CN102227223A - Mineral absorption improver, and method for improving absorption of minerals - Google Patents
Mineral absorption improver, and method for improving absorption of minerals Download PDFInfo
- Publication number
- CN102227223A CN102227223A CN2009801476120A CN200980147612A CN102227223A CN 102227223 A CN102227223 A CN 102227223A CN 2009801476120 A CN2009801476120 A CN 2009801476120A CN 200980147612 A CN200980147612 A CN 200980147612A CN 102227223 A CN102227223 A CN 102227223A
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- Prior art keywords
- mineral
- absorbs
- improving agent
- oligosaccharide
- dairy product
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Abstract
Provided is a mineral absorption improver which has excellent safety and excellent taste, can be ingested for a long period, and can improve the absorption of minerals. The mineral absorption improver comprises an oligosaccharide and a fermented milk product as active ingredients. The mineral absorption improver can improve the absorption of minerals, particularly zinc, by a synergistic effect of the oligosaccharide and the fermented milk product, even though the mineral absorption improver is a composition having a lower oligosaccharide content than those of the conventional mineral absorption improvers. When the mineral absorption improver is prepared using galactooligosaccharide which is a compound hardly decomposed under acidic conditions, as the oligosaccharide, the mineral absorption improver can be added to compositions such as acidic foods and pharmaceutical preparations.
Description
Technical field
The present invention relates to contain that oligosaccharide and fermented dairy product absorb improving agent as the mineral of effective ingredient and mineral absorbs the improvement method.
Background technology
Now, in Japan, the people that the intake of mineral does not reach average requirement is very many.By inference, there is 30～40% Japanese particularly not reach average requirement (non-patent literature 1) for the intake of zinc.And, in recent years, pointed out the potential zinc deficiency patient of Japan very many, the improvement of the nutritional status of zinc begin to come into one's own (non-patent literature 2).As zinc deficiency, known hypoevolutism and unusual, sexual dysfunction, anemia, immunodeficiency, dermatosis, diarrhoea, wound healing are slow, the generation of decubital ulcer and cure slow, inappetence and go down, (non-patent literatures 2) such as dysgeusias, glossodynia, impaired glucose tolerance.It is believed that,, importantly increase the absorbance of zinc intake and increase zinc for the prevention and the improvement of zinc deficiency.On the other hand, the picked-up of known a large amount of zinc hinders the usability (non-patent literature 3) of trace element such as copper.Therefore think,, more preferably increase the absorbance of zinc in order to improve the nutritional status of zinc.
Known, indigestibility saccharides such as oligofructose, inulin, oligomeric galactose make the absorbance of mineral increase (patent documentation 1～6, non-patent literature 4).For example, the supply of the mineral of known oligomeric galactose after to stomach resecting operation is useful (patent documentation 3).
Exist and use the zinc absorption to improve the report that material increases the absorbance of zinc, but the negligible amounts of such report.For example, it is reported, increase as the mixture (non-patent literature 6) of oligofructose (non-patent literature 5), oligofructose and the inulin of indigestibility saccharide, the absorbance that inulin (non-patent literature 7) makes zinc respectively.But, it is big that mineral when these zinc absorb the dosage of improving materials than the absorbance that improves calcium etc. absorbs the dosage of improving material, and these zinc absorptions improve the content of material in the feedstuff of picked-up media such as food compositions and are respectively 10 quality %, 10 quality %, 7.5 quality %.And, reported the absorption to zinc when being lower than this dosage do not exert an influence (non-patent literature 8).And,, do not make the report of the absorption increase of zinc about oligomeric galactose.For indigestibility saccharides such as oligosaccharide, the increase of concomitant dosing amount, the incidence rate of gastrointestinal symptoms such as diarrhoea increases ( non-patent literature 9,10).Therefore think it is desirable to, promote the effect of mineral absorptions such as zinc with less dosage performance.
In addition, existing report, oligofructose can be at hydrolysis under the highly acid (non-patent literatures 11), and oligomeric galactose has under acid condition and heating condition under be difficult to produce the character (non-patent literature 12) of the decay due to decomposing etc.
It is reported,, can enumerate (non-patent literature 13 and non-patent literatures 14) such as trophic factors such as the intake of its mineral itself and dissolubility and other mineral, vitamin, protein as influencing the factor that mineral absorbs.
