CN102228651A - Traditional Chinese medicine composition for treating gynecologic inflammation, and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating gynecologic inflammation, and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating gynecologic inflammation, and a preparation method thereof. The traditional Chinese medicine composition for treating gynecologic inflammation is prepared from the following raw materials in parts by weight: 20-50 parts of rabdosia rubescens, 10-30 parts of kuh-seng, 10-30 parts of phellodendron bark, 10-20 parts of stemona root, 10-20 parts of cnidium fruit and 10-20 parts of mint. The invention also provides a preparation method of the traditional Chinese medicine composition and a clinical preparation of the traditional Chinese medicine composition. The traditional Chinese medicine composition provided by the invention has the efficacies on clearing away heat and toxic material, eliminating dampness, relieving itching, resisting bacteria, destroying parasites and eliminating peculiar smell, has obvious curative effect on treating gynecologic inflammation, has no recurrence, no toxic side effect, no irritation and no allergy to skin, comfort and safety, and can be widely applied to clinical treatment of gynecologic inflammation such as colpitis, cervicitis and the like.
Description
Technical field
The present invention relates to tcm field, relate to a kind of Chinese medicine composition for the treatment of gynecological inflammation and preparation method thereof specifically.
Background technology
Gynecological inflammation is women's a common disease, has data to show, the adult women of China has gynecological inflammation in various degree, accounts for more than 60% of the numerous women of child-bearing age.Gynecological inflammation infects can betide down reproductive tract such as vulvitis, vaginitis and cervicitis; Also can attack reproductive tract is that internal genitalia causes pelvic inflammatory disease.The clinical symptoms of gynecological inflammation shows as " itching ", " wetting ", " bitterly " more, be pruritus vulvae, scorching hotly swell and ache, leucorrhea abnormal, frequent micturition, urgent micturition, dysurea, lower abdomen weigh down and expand etc., also can cause the patient symptoms such as lassitude, whole body discomfort, menoxenia to occur.The untimely treatment of inflammation, may cause inflammation to spread mutually and cross infection in each physiological location, health is in the infringement environment of inflammation for a long time, all can produces harmful effect, to healthy very harmful immunologic function, metabolism and hormonal system.Can bring many complication in addition, even cause the malignant change at some position.Some gynecological inflammations not only endanger the women, but also can involve the household, if pregnant female also can pass through links such as intrauterine infection, birth canal infection and infect neonate, cause serious consequences such as miscarriage, premature labor, congenital development deformity, mental retardation.
At present western medicine gynecological inflammations that adopt more.Yet western medicine exist easily develop immunity to drugs, zest, anaphylaxis, toxic and side effects is big, is not suitable for the women of anemia of pregnant woman and age of sucking, easily causes the intravaginal dysbacteriosis, destroys the self-cleaning system of vagina, and treatment is not thorough, more easily bounce-back of back.And Chinese traditional treatment is from integral body, or eliminating damp-heat, or invigorating the spleen for eliminating dampness, or liver and kidney tonifying, or soothing liver and strengthening spleen, is equipped with killing parasites for relieving itching, in treatment by oral administration of medicines, and in conjunction with external treatment, Chinese medicine, clinical efficacy is good, and side effect is little.
Gynecological inflammation belongs to the traditional Chinese medical science " pudendal pruritus ", " leukorrheal diseases " category.Pudendal pruritus is meant women's pudendum and pruritus of vagina, even itch pain unbearably, feels restless, or increase with leukorrhagia etc.Golden Mirror of Medicine thinks that married woman's pudendal pruritus is many because of parasite caused by accumulation of damp-heat in the body, and insect poison is had an itch." Complete Effective Prescriptions for Women " says: Mr. and Mrs people pudendal pruritus person is that worm-eaten is done.Three worms are between the intestines and stomach, because of deficiency of five ZANG-organs, and the action of three worms, in the ulceration at external genitals, its worm makes heat, and is little then for itching, heavy then be bitterly also.Leukorrhagia too much is meant woman's leukorrhagia amount showed increased, and color, matter, abnormal smells from the patient are unusual, or with part and General Symptoms person." women section brief points " proposes leukorrhagia too much is to be lost due to empty, yang-energy sink by taste, advocates spleen invigorating yang invigorating leukorrhagia stopping.Therefore the main diseases of gynecological inflammation is because of reducing the imbalance of liver spleen renal function, and damp injures to appoint is with two arteries and veins, makes conception vessel lose solid, dai channel and fails to keep an appointment, and can divide again specifically that dampness-heat of the liver, deficiency of YIN folder wet, turbid damp pents up.
