CN102253151A - Novel industrial preparative liquid chromatographic flow control system - Google Patents
Novel industrial preparative liquid chromatographic flow control system Download PDFInfo
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- CN102253151A CN102253151A CN2010101776632A CN201010177663A CN102253151A CN 102253151 A CN102253151 A CN 102253151A CN 2010101776632 A CN2010101776632 A CN 2010101776632A CN 201010177663 A CN201010177663 A CN 201010177663A CN 102253151 A CN102253151 A CN 102253151A
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Abstract
The invention provides a novel industrial preparative liquid chromatographic flow control system. The system mainly comprises a diaphragm infusion pump, a motor, a frequency converter, a programmable logic controller (PLC), a flow adjustment valve, a mass flow meter, an anti-explosion electric control cabinet, a static mixer, a mobile phase inlet connector. The flow control of the system is closed-loop control; the controller automatically adjusts a rotating speed of the motor and a flow control valve on line and in real time according to a deviation between a set flow and an actual flow, so that the accuracy of the flow of the whole system and the gradient flow can be guaranteed; therefore, an experimental effect of the whole industrial chromatogram preparation system can be guaranteed.
Description
Technical field:
A kind of infant industry preparative liquid chromatography of the present invention flow control system for the industrial preparation liquid chromatographic system provides accurately, reliable flow, belongs to the preparative chromatography application.
Background technology:
Traditional industrial liquid phantom preparing chromatogram flow control system adopts open loop control mostly, and promptly controller sends the flow that control signal is controlled infusion pump according to the flow signal of setting, and does not have feedback signal.The drawback of this flow control system flow control is there is not feedback signal, flow for system lacks the detection link, can't know the actual flow of infusion pump, and flow control accuracy is poor, thereby meeting is the reappearance of the whole industrial preparation liquid chromatographic system of influence directly.Therefore, this flow open loop control structure, the very difficult precision that guarantees the transfusion system flow causes the reappearance of industrial preparation liquid chromatographic system relatively poor, influences whole experiment effect.The present invention is intended to improve the precision of whole transfusion system flow, guarantees the accuracy and the stability of whole transfusion system flow, thereby guarantees the experiment effect of whole process-scale chromatography preparation system.
Summary of the invention:
The object of the present invention is to provide a kind of infant industry preparative liquid chromatography flow control system,, improve industrial preparation liquid chromatographic system overall performance, obtain experiment effect preferably to improve the accuracy and the stability of industrial preparation liquid chromatographic system flow.
A kind of infant industry preparative liquid chromatography of the present invention flow control system, this system mainly contain barrier film infusion pump, motor, frequency converter, PLC controller, flow regulator, mass flowmeter, explosion-proof electrification switch board, static mixer, moving phase inlet attack composition.Wherein frequency converter and PLC controller are installed in the explosion-proof electrification switch board.This industrial preparation liquid chromatography flow control system had two infusion pipelines before the barrier film infusion pump, wherein an infusion pipeline is made up of moving phase inlet attack, flow regulator, mass flowmeter, and another infusion pipeline is made up of moving phase inlet attack, flow regulator.Article two, infusion pipeline to the barrier film infusion pump, is a mass flowmeter behind the barrier film infusion pump behind static mixer.Motor and barrier film infusion pump are installed together.
Advantage and effect that a kind of infant industry chromatogram of the present invention prepares flow control system are: closed-loop control is adopted in flow system flow control, regulate motor speed and flowrate control valve according to the automatic online in real time of the deviation control device of setting flow and actual flow, guarantee the accuracy of total system flow and gradient flow.Flow system flow measurement aspect adopts current flux metering mass flowmeter the most accurately, provides accurate and reliable data for measuring flow.
Description of drawings:
Accompanying drawing is included in this instructions providing further understanding of the present invention, and is attached in this instructions and constitutes the part of this instructions, and accompanying drawing shows embodiments of the present invention, and is used from instructions one and explains principle of the present invention.In the accompanying drawing:
Fig. 1 is a kind of industrial preparation liquid chromatography of the present invention flow control system structural drawing.