The prior art document
Patent documentation
Patent documentation 1: Japanese kokai publication hei 4-134031 communique
Patent documentation 2: Japanese kokai publication hei 7-069902 communique
Patent documentation 3:WO98/015196 communique
Patent documentation 4: No. 3933702 communique of Japan Patent
Patent documentation 5: No. 3279695 communique of Japan Patent
Patent documentation 6: No. 3179090 communique of Japan Patent
Non-patent literature
Non-patent literature 1: be Chuan Jia then, the 1st Knitting ミ ネ ラ Le base Foundation know Knowledge, the 2nd chapter ミ ネ ラ Le necessary amount と feeding amount of getting-national health Sakae Raising Tone Check To ょ Ru investigate-, the up-to-date ying of in ミ ネ ラ Le science と with skill Intraoperative (investigation of the rudimentary knowledge of the 1st mineral, the necessary amount of the 2nd chapter mineral and intake-national health and nutritional survey-, in science and the more recent application technology of mineral), CMC publish, the chief editor: a Chuan Jia then, pp.12-20 (2008)
Non-patent literature 2:storehouse Ze Longping, of a specified duration hole Zhou Zhilang, the 2nd Knitting feeding amount of getting To Seki The Ru Ask Questions, the 2nd chapter Pro bed Now Games To ぉ け Ru ミ ネ ラ Le (Ami ) feeding get Ask Questions point, the up-to-date ying of in ミ ネ ラ Le science と with skill Intraoperative (problem of the problem of the 2nd relevant intake, the clinical mineral of the 2nd chapter (zinc) picked-up, in science and the more recent application technology of mineral), CMC publication, edit:be Chuan Jia then, pp.48-61 (2008)
Non-patent literature 3:O ' Dell BL., Mineral interactions relevant tonutrient requirements.J Nutr.119 (12 Suppl), pp.1832-1838 (1989)
Non-patent literature 4:Zafar TA, Weaver CM, Zhao Y, Martin BR, Wastney ME., Nondigestible oligosaccharides increase calcium absorption and suppress bone resorption in ovariecto
Non-patent literature 5:Delzenne N, Aertssens J, Verplaetse H, Roccaro M, Roberfroid M., Effect of fermentable fructo-oligosaccharides onmineral, nitrogen and energy digestive balance in the rat., Life Sci., 57 (17), pp.1579-1587 (1995)
Non-patent literature 6:Raschka L, Daniel H., Diet composition andage determine the effects of inulin-type fructans on intestinal calcium absorption in rat., Eur J Nutr., 44 (6), pp.360-364 (2005)
Non-patent literature 7:Coudray C, Feillet-Coudray C, Gueux E, Mazur A, Rayssiguier Y., Dietary inulin intake and age can affect intestinal absorption of zinc and copper in rats., J Nutr., 136 (1), pp.117-122 (2006)
Non-patent literature 8:Wolf BW, Firkins JL, Zhang X., Varyingdietary concentrations of fructooligosaccharides affect apparent absorption and balance of minerals in growing rats., Nutr Res., 18 (10), pp.1791-1806 (1998)
Non-patent literature 9:Hata Y, Nakajima K., Studies onrelationship between intake of fructooligosaccharides and abdominal symptoms-Estimation of the maximum non-effective dose and 50 % laxative effective dose., Geriatric Medicine., 23 (5), pp.817-828 (1985)
Non-patent literature 10:Marteau P, Flourie B.Tolerance tolow-digestible carbohydrates:symptomatology and methods.Br J Nutr.85 (Suppl 1) pp.S17-21 (2001)
Non-patent literature 11:Atsuko NAKAMURA, Off Le Network ト ォ リ go sugar The changes (used the sweet and sour pork of oligofructose or the dish that boils in sugared variation), university of Tokyo housekeeping institute summary, 43, pp.49-53 (2003) with In sugar in the ぃ jealous woman globefish ゃ Stewed Dish
Non-patent literature 12: the pool go into refined people, ガ ラ Network ト ォ リ ゴ Tang Machine can と food へ ying with (function of oligomeric galactose and in Application in Food), FOOD STYLE 21,2, pp.76-78 (1998)
Non-patent literature 13:Lonnerdal B, Dietary factors influencing zinc absorption, J Nutr, 130, pp.1378S-1383S (2000)
Non-patent literature 14:Sandstrom B, Micronutrient interactions:effects on absorption and bioavailability, Br JNutr, 85, pp.181S-185S (2001)
Summary of the invention
Invent problem to be solved
The object of the present invention is to provide mineral to absorb improving agent and mineral absorption improvement method, its content in the solid constituent total amount of this picked-up medium when using with the form of picked-up media such as food compositions, pharmaceutical composition is lower than in the past although described mineral absorbs improving agent, also can bring into play mineral and absorb facilitation effect.
The means of dealing with problems and being adopted
The inventor finds, absorbs improving agent by containing oligosaccharide and fermented dairy product as the mineral of effective ingredient, the above-mentioned purpose of attainable cost invention, thus finished the present invention.
That is, the invention provides following [1]～[15].
[1] a kind of mineral absorbs improving agent, and it contains oligosaccharide and fermented dairy product as effective ingredient.
[2] absorb improving agent as above-mentioned [1] described mineral, wherein, described oligosaccharide is to contain galactose as the oligosaccharide that constitutes sugar.
[3] absorb improving agent as above-mentioned [2] described mineral, wherein, containing described galactose is oligomeric galactose as the oligosaccharide that constitutes sugar.
[4] each the described mineral as above-mentioned [1]～[3] absorbs improving agent, and wherein, described fermented dairy product is to utilize lactobacillus that belongs to Lactobacillus and the lactobacillus that belongs to Streptococcus that the milk fermentation is obtained.
[5] each the described mineral as above-mentioned [1]～[4] absorbs improving agent, and wherein, described fermented dairy product is non-ripening cheese.
[6] each the described mineral as above-mentioned [1]～[5] absorbs improving agent, is zinc as the mineral that absorbs the object that improves.
[7] each the described mineral as above-mentioned [1]～[6] absorbs improving agent, and wherein, this mineral absorbs improving agent and further contains zinc.
[8] each the described mineral as above-mentioned [1]～[7] absorbs improving agent, and it is a food compositions.
[9] each the described mineral as above-mentioned [1]～[7] absorbs improving agent, and it is a pharmaceutical composition.
