CN102210884B - Preparation method of antibacterial dressing for promoting wound healing - Google Patents
Preparation method of antibacterial dressing for promoting wound healing Download PDFInfo
- Publication number
- CN102210884B CN102210884B CN201010139908.2A CN201010139908A CN102210884B CN 102210884 B CN102210884 B CN 102210884B CN 201010139908 A CN201010139908 A CN 201010139908A CN 102210884 B CN102210884 B CN 102210884B
- Authority
- CN
- China
- Prior art keywords
- bacterial cellulose
- wound healing
- dressing
- promoting wound
- hyaluronic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Landscapes
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a preparation method of an antibacterial dressing for promoting wound healing, comprising the following steps of: carrying out pretreatment on flocculent bacterial cellulose obtained by utilizing a dynamic zymotechnics, and then uniformly implanting nano silver on the bacterial cellulose surface by utilizing an in-situ chemical reduction method to obtain a bacterial cellulose nano silver composite material; and placing the bacterial cellulose nano silver composite material into a hyaluronic acid solution for dipping, dehydrating the bacterial cellulose for adsorbing hyaluronic acid, and carrying out a coupling reaction by utilizing carbodiimide to form a bacterial cellulose/hyaluronic acid-loaded nano silver composite material. The composite material has the effects of a controlled release bacteriacide for controlling wound infection and interaction between cells and a substrate and promoting wound healing. In the invention, a composite film is prepared through bacterial cellulose/hyaluronic acid-loaded nano silver, high flexibility of a bacterial cellulose substrate and favorable skin adhesiveness are exerted, and the antibacterial dressing has the antibacterial effect of promoting wound healing and can be used for preparing multipurpose drug wound dressings for accelerating wound repairing.
Description
Technical field
The invention belongs to the dressing formation function technology in trauma care, be specifically related to a kind of preparation method of antibacterial dressing for promoting wound healing.
Background technology
Wound or postoperative dressing wrapping is very important at burn cosmetic plastic surgery, and the success or failure of operation are sometimes directly related with wound infection, healing time to a great extent.Adopt the wound dressing with antibacterial heal-promoting action function significant to burn orthopedic treatment for this reason.
Adopt the dressing of biosynthetic Bacterial cellulose as treatment skin injury, decubital ulcer, ulcer, or the commodity such as pellicle of making histoorgan occur.But at present by single bacteria cellulose material as dressing, only there is covering wound, when inflammation, can absorb exudate, function (the Microbialcellulose-the natural power to heal wound such as the environment that maintenance wound is wet, Biomaterials, 2006,27,145-15.).In recent years, many dressing before use or all added ingredient while using, and becomes Drug dressing.Commercially available antibacterials dressing at present in use can not carry out controlled release effectively to medicine.There is the short more hyaluronic acid dressing of effect of wound and mix in dressing mainly with adsorption form and add, the hyaluronic acid of free state exists easy degradation problem (characteristic of films made of cross-linked hyaluronic acid and the preliminary study of biocompatibility in use preservation and use procedure, China's biochemical drug magazine, 2006,27,25-28.).
Summary of the invention
The object of the present invention is to provide a kind of good springiness, breathability is high, and sterilizing ability is strong, the preparation method of the short excellent antibacterial heal-promoting type wound dressing of performance of healing.
The technical solution that realizes the object of the invention is: the preparation method of antibacterial dressing for promoting wound healing of the present invention, comprises the following steps:
The first step, will join heat treated in aqueous slkali after cotton-shaped hygrometric state Bacterial cellulose rinsing, then neutralizes with acid solution, then uses deionized water wash until neutral;
Second step, is placed in silver salt solution by first step products therefrom and floods, and then isolated by filtration obtains decorating film, then with after deionized water wash, adds reducing agent and react under stirring condition, then rinsing products therefrom remove moisture;
The 3rd step, adopts hyaluronic acid solution to carry out after immersion treatment second step products therefrom, dewaters and adds cross-linking agent, then Bacterial cellulose and hyaluronic acid solution is carried out to cross-linking reaction, makes Bacterial cellulose and hyaluronic acid composite;
The 4th step, by the 3rd step product isolated by filtration, with washing with alcoholic solution after deionized water wash, removes moisture and ethanol again;
The 5th step, is coated with high viscose as dressing skin at the high-elastic property non-woven fabrics back side, by smooth the 4th step product, be scattered in dressing skin uniformly, make it to be combined with each other with dressing skin;
The 6th step, makes product cutting by the 5th step, adopts Co 60 to carry out sterilizing after monolithic subpackage, obtains antibacterial dressing for promoting wound healing.
