CN102228532B - Composite medicament for treating acne - Google Patents
Composite medicament for treating acne Download PDFInfo
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- CN102228532B CN102228532B CN201110172816A CN201110172816A CN102228532B CN 102228532 B CN102228532 B CN 102228532B CN 201110172816 A CN201110172816 A CN 201110172816A CN 201110172816 A CN201110172816 A CN 201110172816A CN 102228532 B CN102228532 B CN 102228532B
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Abstract
The invention discloses a composite medicament (Qudou Huichui capsule) for treating acne. The composite medicament is composed of the following components in parts by weight: 30-40 parts of loquat leaf, 20-40 parts of Atractylis ovata, 30-40 parts of Scutellaria baicalensis, 30-40 parts of honeysuckle flower and 30-40 parts of Salvia miltiorrhiza. The composite medicament provided by the invention has the effects of clearing heat, discharging fire, clearing stomach, eliminating dampness, invigorating blood circulation, eliminating stasis, improving blood circulation and local microcirculation, promoting metabolism and absorption of inflammation and removing acne and toxin, and is used for treating facial inflammatory papules of adolescent acne, papulo-vesicle, mixed fester and pigmentation left after acne is cured.
Description
Affiliated technical field
The present invention relates to a kind of composition of medicine, is a kind of Chinese medicinal composition preparation of treating acne specifically.
Background technology
Acne is claimed acne again, is the chronic inflammatory disease dermatoses of clinical common multiple hair follicle cortex adipose gland, and sickness rate is higher, is prone to outbreak repeatedly.Acne belongs to motherland's medical science " rosacea caused by lung-wind ", and ancient literature is from age of onset, and different names of disease appears in diseased region and erythra characteristic in succession, like " face Cuo ", " whelk ", " comedo " etc.Primary disease is sent out in the youth well, and main being prone to sends out in face and chest and back, shows as acne, pimple, abscess, tuberosity, cyst, and and is prone to form pigmentation, corse sweat pore, even the infringement of cicatrix appearance.Acne is not only a kind of physical disease, in the heart of social,, aspect such as emotion, the patient is affected.Therefore, the active treatment primary disease to improving patient's physical and mental health, all has crucial meaning.
Summary of the invention
The purpose of this invention is to provide a kind of composition of medicine of treating acne.
Medicine of the present invention is composed of the following components by weight: Folium Eriobotryae 30-40 part, Rhizoma Atractylodis 20-40 part, Radix Scutellariae 30-40 part, Flos Lonicerae 30-40 part, Radix Salviae Miltiorrhizae 30-40 part.
Medicine of the present invention preferred version by weight is:
30 parts of Folium Eriobotryaes, 30 parts of Rhizoma Atractylodis, 30 parts of Radix Scutellariaes, 30 parts of Flos Loniceraes, 30 parts of Radix Salviae Miltiorrhizaes.
Pulverize above medicine, cross 120 mesh sieves, the medicated powder that screening is good passed through 100-110 ℃ of sterilization treatment 15-30 minute again, was sub-packed in capsule.Be applicable to the pilosebaceous chronic inflammatory disease of adolescence men and women, especially with student of college and junior-senior high school part student in the school.Each 6, every day 3 times, warm water delivery service after meal.This enterprise is " anti-acne return of spring capsule " with this drug nomenclature.
Also can process soup, ball, diffusing, the various dosage forms of sheet, be benefit conveniently to take.
Advantage of the present invention is: the present invention has clearing away heat-fire, clearing stomach dehumidifying, blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating stagnation; Improve blood circulation and local microcirculation; Promote the metabolism and the absorption of inflammation, anti-acne is drawn out pus by applying a plaster to the affected part, and is used for the face inflammatory pimple that the adolescence acne occurs; After curing, the assorted mutually and acne of papulovesicle, abscess leaves pigmentation.
Evident in efficacy.
We select for use the present invention to treat acne, and 100 routine clinical efficacies are summed up as follows:
One, observed content and method
1, diagnosis, efficacy determination, medicine typing standard
It is young 1.1 mostly the diagnostic criteria patient is, good sending out in face, and blackhead, papulopustule or tuberosity for being dispersed in property of majority are damaged in the position that sebums such as last breast and back are flourishing, be symmetrically distributed more.Clinical weight classification is with reference to 1. I degree of Pillssbury classification method: blackhead is distributed and is multiple, and the inflammatory erythra is distributed.2. II degree: I degree+shallow in the property abscess; Struvite erythra number increases.Be confined to face portion.3. III degree: the II degree+deeply in the struvite erythra of property, good sending out in face portion, cervical region, chest and back.4. IV degree: III degree+cyst,, be prone to form cicatrix, see above the waist more.