[10] each the described mineral as above-mentioned [1]～[9] absorbs improving agent, wherein, the content of described oligosaccharide in the solid constituent total amount of described mineral absorption improving agent is 1.0～7.0 quality %, and the mass ratio of described fermented dairy product/described oligosaccharide (solid constituent scaled value) is 1.0～49.0.
[11] absorb improving agent as above-mentioned [10] described mineral, wherein, the mass ratio of described fermented dairy product/above-mentioned oligosaccharide (solid constituent scaled value) is 1.0～30.0.
[12] absorb improving agent as above-mentioned [11] described mineral, wherein, the mass ratio of described fermented dairy product/described oligosaccharide (solid constituent scaled value) is 1.0～9.0.
[13] absorb improving agent as above-mentioned [12] described mineral, wherein, the mass ratio of described fermented dairy product/described oligosaccharide (solid constituent scaled value) is 3.0～8.0.
[14] each the described mineral as above-mentioned [1]～[13] absorbs improving agent, and it is used to improve gastric acid secretion minimizing person's mineral absorption.
[15] a kind of mineral absorbs the improvement method, wherein, makes the people absorb oligosaccharide and fermented dairy product simultaneously.
The invention effect
Mineral of the present invention absorbs the cooperative effect of improving agent by oligosaccharide and fermented dairy product, can bring into play the effect of the absorption that promotes mineral, particularly zinc.
More particularly, mineral of the present invention absorbs improving agent when using with the form of picked-up media such as food compositions, pharmaceutical composition, even determine its content in the solid constituent total amount of this picked-up medium to be lower than the content of prior art, it is below the 7.0 quality % that mineral for example of the present invention absorbs improving agent, also can bring into play mineral and absorb facilitation effect.
And mineral of the present invention absorbs improving agent owing to only contain by the secular diet experience of the mankind and confirm to have the oligosaccharide of the excellent security and the sense of taste and fermented dairy product as neccessary composition, so there is not the problem of side effect, can absorb for a long time.
And then, mineral of the present invention absorbs improving agent, can be used with the form of tart food compositions or pharmaceutical composition during as oligosaccharide at the oligosaccharide of the character of the decay due to use has the decomposition that is difficult for being created under the acid condition etc., for example oligomeric galactose.
The accompanying drawing simple declaration
Fig. 1 is that expression is combined with the curve chart of the feedstuff of oligomeric galactose and fermented dairy product to the influence of apparent zinc absorbance (meansigma methods ± standard deviations of the one group 8) generation of rat.
The specific embodiment
Use oligosaccharide to prepare mineral absorption improving agent of the present invention as the part that mineral absorbs improving agent.
In the present invention, oligosaccharide is also referred to as oligosaccharide, is meant that 2～20 sugar carry out the chemical compound that glycoside link forms.As oligosaccharide, can enumerate for example oligomeric lactose, oligomeric isomaltose, oligofructose, oligomeric galactose, oligomeric xylose, soybean oligo saccharide, ニ ゲ ロ ォ リ go sugar (Nigerooligosaccharide), oligomeric dragon gallbladder sugar, lactose, sucrose, maltose, trehalose, palatinose (palatinose) etc., but be not limited to these examples.When mineral absorption improving agent of the present invention was acid, preferred use had difficult generation and decomposes the oligosaccharide of the character of the decay due to waiting.
In the present invention, also can use and contain galactose as the oligosaccharide that constitutes sugar.Constitute the oligosaccharide that comprises galactose in the sugar and be meant that 2～20 sugar carry out chemical compound that glycoside link forms, comprise one or more galactose in the sugar that constitutes chemical compound.As its example, can enumerate raffinose family oligosaccharide (soybean oligo saccharide), oligomeric galactose etc.In the present invention, oligomeric galactose is meant and contains the oligosaccharide of galactose as main formation sugar.With lactose (Gal (β 1-4) Glc) be basic structure and have bonding thereon have the structure of 1～several galactose residues oligosaccharide, have disaccharides (transfer disaccharides), Gal-(Gal) n-Glc (n=1～18), Gal-(Gal) n-Gal (n=1～18) of galactose and glucose to be also contained in the example of oligomeric galactose with mode bondings such as β-1,3 bondings.As an example of the industrially preparing process of oligomeric galactose, can enumerate the beta galactosidase (being mainly derived from Cryptococcus laurentii (Cryptococcus laurentii), Bacillus circulans microorganisms such as (Bacillus circulans) etc.) that makes the galactose transfer ability high and act on the method that lactose makes (refined people, ガ ラ Network ト ォ リ ゴ Tang Machine are gone in the pool can と food へ ying usefulness, FOOD STYLE 21,2, pp.76-78 (1998)).And, in the specification benchmark of specific food for health care (specification reference model) system, oligomeric galactose is defined as by beta galactosidase (derives from β-D-galactoside galactohydrolase (β-D-galactoside galactohydrolase), E.C.3.2.1.23, the Cryptococcus yeast) effect is generated by lactose, glycoside link has one or more galactose on the galactose residue of lactose, with 4 '-galactosyl lactose (Gal (β 1-4) Gal (β 1-4) Glc) is oligosaccharide (the food peace on July 1st, the 2005 No. 0701007 food safety minister of medicine food office of MHLW notice of main constituent, " setting of the specification benchmark of following about the establishment of specific food for health care (specification reference model) system etc. ").Oligomeric galactose is contained in the breast milk, has the effect of the lactobacillus bifidus that increases enteral, and is known as the sugar that is difficult to digest and assimilate.
