器件。这些设计一般都不解决另一个重要的患者需求,即:对于大多数老年患者,多数的视力需求集中在某些中间距离上。构成接受IOL来替代天然晶状体的患者的很大百分比的这些老年患者需要扩展的功能性视力,从远距到中距,以便进行日常事务。当前的IOL设计还不足以提供这种扩展的功能性视力。
因此,需要一种改进的眼科透镜,尤其是需要一种与现有技术IOL相比可以提供增强焦深的改进的IOL。
发明内容
本发明提供的眼科透镜呈现扩展焦深,同时提供足够的对比度,用以分辨在选定范围的散焦距离上的图像。本发明的实施例在IOL中结合了正弦光学器件设计,以便在人眼中提供扩展的焦深。基于经典的正弦技术,本发明的实施例结合了幅值调制和频率调制技术,来提供增强的焦深。一种实施例可以从光瞳中心到透镜外围提供正弦幅值的衰减,从而将更多的光能集中到单个焦平面。另一种实施例可以提供对IOL光学器件的正弦周期进行调制,以作为光瞳半径的函数来改变有效透镜附加光焦度。在正弦曲线上组合幅值调制与频率调制的实施例可以进一步增强IOL的离焦(through focus)性能并产生期望的焦深轮廓,而没有传统设计所经受的某些光学现象。本发明的光学器件设计的实施例可以应用到单焦、多焦和/或适应性的IOL光学器件。
公开了在一定距离范围上校正折射误差或者另外地增强视力的方法,及制造本发明的透镜的方法。本发明的眼科透镜可以用在多种视力校正应用中,包括但不限于既可以用在人工晶状体眼应用又可以用在有晶状体眼应用中的IOL。对于隐形眼镜、基质内移植和其它折射设备,本发明也是有用的。
对于本领域技术人员来说,透镜/IOL背景下的术语“景深”和“焦深”公知且容易理解为指示物空间和像空间中可以分辨出可接受图像的距离。就需要定量测量来描述本发明来说,在此使用的术语“景深”或者“焦深”更特别地可以由与透镜相关联的散焦量来测量,在此散焦量处,以3mm孔径和绿光(例如,具有大约550nm波长的光)所测量的透镜的离焦调制传递函数(MTF)在与和该透镜相关联的衍射受限空间频率的大约三分之一相等的空间频率下呈现出至少大约15%的对比度。也可以应用其它定义,而且应当清楚焦深受许多因素影响,包括例如孔径尺寸、来自图像的光的颜色内容和透镜本身的基本光焦度。
根据本发明教习的IOL可以有适于特定应用的任何额定光焦度。在一种特别适用于白内障患者的IOL应用的实施例中,本发明的眼科透镜可以呈现出在大约17至大约25屈光度范围内的额定光焦度。在其它应用中,可以根据本发明的教习形成具有负额定光焦度的有晶状体眼透镜。
根据本发明教习的透镜的透镜主体可以由任何合适的生物相容材料形成。例如,透镜主体可以由软丙烯酸树脂形成,例如由位于FortWorth,TX的Alcon实验室公司制造的AcrySoft材料、水凝胶或者硅材料。例如,透镜主体可以由聚甲基丙烯酸甲酯(PMMA)形成。在有些实施例中,尤其是当期望可折叠的IOL透镜时,透镜可以由丙烯酸脂和甲基丙烯酸酯的共聚物形成。对于这种共聚物化合物的例示性例子,请参见例如于1999年7月13日授予Lebouef等人的题为“Ophthalmic Lens Polymers”的美国专利5,922,821和于2002年3月5日授予Freeman等人的题为“High Refractive Index OphthalmicDevice Materials”的美国专利6,353,069,这两个专利的教习都通过引用并入于此。
对本发明的进一步理解可以通过参考以下具体描述和关联的附图获得,以下简单地描述附图。
附图说明
图1示意性地示出了根据本发明教习的透镜;
图1A和1B示出了正弦光学器件设计的表面轮廓图;
图2A-2D例示了用于不同光瞳尺寸的正弦透镜设计的离焦性能;
图3A-3I例示了正弦光学器件设计(图3A-3C)、球面透镜设计(图3D-3F)和非球面透镜设计(图3G-3I)在人眼中的离焦性能;
图4A和4B示出了经幅值调制的正弦光学器件设计的表面轮廓图;
图5A和5B示出了经频率调制的正弦光学器件设计的表面轮廓图;
图6A和6B示出了本发明的经幅值调制与频率调制的正弦光学器件设计的实施例的表面轮廓图;及
图7A-7I例示了正弦光学器件设计(图7A-7C)、经幅值调制的正弦光学器件设计(图7D-7F)及本发明的经幅值调制与频率调制的正弦光学器件设计的实施例(图7G-7I)在人眼中的离焦性能。
具体实施方式
本发明提供的眼科透镜通过在正弦曲线上组合幅值调制与频率调制而呈现了扩展的焦深。由此,通过提供足够的对比度用以分辨在选定范围的散焦距离(其与由透镜呈现的增强的景深相当)上的图像,本发明的透镜可以校正折射误差或者另外地增强视力。
图1示意性地例示了根据本发明教习的示例透镜10,该透镜10包括具有两个折射表面14和16的透镜光学器件12。尽管折射表面被绘制为大体上是凸的,但是任何一个表面都可以具有大体上为凹的形状。可选地,表面14和16可以被选择成产生平-凹或者平-凸的透镜。由此,根据本发明教习的透镜可以具有正的或者负的额定光焦度。
透镜光学器件12可以由多种生物相容的软材料形成。例如,透镜光学器件12可以由软丙烯酸树脂材料(例如,丙烯酸脂和和甲基丙烯酸酯的共聚物)或者水凝胶或硅形成。本领域普通技术人员将认识到,实际上呈现用于透镜的特定应用所需折射率的任何软的生物相容材料都可以用于生产本发明的透镜,例如以上的示例透镜10。
折射表面16呈现波状形貌。为了例示的目的,表面调制被夸大了。更具体而言,折射表面16可以由以虚线绘出的基本曲率或者轮廓18表征,在基本轮廓18上叠加有表面偏差的连续模式20。示例基本轮廓18大体上是球面的而且是关于透镜主体/光学器件12的光轴22径向对称的。类似地,在这种示例实施例中,表面偏差的连续模式也是关于光轴22径向对称的。尽管在这种实施例中基本轮廓18是球面的,但是在其它实施例中,非球面的基本轮廓也可以用于本发明的实践。
