CN102245024A - 二酰甘油酰基转移酶抑制剂 - Google Patents
二酰甘油酰基转移酶抑制剂 Download PDFInfo
- Publication number
- CN102245024A CN102245024A CN2009801505265A CN200980150526A CN102245024A CN 102245024 A CN102245024 A CN 102245024A CN 2009801505265 A CN2009801505265 A CN 2009801505265A CN 200980150526 A CN200980150526 A CN 200980150526A CN 102245024 A CN102245024 A CN 102245024A
- Authority
- CN
- China
- Prior art keywords
- phenyl
- trifluoromethyl
- compound
- carboxylic acid
- piperidines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C**(C)S(C)(C)C(C)C(C(**)=O)N Chemical compound C**(C)S(C)(C)C(C)C(C(**)=O)N 0.000 description 3
- ZFUJGWSHPNBAAF-UHFFFAOYSA-N CC(C)c1n[o]c(C(CC2)CCN2c(cc2)ccc2NC(c2c(C(F)(F)F)[o]c(-c3ccccc3)n2)=O)n1 Chemical compound CC(C)c1n[o]c(C(CC2)CCN2c(cc2)ccc2NC(c2c(C(F)(F)F)[o]c(-c3ccccc3)n2)=O)n1 ZFUJGWSHPNBAAF-UHFFFAOYSA-N 0.000 description 1
- DZVMROZIGZSLCX-UHFFFAOYSA-N CCC(C(CC1)CCN1c(cc1)ccc1NC(c1c(C(F)(F)F)[o]c(-c2ccccc2)n1)=O)=O Chemical compound CCC(C(CC1)CCN1c(cc1)ccc1NC(c1c(C(F)(F)F)[o]c(-c2ccccc2)n1)=O)=O DZVMROZIGZSLCX-UHFFFAOYSA-N 0.000 description 1
- BKYKLIXKQJUCNL-UHFFFAOYSA-N COc(cc1)ccc1N(CC1)CCN1c(cc1)ncc1NC(c(nc(-c1ccccc1)[nH]1)c1F)=O Chemical compound COc(cc1)ccc1N(CC1)CCN1c(cc1)ncc1NC(c(nc(-c1ccccc1)[nH]1)c1F)=O BKYKLIXKQJUCNL-UHFFFAOYSA-N 0.000 description 1
- LJPBGEJZLYERKF-UHFFFAOYSA-N COc(cccc1)c1N(CC1)CCN1c(cc1)ncc1NC(c(nc(-c1ccccc1)[o]1)c1[F](F)F)=O Chemical compound COc(cccc1)c1N(CC1)CCN1c(cc1)ncc1NC(c(nc(-c1ccccc1)[o]1)c1[F](F)F)=O LJPBGEJZLYERKF-UHFFFAOYSA-N 0.000 description 1
- BVNNCGZPQQSNIS-UHFFFAOYSA-N O=C(c(nc(-c1ccccc1)[o]1)c1F)Nc(cc1)cnc1N(CC1)CCC1c1cccc(C(F)(F)F)c1 Chemical compound O=C(c(nc(-c1ccccc1)[o]1)c1F)Nc(cc1)cnc1N(CC1)CCC1c1cccc(C(F)(F)F)c1 BVNNCGZPQQSNIS-UHFFFAOYSA-N 0.000 description 1
- IGRBXPWWJRXZHY-UHFFFAOYSA-N O=C(c1c[n](-c2ccccn2)nc1F)Nc(cc1)cnc1N(CC1)CCC1c1cccc(F)c1 Chemical compound O=C(c1c[n](-c2ccccn2)nc1F)Nc(cc1)cnc1N(CC1)CCC1c1cccc(F)c1 IGRBXPWWJRXZHY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13815708P | 2008-12-17 | 2008-12-17 | |
| US61/138,157 | 2008-12-17 | ||
| PCT/US2009/068048 WO2010077861A1 (en) | 2008-12-17 | 2009-12-15 | Inhibitors of diacylglycerol aclytransferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102245024A true CN102245024A (zh) | 2011-11-16 |
Family
ID=42241316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801505265A Pending CN102245024A (zh) | 2008-12-17 | 2009-12-15 | 二酰甘油酰基转移酶抑制剂 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8211914B2 (https=) |
| EP (1) | EP2378878A4 (https=) |
| JP (1) | JP2012512252A (https=) |
| CN (1) | CN102245024A (https=) |
| AU (1) | AU2009333333A1 (https=) |
| CA (1) | CA2745445A1 (https=) |
| IL (1) | IL213164A0 (https=) |