1.2 the Clinical typing standard is primary symptom 1.: face or chest and back color of the leather or red pimple are main, are dispersed in the abscess lesser tubercle, oils and fats is many; 2. inferior disease: increase the weight of before and after thirsty, big dry stool, the yellow urine, women's menstruation, or menoxenia, color secretly has piece, thin lingual fur or yellow greasy, string or sliding number forever.Possess 1 of above primary symptom, 3 persons of inferior disease, dialectical i.e. establishment.
1.3 exclusion standard is hard tubercle, cyst type acne 1., classification reaches the acne of IV degree (severe); 2. chemical substance causes occupational acne, drug-induced acne; 3. Deficiency and coldness of spleen and stomach is prone to diarrhoea person; 4. merge cardiovascular and cerebrovascular vessel, Liver and kidney disease and important organic disease or hemopoietic system serious disease, psychotic; 5. pregnant, women breast-feeding their children.
1.4 1. efficacy assessment standard fully recovers: skin lesion all disappears, and only leaves pigmentation, does not have new rash and occurs;
2. produce effects: skin lesion disappears more than 70%, and accidental new rash occurs; 3. effective: skin lesion disappears more than 30%, still has a little new rash to occur; 4. invalid: through 2-3 course of treatment, skin lesion disappear＜30%, or newly-increasedly do not subtract.
1.5 strict diagnostic criteria selection case 100 examples of carrying out of object of study, male 57 examples, women 43 examples, the course of disease 1 day-10 years average 2.19, is divided into two groups with 100 examples, experimental group 50 examples at random; Man's 29 examples, women 21 examples; Minimum 12 years old of age, maximum 48 years old, average 17.92 ± 4.52 years old, matched group 50 examples, male 28 examples, women 22 examples, minimum 14 years old of age, maximum 46 years old, average 18.80 ± 15.20.The experimental group medicine typing: lung-heat type 29 examples account for 58%; Scorchingly hot type 4 examples account for 8%; Spleen and stomach damp-heat type 7 examples account for 14%; Expectorant stasis of blood type 10 examples account for 20%; Matched group is typing not.
1.6 relatively design between this research of research contents employing group, random packet is an experimental group with drug oral of the present invention, and " PAIDU YANGYAN JIAONANG " is oral to be matched group, observes the curative effect of Drug therapy acne of the present invention.This research has also been carried out clinical observation to the acne of the different disease types of Drug therapy of the present invention.
1.7 research method
(1) sample 100 examples are observed in this research, and (digital watch method) is divided into two groups of A, B with the patient at random, and every group 50 example arranged 100 examples sequentially; Check the number by the sequence number table of random number, odd numbers gets into the A group, i.e. experimental group, and even numbers gets into the B group; Be matched group, no matter 6 of what all oral medicines of the present invention of disease type of experimental group, days three times oral, and 4 weeks were a course of treatment; 6 of matched groups oral " PAIDU YANGYAN JIAONANG ", days three times are oral, and 4 weeks were a course of treatment.
Medicine of the present invention is formed: Rhizoma Atractylodis 30g Radix Scutellariae 30g Radix Salviae Miltiorrhizae 30g Folium Eriobotryae 30g Flos Lonicerae 30g
Above medicine is commercially available certified products, and selected decontamination meets the pharmacopeia regulation, pulverizes big 60 orders of smalls, capsule machine fill (capsule 0.5g specification) altogether." PAIDU YANGYAN JIAONANG " produced by interwined dragon sea of clouds Pharmaceutical.Be a course of treatment all around, two groups of other medicines of during treating, all stopping using, stable emotion is lain up, and strictly avoids tobacco and wine and pungent article.