本发明的经幅值和/或频率调制的正弦光学器件设计的实施例可以提供期望的增强焦深光学器件设计。基于经典的正弦技术,公开了基于幅值调制和频率调制的两种设计。第一种设计从光瞳中心向光学器件外围衰减光学器件的正弦幅值,以便将更多的光能集中到单个焦平面。第二种设计调制光学器件的正弦周期,以便作为光瞳半径的函数来改变有效附加光焦度。本发明的实施例将这两种设计类型组合到一起,进一步增强离焦光学器件性能并产生期望的焦深轮廓。本发明的实施例可以实现为单焦点、适应性和/或多焦点眼内透镜。
用于建模本发明实施例的数值计算是利用Matlab程序来执行的。选择了波动光学方法来建模正弦光学器件结构,而且性能评估主要集中在50(20/40VA)和100lp/mm(20/20VA)的离焦调制传递函数。
经典的正弦设计作为可选方式被提出,用以产生三焦点行为,而不会在诸如IOL光学器件的光学器件中有尖锐衍射台阶的不利光学影响。正弦曲线可以由等式1来描述。
其中a是确定正弦曲线的幅值和在不同焦距的衍射效率的参数,而b是指定周期和附加光焦度的参数。
在研究中,使用参数值a=0.5877和b=2.2,这产生±0.5D的附加光焦度。可以调整参数a,以考虑从空气到水状体的设计环境变化,如这里将要讨论的。图1A和1B中例示了正弦光学器件设计的光学器件表面轮廓。图1A是1-D表面轮廓图,而1B是表面高度图。以类似于典型多焦点透镜的方式,从光学器件/光瞳中心到光学器件外围,正弦曲线变得越来越密。在没有高阶像差的假设下,在常规湿单元(wet-cell)内针对3.0mm、4.5mm和5.0mm的光瞳,计算具有这种设计的透镜的离焦性能。图2A、2C和2D分别例示了这些结果。
计算结果如实地反映了正弦光学器件设计的独特特性。对于小光瞳(例如,大约3mm),在周期性结构之间的干扰发生之前,暴露的中心部分被折射效果主导(+0.5D附加光焦度)。峰值在-0.57D散焦量(对应于+0.57D的附加光焦度)的离焦MTF显现出这种效果。如图2B中所示,MTF在这个散焦水平下证实有良好的光学质量。在大光瞳(4.5mm和5.0mm)下,衍射效果越来越明显,如由在100lp/mm处的三个不同的离焦峰值所指示的。所评估的波长是550nm。
将以上所述的正弦设计的离焦性能与现有的球面和非球面IOL光学器件设计进行比较。结果在图3A-3I中示出。针对正弦设计(图3A-3C)、球面透镜设计(图3D-3F)和非球面透镜设计(图3G-3I),计算人眼(具有0.28μm球面像差的眼角膜)中的离焦性能。评估在三个不同光瞳尺寸下的性能:3.5mm光瞳(图3A、3D、3G)、4.5mm光瞳(图3B、3E、3H)和6.0mm光瞳(图3C、3F、3I)。为了评估,使用四种典型的空间频率:25lp/mm、50lp/mm、75lp/mm和100lp/mm。
总的来说,与现有技术的球面和非球面IOL光学器件设计相比,正弦设计扩展了焦深。球面光学器件设计中大量的球面像差迅速地减少了对大光瞳的调制。非球面IOL光学器件设计对所有光瞳都维持良好的峰值光学性能。然而,非球面透镜设计具有有限的焦深。
对于大光瞳,由于光分散到三个不同的焦距,因此经典正弦设计的衍射效果导致非常低的调制传递函数。减少的调制传递一般导致减少的对比度灵敏度,并使夜间驾驶性能劣化。在过去,多焦点IOL设计中低调制传递的影响是利用变迹(apodization)方法来解决的。类似地,当光瞳尺寸增大时(例如,在暗的条件下),正弦光学器件的正弦幅值可以利用余弦函数来调制,其中余弦函数可以将更多的光偏移到所选的衍射级,例如0衍射级。
幅值调制(AM)正弦光学器件设计在图4A和4B中例示。图4A示出了1-D表面轮廓图,而图4B示出了2-D表面高度图。余弦调制函数在光瞳(光学器件)中心从1.0开始,并逐渐减小到在5.0mm光瞳直径处的0。对幅值调制的分析性描述由等式2提供。
其中r0是余弦调制的终止光瞳半径。
图7D-7F例示了经幅值调制的正弦设计的离焦性能,如以下将进一步讨论的。如图7F中所示,对于6.0mm的入射光瞳,100lp/mm的峰值性能从正弦设计的0.28提高到0.40(增加了大约40%)。
增强的焦深可能对于大光瞳(夜间驾驶条件)具有较少的好处,因此,对于大光瞳来说,减小的焦深可能有助于将更多的能量集中到远距焦点。当光瞳尺寸增大时,一种创新技术即频率调制有助于减少正弦设计的附加光焦度。经频率调制的正弦光学器件设计的表面轮廓在图5A和5B中示出。图5A示出了1-D表面轮廓图,而图5B示出了2-D表面高度图。为了比较,图5A还示出了未调制的正弦光学器件设计。由于附加光焦度减小的本质,峰值之间的间距从透镜/光瞳中心到透镜外围变得更稀疏,这是由以下的等式3分析性地表达的。
其中f(r)是光瞳半径的平方根。
为了进一步增强在大光瞳尺寸下的光学性能,本发明的实施例在正弦光学器件设计上组合了幅值调制和频率调制,从而将光能集中到单个焦平面。本发明的经幅值与频率调制的正弦光学器件设计的实施例的表面轮廓可以由等式(4)来描述,而且表面轮廓在图6A和6B中示出。
图6A示出了本发明的经幅值调制与频率调制的正弦光学器件设计的实施例的1-D表面轮廓图,而图6B示出了其2-D表面高度图。幅值调制和频率调制的组合显著地提高了光学器件的离焦性能。对于小(3.5mm)和中(4.5mm)光瞳,峰值调制传递被重新集中到正视眼条件,这很大程度上是由于频率调制的效果。峰值MTF性能对于3.5mm、4.5mm和6.0mm分别粗略地达到0.30、0.40和0.50。
