CN102221486B

CN102221486B - Sampling and liquid level detection device for automatic sampling system

Info

Publication number: CN102221486B
Application number: CN2011101478445A
Authority: CN
Inventors: 侯巍; 吴再辉; 吴军
Original assignee: 侯巍; 吴再辉; 吴军
Current assignee: CHANGCHUN BITE MEDICAL INSTRUMENT CO., LTD.
Priority date: 2011-06-03
Filing date: 2011-06-03
Publication date: 2012-11-07
Anticipated expiration: 2031-06-03
Also published as: CN102221486A

Abstract

The invention discloses a sampling and liquid level detection device for an automatic sampling system, which belongs to the technical field of medical, food testing and biological experimental equipment. The device is characterized in that: an elastic board is arranged on a sampling arm beam; the inner end of the elastic board is fixed with the sampling arm beam; a sampling nozzle connecting mechanism vertically runs through the sampling arm beam to be fixed with the outer end of the elastic board; a sampling nozzle in-place detection sensor is fixed at the outer end of the sampling arm beam; a sampling nozzle in-place separation blade is arranged on the sampling nozzle in-place detection sensor and the outer end of the elastic board; a negative pressure generation mechanism and a plunger pump are in closed communication with the sampling nozzle connecting mechanism by a three way valve and a pressure difference sensor; and the sampling nozzle connecting mechanism is a conical pipe body. The device has the advantages of 1, avoiding the risk of cross contamination caused by spur sampling adopted by most of conventional apparatuses; and 2, avoiding the high cost of one-off conductive plastic sampling nozzles mostly independent on import at present by adopting ordinary sampling nozzles so as to reduce the apparatus cost.

Description

Sampling and liquid detection device in the automatic sample adding system

Technical field

The invention belongs to medical test, food testing, biological experiment equipment technical field.

Background technology

In medical test, food testing, biological experiment process; ELISA and CLIA are the routine inspection methods that clinical labororatory carries out; Present checkout procedure does, on 96 orifice plates, carries out the interpolation of sample and reagent, hatches, washes work such as plate, DATA REASONING then; The link workload that in whole process, adds sample and reagent is maximum, and its application of sample precision and position accuracy play critical effect in whole testing process.The at present domestic sample that adds mainly divides manual and automatic two kinds of methods of application of sample with reagent.The middle-size and small-size medical institutions of China are owing to condition restriction, and there are phenomenons such as application of sample position and application of sample trueness error in the application of sample process all by manual completion, influences testing result.And the automatic sample adding system of import exists drawbacks such as expensive, volume are big, complicated operation, maintenance cost height are difficult to popularized.

Sampling mechanism is a core in automatic sample adding system, and the accuracy aspect imbibition, separatory of existing domestic equipment is not high, and overseas equipment costs an arm and a leg.Also there is the problem that occurs cross pollution between sample easily in existing in addition loading device, has a strong impact on the quality of work for inspection.

Summary of the invention

The objective of the invention is: sampling and liquid detection device in a kind of automatic sample adding system are provided, and it can improve the application of sample precision and the application of sample position accuracy of automatic sample adding system, adopts common disposable TIP head simultaneously, reduces and detects cost, overcomes cross pollution.Sampling mechanism has at lower cost been realized the high speed of automatic sampling system, high-quality work.

Technical scheme of the present invention is: an elastic plate is installed on the sampling arm crossbeam; Elastic plate is inner to be fixed with the sampling arm crossbeam; The sampling arm crossbeam vertically passes in sampling head bindiny mechanism and the elastic plate outer end is fixed; Be fixed with the sampling head detecting sensor that puts in place in sampling arm crossbeam outer end; In put in place detecting sensor and be provided with the sampling head catch that puts in place above the elastic plate outer end of sampling head, negative pressure generating mechanism and ram pump are communicated with kind a bindiny mechanism is airtight through T-valve and differential pressure pickup, and sampling head bindiny mechanism is a conical tube.

