CN102232472B - Water-soluble compound used as feed additive and preparation method thereof - Google Patents
Water-soluble compound used as feed additive and preparation method thereof Download PDFInfo
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- CN102232472B CN102232472B CN2010101577018A CN201010157701A CN102232472B CN 102232472 B CN102232472 B CN 102232472B CN 2010101577018 A CN2010101577018 A CN 2010101577018A CN 201010157701 A CN201010157701 A CN 201010157701A CN 102232472 B CN102232472 B CN 102232472B
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- water
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- chelate
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Abstract
The invention relates to a water-soluble compound used as a feed additive and a preparation method thereof. The water-soluble compound is prepared by compounding a metal chelate and a cosolvent in a mass ratio of (0.01-1):1. The water-soluble compound used as the feed additive has the characteristics of improving the absorption rate of animals and the bioavailability, saving raw materials and protecting environment.
Description
[technical field]
The present invention relates to modification and the preparation thereof of feed additive field material, relate to a kind of water-soluble compound that is used as feed addictive and preparation method thereof specifically.
[background technology]
Microelement chelate 2-chromium picolinate, nicotinic acid chromium, 2-pyridine carboxylic acid copper, copper nicotinate, 2-zinc picolinate, nicotinic acid chelates of zinc have been widely used in the feed addictive, are the necessary trace elements of animal.
But at present, employed 2-chromium picolinate, nicotinic acid chromium, 2-pyridine carboxylic acid copper, copper nicotinate, 2-zinc picolinate, nicotinic acid chelates of zinc make that because solubility is relatively poor the meltage of chelate is very little in the feed addictive, make that the animal absorptivity is low, bioavilability is also lower; Have only the injected volume that increases raw material, could improve the absorptivity of animal, caused the very big waste of raw material and caused some problem of environmental pollutions.
[summary of the invention]
The objective of the invention is to the above-mentioned defective at the prior art existence, a kind of water-soluble compound as feed addictive that provides; This water-soluble compound has and improves animal absorptivity and bioavilability, economizes in raw materials and protects the characteristics of environment.
Another object of the present invention is to provide a kind of preparation method who is used as the water-soluble compound of feed addictive.
A kind of water-soluble compound as feed addictive of the present invention, the mass ratio that adopts metallo-chelate and cosolvent are 0.01~1: 1 the compound preparation of ratio.
Water-soluble compound as feed addictive provided by the invention, the mass ratio of described water-soluble compound employing metallo-chelate and cosolvent are 0.02~0.6: 1 the compound preparation of ratio.
Water-soluble compound as feed addictive provided by the invention, the mass ratio of described water-soluble compound employing metallo-chelate and cosolvent are 0.7~1: 1 the compound preparation of ratio.
Water-soluble compound as feed addictive provided by the invention, described metallo-chelate is slightly solubility pyridine carboxylic acid metalloid chelate.
Water-soluble compound as feed addictive provided by the invention, described slightly solubility pyridine carboxylic acid metalloid chelate is selected from one or more in the following compound:
2-chromium picolinate, 2-pyridine carboxylic acid copper, 2-zinc picolinate, nicotinic acid chromium, copper nicotinate and nicotinic acid zinc.
Water-soluble compound as feed addictive provided by the invention, described cosolvent comprises small molecular organic acid salt and organic amine cosolvent.
Acylate comprises organic acid potassium salt and organic acid sodium salt.
Water-soluble compound as feed addictive provided by the invention, described organic amine cosolvent comprises one or more in the compound that is selected from following arbitrary proportion:
Sodium Benzoate, para-phthalic sodium, para aminobenzoic acid sodium salt, P-hydroxybenzoic acid sodium, sodium sulfanilate, p-methyl benzenesulfonic acid sodium, natrium citricum, niacinamide, urea, ethylenediamine and acetamide.
Water-soluble compound as feed addictive provided by the invention, described natrium citricum comprises sodium dihydrogen citrate, disodium citrate and trisodium citrate.
A kind of preparation method who is used as the water-soluble compound of feed addictive of the present invention may further comprise the steps:
A), under stirring, cosolvent is added to the water dissolving;
B), treat that cosolvent dissolves fully after, to wherein adding slightly solubility pyridine carboxylic acid metalloid chelate;-0.01MPa~0.5MPa, under 10 ℃~180 ℃ conditions, heating 0.01h~10h dissolves the pyridine carboxylic acid metalloid chelate that adds fully;
C), the solution of the water-soluble compound that obtains, namely get the solid, water soluble composite product after the drying.