Use fermented dairy product to prepare mineral absorption improving agent of the present invention as the part that mineral absorbs improving agent.
The fermented dairy product that uses among the present invention is meant that leavens such as using lactobacillus makes the liquid milk fermentation and whole milk product of obtaining, and described liquid milk is with the combination more than a kind or 2 kinds in domestic animals such as milk, buffalo milk, Goat Milk, sheep milk, horse milk milk and/or these partially skimmed milk, defatted milk, recombined milk, reduction defatted milk, reduction partially skimmed milk, milk surum, casein, defatted milk powder, Lactalbumin concentrate (WPC), lactalbumin isolate (WPI), butter, buttermilk, the milk wet goods milk material and synthetic.For example cheese, natural cheese, yoghourt, fermented milk, milk surum (whey) fermented product, zieger etc. are included in the fermented dairy product used in the present invention.
And, as the cheese of fermented dairy product be meant liquid milk fermented after, add enzyme or add acid, from the curdled milk that forms thus, remove the material after the milk surum, described liquid milk be with in milk, partially skimmed milk, defatted milk, recombined milk, reduction defatted milk, reduction partially skimmed milk, milk surum, casein, defatted milk powder, Lactalbumin concentrate (WPC), lactalbumin isolate (WPI), butter, buttermilk or the milk wet goods milk material make up more than a kind or 2 kinds and synthetic.In the present invention, cheese can use the cheese of solid state and any of cheese of solid state not.And, in the present invention cheese can use (the ripening cheese) of ripening and do not have ripening (non-ripening cheese) any.
As the fermentation leaven that is used to make fermented dairy product, mainly can use the lactobacillus that belongs to lactobacillus (Lactobacillus) genus, streptococcus (Streptococcus) genus, Lactococcus (Lactococcus) genus, leukonid (Leuconostoc) genus, pediococci (Pediococcus) genus etc.But, be not limited to these, for example can use Streptococcus lactis (Lister) Lohnis 1909.554. (Streptococcus lactis), Streptococcus cremoris (Streptococcus cremoris), biacetyl streptococcus acidi lactici (Streptococcus diacetylactis), enterococcus faecalis (Enterococcus faecium), enterococcus faecalis (Enterococcus faecalis), bacillus acidophilus (Lactobacillus acidophilus), Lactobacillus brevis (Lactobacillus brevis), lactobacillus casei (Lactobacillus casei), lactobacillus helveticus (Lactobacillus helveticus), lactobacillus delbruockii subspecies bulgaricus (Lactobacillus delbrueckii subsp.Bulgaricus), Deshi Lactobacillus lactic acid subspecies (Lactobacillus delbrueckii subsp.lactis), Lactobacillus gasseri (Lactobacillus gasseri), mucosa lactobacillus (Lactobacillus mucosae), Lactobacillus murinus (Lactobacillus murinus), Lactobacillus plantarum (Lactobacillus plantarum), oral cavity lactobacillus (Lactobacillus oris), Lactobacillus reuteri (Lactobacillus reuteri), lactobacillus rhamnosus (lactobacillus such as Lactobacillus rhamnosus, bifidobacterium longum (Bifidobacterium longum), bifidobacterium (Bifidobacterium bifidum), bifidobacterium breve lactobacillus bifiduses such as (Bifidobacterium breve).In addition, these bacterium and the bacterium that the bacterium (Propionibacterium) etc. that belongs to propionibacterium is generally used for the manufacturing of fermented dairy product can be share.
In the present invention, these leavens can use a kind or make up more than 2 kinds and to use.
Mineral of the present invention absorbs improving agent so long as fermented dairy product just can use any to prepare.Fermented dairy product is preferably non-ripening cheese (fresh cheese) or yoghourt.
The general autofrettage of non-ripening cheese below is described.With standardization such as raw material milk, bactofugation, homogenize, after the heat treated, carry out curdled milk manufacturing (leaven inoculation, Chymosin interpolation etc.).And then, carry out milk surum and separate (heating, curdled milk cutting, centrifugalize, membrance separation etc.), can obtain final curdled milk as non-ripening cheese.For example, with the defatted milk pasteurization, with respect to defatted milk (100 quality %) be 0.5～5 quality % amount inoculating lactic acid bacterium leavening agent (for example belong to Lactobacillus lactobacillus, belong to the lactobacillus of Streptococcus etc.), make its fermentation.Thereafter, with pH reach 4.6 and the curdled milk that forms with cheese seperator (quark separator) centrifugal separator of etc.ing, sepg whey cools off resulting curdled milk.Thus, can access non-ripening cheese.
One example of the composition (mass unit) of the non-ripening cheese that obtains like this is, total solid composition 17～19%, protein 11～13%, fat below 1%, carbohydrate 2～8%, lactose are below 2%.
In addition, use Chymosin to solidify and the curdled milk that obtains also belongs to non-ripening cheese of the present invention.
Behind the defatted milk pasteurization, use the bacterium belong to Lactococcus also to can be used as non-ripening cheese of the present invention as the lactobacillus leaven fermented dairy product (cheese (quark) etc.) that forms that ferments.
And, also the mixed culture that belongs to the lactis bacterium and the cremoris bacterium of Lactococcus and belong to the strain of Leuconostoc can be added in the defatted milk, after the cultivation, remove milk surum, make non-ripening cheese.
And, the curdled milk that will obtain by fermentation with cutter cuts after, heating is sepg whey down, resulting non-ripening cheese also can use in the present invention.