The invention has the beneficial effects as follows: the risk of 1, having avoided the cross pollution that the sampling of institute's employing draw point is brought in most of instruments at present.2, adopt common sampling head to avoid at present the mainly price of the costliness of the disposable conductive plastic sampling head of dependence on import (price of conduction sampling head is about ten times of common syringe needle), reduced instrument cost.

Description of drawings

Fig. 1 is a structural representation of the present invention;

Fig. 2 is that sampling head loads synoptic diagram among the present invention.

Embodiment

Embodiment 1

Below in conjunction with accompanying drawing the present invention is done and to further describe:

As shown in Figure 1,1 sampling head bindiny mechanism; The 2 sampling heads detecting sensor that puts in place; The 3 sampling heads catch that puts in place; 4 differential pressure pickups; 5 three-dimensional communicating valves; 6 negative pressure generating mechanisms; 7 ram pumps; 8 sampling arm crossbeams; 9 influidic pipes; 10 are connected influidic pipe with depression generator; 11 are connected influidic pipe with ram pump; 12 elastic plates.

As shown in Figure 2,21 a little TIP " loaded " position; 22 big TIP " loaded " position.

When sampling arm mechanism moves to TIP head region (not embodying among the figure); Sampling arm crossbeam 8 descends; Drive sampling head bindiny mechanism 1 and move down, after touching the TIP head, catch 3 moves up because pressure elastic device 12 generation deformation drive sampling heads put in place; The sampling head detecting sensor 2 that puts in place detects variation when moving to certain position, loads the TIP head thereby judge.The strength that can guarantee each TIP head of getting through this device is consistent, avoids producing maloperation.

Sampling arm crossbeam 8 rises after getting the TIP head, drives whole sampling mechanism and moves to sample position (not embodying among the figure), makes influidic pipe 9 be connected influidic pipe 10 with depression generator through control three-dimensional communicating valve 5 and is connected; Simultaneously differential pressure pickup 4 pressure that begins to monitor in the pipeline changes, when the pressure in the time of in air is a relative steady state value, after the TIP head touches liquid; Because action of negative pressure, liquid can enter into the TIP head on a small quantity, because media variations; Pressure can change suddenly in the pipeline; Pressure transducer detects this to be changed, and when variable quantity reaches certain value, then thinks to have detected liquid level.T-valve switches that to make be that influidic pipe 9 is connected influidic pipe 11 and is conducted with ram pump after detecting liquid level, ram pump 7 mobile pistons then, thus realized primary sample.

In the application of sample process of total system, be usually directed to add multiple liquid, wherein some liquid can once suck in the TIP head in a large number, carries out repeatedly setting-out to the setting-out position then, can effectively save the working time like this, increases work efficiency.

Sampling head loader mechanism as shown in Figure 2 is divided into two sections, and the thin narrow part of its middle and lower part is a little TIP " loaded " position 1, is used for getting little TIP head, can draw the liquid of (less than 100 microlitres) in a small amount, to realize precise sampling.The slightly slightly part at middle part is a big TIP " loaded " position 2, is used for winning big TIP head, can draw more a large amount of liquid (1000 microlitre), realizes once inhaling appearance, arrives the repeatedly function of a small amount of setting-out of setting-out position, has improved the efficient that sample circuit is added reagent.

Claims

1. sampling and the liquid detection device in the automatic sample adding system; It is characterized in that: an elastic plate is installed on the sampling arm crossbeam; Elastic plate is inner to be fixed with the sampling arm crossbeam; The sampling arm crossbeam vertically passes in sampling head bindiny mechanism and the elastic plate outer end is fixed, and is fixed with the sampling head detecting sensor that puts in place in sampling arm crossbeam outer end, in put in place detecting sensor and be provided with the sampling head catch that puts in place above the elastic plate outer end of sampling head; The negative pressure generating mechanism is communicated with a port of T-valve; Ram pump is communicated with another port of T-valve, and sampling head bindiny mechanism is communicated with the 3rd port of T-valve through differential pressure pickup, and sampling head bindiny mechanism is a conical tube.