Concrete label is as follows among the figure:
1, moving phase inlet attack A 2, flow regulator A
3, mass flowmeter A 4, moving phase inlet attack B
5, flow regulator B 6, static mixer
7, barrier film infusion pump 8, mass flowmeter B
9, explosion-proof electrification switch board 10, PLC controller
11, frequency converter 12, motor
Embodiment:
A kind of industrial preparation liquid chromatography of the present invention flow control system structure, as shown in Figure 1, this system mainly is made up of moving phase inlet attack A1, flow regulator A2, mass flowmeter A3, moving phase inlet attack B4, flow regulator B5, static mixer 6, barrier film infusion pump 7, mass flowmeter B8, explosion-proof electrification switch board 9, PLC controller 10, frequency converter 11, motor 12.Liquid enters first through flow regulator A2 by moving phase inlet attack A1, flow regulator A2 can regulate the flow size of article one branch infusion pipeline, through mass flowmeter A3, mass flowmeter A3 is used for measuring the flow of article one branch infusion pipeline.Liquid enters second branch infusion pipeline by moving phase inlet attack B4, and through flow control valve B5, flow control valve B5 can regulate the flow size of second branch infusion pipeline.Article one, the liquid of branch's woven hose and second branch woven hose enters barrier film infusion pump 7 after mixing through static mixer 6, and by process mass flowmeter B8, mass flowmeter B8 is used for measuring the total flow of infusion pipeline.PLC controller 10 and frequency converter 11 are installed in the explosion-proof electrification switch board 9, and motor 12 and barrier film infusion pump 7 are installed together.The rotating speed that PLC controller 10 is adjusted motor 12 according to the total flow signal and the deviation between the setting signal of mass flowmeter B8 feedback, the accuracy of assurance system total flow.The aperture that PLC controller 10 is adjusted flow regulator A2 according to article one branch infusion pipeline flow signal and the deviation between the setting signal of mass flowmeter A3 feedback, the accuracy of the flow of assurance article one branch infusion pipeline.Difference between article one branch infusion pipeline flow signal that is fed back by the total flow signal of mass flowmeter B8 feedback and mass flowmeter A3 can obtain the flow signal of second branch infusion pipeline, the aperture that second branch infusion pipeline flow signal that PLC controller 10 bases obtain and the deviation between the setting signal are adjusted flow regulator B5, the accuracy of the flow of assurance second branch infusion pipeline.
In above-mentioned instructions, the present invention has been described with reference to certain exemplary embodiments.Yet, should recognize, as described in following claim, can under the situation that does not depart from scope of the present invention, make various modifications and variations.Term " comprises " does not get rid of other elements or step.Instructions and accompanying drawing are considered to illustrative approach, rather than ways to restrain, and all this modifications all are included in the scope of the present invention.Therefore, scope of the present invention appending claims from here is equal to decision with the legal of them, rather than only by above-mentioned example decision.
Claims (3)
- A kind of infant industry preparative liquid chromatography of the present invention flow control system, this system mainly contain barrier film infusion pump, motor, frequency converter, PLC controller, flow regulator, mass flowmeter, explosion-proof electrification switch board, static mixer, moving phase inlet attack composition.It is characterized in that:1. closed-loop control is adopted in flow system flow control, regulates motor speed and flowrate control valve according to the automatic online in real time of the deviation control device of setting flow and actual flow, guarantees the accuracy of total system flow and gradient flow.
- 2. flow system flow measurement aspect adopts current flux metering mass flowmeter the most accurately, provides accurate and reliable data for measuring flow.
- 3. system adopts variable-frequency control technique, can make the motor economical operation, reduces the idle work of motor, prolongs the life-span of motor, and saves energy is saved cost, obtains good economic benefit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101776632A CN102253151A (en) | 2010-05-20 | 2010-05-20 | Novel industrial preparative liquid chromatographic flow control system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101776632A CN102253151A (en) | 2010-05-20 | 2010-05-20 | Novel industrial preparative liquid chromatographic flow control system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102253151A true CN102253151A (en) | 2011-11-23 |
Family
ID=44980531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101776632A Pending CN102253151A (en) | 2010-05-20 | 2010-05-20 | Novel industrial preparative liquid chromatographic flow control system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102253151A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103512985A (en) * | 2012-06-21 | 2014-01-15 | 株式会社岛津制作所 | Mobile phase delivery device and liquid chromatograph |
| CN107860846A (en) * | 2017-11-10 | 2018-03-30 | 广东恒畅环保节能检测科技有限公司 | A kind of ion chromatograph |
| CN116879474A (en) * | 2023-07-11 | 2023-10-13 | 常州三泰科技有限公司 | Mobile phase proportion control device and control method thereof |
-
2010
- 2010-05-20 CN CN2010101776632A patent/CN102253151A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103512985A (en) * | 2012-06-21 | 2014-01-15 | 株式会社岛津制作所 | Mobile phase delivery device and liquid chromatograph |
| CN103512985B (en) * | 2012-06-21 | 2016-01-06 | 株式会社岛津制作所 | Mobile phase liquid feeding device and liquid chromatograph |
| CN107860846A (en) * | 2017-11-10 | 2018-03-30 | 广东恒畅环保节能检测科技有限公司 | A kind of ion chromatograph |
| CN116879474A (en) * | 2023-07-11 | 2023-10-13 | 常州三泰科技有限公司 | Mobile phase proportion control device and control method thereof |
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| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20111123 |