As the absorption approach of the mineral that absorbs, known cellular pathways (transcellular pathway) and the paracellular pathway (paracellular pathway) worn.For example under the situation of zinc, mainly absorb at duodenum and jejunum.At the intraluminal zinc of small intestinal is under the condition of low concentration, and the absorbing activity of wearing cellular pathways (transcellular pathway) increases.The intraluminal zinc of small intestinal is under the condition of high concentration, we can say the help of paracellular pathway (paracellular pathway) big.And, pointed out ileum and colon also can absorb zinc (long Tian Changshi, Ami -biological meaning Righteousness, must Shall, そ て food To ぉ け Ru ying is with (zinc-biological meaning, essential and in Application in Food), chemical と biology (chemistry is with biological), 46, pp.629-635 (2008); With Cousins RJ, the up-to-date Sakae Raising of the 35:Ami in Graduate Door Collar up-to-date feelings Reported in territory learns (zinc is the up-to-date threpsology of the up-to-date information of specialized field) the 9th edition, translation chief editor:the Kimura repaiies one, the holt equating, build silks society, pp.443-455 (2007)) .Mineral of the present invention absorbs improving agent and is not limited to above-mentioned various mechanism, has to improve the effect that mineral absorbs.
Mineral of the present invention absorbs the effect that improving agent has the absorption that improves zinc.Therefore, can be used to prevent and/or treat that hypoevolutism and unusual, sexual dysfunction, anemia, immunodeficiency, dermatosis, diarrhoea, wound healing are slow, the generation of decubital ulcer and cure slow, inappetence and go down, zinc deficiencys such as dysgeusia, glossodynia, impaired glucose tolerance.Mineral of the present invention absorbs improving agent except being used for healthy people, can also excise the patient with people, the stomach of taking gastric acid nertralizer (sodium bicarbonate, gel aluminum hydroxide and magnesium hydroxide compounding ingredient etc.) or gastric acid secretion depressant (proton pump inhibitor, H2 blocker etc.) etc. or the such gastric acid secretion minimizing person of person etc. at advanced age is the administration object.And then mineral of the present invention absorbs improving agent also can be used utilizing feeding tube and the people who accepts enteral nutrition.
Mineral of the present invention absorbs improving agent by fermented dairy product and oligosaccharide are made up the cooperative effect of bringing into play these two kinds of materials, can be to be lower than the absorption of amount (content in the solid constituent total amount) the promotion zinc of the dosage of the indigestibility saccharide (oligosaccharide etc.) of the promotion zinc absorption of report in the past.Therefore, follow the picked-up of a large amount of indigestibility saccharides and to produce the probability of gastrointestinal symptoms such as diarrhoea low.And to block the probability that other mineral such as copper absorb also low because of absorbing excessive zinc.
It is to have the empirical material of secular diet concerning the mankind that mineral of the present invention absorbs the oligosaccharide and the fermented dairy product that contain as effective ingredient in the improving agent, no problem on the sense of taste, safe, so can absorb for a long time.
Mineral of the present invention absorbs improving agent usually as oligosaccharide, fermented dairy product and other any mixture of ingredients preparations, but also can be prepared into other forms, for example separately is prepared into preparation that contains oligosaccharide and the preparation that contains fermented dairy product.When separately being prepared into the preparation that contains oligosaccharide and containing the preparation of fermented dairy product, preferably take the photograph taker and absorb preparation that contains oligosaccharide and the preparation that contains fermented dairy product simultaneously.
Mineral of the present invention absorbs improving agent and can utilize with arbitrary form of food compositions (diet product) and pharmaceutical composition (pharmaceuticals).For example, by as the direct administration of pharmaceutical composition, or directly absorb, can expect to improve the absorption of mineral as food compositions such as special purposes food such as specific food for health care or trophic function food.And mineral of the present invention absorbs improving agent also can be with arbitrary form utilization of liquid state, pasty state, gel, solid-state (for example powder, tablet etc.).
In the present invention, as food compositions, can enumerate milk for example, cold drink, fermented milk, yoghourt, cheese, bread, cookies, cracker, pizza, formula milk, liquid food, patient with food, nutraceutical, frozen food, food compositions, processed food, other delicatessen food etc.
When using mineral of the present invention to absorb improving agent with the form of tart pharmaceutical composition or food compositions, its pH is preferably pH2.0～pH6.0, pH3.0～pH5.0 more preferably.
Mineral of the present invention absorbs improving agent can contain water, protein, saccharic, lipid, vitamins, minerals, organic acid, organic base, fruit juice, flavoring agent class etc.
As protein, for example can enumerate various newborn derived components such as of animal or plant nature protein such as whole milk powder, defatted milk powder, partially skimmed milk powder, casein, whey powder, whey protein, whey protein concentrate, whey protein sepd, alpha-casein, beta-casein, κ-casein, beta lactoglobulin, lactoferrin, soybean protein, egg protein, meat protein or their analyte, butter, whey mineral, butter, milk surum, non-protein nitrogen, sialic acid, phospholipid, lactose etc.
Protein also can contain peptide or aminoacid such as phosphopeptide caseinate, arginine, lysine.
As saccharic, can enumerate for example saccharide, producing starch (dextrin (maltodextrin, difficult digestion dextrin etc.) and soluble starch, Britain starch (British starch), Oxytarch, starch ester, starch ether etc.), dietary fiber etc.