图7A-7I例示了正弦光学器件设计(图7A-7C)、经幅值调制的正弦光学器件设计(图7D-7F)及本发明的经幅值调制与频率调制的正弦光学器件设计的实施例(图7G-7I)在人眼(具有0.28μm球面像差的眼角膜)中的离焦性能。评估在三个不同光瞳尺寸下的性能:3.5mm光瞳(图7A、7D、7G);4.5mm光瞳(图7B、7E、7H);及6.0mm光瞳(图7C、7F、7I)。为了评估,使用四种典型的空间频率:25lp/mm、50lp/mm、75lp/mm和100lp/mm。
根据本发明教习的眼科透镜可以在多种视力校正应用中采用。此类应用包括但不限于眼内透镜(IOL)、隐形眼镜、基质内移植和其它折射器件。例如,本发明的透镜可以用作改进的IOL,用以改善一般在白内障手术后存在的残留折射误差。在白内障手术的实践中,众所周知诸如外科手术仪器的精度、IOL产品的精度、术前的生物统计数据、外科医生的技术水平和个体之间的囊袋差异的因素会造成术后期望折射误差的变化。这种折射误差变化的一种标准偏差可以大到0.5屈光度。这种会持续很长时间的残留折射误差会削弱患者的视力敏锐度。因此,许多患者都需要眼镜来实现增强的术后视力敏锐度。
根据本发明教习形成的IOL可以用于使白内障手术的结果更可预测,由此减少在白内障手术后对眼镜的依赖。特别地,本发明的IOL可以包括具有表面偏差的折射表面,这会增强IOL的焦深并由此降低IOL对上述误差的灵敏度。换句话说,植入了本发明的IOL的患者的眼睛呈现出增加的焦深,并由此在更宽范围的散焦量内提供改进的视力性能。相应地,术后的折射误差变化对患者的视力性能有减少的影响。
本领域技术人员将认识到,在不背离本发明范围的情况下,可以对以上实施例进行各种修改。
Claims (17)
1.一种眼科透镜,包括:
光学器件,该光学器件具有关于光轴布置的前表面和后表面,其中:
至少一个所述表面具有由基本轮廓和辅助轮廓的叠加表征的轮廓,所述辅助轮廓包括从所述基本轮廓起的连续模式的表面偏差。
2.如权利要求1所述的眼科透镜,其中,所述前表面和后表面是凸的。
3.如权利要求1所述的眼科透镜,其中,所述前表面和后表面是凹的。
4.如权利要求1所述的眼科透镜,其中,所述基本轮廓大体上是球面的。
5.如权利要求1所述的眼科透镜,其中,所述基本轮廓关于眼科透镜的光轴对称。
6.如权利要求1所述的眼科透镜,其中,所述基本轮廓大体上是非球面的。
7.如权利要求1所述的眼科透镜,其中,所述辅助轮廓关于眼科透镜的光轴对称。
8.如权利要求1所述的眼科透镜,其中,所述辅助轮廓是正弦轮廓。
9.如权利要求8所述的眼科透镜,其中,具有所述辅助轮廓的表面的轮廓由以下关系式定义:
其中,
a指示正弦曲线的幅值和在不同焦距处的衍射效率;及
b指示周期和附加光焦度。
10.如权利要求8所述的眼科透镜,其中,所述正弦轮廓是利用能将光偏移到所选衍射级的余弦函数进行幅值调制的,其中具有所述辅助轮廓的表面的幅值调制轮廓由以下关系式定义:
其中,
a指示正弦曲线的幅值和在不同焦距处的衍射效率;
b指示周期和附加光焦度;
r指示距透镜的光轴的径向距离;及
r0是余弦调制的终止光瞳半径。
11.如权利要求8所述的眼科透镜,其中,正弦轮廓是利用能作为光瞳半径的函数来改变光学器件的有效附加光焦度的余弦函数进行频率调制的,其中具有所述辅助轮廓的表面的频率调制轮廓由以下关系式定义:
其中,
a指示正弦曲线的幅值和在不同焦距处的衍射效率;
b指示周期和附加光焦度;
r指示距透镜的光轴的径向距离;及
f(r)是光瞳半径的平方根。
12.如权利要求8所述的眼科透镜,其中,正弦轮廓是利用能将光偏移到所选焦平面的余弦函数进行幅值和频率调制的,其中具有所述辅助轮廓的表面的幅值与频率调制轮廓由以下关系式定义:
其中,
a指示正弦曲线的幅值和在不同焦距处的衍射效率;
b指示周期和附加光角度;
r指示距透镜的光轴的径向距离;
r0是余弦调制的终止光瞳半径;及
f(r)是光瞳半径的平方根。
13.如权利要求1所述的眼科透镜,其中,眼科透镜包括IOL。
14.如权利要求13所述的眼科透镜,其中,IOL是单焦点IOL。
15.如权利要求13所述的眼科透镜,其中,IOL是适应性IOL。
16.如权利要求13所述的眼科透镜,其中,IOL是多焦点IOL。
17.如权利要求1所述的眼科透镜,其中,所述前表面和后表面是折射表面。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13881608P | 2008-12-18 | 2008-12-18 | |
US61/138,816 | 2008-12-18 | ||
PCT/US2009/067287 WO2010071751A1 (en) | 2008-12-18 | 2009-12-09 | Intraocular lens with extended depth of focus |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102256567A true CN102256567A (zh) | 2011-11-23 |
CN102256567B CN102256567B (zh) | 2015-05-27 |
Family
ID=42267230
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200980150723.7A Active CN102256567B (zh) | 2008-12-18 | 2009-12-09 | 具有扩展焦深的眼内透镜 |