Preferably:
A kind of water-soluble compound as feed addictive of the present invention, the mass ratio that adopts metallo-chelate and cosolvent are 0.1~0.5: 1 the compound preparation of ratio.
A kind of preparation method who is used as the water-soluble compound of feed addictive of the present invention comprises step:
A), under stirring, cosolvent is added to the water;
B), treat that cosolvent dissolves fully after, to wherein adding slightly solubility pyridine carboxylic acid metalloid chelate;-0.01MPa~0.5MPa, under 10 ℃~180 ℃ conditions, heating is dissolved the pyridine carboxylic acid metalloid chelate that adds fully;
C), namely get the solution of water-soluble compound behind 0.01h~10h, namely get the solid, water soluble compound after the spray-drying.
Water-soluble compound contains one or more crystallizations water or does not contain the crystallization water; Its final application form comprises: the aqueous solution, dry powder, premix.
Wherein drying can select for use spray dryer to implement, and also can realize with other equipment with same function.
In such scheme:
Chromium is the essential trace element of humans and animals body, to keeping and to strengthen insulin function very important, can improve anti-stress ability and immunity of organisms.Copper is trace element essential in the raising poultry nutritive, and it participates in the synthetic of hemoglobin, also participates in synthetic and the necessary oxidizing ferment of activation eubolism.Zinc participates in nucleic acid and protein metabolism, and zinc also plays an important role in fibroblasts proliferation and collagen building-up process, and while zinc also is that the important composition composition of many enzymes maybe must have zinc to participate in just being activated.
In addition, slightly solubility chelate and cosolvent can form complex compound, associated matter or the double salt etc. between shla molecule in solvent.
The combination of said components and proportion are determined by a large amount of experiments; And combinations thereof and proportion make the present invention have the animal absorptivity of raising and bioavilability, economizes in raw materials and protect the characteristics of environment.
The using method of water-soluble compound of the present invention is identical with using dosage and routine, and micro-use amount is suitable in the feed addictive with national regulation during use.
Compared with prior art, a kind of water-soluble compound as feed addictive provided by the invention has following beneficial effect:
1. the water-soluble compound solid is dissolved in water, can improve the bioavailability of metal trace element;
2. can improve the animal absorptivity, and can not change the nutritive value of trace element;
3. namely can be made into product by simple preparation method;
4. can reduce the cost of feed addictive, reduce because not absorbed the environmental pollution that brings by the animal body.
[specific embodiment]
By illustrating further the present invention by following examples.
[related experiment]
The immature fowl that is 50 kilograms held be divided into two groups, feed the feed that contains the prior art additive for one group, another group is fed the feed that contains additive of the present invention, and the amount of the amount of two groups of used additives and feed is all identical.
Table 1 is that the relevant parameter that two groups of fowl are held compares
10 months body weight recruitment (units: kilogram) | Fowl is held the (unit: milligram) of chromium constituent content in the body | Fowl is held copper content in the body | Fowl is held zinc constituent content in the body | |
Employing contains the forage feed fowl of prior art additive and holds | 100kg | 7.5mg | 6.2mg | 5.8mg |
Employing contains the forage feed fowl of additive of the present invention and holds | 150kg | 10mg | 9.5mg | 8.7mg |
[embodiment 1]
Under stirring, 100 gram Sodium Benzoates are added in the 400 gram water, the dissolving back is under the 0.1MPa condition fully, be heated to 90 ℃, slowly add 25 gram chromium picolinates, be incubated to chromium picolinate and dissolve fully, namely get the solution of water-soluble pyridine carboxylic acid chromium complexes behind the 0.01h, namely get solid, water soluble pyridine carboxylic acid chromium complexes by spray-drying.
[embodiment 2]
Under stirring, 100 gram para-phthalic sodiums are added in the 400 gram water, fully under the 0.5MPa condition of dissolving back, be heated to 180 ℃, slowly add 25 gram chromium picolinates, be incubated to chromium picolinate and dissolve fully, namely get the solution of water-soluble pyridine carboxylic acid chromium complexes behind the 0.01h, namely get solid, water soluble pyridine carboxylic acid chromium complexes by spray-drying.