As lipid, can enumerate for example Adeps Sus domestica, fish oil etc., their distillate oil, hydrogenated oil and fat, ester exchange wet goods animal raw fat; Petiolus Trachycarpi oil, safflower oil, Semen Maydis oil, Oleum Brassicae campestris, Oleum Cocois, their distillate oil, hydrogenated oil and fat, ester exchange wet goods vegetative grease etc.
As vitamins, can enumerate for example vitamin A, carotenoid, vitamin B complex, vitamin C, vitamin D family, vitamin E, vitamin K family, Citrin, vitamin Q, nicotinic acid (niacin), nicotinic acid, pantothenic acid, biotin, inositol, choline, folic acid etc.
As minerals, can enumerate for example calcium, phosphorus, potassium, chlorine, magnesium, sodium, copper, ferrum, manganese, zinc, selenium, chromium, molybdenum etc.
Wherein, preferred zinc, this be because, even do not absorb zinciferous other food simultaneously, only absorb mineral of the present invention and absorb improving agent, just can absorb for the enough zinc of organism.
As organic acid, can enumerate for example malic acid, citric acid, lactic acid, tartaric acid etc.
Mineral of the present invention absorbs improving agent can and derive from the goods of natural goods any for composite.
When mineral of the present invention is absorbed improving agent as pharmaceutical composition, can be with various form administrations.As its form, for example can enumerate oral administration based on tablet, capsule, granule, powder, syrup etc.Also can be processed into preparations such as injection, liquid preparation, by other administration form administrations such as feeding tube feeding, enteral nutrition.For these various preparations, can use usually available known adjuvant in the pharmaceutical preparations technology field and preparationization in host according to conventional method, described adjuvant is excipient, binding agent, disintegrating agent, lubricant, flavoring agent, cosolvent, suspending agent, coating materials, solvent, isotonic agent etc.And, also can contain an amount of calcium.And then, also can add an amount of vitamin, mineral, organic acid, saccharide, aminoacid, peptide class etc.
The concentration that mineral of the present invention absorbs the oligosaccharide that is contained in the solid constituent total amount (100 quality %) of improving agent be preferably 1.0～7.0 quality %, more preferably 1.5～6.5 quality %, more preferably 2.5～6.0 quality %, be preferably 4.0～6.0 quality % especially.
The concentration that mineral of the present invention absorbs the fermented dairy product that is contained in the solid constituent total amount (100 quality %) of improving agent be preferably 5.0～98 quality %, more preferably 10～98 quality %, more preferably 15～98 quality %, be preferably 18～96 quality % especially.
Need to prove, in this description, only otherwise special declaration, the quality of solid constituent just means dried quality (comprising liquid greasy quality) under 20 ℃ the dry atmosphere in exsiccator, and does not mean that the quality of the aqueous solid composition that powder feed is such.
The administration (picked-up) of oligosaccharide that absorbs the effective ingredient of improving agent as mineral of the present invention is measured per 1 day every 1kg body weight and is preferably 0.05mg～2g, more preferably 0.5mg～1g, 5mg～0.2g more preferably in solid component content.
The administration (picked-up) of fermented dairy product that absorbs the effective ingredient of improving agent as mineral of the present invention is measured per 1 day every 1kg body weight and is preferably 1mg～10g, more preferably 10mg～5g, 50mg～2.5g more preferably in solid component content.
Absorb as mineral of the present invention improving agent effective ingredient oligosaccharide to dosage every day of people in solid component content be preferably 0.01g～15g, more preferably 0.1g～10g, be preferably 1g～8g especially.
Absorb as mineral of the present invention improving agent effective ingredient fermented dairy product to dosage every day of people in solid component content be preferably 0.1g～500g, more preferably 1g～250g, be preferably 2.5g～150g especially.
To needing mineral of the present invention to absorb the people of the treatment of improving agent, aptly in ante cibum, after meal, between meal and/or before sleeping once or the gradation administration.Dosage is independently determined according to patient's age, body weight and the administration purpose of administration.Dosage not necessarily is limited in the above-mentioned numerical range.
In the present invention, the mass ratio of fermented dairy product/oligosaccharide (solid constituent scaled value) is preferably 1.0～49.0, more preferably 1.0～30.0, more preferably 1.0～9.0, is preferably 3.0～8.0 especially.
Absorb improving agent at mineral of the present invention and contain under the situation of zinc, mineral absorb the zinc concentration that is contained in the solid constituent total amount (100 quality %) of improving agent when considering the intake of the desirable zinc of people, be preferably 0.01～1.0 quality %, more preferably 0.01～0.8 quality %, be preferably 0.1～0.6 quality % especially.
Need to prove that the content of whole prior art document records of being quoted in this description is included in this description by reference.
Embodiment
Below, the present invention will be described to enumerate embodiment, but the invention is not restricted to these embodiment.
[embodiment 1] (effect that gives zinc is absorbed generation of fermented dairy product and oligosaccharide)
Present embodiment checked fermented dairy product and oligomeric galactose (below be also referred to as GOS) give zinc is absorbed the influence that produces.
(preparation of fermented dairy product)
Make non-ripening cheese according to conventional method.Specifically, after the defatted milk powder sterilization, ferment, and then add Chymosin with lactobacillus that belongs to Lactobacillus and the lactobacillus that belongs to Streptococcus.And then, with formed curdled milk cutting, carry out centrifugalize and handle, the precipitate (non-ripening cheese) that obtains is supplied in test as fermented dairy product.