| WO (1) | WO2010077861A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8153644B2 (en) * | 2007-05-22 | 2012-04-10 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8115011B2 (en) * | 2007-05-22 | 2012-02-14 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8211884B2 (en) * | 2008-08-06 | 2012-07-03 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8324385B2 (en) * | 2008-10-30 | 2012-12-04 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| AU2009333333A1 (en) | 2008-12-17 | 2011-06-30 | Via Pharmaceuticals, Inc | Inhibitors of diacylglycerol aclytransferase |
| WO2012173219A1 (ja) * | 2011-06-17 | 2012-12-20 | 第一三共株式会社 | 新規ビアリールエーテル誘導体 |
| TW201400475A (zh) | 2012-04-13 | 2014-01-01 | Mitsubishi Tanabe Pharma Corp | 醯胺吡啶衍生物及其用途 |
| HRP20220522T1 (hr) | 2014-08-04 | 2022-06-10 | Nuevolution A/S | Proizvoljno kondenzirani heterociklil-supstituirani derivati pirimidina koji su korisni za liječenje upalnih, metaboličkih, onkoloških i autoimunih bolesti |
| AR109179A1 (es) | 2016-08-19 | 2018-11-07 | Pfizer | Inhibidores de diacilglicerol aciltransferasa 2 |
| US11685727B2 (en) | 2019-12-20 | 2023-06-27 | Nuevolution A/S | Compounds active towards nuclear receptors |
| MX2022007265A (es) | 2019-12-20 | 2022-09-09 | Nuevolution As | Compuestos activos frente a receptores nucleares. |
| EP4126874A1 (en) | 2020-03-31 | 2023-02-08 | Nuevolution A/S | Compounds active towards nuclear receptors |
| CA3174176A1 (en) | 2020-03-31 | 2021-10-07 | Sanne Schroder Glad | Compounds active towards nuclear receptors |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1753897A (zh) * | 2002-11-22 | 2006-03-29 | 日本烟草产业株式会社 | 稠合双环含氮杂环 |
| WO2008141976A1 (en) * | 2007-05-22 | 2008-11-27 | Via Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| CN101316844A (zh) * | 2005-11-28 | 2008-12-03 | 霍夫曼-拉罗奇有限公司 | 二酰甘油酰基转移酶(dgat)抑制剂 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3250771A (en) | 1962-12-17 | 1966-05-10 | Geigy Chem Corp | 5-monocarbocyclic aryl-n-lower alkyl-2-pyrrolidine carboxylic acid, esters, amides and derivatives thereof |
| DE2337461A1 (de) | 1973-07-24 | 1975-02-06 | Boehringer Mannheim Gmbh | Neue indolderivate und verfahren zu deren herstellung |
| US4066654A (en) | 1975-04-16 | 1978-01-03 | G. D. Searle & Co. | 1-triarylalkyl-4-phenyl-4-piperidine carboxylic acids and derivatives |
| US6495558B1 (en) | 1999-01-22 | 2002-12-17 | Amgen Inc. | Kinase inhibitors |
| CN1230421C (zh) | 1999-02-10 | 2005-12-07 | 三菱制药株式会社 | 酰胺化合物及其药物用途 |
| US6756374B2 (en) | 2001-01-22 | 2004-06-29 | Hoffmann-La Roche Inc. | Diaminothiazoles having antiproliferative activity |
| HRP20040199A2 (en) | 2001-08-31 | 2005-04-30 | Aventis Pharma Deutschland Gmbh | Diaryl cycloalkyl derivatives, method for producing the same and the use thereof as ppar activators |
| AU2003261935A1 (en) | 2002-09-06 | 2004-03-29 | Takeda Pharmaceutical Company Limited | Furan or thiophene derivative and medicinal use thereof |
