CN102216448A - Foxp3+天然杀伤t细胞及免疫相关疾病的治疗 - Google Patents

Foxp3+天然杀伤t细胞及免疫相关疾病的治疗 Download PDF

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Publication number
CN102216448A
CN102216448A CN2009801452249A CN200980145224A CN102216448A CN 102216448 A CN102216448 A CN 102216448A CN 2009801452249 A CN2009801452249 A CN 2009801452249A CN 200980145224 A CN200980145224 A CN 200980145224A CN 102216448 A CN102216448 A CN 102216448A
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cells
foxp3
cell
natural killer
nkt
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Pending
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CN2009801452249A
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Chinese (zh)
Inventor
路易斯·里卡多·西蒙斯·达·席尔瓦·格拉萨
玛尔塔·索非亚·费雷拉·蒙泰罗
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Universidade de Lisboa
Instituto de Medicina Molecular Joao Lobo Antunes
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Universidade de Lisboa
Instituto de Medicina Molecular Joao Lobo Antunes
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Application filed by Universidade de Lisboa, Instituto de Medicina Molecular Joao Lobo Antunes filed Critical Universidade de Lisboa
Publication of CN102216448A publication Critical patent/CN102216448A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22—Immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/416—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN2009801452249A 2008-11-13 2009-11-13 Foxp3+天然杀伤t细胞及免疫相关疾病的治疗 Pending CN102216448A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11436208P 2008-11-13 2008-11-13
US61/114,362 2008-11-13
PT10476409 2009-09-25
PT104764 2009-09-25
PCT/PT2009/000060 WO2010056144A2 (en) 2008-11-13 2009-11-13 Foxp3+ natural kiler t-cells and the treatment of immune related diseases

Publications (1)

Publication Number Publication Date
CN102216448A true CN102216448A (zh) 2011-10-12

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CN2009801452249A Pending CN102216448A (zh) 2008-11-13 2009-11-13 Foxp3+天然杀伤t细胞及免疫相关疾病的治疗

Country Status (8)

Country Link
US (1) US20120114675A1 (https=)
EP (1) EP2356222A2 (https=)
JP (1) JP2012508575A (https=)
CN (1) CN102216448A (https=)
AU (1) AU2009314704A1 (https=)
BR (1) BRPI0915255A2 (https=)
CA (1) CA2743502A1 (https=)
WO (1) WO2010056144A2 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102603892A (zh) * 2012-02-22 2012-07-25 尉军 一种肿瘤标志物foxp3自身抗体及应用
CN105039255A (zh) * 2015-09-09 2015-11-11 广州赛莱拉干细胞科技股份有限公司 一种nkt细胞诱导培养的添加剂及诱导培养的方法
CN106047808A (zh) * 2015-04-07 2016-10-26 富禾生医股份有限公司 经修饰的自然杀伤t细胞、医药组合物和其用途
CN114081946A (zh) * 2014-03-12 2022-02-25 耶达研究与开发有限公司 降低系统性调节性t细胞水平或活性来治疗cns疾病和损伤

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015273501B2 (en) * 2014-06-11 2021-01-21 Polybiocept Gmbh Expansion of lymphocytes with a cytokine composition for active cellular immunotherapy
CN107475194B (zh) * 2017-10-09 2018-07-24 天津长和生物技术有限公司 Nkt细胞培养基、培养方法及二者的应用
US20220184172A1 (en) * 2019-04-19 2022-06-16 The Regents Of The University Of California Ampk/caspase-6 axis controls liver damage in nonalcoholic steatohepatitis
US12365871B2 (en) 2020-04-28 2025-07-22 Lyell Immunopharma, Inc. Methods for culturing cells
WO2025221808A1 (en) * 2024-04-15 2025-10-23 Trustees Of Tufts College Efficient epigenetic reprogramming of t effector cells into stable regulatory t cells

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU643141B2 (en) 1991-03-15 1993-11-04 Amgen, Inc. Pulmonary administration of granulocyte colony stimulating factor
US5451569A (en) 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
DE60141510D1 (de) * 2000-04-11 2010-04-22 Univ Southern California Methode zur verhinderung der transplantatabstossung unter verwendung von tgf-beta zur induktion von t-suppressorzellen
JP4989850B2 (ja) * 2002-10-25 2012-08-01 アメリカ合衆国 ＴＧＦ−βの遮断により腫瘍再発を防ぐ方法

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102603892A (zh) * 2012-02-22 2012-07-25 尉军 一种肿瘤标志物foxp3自身抗体及应用
CN114081946A (zh) * 2014-03-12 2022-02-25 耶达研究与开发有限公司 降低系统性调节性t细胞水平或活性来治疗cns疾病和损伤
CN106047808A (zh) * 2015-04-07 2016-10-26 富禾生医股份有限公司 经修饰的自然杀伤t细胞、医药组合物和其用途
CN106047808B (zh) * 2015-04-07 2020-08-04 富禾生医股份有限公司 经修饰的自然杀伤t细胞、医药组合物和其用途
US10864232B2 (en) 2015-04-07 2020-12-15 FullHope Biomedical Co., Ltd. Modified natural killer T cells, pharmaceutical compositions and uses thereof
CN105039255A (zh) * 2015-09-09 2015-11-11 广州赛莱拉干细胞科技股份有限公司 一种nkt细胞诱导培养的添加剂及诱导培养的方法

Also Published As

Publication number Publication date
WO2010056144A2 (en) 2010-05-20
JP2012508575A (ja) 2012-04-12
AU2009314704A1 (en) 2010-05-20
WO2010056144A3 (en) 2010-07-22
US20120114675A1 (en) 2012-05-10
CA2743502A1 (en) 2010-05-20
EP2356222A2 (en) 2011-08-17
BRPI0915255A2 (pt) 2018-02-06

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Application publication date: 20111012