Summary of the invention
In view of this, the object of the invention provides a kind of Chinese medicine composition of treatment gynecological inflammation of determined curative effect.
For realizing purpose of the present invention, the present invention adopts following technical scheme:
A kind of Chinese medicine composition for the treatment of gynecological inflammation, its raw material comprises in weight portion:
Rabdosia rubescens 20-50 part Radix Sophorae Flavescentis 10-30 part Cortex Phellodendri 10-30 part
Radix Stemonae 10-20 part Fructus Cnidii 10-20 part Herba Menthae 10-20 part.
Chinese medicine composition of the present invention is selected Six-element Chinese crude drugs such as Rabdosia rubescens, Radix Sophorae Flavescentis, Cortex Phellodendri, the Radix Stemonae, Fructus Cnidii and Herba Menthae for use.
Wherein, Rabdosia rubescens has another name called Rabdosia rubescens.Ice slush is colored, snowflake is careless, for Labiatae scented tea belongs to perennial herb or undershrub, because of its plant butterfly-shaped ice slush sheet as thin as cicada's wings, that come in every shape that condenses winter is gained the name.Winter, Pedicellus et Pericarpium Trapae was with all herbal medicine, bitter in the mouth, sweet, and cold nature has heat-clearing and toxic substances removing, and the promoting blood circulation and stopping pain effect is used for the treatment of laryngopharynx swelling and pain, tonsillitis, headache due to common cold, tracheitis, chronic hepatitis, joint rheumatalgia, snake bite and insect sting.
Radix Sophorae Flavescentis, latin name Sophora flavescens, for the pulse family Radix Sophorae Flavescentis belongs to perennial fallen leaves semishrub plant, be used as medicine with root, bitter in the mouth, cold in nature, have heat clearing and damp drying, wind dispelling insecticide effect, be used for the treatment of hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, scabies leprosy, skin pruritus, noxious dampness skin infection.
Cortex Phellodendri, latin name Cortex Phellodendri Chinensis, another name Cortex Phellodendri, Cortex Phellodendri, bark of a cork tree wood Cortex Phellodendri are the dry bark of rutaceae wampee or Cortex Phellodendri.Cortex Phellodendri nature and flavor, bitter cold have heat clearing and damp drying, and pathogenic fire purging removes steams, and the effect of skin ulcer is treated in detoxifcation, is used for damp-heat dysentery, jaundice, and leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.
The Radix Stemonae is the dried root of Stemonaceae plant Radix Stemonae (Stemona sessilifolia Miq.), Radix stemonae japonicae (Stemona japonica Miq.) or radix stemonae tuberosae (Stemona tuberosa Lour.), sweet in the mouth, hardship, slightly warm in nature, effect with nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing, energy nourishing the lung to arrest cough for oral administration, can be used for the delousing parasite killing outward, pudendum Pruritus, tool itching-relieving action.
Fructus Cnidii, call wild Fructus Foeniculi, Daucus carota L., Serpentis rice, She Li, dry mature fruit for the samphire cnidium monnieri, warm in nature, acrid in the mouth, hardship, have warming the kidney to invigorate YANG, dampness, wind dispelling insecticide effect, be used for sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago, external treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis.
Herba Menthae, be the herbal aerial parts of perennial perennial root in the Labiatae Mentha, cool in nature, acrid in the mouth, have the effect of dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, soothing the liver circulation of qi promoting, be used to control affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria.
