CN102243217B - Backwashing flow path system of glycated hemoglobin analyzer - Google Patents
Backwashing flow path system of glycated hemoglobin analyzer Download PDFInfo
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- CN102243217B CN102243217B CN 201110100181 CN201110100181A CN102243217B CN 102243217 B CN102243217 B CN 102243217B CN 201110100181 CN201110100181 CN 201110100181 CN 201110100181 A CN201110100181 A CN 201110100181A CN 102243217 B CN102243217 B CN 102243217B
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- chromatographic column
- flow path
- glycated hemoglobin
- peristaltic pump
- pipeline
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Abstract
The invention belongs to medical equipment, relates to a flow path structure of a glycated hemoglobin analyzer, in particular to a backwashing flow path structure of a glycated hemoglobin analyzer. The backwashing flow path system of the glycated hemoglobin analyzer comprises a peristaltic pump positioned on a liquid feeding pipeline, wherein a liquid discharging hole of the peristaltic pump is introduced into a waste liquid bottle through a liquid discharging pipe after sequentially passing through a first electromagnetic valve, a cation exchange resin chromatographic column, a cuvette cell and a second electromagnetic valve; and a third electromagnetic valve is connected between the liquid discharging hole of the peristaltic pump and an outlet of the cuvette cell, and a branching pipeline is arranged in front of the inlet end of the cation exchange resin chromatographic column and is connected with the liquid discharging pipeline through a fourth electromagnetic pipeline. The invention has the advantages of being capable of avoiding aggregation and blockage of floccules in a detected sample at the chromatographic column and a filter screen of the glycated hemoglobin analyzer, prolonging the service life of the chromatographic column, improving reliability of a detection process, and being convenient for operation and maintenance and low in cost.
Description
Technical field
The invention belongs to Medical Devices, relate to the flow passage structure of glycolated hemoglobin analysis, specifically a kind of glycolated hemoglobin analysis back flush flow path system.
Background technology
When adopting ion exchange chromatography to separate glycosylated hemoglobin in the clinical whole blood sample, need the effect by peristaltic pump that sample is transported in the canned chromatographic column that Zeo-karb arranged, eluent by filling different ions concentration will be adsorbed in the sample on the resin different glycosylated hemoglobin subfraction gradient elutions and separate again, carry out chromatogram through colorimetric pool again and detect and analyze.
Because clinical whole blood sample in actual applications can be with floccuss such as a small amount of cell membrane, grumeleuses, increase along with the sample analysis number of times, these floccuss can enter chromatographic column by sieve plate gradually, after use after a while, floccus can hinder sample and enter chromatographic column, the chromatography effect is descended, even make sample can not enter chromatographic column, glycosylated hemoglobin can not separate.When serious, chromatographic column is scrapped.Be anti-appearance of planting here phenomenon, current method all is the inlet ends at chromatographic column at present, installs pretreatment unit additional, the probability that stops up to reduce chromatographic column.In actual use, then generally take constantly to change the method for sieve plate filter screen, reduce the appearance of obstruction, or the chromatographic column that directly more renews, it is complex operation, maintenance cost height not only, and the reliability of testing process also can not be guaranteed.
Summary of the invention
Technical matters to be solved by this invention is, the glycolated hemoglobin analysis back flush flow path system of provide a kind of floccus that can avoid detecting in the sample to assemble at the chromatographic column of glycolated hemoglobin analysis and filter screen place thereof to stop up, improve chromatographic column serviceable life, improve the testing process reliability, operation and maintenance is easy, cost is low.
Glycolated hemoglobin analysis back flush flow path system of the present invention includes the peristaltic pump that is positioned on the feed liquor pipeline, and the liquid outlet of peristaltic pump is analysed post, colorimetric pool, the second solenoid valve through the first solenoid valve, cation exchange resin layer successively and passed into waste liquid bottle by discharging tube; Be connected with the 3rd solenoid valve between the liquid outlet of described peristaltic pump and the outlet of colorimetric pool, simultaneously before cation exchange resin layer is analysed the inlet end of post branch line be set, branch line is connected with discharging tube through the 4th solenoid valve.
