CN102225129B - Traditional Chinese medicine composite for treating degenerative osteoarthritis and preparation method thereof - Google Patents
Traditional Chinese medicine composite for treating degenerative osteoarthritis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composite for treating degenerative osteoarthritis, which is characterized by comprising the following materials: 6-7g of caulis spatholobi, 15-17g of ligusticum wallichii, 6-8g of angelica dahurica, 10-11g of ephedra, 11-12g of glossy ganoderma, 6-7g of rhizome homalomenae, 2-3g of drynaria rhizome, 3-5g of rhizoma cibotii, 2-4g of teasel root, 5-6g of angelica sinensis, 5-6g of nux vomica, 2-3g of stephania tetrandra, 9-10g of frankincense, 13-15g of rhizoma corydalis, 9-10g of liquorice, 4-5g of garden balsam stem, 15-16g of ginseng and 18-20g of liquorice. In the invention, the compatibility of the Chinese herbal medicine composite is simple; the medicines in the medicine formula are completely natural herbal medicines; and the traditional Chinese medicine composite is convenient to prepare and use and has the advantages of good administration and treatment effects and low price.
Description
Technical field
The present invention relates to Chinese medicine composition (Shujin bone setting pills capsule) of a kind of treatment of arthritis and preparation method thereof, particularly Chinese medicine composition of a kind of degenerative osteoarthritis and preparation method thereof.
Background technology
Degenerative osteoarthritis is called knee osteoarthritis, hyperplastic osteoarthritis again.Because osteoarthritis is the evolution of a kind of pathology slowly, is representing the aging in joint, mostly clinically is that middle-aged and elderly people is ill, so be called senile osteoarthritis again.Research is thought: in each joint of human body, the joint susceptible disease many with quantity of motion, that loading weight is big is like cervical vertebra, lumbar vertebra, knee joint, hip joint etc.According to relevant bibliographical information, knee osteoarthritis accounts for about 31% of each osteoarthritis of whole body.From the age, 50 years old person have 80% approximately, 60 years old person 90%, person 100% has the pathological manifestations of X line iconography more than 70 years old, only accounts for about 18% but clinical symptoms person occurs.Difference on sex shows as the sickness rate woman and is higher than the man.
The main pathological change of degenerative osteoarthritis is an articular cartilage degeneration, and articular cartilage is to be made up of special dense connective tissue, comprises chondrocyte, collagen fiber, gel-like matrix composition.Wherein gel-like matrix is made up of chondroitin sulfate, cutin sulfate, glycoprotein, salt and water; Collagen fiber normally are three layers of arrangement, and the top layer is made up of the stage casing of collagen fiber, closely arrange, and are parallel with the surface, smooth, and this layer is about 10% of holostrome thickness, and suitable loading surface can be provided.The collagen fiber in middle level are tangential direction to be arranged, and this layer is about 30% of holostrome thickness.Bottom fiber is vertical configuration to be arranged, and is about 60% of holostrome thickness.
Be under pressure down in the joint, the cartilage compressing and stretching produces the effect of mat dispersive pressure, protects subchondral skeleton not to be damaged.Collagen fiber in the cartilage have elastic force, can restore to the original state rapidly.Therefore, the elastic force effect of collagen fiber under young or interrupted pressure, acts on byer force, and buffering effect is also good.But under old or lasting compressing, elastic force weakens, and the extension ability goes down, and prolong recovery time.
This disease mainly occurs in the old people, and present therapeutic modality mainly is: oral diclofenac sodium is perhaps injected methods such as hyaluronic acid.But have bigger side effect, especially oral western medicine can cause serious the intestines and stomach untoward reaction.
Summary of the invention
The purpose of this invention is to provide a kind of: Chinese medicine composition (Shujin bone setting pills capsule) of a kind of degenerative osteoarthritis of treatment that cost, effect are splendid and preparation method thereof.
The technical scheme that solves its technical problem employing is: Chinese medicine composition of the present invention is made up of following materials of weight proportions: Caulis Spatholobi 6-7g, Rhizoma Chuanxiong 15-17g, Radix Angelicae Dahuricae 6-8g, Herba Ephedrae 10-11g, Ganoderma 11-12g, Rhizoma Homalomenae 6-7g, Rhizoma Drynariae 2-3g, Rhizoma Cibotii 3-5g, Radix Dipsaci 2-4g, Radix Angelicae Sinensis 5-6g, Semen Strychni 5-6g, Radix Stephaniae Tetrandrae 2-3g, Olibanum 9-10g, Rhizoma Corydalis 13-15g, Radix Glycyrrhizae 9-10g, Herba speranskiae tuberculatae 4-5g, Radix Ginseng 15-16g, Radix Glycyrrhizae 18-20g.