As preferably, Chinese medicine composition of the present invention, its raw material comprises in weight portion:
20 parts of 20 portions of Cortex Phellodendris of 40 parts of Radix Sophorae Flavescentiss of Rabdosia rubescens
10 parts of 15 portions of Herba Menthaes of 15 parts of Fructus Cnidiis of the Radix Stemonae.
The present invention also provides the clinical preparation of described Chinese medicine composition.It is required various pharmaceutically conventional adjuvants that those skilled in the art can add the preparation different dosage form with Chinese medicine composition of the present invention according to requirement of different patients, as disintegrating agent, lubricant, emulsifying agent, binding agent etc., with conventional method of Chinese medicinal, make gynecological's common dosage forms such as effervescent, washing liquid, suppository, gel, ointment, membrane, capsule, Emulsion, paste etc. through the direct or indirect adding acceptable auxiliary pharmaceutically of routine processing.
Preferably, the clinical preparation of Chinese medicine composition of the present invention is effervescent tablet, washing liquid or suppository, can directly act on the affected part, and with strong points, curative effect is obvious.
The present invention also provides the preparation method of described Chinese medicine composition.
A kind of preparation method for the treatment of the Chinese medicine composition of gynecological inflammation, it is characterized in that, get the Rabdosia rubescens of 20-50 weight portion, the Radix Sophorae Flavescentis of 10-30 weight portion, the Cortex Phellodendri of 10-30 weight portion, the Radix Stemonae of 10-20 weight portion, the Fructus Cnidii of 10-20 weight portion and the Herba Menthae extracting in water of 10-20 weight portion, extracting solution filters, and collects filtrate promptly.
As preferably, preparation method of the present invention, described extracting in water is that the decocting that adds 6-8 times of weight boils 2-4 time, each 1-3 hour, merge extractive liquid.
The present invention also provides the Chinese medicine composition that above-mentioned preparation method preparation is arranged.
The invention provides a kind of effervescent tablet for the treatment of gynecological's inflammation; the Chinese medicine composition concentrate drying that is about to method for preparing is made extractum; then extractum is divided equally; half and citric acid mixing granulation; the sodium bicarbonate mixing granulation that half and PEG6000 wrap up; with two kinds of granule mixings, tabletting promptly afterwards.
The present invention provides a kind of washing liquid for the treatment of gynecological's inflammation simultaneously, and it is 1.10-1.20 that the Chinese medicine composition that is about to method for preparing is concentrated into relative density, adds sodium benzoate, and high temperature sterilize promptly.
The present invention also provides a kind of suppository for the treatment of gynecological's inflammation, and the Chinese medicine composition that is about to method for preparing is concentrated, dry, and with the water-soluble base PEG4000 mixing that melts, typing promptly then.
The present invention in 64 routine vaginitiss and cervicitis patient, after 5 days, cures 53 examples with Chinese medicine composition effervescent tablet treatment of the present invention through clinical observation on the therapeutic effect, cure rate accounts for 82.8%, 10 examples that take a turn for the better, and obvious effective rate accounts for 15.6%, total effective rate is 98.4%, invalid 1 example, and inefficiency accounts for 1.6%.
The invention provides a kind of Chinese medicine composition of treatment gynecological inflammation of determined curative effect, modern pharmacology research and clinical trial show, Chinese medicine composition of the present invention has heat-clearing and toxic substances removing, dampness removing to stop itchin, antibiotic parasite killing, eliminates the effect of abnormal flavour, the treatment gynecological inflammation is evident in efficacy, more do not rebound after, have no side effect, and to skin nonirritant, no anaphylaxis, comfortable safety, be the good medicine of prevention and treatment gynecological inflammation, can be widely used in the clinical treatment of gynecological inflammations such as vaginitis, cervicitis.