2, result
2.1 experimental group and matched group Comparison of therapeutic
Based on curative effect determinate standard, with invalid with to increase the weight of to merge into one group be invalid.Comparing result, experimental group total effective rate 98%, matched group 96%, experimental group is higher than matched group, two groups of Comparison of therapeutic, significant difference, promptly oral curative effect of medication of the present invention obviously is superior to " PAIDU YANGYAN JIAONANG " curative effect, sees table 1
Table 1 liang group observation of curative effect result
| N (example) | Cure | Produce effects | Effectively | Invalid | Total effective rate % | |
| Experimental group | 50 | 38 | 8 | 3 | 1 | 98.0 |
| Matched group | 50 | 34 | 6 | 5 | 2 | 96.0 |
X
2＝110.0＞X
2 0.005＝14.7 P＜0.005
2.2 experimental group symptom curative effect
Through symptom variation contrast before and after the experimental group treatment, curative effect difference highly significant explains that Drug therapy acne of the present invention has curative effect preferably, sees table 2
Table 2 experimental group symptom curative effect
More than 4 last all P＜0.01 of treatment
2.3 experimental group medicine typing curative effect
Experimental group 50 routine lung-heat type 29 examples account for 58%, and scorchingly hot type 4 examples account for 8%, and spleen and stomach damp-heat type 7 examples account for 14%, and expectorant stasis of blood type 10 examples account for 20%, various between curative effect do not have significant difference, see table 3
The curative effect of table 3 experimental group medicine typing
| Cure (n) | Produce effects (n) | Effectively (n) | Invalid (n) | |
| The lung-heat type | ?21 | ?5 | ?2 | ?1 |
| Scorchingly hot type | ?4 | ?- | ?- | ?- |
| Spleen and stomach damp-heat type | ?5 | ?2 | ?- | ?- |
| Expectorant stasis of blood type | ?9 | ?- | ?1 | ?- |
| Add up to | ?39 | ?7 | ?3 | ?1 |
X
2＝15.935＜X
2 0.05＝16.919 P＞0.005＞0.01
2.4 the course of disease and curative effect
The course of treatment and curative effect through contrasting total case find that the course of disease was 86.9% at 3 months with interior cure rate, and apparently higher than the average cure rate 66.6% more than 3 months, remedy of acne is described, and the early treatment curative effect is good more more.See table 4
Table 4 course of disease and Comparison of therapeutic
| The course of disease (moon) | ?n | Cure (n) | Produce effects (n) | Effectively (n) | Invalid (n) |
| 0-3 | ?46 | ?40 | ?5 | ?1 | ?- |
| 3 +-June | ?13 | ?11 | ?1 | ?1 | ?- |
| 6 +-12 | ?9 | ?5 | ?2 | ?1 | ?1 |
| 12 +- | ?32 | ?20 | ?7 | ?3 | ?2 |
| Add up to | ?100 | ?76 | ?15 | ?6 | ?3 |
3, brief summary
Folium Eriobotryae has purte the white clearly in the medicine of the present invention, the cooling stomach to stop hiccup effect, and Folium Eriobotryae contains vitamin B complex and vitamin C simultaneously, but nourishes rough skin suppresses smegma; Radix Scutellariae lung heat clearing pathogenic fire purging has stronger inhibitory action to the whole body allergy; Also have certain anti-acetylcholine effect, in addition, Radix Scutellariae can also suppress antigen and combine with IgE, suppresses mastocyte and discharges and become clinical allergy agent preferably.In addition, also have the effect of faint inhibition adenosine cyclase, the di(2-ethylhexyl)phosphate fat acid is then had stronger inhibitory action; The Flos Lonicerae heat-clearing and toxic substances removing, wind-heat dissipating is treated the skin ulcer detumescence, and various pathogens is had better inhibited and killing action; Tangible exudation and anti-proliferative effect are arranged simultaneously, in addition, immune system is had obvious promotion inflammatory cell phagocytosis, going back the pair cell immunity has inhibitory action.Radix Salviae Miltiorrhizae clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing has stronger inhibitory action to staphylococcus aureus and Bacillus tuberculosis, can improve humoral immune function, regulates the immunologic function of protein metabolism.In addition, hemocyte slow or that the stasis of blood stagnates quickened to flow before Radix Salviae Miltiorrhizae can also make treatment, and in accumulative hemocyte generation depolymerization in varying degrees, the open number showed increased of capillary network has role of correcting to microcirculation disturbance.Therefore, Radix Salviae Miltiorrhizae can improve acne inflammation focus, promotes tissue repair.The Rhizoma Atractylodis clearing away heat-fire, the volume vitamin A is rich in spleen invigorating, can suppress smegma, promotes the reparation of acne inflammation.In a word, " anti-acne return of spring capsule " has clearing away heat-fire, the clearing stomach dehumidifying, and blood circulation promoting and blood stasis dispelling, removing heat from blood loose and separate, and improve blood circulation and local microcirculation, promote the metabolism and the absorption of inflammation, the effect that anti-acne is drawn out pus by applying a plaster to the affected part.