Said Chinese medicine composition is prepared from according to following method:
Above-mentioned raw materials is mixed,, each 3 hours, use the 1000ml alcohol reflux at every turn with alcohol reflux 2 times; Filter and collect filtrating, be condensed into extractum, add 250ml water, make extractum become suspension; Reuse n-butanol extraction 2 times is concentrated into after each 250ml, extract filter and merge and does the acquisition extract, extract is ground into uniform powder be packed in the Capsules; Fit seals, and packing promptly gets Chinese medicinal capsule granule of the present invention, every 400mg.
Take mode: each one sooner or later of every day, seven days courses of treatment, take 4-5 the course of treatment.
Beneficial effect: the present invention has adopted such scheme, and the material that makes up a prescription in the prescription all uses natural Chinese herbal medicines, adds that then traditional concocting method is made; Material is prone to get; Prescription and method for preparing are simple, and preparation medicine cost has reached the object of the invention.This Chinese herbal medicine compatibility is simple, and employed medicine uses natural herbal fully in the pharmaceutical formulation, and it is convenient to get, use, and it is good to take therapeutic effect, and drug price is cheap.
The specific embodiment
Embodiment 1,
Chinese medicinal capsule of the present invention is made up of following raw material: Caulis Spatholobi 6g, Rhizoma Chuanxiong 15g, Radix Angelicae Dahuricae 6g, Herba Ephedrae 10g, Ganoderma 11g, Rhizoma Homalomenae 6g, Rhizoma Drynariae 2g, Rhizoma Cibotii 3g, Radix Dipsaci 2g, Radix Angelicae Sinensis 5g, Semen Strychni 5g, Radix Stephaniae Tetrandrae 2g, Olibanum 9g, Rhizoma Corydalis 13g, Radix Glycyrrhizae 9g, Herba speranskiae tuberculatae 4g, Radix Ginseng 15g, Radix Glycyrrhizae 18g.
Chinese medicine composition of the present invention is prepared from according to following method:
Above-mentioned raw materials is mixed,, each 3 hours, use the 1000ml alcohol reflux at every turn with alcohol reflux 2 times; Filter and collect filtrating, be condensed into extractum, add 250ml water, make extractum become suspension; Reuse n-butanol extraction 2 times is concentrated into after each 250ml, extract filter and merge and does the acquisition extract, extract is ground into uniform powder be packed in the Capsules; Fit seals, and packing promptly gets Chinese medicinal capsule granule of the present invention, every 400mg.
Take mode: each one sooner or later of every day, seven days courses of treatment, take 4-5 the course of treatment.
Embodiment 2,
Chinese medicinal capsule of the present invention is made up of following raw material:: Caulis Spatholobi 7g, Rhizoma Chuanxiong 17g, Radix Angelicae Dahuricae 8g, Herba Ephedrae 11g, Ganoderma 12g, Rhizoma Homalomenae 7g, Rhizoma Drynariae 3g, Rhizoma Cibotii 5g, Radix Dipsaci 4g, Radix Angelicae Sinensis 6g, Semen Strychni 6g, Radix Stephaniae Tetrandrae 3g, Olibanum 10g, Rhizoma Corydalis 15g, Radix Glycyrrhizae 10g, Herba speranskiae tuberculatae 5g, Radix Ginseng 16g, Radix Glycyrrhizae 20g.
Chinese medicine composition of the present invention is prepared from according to following method:
Above-mentioned raw materials is mixed,, each 3 hours, use the 1000ml alcohol reflux at every turn with alcohol reflux 2 times; Filter and collect filtrating, be condensed into extractum, add 250ml water, make extractum become suspension; Reuse n-butanol extraction 2 times is concentrated into after each 250ml, extract filter and merge and does the acquisition extract, extract is ground into uniform powder be packed in the Capsules; Fit seals, and packing promptly gets Chinese medicinal capsule granule of the present invention, every 400mg.
Take mode: each one sooner or later of every day, seven days courses of treatment, take 4-5 the course of treatment.
The present invention has further verified that through clinical trial pharmaceutical composition of the present invention gets therapeutic effect, adopts a large amount of clinical cases in the outpatient service in recent years to verify.
Bronchitic clinical efficacy of medicine composite for curing of the present invention and safety.