System architecture of the present invention is applied to glycolated hemoglobin analysis counter-flushing pipeline and feed liquor pipeline is organically combined, separate in the process of glycosylated hemoglobin at wash-out, each forward the clinical sample application of sample after haemolysis is processed being input to carried out in the chromatographic column chromatography separates end with gradient elution after, can wash chromatographic column by the method for reverse feed flow, may exist the floccus punching of stopping up screen cloth, to avoid stopping up outside the discharge machine from chromatographic column on chromatographic column sieve plate surface; Can also carry out balance, regeneration to chromatographic column in the time of flushing, chromatographic column can constantly be reused, increase the service life, also can carry out back flush to liquid feeding channel simultaneously, make the sample flow of instrument be difficult for by the road stopping up, improved the reliability of testing process, and operation and maintenance is easy, cost is low.
Description of drawings
Fig. 1 is the synoptic diagram of system of the present invention when normal feed liquor;
Fig. 2 is the synoptic diagram of system of the present invention in backwash process.
Embodiment
As shown in Figure 1, this glycolated hemoglobin analysis back flush flow path system is at normal feed liquor when (the clinical sample application of sample separates with gradient elution) forward, and the liquid outlet of the peristaltic pump 2 on the feed liquor pipeline 1 is analysed post 4, colorimetric pool 5, the second solenoid valve 6 through the first solenoid valve 3, cation exchange resin layer successively and passed into waste liquid bottle 8 by discharging tube 7.
As shown in Figure 2, after forward feed liquor finishes at every turn, the first and second closed electromagnetic valves, the liquid outlet of peristaltic pump 2 successively through the 3rd solenoid valve 9, colorimetric pool 5(from being exported to entrance), cation exchange resin layer analyses post 4(from being exported to entrance), the 4th solenoid valve 10 passes into waste liquid bottle 8 by discharging tube 7, finishes backwash process.
Claims (1)
1. glycolated hemoglobin analysis back flush flow path system, include the peristaltic pump (2) that is positioned on the feed liquor pipeline (1), the liquid outlet of peristaltic pump is successively through the first solenoid valve (3), cation exchange resin layer is analysed post (4), colorimetric pool (5), the second solenoid valve (6) passes into waste liquid bottle (8) by discharging tube (7), it is characterized in that: be connected with the 3rd solenoid valve (9) between the outlet of the liquid outlet of described peristaltic pump (2) and colorimetric pool (5), the inlet end that while is analysed post (4) at cation exchange resin layer arranges branch line before, and branch line is connected with discharging tube (7) through the 4th solenoid valve (10).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110100181 CN102243217B (en) | 2011-04-21 | 2011-04-21 | Backwashing flow path system of glycated hemoglobin analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110100181 CN102243217B (en) | 2011-04-21 | 2011-04-21 | Backwashing flow path system of glycated hemoglobin analyzer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102243217A CN102243217A (en) | 2011-11-16 |
| CN102243217B true CN102243217B (en) | 2013-02-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110100181 Expired - Fee Related CN102243217B (en) | 2011-04-21 | 2011-04-21 | Backwashing flow path system of glycated hemoglobin analyzer |
Country Status (1)
| Country | Link |
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| CN (1) | CN102243217B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103245791B (en) * | 2013-05-02 | 2014-11-12 | 深圳市凯特生物医疗电子科技有限公司 | Integral low-pressure ion exchange glycosylated hemoglobin analyzer |
| CN103278655B (en) * | 2013-05-23 | 2014-06-11 | 南京工业大学 | Flow path system suitable for glycosylated hemoglobin analysis based on multichannel peristaltic pump |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001174374A (en) * | 1999-12-15 | 2001-06-29 | Ebara Udylite Kk | Solution sampling system |
| CN202083677U (en) * | 2011-04-21 | 2011-12-21 | 江苏奥迪康医学科技有限公司 | Back-washing stream system for glycosylated hemoglobin analyzer |
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2011
- 2011-04-21 CN CN 201110100181 patent/CN102243217B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN102243217A (en) | 2011-11-16 |
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
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| CP01 | Change in the name or title of a patent holder |
Address after: 212009 Zhenjiang city Jiangsu province area Dingmao latitude four Road No. 36 high tech Industrial Park, No. 4 Building 4 layer Patentee after: JIANGSU AUDICOM MEDICAL TECHNOLOGY CO., LTD. Address before: 212009 Zhenjiang city Jiangsu province area Dingmao latitude four Road No. 36 high tech Industrial Park, No. 4 Building 4 layer Patentee before: Jiangsu Audicom Medical Technology Co., Ltd. |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130227 Termination date: 20200421 |
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| CF01 | Termination of patent right due to non-payment of annual fee |