[embodiment 3]
Under stirring, 100 gram para aminobenzoic acid sodium salts are added in the 400 gram water, fully under the 0.25MPa condition of dissolving back, be heated to 110 ℃, slowly add 20 gram nicotinic acid chromium, be incubated to nicotinic acid chromium and dissolve fully, namely get the solution of water-soluble nicotinic acid chromium complexes behind the 5.5h, namely get solid, water soluble nicotinic acid chromium complexes by spray-drying.
[embodiment 4]
Under stirring, 100 gram septichen sodium are added in the 400 gram water, fully under the 0.15MPa condition of dissolving back, be heated to 85 ℃, slowly add 20 gram pyridine carboxylic acid copper, be incubated to pyridine carboxylic acid copper and dissolve fully, namely get the solution of water-soluble pyridine carboxylic acid copper composition behind the 10h, namely get solid, water soluble pyridine carboxylic acid copper composition by spray-drying.
[embodiment 5]
Under stirring, 100 gram sodium dihydrogen citrates (or disodium citrate, trisodium citrate) are added in the 400 gram water, fully under the 0.3MPa condition of dissolving back, be heated to 75 ℃, slowly add 10 gram chromium picolinates, be incubated to chromium picolinate and dissolve fully, namely get the solution of water-soluble pyridine carboxylic acid chromium complexes behind the 8h, namely get solid, water soluble pyridine carboxylic acid chromium complexes by spray-drying.
[embodiment 6]
Under stirring, 100 gram ethylenediamines are added in the 400 gram water, fully under the dissolving back-0.01MPa condition, be heated to 85 ℃, slowly add 25 gram zinc picolinates, be incubated to zinc picolinate and dissolve fully, namely get the solution of water-soluble pyridine carboxylic acid zinc complexes behind the 5.0h, namely get solid, water soluble pyridine carboxylic acid zinc complexes by spray-drying.
[embodiment 7]
Under stirring, 100 gram niacinamide are added in the 400 gram water, fully under the 0.4MPa condition of dissolving back, be heated to 100 ℃, slowly add 20 gram copper nicotinates, be incubated to copper nicotinate and dissolve fully, namely get the solution of water-soluble copper nicotinate compound behind the 7h, spray-drying namely gets solid, water soluble copper nicotinate compound.
[embodiment 8]
Under stirring, 100 gram urea are added in the 400 gram water, fully under the 0.2MPa condition of dissolving back, be heated to 80 ℃, slowly add 25 gram nicotinic acid zinc, be incubated to nicotinic acid zinc and dissolve fully, namely get the solution of water-soluble nicotinic acid zinc complexes behind the 9h, namely get solid, water soluble nicotinic acid zinc complexes by spray-drying.
[embodiment 9]
Under stirring, 100 gram Sodium Benzoates are added in the 400 gram water, fully under the 0.3MPa condition of dissolving back, be heated to 120 ℃, slowly add 13 gram chromium picolinates, be incubated to chromium picolinate and dissolve fully, namely get the solution of water-soluble pyridine carboxylic acid chromium complexes behind the 6h, namely get solid, water soluble pyridine carboxylic acid chromium complexes by spray-drying.
[embodiment 10]
Under stirring, 100 gram Sodium Benzoates are added in the 400 gram water, fully under the 0.5MPa condition of dissolving back, be heated to 90 ℃, slowly add 2 gram chromium picolinates, be incubated to chromium picolinate and dissolve fully, namely get the solution of water-soluble pyridine carboxylic acid chromium complexes behind the 7h, namely get solid, water soluble pyridine carboxylic acid chromium complexes by spray-drying.
[embodiment 11]
Under stirring, 100 gram septichen sodium are added in the 400 gram water, fully under the 0.3MPa condition of dissolving back, be heated to 85 ℃, slowly add 60 gram pyridine carboxylic acid copper, be incubated to pyridine carboxylic acid copper and dissolve fully, namely get the solution of water-soluble pyridine carboxylic acid copper composition behind the 8h, namely get solid, water soluble pyridine carboxylic acid copper composition by spray-drying.