(animal experiment method)
56 of the male SD rats in 3 ages in week are divided into following 5 groups (n=8) so that average weight homogeneous (about 47g).
(a) health+casein feedstuff is organized [matched group]
(b) gastric acid minimizing+casein feedstuff is organized [casein group]
(c) gastric acid minimizing+5.0 quality %GOS cooperate the casein feedstuff to organize [casein G group]
(d) gastric acid minimizing+fermented dairy product feedstuff is organized [fermented dairy product group]
(e) gastric acid minimizing+5.0 quality %GOS cooperate the fermented dairy product feedstuff to organize [fermented dairy product G group]
Each group to (a)～(e) gives each test feed 9 days (day1～9), freely absorbs.Wherein, the casein feedstuff is common AlN-93G to be carried out part change and the feedstuff of preparation.The fermented dairy product feedstuff is to cooperate fermented dairy product to replace casein so that the protein content feedstuff (table 1) identical with the casein feedstuff.And 5.0 quality %GOS mixed feeds are to cooperate 5.0 quality %GOS and the feedstuff (table 1) that obtains in feedstuff 100 quality %.Need to prove, adjust the content identical (table 1) in whole feedstuffs of calcium, phosphorus, magnesium, ferrum, zinc, copper.
For gastric acid minimizing group (above-mentioned (b)～(e)), from the 5th day on-test to off-test (day5～9) 7:00 every day, twice subcutaneous administration proton pump inhibitor of 19:00 (PPI, gastric acid secretion inhibitor) Omepral (below be also referred to as OM, omeprazole sodium injection, AstraZeneca Co., Ltd. make), dosage is 20mg/kg (body weight) (OM concentration: 4mg/ml, administration volume: 5ml/kg (body weight)), makes the gastric acid secretion continuous decrease.To health group (above-mentioned (a)), with the normal saline 5ml/kg (body weight) of the same process subcutaneous administration of the PPI administration of gastric acid minimizing group as the solvent of OM.From second day (day6) of beginning PPI administration, use metabolic cage to carry out (day6～9) energy balance test in 4 days, by each individual full excrement that reclaims whole rats.The mensuration that the excrement of gathering is used for the excretion of zinc.And, from second day (day6) of beginning PPI administration, to the feed intake of each body measurement 4 days (day6～9).Calculate the zinc intake by 4 days feed intakes, calculate the apparent absorbance (quality %) of each individual zinc with following formula.
The apparent absorbance (%) of zinc=(zinc excretion in zinc intake-excrement) * 100/ (zinc intake)
Need to prove,, make rat freely absorb ion exchange water at whole duration of test.And the average feed intake of every day is about 114g/kg (body weight), and the average weight at initial stage on-test (day2) is 57g, and the average weight of (day9) is 110g during off-test.Do not observe the difference that has feed intake, body weight between each group.
[table 1]
Table 1 has provided the composition of feedstuff used among the embodiment 1.In the table 1, mineral mixture uses to be removed calcium source, phosphorus source, the magnesium source of AlN-93G mineral mixture and replaces with mineral mixture after the sucrose.The vitamin compound uses AlN-93 vitamin compound.Cup-oligo (trade name, NISSIN CUP society make, oligomeric galactose content: 73 quality %, " Cup-oligo " are registered trade mark) is to contain the goods of oligomeric galactose as main constituent, contains with several compositions headed by 4 '-galactosyl lactose (Gal-(Gal) n-Glc, Gal-(Gal) n-Gal (n=1～3, β bonding)).The proportioning of mineral mixture used among the embodiment 1 and vitamin compound is listed in table 2 and table 3.
[table 2]
Mineral mixture
The use level of every 1000g
[table 3]
The vitamin compound
The use level of every 1000g
Need to prove, AlN-93G mineral mixture and AlN-93 vitamin compound are the standard refined feedstuffs that the nutrient research of the mice of being delivered in 1993 by U.S.'s National Nutrition Research Institute (AlN) and rat is used, and are meant the vitamin compound and the mineral mixture that are engaged in the AlN-93G that is used for growth stage, trimester of pregnancy, age of sucking.
(result)
(a) the apparent absorbance of the zinc between matched group and (b) casein group is identical.Think that by this result the gastric acid secretion due to the PPI administration reduces the almost not influence (Fig. 1) of apparent zinc absorbance.And, compare with other groups, (e) the apparent zinc absorbance of fermented dairy product G group shows obviously (p＜0.05, Tukey-Kramer multiple check) high value, and is relative therewith, (c) casein G group is compared with (d) fermented dairy product group with (b) casein group, does not confirm notable difference.By this result as can be known, even contain the feedstuff of GOS separately, do not have zinc to absorb facilitation yet, but, promoted to concertedness the absorption (Fig. 1) of zinc by itself and fermented dairy product are given simultaneously.
Need to prove that among Fig. 1, literal a, the b of the top of bar diagram represents that notable difference is arranged between different literal (p＜0.05, Tukey-Kramer multiple check).And " w/w% " among Fig. 1 is meant quality %.
Industrial applicibility
Mineral matter of the present invention absorbs improver and can be effective to prevention and/or treat various mineral deficiencies.
Claims (15)
1. a mineral absorbs improving agent, and it contains oligosaccharide and fermented dairy product as effective ingredient.