Country Status (15)
Country | Link |
---|---|
US (2) | US20100161051A1 (zh) |
EP (1) | EP2358306B1 (zh) |
JP (1) | JP5513521B2 (zh) |
KR (1) | KR101436300B1 (zh) |
CN (1) | CN102256567B (zh) |
AR (1) | AR076831A1 (zh) |
AU (1) | AU2009327455C1 (zh) |
BR (1) | BRPI0923031B1 (zh) |
CA (1) | CA2744049C (zh) |
ES (1) | ES2441946T3 (zh) |
IL (1) | IL213036A (zh) |
MX (1) | MX2011006007A (zh) |
RU (1) | RU2523130C2 (zh) |
TW (1) | TWI496567B (zh) |
WO (1) | WO2010071751A1 (zh) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106491244A (zh) * | 2016-12-05 | 2017-03-15 | 南开大学 | 大焦深非球面衍射型人工晶体 |
CN108013952A (zh) * | 2012-08-31 | 2018-05-11 | Amo格罗宁根私人有限公司 | 用于扩展焦深的多环晶状体、系统和方法 |
CN108348325A (zh) * | 2015-10-02 | 2018-07-31 | 瑞纳人工晶体有限公司 | 多焦点透镜 |
CN108697501A (zh) * | 2016-02-29 | 2018-10-23 | 诺华股份有限公司 | 具有扩展的焦深的眼科镜片 |
CN109009567A (zh) * | 2018-09-05 | 2018-12-18 | 爱博诺德(北京)医疗科技有限公司 | 人工晶状体及其制造方法 |
CN113331993A (zh) * | 2017-07-24 | 2021-09-03 | 爱尔康公司 | 具有变形正弦相移结构的眼科透镜 |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8974526B2 (en) | 2007-08-27 | 2015-03-10 | Amo Groningen B.V. | Multizonal lens with extended depth of focus |
WO2012073112A1 (en) | 2010-12-01 | 2012-06-07 | Amo Groningen B.V. | A multifocal lens having an optical add power progression, and a system and method of providing same |
EP2739248B1 (en) * | 2011-08-04 | 2016-09-14 | BARRETT, Graham David | Extended depth of focus intraocular lenses |
TWI588560B (zh) | 2012-04-05 | 2017-06-21 | 布萊恩荷登視覺協會 | 用於屈光不正之鏡片、裝置、方法及系統 |
EP2870503A1 (en) * | 2012-07-03 | 2015-05-13 | Abbott Medical Optics Inc. | High efficiency optic |
US9201250B2 (en) | 2012-10-17 | 2015-12-01 | Brien Holden Vision Institute | Lenses, devices, methods and systems for refractive error |
CA2887655C (en) | 2012-10-17 | 2021-11-02 | Brien Holden Vision Institute | Lenses, devices, methods and systems for refractive error |
EP4029475A1 (en) | 2014-09-09 | 2022-07-20 | Staar Surgical Company | Ophthalmic implants with extended depth of field and enhanced distance visual acuity |
JP6374345B2 (ja) * | 2015-04-20 | 2018-08-15 | 伊藤光学工業株式会社 | 視力矯正用レンズの設計方法及び視力矯正用レンズ |
WO2017137840A1 (en) | 2016-02-09 | 2017-08-17 | Amo Groningen B.V. | Progressive power intraocular lens, and methods of use and manufacture |
US11083566B2 (en) | 2016-02-29 | 2021-08-10 | Alcon Inc. | Ophthalmic lens having an extended depth of focus |