The specific embodiment
The embodiment of the invention discloses a kind of Chinese medicine composition for the treatment of gynecological inflammation and preparation method thereof.Those skilled in the art can use for reference this paper content, suitably improve technological parameter and realize.Special needs to be pointed out is that all similarly replace and change apparent to those skilled in the art, they all are regarded as being included in the present invention.Product of the present invention and method are described by preferred embodiment, the related personnel obviously can be in not breaking away from content of the present invention, spirit and scope to product as herein described with method is changed or suitably change and combination, realize and use the technology of the present invention.
In order further to understand the present invention, the present invention is described in detail below in conjunction with embodiment.
Embodiment 1: the Chinese medicine composition of treatment gynecological inflammation of the present invention
Described Chinese medicine composition is to be made by following bulk drugs:
Rabdosia rubescens 40g Radix Sophorae Flavescentis 20g Cortex Phellodendri 20g
Radix Stemonae 15g Fructus Cnidii 15g Herba Menthae 10g
Preparation method is that the decocting that the Rabdosia rubescens of getting described weight, Radix Sophorae Flavescentis, Cortex Phellodendri, the Radix Stemonae, Fructus Cnidii and Herba Menthae add 8 times of weight boils 2-4 time, and each 1-3 hour, merge extractive liquid, filtered, and collection filtrate promptly.
Embodiment 2: the Chinese medicine composition of treatment gynecological inflammation of the present invention
Described Chinese medicine composition is to be made by following bulk drugs:
Rabdosia rubescens 50g Radix Sophorae Flavescentis 10g Cortex Phellodendri 30g
Radix Stemonae 10g Fructus Cnidii 20g Herba Menthae 20g
Preparation method is that the decocting that the Rabdosia rubescens of getting described weight, Radix Sophorae Flavescentis, Cortex Phellodendri, the Radix Stemonae, Fructus Cnidii and Herba Menthae add 6 times of weight boils 4 times, and each 2 hours, merge extractive liquid, filtered, and collects filtrate promptly.
Embodiment 3: the Chinese medicine composition of treatment gynecological inflammation of the present invention
Described Chinese medicine composition is to be made by following bulk drugs:
Rabdosia rubescens 20g Radix Sophorae Flavescentis 30g Cortex Phellodendri 10g
Radix Stemonae 20g Fructus Cnidii 10g Herba Menthae 15g
Preparation method is that the decocting that the Rabdosia rubescens of getting described weight, Radix Sophorae Flavescentis, Cortex Phellodendri, the Radix Stemonae, Fructus Cnidii and Herba Menthae add 7 times of weight boils 2 times, and each 3 hours, merge extractive liquid, filtered, and collects filtrate promptly.
Embodiment 4: the effervescent tablet of treatment gynecological inflammation of the present invention
Make by following bulk drugs:
Rabdosia rubescens 40g Radix Sophorae Flavescentis 20g Cortex Phellodendri 20g
Radix Stemonae 15g Fructus Cnidii 15g Herba Menthae 10g
Preparation method is that the decocting that the Rabdosia rubescens of getting described weight, Radix Sophorae Flavescentis, Cortex Phellodendri, the Radix Stemonae, Fructus Cnidii and Herba Menthae add 8 times of weight boils 2 times, and each 3 hours, merge extractive liquid, filtered, is condensed into thick paste, and spray drying gets powder 10g.Get 5g medicated powder and 9g citric acid mix homogeneously, it is dry to granulate.Get the 5.5gPEG6000 heat fused, the sodium bicarbonate of 11g is added wherein, mixing carries out the parcel of sodium bicarbonate, and cooling adds other 5g medicated powder after pulverizing, mixing, the drying of granulating.With two kinds of granule mixings, granulate adds the 1g magnesium stearate then, total mixing, and tabletting (oval special-shaped sheet), promptly.