Case is selected:
According to degenerative osteoarthritis patient 90 examples that conventional method is made a definite diagnosis, wherein 46 examples are organized in treatment, oral pharmaceutical composition of the present invention, and the 400mg/ grain, is taken a course of treatment altogether at each one sooner or later of every day; Matched group 44 examples are taken diclofenac sodium 75mg, and 1 time/d, totally 4 courses of treatment; Above-mentioned two groups are 7 days the course of treatment.
The pathology index: morning stiff index, dysfunction index, pain index, c reactive protein CRP.
Statistical procedures: use SPSS 10.0 softwares to carry out statistical analysis, data are represented with x ± s, relatively adopt variance analysis between group, and enumeration data adopts X
2Check, P＜0.05 is for there being significant difference.
3. therapeutic effect compares, referring to table 1
Table 1
And with above-mentioned 4 indexs improve percentage rate ((value before treatment back value-treatment)/treat preceding value * 100%) addition after ask its grand mean to improve percentage rate; Carry out therapeutic evaluation then; Standard is: grand mean improves percentage rate＜30% for invalid; Improving 30%～75% is effectively, and improving >=75% is produce effects.Take efficacy analysis after four courses of treatment, treatment group and treatment of control group effective percentage are respectively 84.8% (39/46) and 68.2% (30/44).Two groups relatively have remarkable significant difference (P＜0.05).
Conclusion: pharmaceutical composition of the present invention can be treated degenerative osteoarthritis safely and effectively, and more effective than conventional western medicine means, can be used as a kind of good curing medicine.
Claims (1)
- One kind treat degenerative osteoarthritis Chinese medicine composition, it is characterized in that: said Chinese medicine composition is processed by the raw material of following weight: Caulis Spatholobi 6g, Rhizoma Chuanxiong 15g, Radix Angelicae Dahuricae 6g, Herba Ephedrae 10g, Ganoderma 11g, Rhizoma Homalomenae 6g, Rhizoma Drynariae 2g, Rhizoma Cibotii 3g, Radix Dipsaci 2g, Radix Angelicae Sinensis 5g, Semen Strychni 5g, Radix Stephaniae Tetrandrae 2g, Olibanum 9g, Rhizoma Corydalis 13g, Radix Glycyrrhizae 27g, Herba speranskiae tuberculatae 4g, Radix Ginseng 15g; Said Chinese medicine composition is prepared from according to following method:Above-mentioned raw materials is mixed,, each 3 hours, use the 1000ml alcohol reflux at every turn with alcohol reflux 2 times; Filter and collect filtrating, be condensed into extractum, add 250ml water, make extractum become suspension; Reuse n-butanol extraction 2 times is concentrated into after each 250ml, extract filter and merge and does the acquisition extract, extract is ground into uniform powder be packed in the Capsules; Fit seals, and packing promptly gets said Chinese medicine composition.
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| CN201110166585A CN102225129B (en) | 2011-06-21 | 2011-06-21 | Traditional Chinese medicine composite for treating degenerative osteoarthritis and preparation method thereof |
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| CN102225129B true CN102225129B (en) | 2012-10-10 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102319320B (en) * | 2011-09-23 | 2013-07-31 | 于刚 | Medicament for treating osteopathy |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031029A (en) * | 2015-06-30 | 2015-11-11 | 蒋亚静 | Traditional Chinese medicinal capsules for treating degenerative osteoarthritis |
| CN105663901A (en) * | 2016-03-10 | 2016-06-15 | 郎继孝 | Traditional Chinese medicine preparation for treating degenerative osteoarthropathy |
| CN105833139A (en) * | 2016-04-01 | 2016-08-10 | 苏山林 | Medicine for treating degenerative arthritis |
| CN115606793A (en) * | 2022-09-12 | 2023-01-17 | 宁波御坊堂生物科技有限公司 | Compound herbal composition capable of relieving osteoarthritis and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1180831C (en) * | 2003-02-09 | 2004-12-22 | 卫永生 | New preparation of compound Chinese medicine for treating osteoarthritis and its preparation method |
| CN100488549C (en) * | 2006-11-22 | 2009-05-20 | 姜方森 | Externally applied medicament for treating rheumatism |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1180831C (en) * | 2003-02-09 | 2004-12-22 | 卫永生 | New preparation of compound Chinese medicine for treating osteoarthritis and its preparation method |
| CN100488549C (en) * | 2006-11-22 | 2009-05-20 | 姜方森 | Externally applied medicament for treating rheumatism |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102319320B (en) * | 2011-09-23 | 2013-07-31 | 于刚 | Medicament for treating osteopathy |
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