CA3016987A1 (en) | 2016-03-09 | 2017-09-14 | Staar Surgical Company | Ophthalmic implants with extended depth of field and enhanced distance visual acuity |
TW201808236A (zh) * | 2016-06-09 | 2018-03-16 | 參天製藥股份有限公司 | 單焦點人工水晶體 |
JP6826843B2 (ja) * | 2016-08-31 | 2021-02-10 | Hoya株式会社 | 眼内レンズ、その設計方法、およびその製造方法 |
US10531950B2 (en) * | 2016-11-16 | 2020-01-14 | Tatvum LLC | Intraocular lens having an extended depth of focus |
CA3056707A1 (en) | 2017-03-17 | 2018-09-20 | Amo Groningen B.V. | Diffractive intraocular lenses for extended range of vision |
US11523897B2 (en) | 2017-06-23 | 2022-12-13 | Amo Groningen B.V. | Intraocular lenses for presbyopia treatment |
AU2018292030B2 (en) | 2017-06-28 | 2024-02-08 | Amo Groningen B.V. | Extended range and related intraocular lenses for presbyopia treatment |
CA3067116A1 (en) | 2017-06-28 | 2019-01-03 | Amo Groningen B.V. | Diffractive lenses and related intraocular lenses for presbyopia treatment |
US11327210B2 (en) | 2017-06-30 | 2022-05-10 | Amo Groningen B.V. | Non-repeating echelettes and related intraocular lenses for presbyopia treatment |
HUE050405T2 (hu) * | 2017-07-26 | 2020-12-28 | Vsy Biyoteknoloji Ve Ilac Sanayi Anonim Sirketi | Multifokális szemészeti diffrakciós lencse |
FR3072020B1 (fr) * | 2017-10-05 | 2019-11-08 | Cristalens Industrie | Ensemble constitue d'une paire d'implants oculaires multifocaux |
WO2020031321A1 (ja) | 2018-08-09 | 2020-02-13 | 株式会社ニコン | 眼科用レンズ及び眼科用レンズの製造方法 |
JP7203223B2 (ja) | 2018-08-17 | 2023-01-12 | スター サージカル カンパニー | 屈折率のナノ勾配を示すポリマー組成物 |
AU2019362472A1 (en) * | 2018-10-18 | 2021-05-13 | Alcon Inc. | Extended depth of focus intraocular lens |
WO2020194713A1 (ja) * | 2019-03-28 | 2020-10-01 | 株式会社ニコン | 眼科用レンズ及び眼科用レンズの製造方法 |
WO2020194712A1 (ja) * | 2019-03-28 | 2020-10-01 | 株式会社ニコン | 眼科用レンズ及び眼科用レンズの製造方法 |
US11886046B2 (en) | 2019-12-30 | 2024-01-30 | Amo Groningen B.V. | Multi-region refractive lenses for vision treatment |
WO2021136617A1 (en) | 2019-12-30 | 2021-07-08 | Amo Groningen B.V. | Lenses having diffractive profiles with irregular width for vision treatment |
AU2021283398A1 (en) | 2020-06-01 | 2023-01-05 | Icares Medicus, Inc. | Double-sided aspheric diffractive multifocal lens, manufacture, and uses thereof |
CN113599021B (zh) * | 2021-06-04 | 2024-04-16 | 天津世纪康泰生物医学工程有限公司 | 一种对抗术后残余屈光不正的非球面人工晶状体 |