2. mineral as claimed in claim 1 absorbs improving agent, and wherein, described oligosaccharide is to contain galactose as the oligosaccharide that constitutes sugar.
3. mineral as claimed in claim 2 absorbs improving agent, and wherein, the described galactose that contains is an oligomeric galactose as the oligosaccharide that constitutes sugar.
4. each the described mineral as claim 1～3 absorbs improving agent, and wherein, described fermented dairy product is to utilize lactobacillus that belongs to Lactobacillus and the lactobacillus that belongs to Streptococcus that the milk fermentation is obtained.
5. each the described mineral as claim 1～4 absorbs improving agent, and wherein, described fermented dairy product is non-ripening cheese.
6. each the described mineral as claim 1～5 absorbs improving agent, wherein, is zinc as the mineral that absorbs the object that improves.
7. each the described mineral as claim 1～6 absorbs improving agent, and wherein, this mineral absorbs improving agent and further contains zinc.
8. each the described mineral as claim 1～7 absorbs improving agent, and it is a food compositions.
9. each the described mineral as claim 1～7 absorbs improving agent, and it is a pharmaceutical composition.
10. each the described mineral as claim 1～9 absorbs improving agent, wherein, the content of described oligosaccharide in the solid constituent total amount of described mineral absorption improving agent is 1.0～7.0 quality %, and the mass ratio of described fermented dairy product/described oligosaccharide is 1.0～49.0 by the value that solid constituent converts.
11. mineral as claimed in claim 10 absorbs improving agent, wherein, the mass ratio of described fermented dairy product/described oligosaccharide is 1.0～30.0 by the value that solid constituent converts.
12. mineral as claimed in claim 11 absorbs improving agent, wherein, the mass ratio of described fermented dairy product/described oligosaccharide is 1.0～9.0 by the value that solid constituent converts.
13. mineral as claimed in claim 12 absorbs improving agent, wherein, the mass ratio of described fermented dairy product/described oligosaccharide is 3.0～8.0 by the value that solid constituent converts.
14. each the described mineral as claim 1～13 absorbs improving agent, it is used to improve gastric acid secretion minimizing person's mineral absorption.
15. a mineral absorbs the improvement method, wherein, makes the people absorb oligosaccharide and fermented dairy product simultaneously.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008303517 | 2008-11-28 | ||
| JP2008-303517 | 2008-11-28 | ||
| PCT/JP2009/069930 WO2010061877A1 (en) | 2008-11-28 | 2009-11-26 | Mineral absorption improver, and method for improving absorption of minerals |
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| Publication Number | Publication Date |
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| CN102227223A true CN102227223A (en) | 2011-10-26 |
| CN102227223B CN102227223B (en) | 2013-03-20 |
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| CN2009801476120A Expired - Fee Related CN102227223B (en) | 2008-11-28 | 2009-11-26 | Mineral absorption improver, and method for improving absorption of minerals |
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| Country | Link |
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| JP (1) | JP5971893B2 (en) |
| CN (1) | CN102227223B (en) |
| HK (1) | HK1158060A1 (en) |
| WO (1) | WO2010061877A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105228471A (en) * | 2013-03-22 | 2016-01-06 | N·V·努特里奇亚 | The Nutrious fermented thing with indigestible oligosaccharides that iron bioavailability improves |
| CN105324033A (en) * | 2013-03-22 | 2016-02-10 | N·V·努特里奇亚 | Fermented nutrition high in lactose with increased iron bioavailability |
| TWI692360B (en) * | 2015-01-20 | 2020-05-01 | 日商明治股份有限公司 | Composition for inhibiting phosphorus absorption |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6088821B2 (en) * | 2010-08-19 | 2017-03-01 | 株式会社明治 | Survivability improver for lactic acid bacteria and / or bifidobacteria |
| JP2012192339A (en) * | 2011-03-16 | 2012-10-11 | Denso Corp | Method and apparatus for treating wastewater containing organic matter |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5871842A (en) * | 1981-10-21 | 1983-04-28 | Meiji Milk Prod Co Ltd | Preparation of unaged soft cheese capable of being preserved for a long period |
| JPH09194384A (en) * | 1996-01-19 | 1997-07-29 | Snow Brand Milk Prod Co Ltd | Mineral absorption accelerating agent |
| IL133412A (en) * | 1997-07-05 | 2003-04-10 | Nestle Sa | Composition for improving absorption of minerals by intestinal cells |
-
2009
- 2009-11-26 JP JP2010540500A patent/JP5971893B2/en active Active
- 2009-11-26 WO PCT/JP2009/069930 patent/WO2010061877A1/en active Application Filing
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105228471A (en) * | 2013-03-22 | 2016-01-06 | N·V·努特里奇亚 | The Nutrious fermented thing with indigestible oligosaccharides that iron bioavailability improves |
| CN105324033A (en) * | 2013-03-22 | 2016-02-10 | N·V·努特里奇亚 | Fermented nutrition high in lactose with increased iron bioavailability |
| TWI692360B (en) * | 2015-01-20 | 2020-05-01 | 日商明治股份有限公司 | Composition for inhibiting phosphorus absorption |
Also Published As
| Publication number | Publication date |
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| JPWO2010061877A1 (en) | 2012-04-26 |
| WO2010061877A1 (en) | 2010-06-03 |
| CN102227223B (en) | 2013-03-20 |
| HK1158060A1 (en) | 2012-07-13 |
| JP5971893B2 (en) | 2016-08-17 |
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