Embodiment 5: the washing liquid of treatment gynecological inflammation of the present invention
Make by following bulk drugs:
Rabdosia rubescens 30g Radix Sophorae Flavescentis 15g Cortex Phellodendri 20g
Radix Stemonae 10g Fructus Cnidii 15g Herba Menthae 20g
Preparation method is that the decocting that the Rabdosia rubescens of getting described weight, Radix Sophorae Flavescentis, Cortex Phellodendri, the Radix Stemonae, Fructus Cnidii and Herba Menthae add 8 times of weight boils 2 times, and each 3 hours, merge extractive liquid, filtered, leaves standstill, and getting supernatant concentration, to become density be 1.03-1.04.Get the about 500mL of supernatant concentrated solution, add 0.5% sodium benzoate, high temperature sterilize, fill, promptly.
Embodiment 6: the suppository of treatment gynecological inflammation of the present invention
Make by following bulk drugs:
Rabdosia rubescens 50g Radix Sophorae Flavescentis 10g Cortex Phellodendri 10g
Radix Stemonae 20g Fructus Cnidii 10g Herba Menthae 15g
Preparation method is that the decocting that the Rabdosia rubescens of getting described weight, Radix Sophorae Flavescentis, Cortex Phellodendri, the Radix Stemonae, Fructus Cnidii and Herba Menthae add 8 times of weight boils 2 times, each 3 hours, and merge extractive liquid,, filtering and concentrating, spray drying.Get the about 10g of medicated powder.Get PEG4000 water-soluble base 100g, the heating in water bath fusing adds medicated powder, and mixing injects mould, and take out the cooling back, makes 55 of suppositorys altogether, every heavy 2g of suppository.
Embodiment 7: the ointment of treatment gynecological inflammation of the present invention
Make by following bulk drugs:
Rabdosia rubescens 20g Radix Sophorae Flavescentis 30g Cortex Phellodendri 30g
Radix Stemonae 20g Fructus Cnidii 20g Herba Menthae 20g
According to the extracting solution of embodiment 1～3 described method preparation, spray drying or drying under reduced pressure, the conventional adjuvant that adds ointment is prepared into ointment according to a conventional method.
The observation of curative effect of embodiment 8 Chinese medicine compositions of the present invention
Observe the curative effect of using traditional Chinese medicine composition for treating vaginitis of the present invention, cervicitis.
320 routine vaginitis patients are divided into four experimental grouies and a matched group at random, every group 64 example, the scorching clean demibain of effervescent tablet, washing liquid, suppository or the ointment of the Chinese medicine composition of Application Example 4-7 preparation and commercially available woman is treated respectively.
Diagnostic criteria: with reference to the clinical diagnosis standard, and light with the symptom calibration, in, severe.
Therapeutic Method: experimental group is sent into vagina deep indwelling 6-8 hour with the washing liquid morning and evening washing vagina of Chinese medicine composition of the present invention or with effervescent tablet, suppository, ointment, and suppository and ointment take out with the back.Stop other western medicines in treatment during the treatment.
Observation of curative effect: the present invention has obtained curative effect preferably clinically, in 64 routine vaginitiss and cervicitis patient, after 5 days, cure 53 examples with Chinese medicine composition effervescent tablet treatment of the present invention, cure rate accounts for 82.8%, 10 examples take a turn for the better, obvious effective rate accounts for 15.6%, and total effective rate is 98.4%, invalid 1 example, inefficiency accounts for 1.6%, no difference of science of statistics between compositions washing liquid of the present invention, suppository, ointment group and effervescent tablet group.The matched group cure rate is that 58.7%, two group of cure rate relatively has significant difference (P＜0.05).
The explanation of above embodiment just is used for helping to understand method of the present invention and core concept thereof.Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention, can also carry out some improvement and modification to the present invention, these improvement and modification also fall in the protection domain of claim of the present invention.
Claims (10)
1. Chinese medicine composition for the treatment of gynecological inflammation, its raw material comprises in weight portion:
Rabdosia rubescens 20-50 part Radix Sophorae Flavescentis 10-30 part Cortex Phellodendri 10-30 part
Radix Stemonae 10-20 part Fructus Cnidii 10-20 part Herba Menthae 10-20 part.