EP4115850A1 (en) * | 2021-07-05 | 2023-01-11 | Nidek Co., Ltd. | Intraocular lens |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4995715A (en) * | 1988-07-20 | 1991-02-26 | Cohen Allen L | Diffractive multifocal optical device |
EP0605841A1 (en) * | 1993-01-06 | 1994-07-13 | Holo-Or Ltd. | Diffractive multi-focal lens |
US5699142A (en) * | 1994-09-01 | 1997-12-16 | Alcon Laboratories, Inc. | Diffractive multifocal ophthalmic lens |
US6338559B1 (en) * | 2000-04-28 | 2002-01-15 | University Of Rochester | Apparatus and method for improving vision and retinal imaging |
US6884263B2 (en) * | 2001-07-17 | 2005-04-26 | Medennium, Inc. | Accommodative intraocular lens |
US6923539B2 (en) * | 2003-05-12 | 2005-08-02 | Alcon, Inc. | Aspheric lenses |
WO2006023404A2 (en) * | 2004-08-20 | 2006-03-02 | Apollo Optical Systems, Inc. | Diffractive lenses for vision correction |
US20070258143A1 (en) * | 2006-05-08 | 2007-11-08 | Valdemar Portney | Aspheric multifocal diffractive ophthalmic lens |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5669142A (en) * | 1996-05-31 | 1997-09-23 | Beckers; William J. | Knife for cutting insulation batts |
US5922821A (en) * | 1996-08-09 | 1999-07-13 | Alcon Laboratories, Inc. | Ophthalmic lens polymers |
US6786928B2 (en) * | 1997-08-20 | 2004-09-07 | Thinoptx, Inc. | Small incision lens |
US6353069B1 (en) * | 1998-04-15 | 2002-03-05 | Alcon Manufacturing, Ltd. | High refractive index ophthalmic device materials |
RU2186417C2 (ru) * | 2000-02-22 | 2002-07-27 | Институт автоматики и электрометрии СО РАН | Дифракционная интраокулярная линза |
US6533416B1 (en) * | 2001-07-20 | 2003-03-18 | Ocular Sciences, Inc. | Contact or intraocular lens and method for its preparation |
US7063422B2 (en) * | 2003-04-16 | 2006-06-20 | Novartis Ag | Multifocal ophthalmic lens |
RU2306117C2 (ru) * | 2004-07-07 | 2007-09-20 | Сергей Леонидович Кузнецов | Интраокулярная линза |
-
2009
- 2009-12-09 KR KR1020117016403A patent/KR101436300B1/ko active IP Right Grant
- 2009-12-09 ES ES09833807.2T patent/ES2441946T3/es active Active
- 2009-12-09 CA CA2744049A patent/CA2744049C/en active Active
- 2009-12-09 WO PCT/US2009/067287 patent/WO2010071751A1/en active Application Filing
- 2009-12-09 BR BRPI0923031-9A patent/BRPI0923031B1/pt not_active IP Right Cessation
- 2009-12-09 US US12/634,026 patent/US20100161051A1/en not_active Abandoned
- 2009-12-09 AU AU2009327455A patent/AU2009327455C1/en active Active