Experimental group and matched group curative effect have the difference of highly significant, experimental group total effective rate 98%, cure rate 76%; This is with fixing prescription quality acne aspect for oral administration, and is though it is more to write out a prescription, less with this prescription flavour of a drug; And in nearly 10 years clinical research to acne; Determined curative effect, stable disease, cure rate is high.
Drug administration of the present invention is convenient, is convenient to quality and uses, and thinks that through the UR that the patient is nearly a year patient takes " anti-acne return of spring capsule " and has no side effect, and is safe and effective.Therefore, medicine of the present invention " be the comparatively ideal medicine of treatment acne, be the medicine that vast patients with acne is rejuvenated.
The specific embodiment
Embodiment 1: 30 parts of Folium Eriobotryaes, 20 parts of Rhizoma Atractylodis, 30 parts of Radix Scutellariaes, 30 parts of Flos Loniceraes, Radix Salviae Miltiorrhizae 30.
Pulverize above medicine, cross 60 mesh sieves, through 100 ℃ of sterilization treatment 30 minutes, fill promptly became medicine of the present invention in capsule to the medicated powder that screening is good again, and each 6, every day 3 times.
Embodiment 2: 40 parts of Folium Eriobotryaes, 40 parts of Rhizoma Atractylodis, 40 parts of Radix Scutellariaes, 40 parts of Flos Loniceraes, Radix Salviae Miltiorrhizae 40.
Pulverize above medicine, cross 60 mesh sieves, through 110 ℃ of sterilization treatment 15 minutes, fill promptly became medicine of the present invention in capsule to the medicated powder that screening is good, is grown up each 6, every day 3 times again.。
Embodiment 3: 35 parts of Folium Eriobotryaes, 30 parts of Rhizoma Atractylodis, 35 parts of Radix Scutellariaes, 35 parts of Flos Loniceraes, Radix Salviae Miltiorrhizae 35.
Pulverize above medicine, cross 60 mesh sieves, through 110 ℃ of sterilization treatment 15 minutes, fill promptly became medicine of the present invention in capsule to the medicated powder that screening is good, is grown up each 6, every day 3 times again.
Embodiment 4: 30 parts of Folium Eriobotryaes, 30 parts of Rhizoma Atractylodis, 30 parts of Radix Scutellariaes, 30 parts of Flos Loniceraes, Radix Salviae Miltiorrhizae 30.
Pulverize above medicine, cross 60 mesh sieves, through 100 ℃ of sterilization treatment 30 minutes, fill promptly became medicine of the present invention in capsule to the medicated powder that screening is good again, and each 6, every day 3 times.
Claims (2)
1. a composition of medicine of treating acne is characterized in that: composed of the following components by weight: Folium Eriobotryae 30-40 part, Rhizoma Atractylodis 20-40 part, Radix Scutellariae 30-40 part, Flos Lonicerae 30-40 part, Radix Salviae Miltiorrhizae 30-40 part.
2. a kind of composition of medicine of treating acne according to claim 1 is characterized in that: 30 parts of Folium Eriobotryaes, 30 parts of Rhizoma Atractylodis, 30 parts of Radix Scutellariaes, 30 parts of Flos Loniceraes, 30 parts of Radix Salviae Miltiorrhizaes.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101224287A (en) * | 2007-12-27 | 2008-07-23 | 佟家勇 | Oral administration Chinese traditional medicine for treating acne and preparing method thereof |
| CN101642546A (en) * | 2009-06-14 | 2010-02-10 | 李承平 | Chinese patent medicine for eliminating toxin and beautifying faces |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101224287A (en) * | 2007-12-27 | 2008-07-23 | 佟家勇 | Oral administration Chinese traditional medicine for treating acne and preparing method thereof |
| CN101642546A (en) * | 2009-06-14 | 2010-02-10 | 李承平 | Chinese patent medicine for eliminating toxin and beautifying faces |
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