2. Chinese medicine composition according to claim 1 is characterized in that, its raw material comprises in weight portion:
20 parts of 20 portions of Cortex Phellodendris of 40 parts of Radix Sophorae Flavescentiss of Rabdosia rubescens
10 parts of 15 portions of Herba Menthaes of 15 parts of Fructus Cnidiis of the Radix Stemonae.
3. the clinical preparation that comprises claim 1 or 2 described Chinese medicine compositions.
4. according to the described clinical preparation of claim 3, it is characterized in that it is effervescent tablet, washing liquid or suppository.
5. preparation method for the treatment of the Chinese medicine composition of gynecological inflammation, it is characterized in that, get the Rabdosia rubescens of 20-50 weight portion, the Radix Sophorae Flavescentis of 10-30 weight portion, the Cortex Phellodendri of 10-30 weight portion, the Radix Stemonae of 10-20 weight portion, the Fructus Cnidii of 10-20 weight portion and the Herba Menthae extracting in water of 10-20 weight portion, extracting solution filters, and collects filtrate promptly.
6. according to the described preparation method of claim 5, it is characterized in that described extracting in water is that the decocting that adds 6-8 times of weight boils 2-4 time, each 1-3 hour, merge extractive liquid.
7. according to the Chinese medicine composition of claim 5 or the preparation of 6 described preparation methoies.
8. effervescent tablet for the treatment of gynecological inflammation; it is characterized in that; the described Chinese medicine composition concentrate drying of claim 7 is made extractum; then extractum is divided equally; half and citric acid mixing granulation; the sodium bicarbonate mixing granulation that half and PEG6000 wrap up, with two kinds of granule mixings, tabletting promptly afterwards.
9. a washing liquid for the treatment of gynecological inflammation is characterized in that, it is 1.10-1.20 that the described Chinese medicine composition of claim 7 is concentrated into relative density, adds sodium benzoate, and high temperature sterilize promptly.
10. a suppository for the treatment of gynecological inflammation is characterized in that, the described Chinese medicine composition of claim 7 is concentrated, dry, and with the water-soluble base PEG4000 mixing that melts, typing promptly then.
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| CN103495090A (en) * | 2013-09-29 | 2014-01-08 | 黄德明 | Traditional Chinese medicine composition for treating vaginitis and preparation method thereof |
| CN105169263A (en) * | 2015-09-28 | 2015-12-23 | 公晓琳 | Flushing type traditional Chinese medicine for chronic cervicitis |
| CN105770767A (en) * | 2016-05-06 | 2016-07-20 | 刘晓朋 | Traditional Chinese medicine pill formula for tightening vaginas and treating gynecological inflammation |
| CN108815434A (en) * | 2018-08-13 | 2018-11-16 | 彭水县绿忆环保科技有限公司 | Antibacterial conditioning liquid |
| CN109771595A (en) * | 2018-12-28 | 2019-05-21 | 合肥卡迪尔生物科技有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating gynaecological imflammation |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103495090A (en) * | 2013-09-29 | 2014-01-08 | 黄德明 | Traditional Chinese medicine composition for treating vaginitis and preparation method thereof |
| CN103495090B (en) * | 2013-09-29 | 2016-04-27 | 黄德明 | Treat colpitic Chinese medicine composition and preparation method thereof |
| CN105169263A (en) * | 2015-09-28 | 2015-12-23 | 公晓琳 | Flushing type traditional Chinese medicine for chronic cervicitis |
| CN105770767A (en) * | 2016-05-06 | 2016-07-20 | 刘晓朋 | Traditional Chinese medicine pill formula for tightening vaginas and treating gynecological inflammation |
| CN108815434A (en) * | 2018-08-13 | 2018-11-16 | 彭水县绿忆环保科技有限公司 | Antibacterial conditioning liquid |
| CN109771595A (en) * | 2018-12-28 | 2019-05-21 | 合肥卡迪尔生物科技有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating gynaecological imflammation |
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Application publication date: 20111102 |