- 2009-12-09 MX MX2011006007A patent/MX2011006007A/es active IP Right Grant
- 2009-12-09 EP EP09833807.2A patent/EP2358306B1/en active Active
- 2009-12-09 JP JP2011542250A patent/JP5513521B2/ja active Active
- 2009-12-09 CN CN200980150723.7A patent/CN102256567B/zh active Active
- 2009-12-09 RU RU2011129463/14A patent/RU2523130C2/ru not_active IP Right Cessation
- 2009-12-17 AR ARP090104949A patent/AR076831A1/es unknown
- 2009-12-17 TW TW098143330A patent/TWI496567B/zh not_active IP Right Cessation
-
2011
- 2011-05-19 IL IL213036A patent/IL213036A/en not_active IP Right Cessation
-
2014
- 2014-08-07 US US14/454,251 patent/US9101466B2/en active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4995715A (en) * | 1988-07-20 | 1991-02-26 | Cohen Allen L | Diffractive multifocal optical device |
EP0605841A1 (en) * | 1993-01-06 | 1994-07-13 | Holo-Or Ltd. | Diffractive multi-focal lens |
US5699142A (en) * | 1994-09-01 | 1997-12-16 | Alcon Laboratories, Inc. | Diffractive multifocal ophthalmic lens |
US6338559B1 (en) * | 2000-04-28 | 2002-01-15 | University Of Rochester | Apparatus and method for improving vision and retinal imaging |
US6884263B2 (en) * | 2001-07-17 | 2005-04-26 | Medennium, Inc. | Accommodative intraocular lens |
US6923539B2 (en) * | 2003-05-12 | 2005-08-02 | Alcon, Inc. | Aspheric lenses |
WO2006023404A2 (en) * | 2004-08-20 | 2006-03-02 | Apollo Optical Systems, Inc. | Diffractive lenses for vision correction |
US20070258143A1 (en) * | 2006-05-08 | 2007-11-08 | Valdemar Portney | Aspheric multifocal diffractive ophthalmic lens |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108013952A (zh) * | 2012-08-31 | 2018-05-11 | Amo格罗宁根私人有限公司 | 用于扩展焦深的多环晶状体、系统和方法 |
CN108348325A (zh) * | 2015-10-02 | 2018-07-31 | 瑞纳人工晶体有限公司 | 多焦点透镜 |
US10463474B2 (en) | 2015-10-02 | 2019-11-05 | Rayner Intraocular Lenses Limited | Multifocal lens |
CN108348325B (zh) * | 2015-10-02 | 2019-12-17 | 瑞纳人工晶体有限公司 | 多焦点透镜 |
US11029536B2 (en) | 2015-10-02 | 2021-06-08 | Rayner Intraocular Lenses Limited | Multifocal lens |
CN108697501A (zh) * | 2016-02-29 | 2018-10-23 | 诺华股份有限公司 | 具有扩展的焦深的眼科镜片 |
CN108697501B (zh) * | 2016-02-29 | 2021-02-02 | 爱尔康公司 | 具有扩展的焦深的眼科镜片 |
CN106491244A (zh) * | 2016-12-05 | 2017-03-15 | 南开大学 | 大焦深非球面衍射型人工晶体 |
CN106491244B (zh) * | 2016-12-05 | 2018-12-28 | 南开大学 | 大焦深非球面衍射型人工晶体 |
CN113331993A (zh) * | 2017-07-24 | 2021-09-03 | 爱尔康公司 | 具有变形正弦相移结构的眼科透镜 |