[embodiment 12]
Under stirring, 100 gram Sodium Benzoates are added in the 400 gram water, under-0.01MPa condition, fully under the 0.2MPa condition of dissolving back, be heated to 115 ℃, slowly add 100 gram chromium picolinates, be incubated to chromium picolinate and dissolve fully, namely get the solution of water-soluble pyridine carboxylic acid chromium complexes behind the 10h, namely get solid, water soluble pyridine carboxylic acid chromium complexes by spray-drying.
[embodiment 13]
Under stirring, 100 gram Sodium Benzoates are added in the 400 gram water, fully under the dissolving back-0.5MPa condition, be heated to 120 ℃, slowly add 70 gram chromium picolinates, be incubated to chromium picolinate and dissolve fully, namely get the solution of water-soluble pyridine carboxylic acid chromium complexes behind the 10h, namely get solid, water soluble pyridine carboxylic acid chromium complexes by spray-drying.
[embodiment 14]
Under stirring, 100 gram Sodium Benzoates are added in the 400 gram water, fully under the 0.5MPa condition of dissolving back, be heated to 100 ℃, slowly add 50 gram chromium picolinates, be incubated to chromium picolinate and dissolve fully, namely get the solution of water-soluble pyridine carboxylic acid chromium complexes behind the 10h, namely get solid, water soluble pyridine carboxylic acid chromium complexes by spray-drying.
[embodiment 15]
Under stirring, 100 gram septichen sodium are added in the 400 gram water, fully under the 0.5MPa condition of dissolving back, be heated to 180 ℃, slowly add 10 gram pyridine carboxylic acid copper, be incubated to pyridine carboxylic acid copper and dissolve fully, namely get the solution of water-soluble pyridine carboxylic acid copper composition behind the 10h, namely get solid, water soluble pyridine carboxylic acid copper composition by spray-drying.
Should be noted that at last: above embodiment is only in order to illustrate that technical scheme of the present invention is not intended to limit; although with reference to above-described embodiment the present invention is had been described in detail; those of ordinary skill in the field are to be understood that: the technical staff reads after the present specification still and can make amendment or be equal to replacement the specific embodiment of the present invention, does not await the reply within the claim protection domain but these modifications or change all break away from the present patent application.
Claims (4)
1. the water-soluble compound as feed addictive is characterized in that it is the compound preparation of ratio of 0.01~1:1 that described water-soluble compound adopts the mass ratio of metallo-chelate and cosolvent;
Described metallo-chelate is a kind of in 2-chromium picolinate, 2-pyridine carboxylic acid copper, the 2-zinc picolinate;
Described cosolvent is a kind of in Sodium Benzoate, para-phthalic sodium, para aminobenzoic acid sodium salt, P-hydroxybenzoic acid sodium, sodium sulfanilate, p-methyl benzenesulfonic acid sodium, natrium citricum, niacinamide, urea, ethylenediamine and the acetamide;
The preparation method of described water-soluble compound may further comprise the steps:
A), under stirring, cosolvent is added to the water dissolving;
B), treat that cosolvent dissolves fully after, to wherein adding described metallo-chelate;-0.01MPa~0.5MPa, under 10 ℃~180 ℃ conditions, heating 0.01h~10h dissolves the metallo-chelate that adds fully;
C), the solution of the water-soluble compound that obtains, namely get the solid, water soluble composite product after the drying.
2. the water-soluble compound of claim 1 is characterized in that it is 0.02~0.6: 1 the compound preparation of ratio that described water-soluble compound adopts the mass ratio of metallo-chelate and cosolvent.
3. the water-soluble compound of claim 1 is characterized in that it is 0.7~1: 1 the compound preparation of ratio that described water-soluble compound adopts the mass ratio of metallo-chelate and cosolvent.
4. the water-soluble compound of claim 3 is characterized in that described natrium citricum comprises sodium dihydrogen citrate, disodium citrate or trisodium citrate.
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US8968807B1 (en) * | 2013-09-24 | 2015-03-03 | Zinpro Corporation | Use of ethylene diamine metal complexes to deliver highly absorbable metals for animal nutrition |
CN103613536B (en) * | 2013-12-13 | 2015-11-04 | 四川生科力科技有限公司 | The industrialized process for preparing of 2-pyridine carboxylic acid copper |
CN107518175A (en) * | 2016-06-29 | 2017-12-29 | 湖南晶天科技实业有限公司 | A kind of feed addictive coating aliphatic acid copper and preparation method thereof and a kind of feed |
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