| DE10308353A1 (de) | 2003-02-27 | 2004-12-02 | Aventis Pharma Deutschland Gmbh | Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7148246B2 (en) | 2003-02-27 | 2006-12-12 | Sanofi-Aventis Deutschland Gmbh | Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals |
| KR100883694B1 (ko) | 2005-02-07 | 2009-02-12 | 에프. 호프만-라 로슈 아게 | 디아실글리세롤 아실트랜스퍼라제 억제제 |
| KR20080015113A (ko) | 2005-06-11 | 2008-02-18 | 아스트라제네카 아베 | Ｄｇａｔ 억제제로서의 옥사디아졸 유도체 |
| CA2630269C (en) | 2005-11-28 | 2011-07-05 | F. Hoffmann-La Roche Ag | Inhibitors of diacyglycerol acyltransferase (dgat) |
| US8058299B2 (en) | 2007-05-22 | 2011-11-15 | Via Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US20090099201A1 (en) | 2007-05-22 | 2009-04-16 | David Robert Bolin | Diacylglycerol Acyltransferase Inhibitors |
| US8153644B2 (en) | 2007-05-22 | 2012-04-10 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8115011B2 (en) | 2007-05-22 | 2012-02-14 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8211884B2 (en) | 2008-08-06 | 2012-07-03 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| CN102282132A (zh) * | 2008-11-19 | 2011-12-14 | 先灵公司 | 二酰基甘油酰基转移酶的抑制剂 |
| WO2010065310A1 (en) | 2008-12-03 | 2010-06-10 | Via Pharmaceuticals, Inc | Inhibitors of diacylglycerol acyltransferase |
| AU2009333333A1 (en) | 2008-12-17 | 2011-06-30 | Via Pharmaceuticals, Inc | Inhibitors of diacylglycerol aclytransferase |
-
2009
- 2009-12-15 AU AU2009333333A patent/AU2009333333A1/en not_active Abandoned
- 2009-12-15 CA CA2745445A patent/CA2745445A1/en not_active Abandoned
- 2009-12-15 CN CN2009801505265A patent/CN102245024A/zh active Pending
- 2009-12-15 EP EP09836834A patent/EP2378878A4/en not_active Withdrawn
- 2009-12-15 WO PCT/US2009/068048 patent/WO2010077861A1/en not_active Ceased
- 2009-12-15 JP JP2011542339A patent/JP2012512252A/ja not_active Withdrawn
- 2009-12-15 US US12/638,244 patent/US8211914B2/en not_active Expired - Fee Related
-
2011
- 2011-05-26 IL IL213164A patent/IL213164A0/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1753897A (zh) * | 2002-11-22 | 2006-03-29 | 日本烟草产业株式会社 | 稠合双环含氮杂环 |
| CN101316844A (zh) * | 2005-11-28 | 2008-12-03 | 霍夫曼-拉罗奇有限公司 | 二酰甘油酰基转移酶(dgat)抑制剂 |
| WO2008141976A1 (en) * | 2007-05-22 | 2008-11-27 | Via Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009333333A1 (en) | 2011-06-30 |
| JP2012512252A (ja) | 2012-05-31 |
| EP2378878A1 (en) | 2011-10-26 |
| WO2010077861A1 (en) | 2010-07-08 |
| CA2745445A1 (en) | 2010-07-08 |
| IL213164A0 (en) | 2011-07-31 |
| US8211914B2 (en) | 2012-07-03 |
| EP2378878A4 (en) | 2012-08-01 |
| US20100152445A1 (en) | 2010-06-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1163446 Country of ref document: HK |
|
| AD01 | Patent right deemed abandoned |
Effective date of abandoning: 20111116 |
|
| C20 | Patent right or utility model deemed to be abandoned or is abandoned | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1163446 Country of ref document: HK |