CN109009567A (zh) * | 2018-09-05 | 2018-12-18 | 爱博诺德(北京)医疗科技有限公司 | 人工晶状体及其制造方法 |
Also Published As
Publication number | Publication date |
---|---|
EP2358306A4 (en) | 2012-05-30 |
BRPI0923031B1 (pt) | 2019-10-15 |
TWI496567B (zh) | 2015-08-21 |
CA2744049C (en) | 2014-09-23 |
TW201029639A (en) | 2010-08-16 |
KR20110102903A (ko) | 2011-09-19 |
ES2441946T3 (es) | 2014-02-07 |
US20100161051A1 (en) | 2010-06-24 |
IL213036A (en) | 2015-06-30 |
JP2012512709A (ja) | 2012-06-07 |
KR101436300B1 (ko) | 2014-09-01 |
AU2009327455A1 (en) | 2010-06-24 |
RU2011129463A (ru) | 2013-01-27 |
BRPI0923031A2 (pt) | 2015-12-15 |
MX2011006007A (es) | 2011-06-28 |
JP5513521B2 (ja) | 2014-06-04 |
RU2523130C2 (ru) | 2014-07-20 |
EP2358306B1 (en) | 2013-10-23 |
US20140350672A1 (en) | 2014-11-27 |
AU2009327455C1 (en) | 2014-04-24 |
CA2744049A1 (en) | 2010-06-24 |
US9101466B2 (en) | 2015-08-11 |
AR076831A1 (es) | 2011-07-13 |
IL213036A0 (en) | 2011-07-31 |
EP2358306A1 (en) | 2011-08-24 |
AU2009327455B2 (en) | 2013-11-28 |
CN102256567B (zh) | 2015-05-27 |
WO2010071751A1 (en) | 2010-06-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102256567B (zh) | 具有扩展焦深的眼内透镜 | |
US10531950B2 (en) | Intraocular lens having an extended depth of focus | |
RU2427865C2 (ru) | Интраокулярные линзы с улучшенными внеосевыми визуальными характеристиками | |
US6923539B2 (en) | Aspheric lenses | |
EP1838245B1 (en) | Contrast-enhancing aspheric intraocular lens | |
AU2005311949B2 (en) | Apodized aspheric diffractive lenses | |
US10485655B2 (en) | Ophthalmic implants with extended depth of field and enhanced distance visual acuity | |
US20080147185A1 (en) | Correction of chromatic aberrations in intraocular lenses | |
CN104127263B (zh) | 多焦点人工晶状体 | |
US11963868B2 (en) | Double-sided aspheric diffractive multifocal lens, manufacture, and uses thereof | |
US10663763B2 (en) | Multifocal intraocular lens | |
CN203647536U (zh) | 多焦点人工晶状体 | |
Villegas-Ruiz et al. | Image quality in pseudophakic eyes with two different types of intraocular lenses ranging in the degree of high myopia |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20200420 Address after: Fribourg Patentee after: ALCON, Inc. Address before: Basel, Switzerland Patentee before: NOVARTIS AG Effective date of registration: 20200420 Address after: Basel, Switzerland Patentee after: NOVARTIS AG Address before: Humboldt, Switzerland Patentee before: ALCON, Inc. |