The present invention compared with prior art, its remarkable advantage: (1) adopts dynamic Bacterial cellulose is template, and the particle diameter of preparing nanometer silver by one dimension chemical reduction method is less, and antibacterial ability is strong; (2) adopt dynamic fermentation legal system to carry out cross-linking modified for cotton-shaped Bacterial cellulose and hyaluronic acid, be conducive to form high moisturizing, urge the more composite of effect with wound repair factor wound, the hyaluronic acid simultaneously connecing after propping up can be stablized preservation and use; (3) owing to adopting the hyaluronic acid/Bacterial cellulose etc. of good biocompatibility as matrix material, implant after the nanometer silver that antibacterial ability is strong, effect that the dressing of preparing has antibacterial heal-promoting can obtain application in skin burn and plastic surgery operations.
Accompanying drawing explanation
Accompanying drawing is to prepare nano silver particles electromicroscopic photograph in embodiment 1 process.
The specific embodiment
Below in conjunction with accompanying drawing, the present invention is described in further detail.
The preparation method of antibacterial dressing for promoting wound healing of the present invention, comprises the following steps:
The first step, will join heat treated in aqueous slkali after cotton-shaped hygrometric state Bacterial cellulose rinsing, then neutralizes with acid solution, then uses deionized water wash until neutral; Bacterial cellulose is that dynamic fermentation legal system is standby, and aqueous slkali is one or more the mixing of sodium hydroxide, potassium hydroxide, sodium carbonate, and alkaline concentration is 1%-4%.
Second step, is placed in silver salt solution by first step products therefrom and floods, and then isolated by filtration obtains decorating film, then with after deionized water wash, adds reducing agent and react under stirring condition, then rinsing products therefrom remove moisture; Silver salt is silver nitrate or 2 ethyl hexanoic acid silver, the consumption mass ratio of silver salt and Bacterial cellulose is 0.01: 1-0.1: 1, the time of reacting under stirring condition is 2-6 hour, and reducing agent is one or more mixing of ascorbic acid solution, boron potassium cyanide, boron Cyanogran., formaldehyde.
The 3rd step, adopts hyaluronic acid solution to carry out after immersion treatment second step products therefrom, dewaters and adds cross-linking agent, then Bacterial cellulose and hyaluronic acid solution is carried out to cross-linking reaction, makes Bacterial cellulose and hyaluronic acid composite; Hyaluronic acid solution concentration is 0.05-5.0%, and hyaluronan molecule amount is 10
5-10
7cross-linking agent is Carbodiimides, as 1-(3-dimethylamino-propyl)-3-ethyl carbodiimide, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride or N, N-dicyclohexyl carbodiimide, the consumption of cross-linking agent is the 0.5-5% of cellulose amount, reaction temperature is 20-80 ℃, response time 1-24h.
The 4th step, by the 3rd step product isolated by filtration, with washing with alcoholic solution after deionized water wash, removes moisture and ethanol again; With the number of times of deionized water wash be 1-5 time, with the number of times of alcoholic solution washing be 1-3 time.
The 5th step, is coated with high viscose as dressing skin at the high-elastic property non-woven fabrics back side, by smooth the 4th step product, be scattered in dressing skin uniformly, make it to be combined with each other with dressing skin; High-elastic property non-woven fabrics can be bacteria cellulose film, chitosan film, polyethylene film or containing paraffin paper, high viscose is polysiloxanes, hydrogel or soft adhesion heat melten gel.
The 6th step, makes product cutting by the 5th step, adopts Co 60 to carry out sterilizing after monolithic subpackage, obtains antibacterial dressing for promoting wound healing.
Below in conjunction with embodiment, the present invention is described in further detail.
Embodiment 1:
The first step, by cotton-shaped hygrometric state Bacterial cellulose pretreatment, adds 90 ℃ of 1% sodium hydroxide aqueous slkalis insulation 3h after rinsing, then neutralizes with acetum, then uses deionized water wash until neutral;
Second step, the AgNO3 silver salt solution that first step products therefrom is placed in to 0.005mol/L floods, then isolated by filtration obtains decorating film, again with after deionized water wash, under mechanical agitation condition, add ascorbic acid reduction silver ion, under room temperature, react 3 hours, rinsing product also removes 80% moisture in system;
The 3rd step, adopting concentration is that 3% hyaluronic acid carries out after immersion treatment second step products therefrom, removes in system 80% moisture, adds 2% carbodiimides cross-linking agent, reacts 24h in the time of 30 ℃.
The 4th step, by the 3rd step product isolated by filtration, with after deionized water wash 3 times again with alcoholic solution washing 1 time, remove moisture and ethanol.
The 5th step, is coated with polysiloxanes viscose as dressing skin at bacteria cellulose film, by smooth the 4th step product, is scattered in uniformly dressing skin, is combined with each other;
The 6th step, makes product cutting by the 5th step, adopts Co 60 to carry out sterilizing after monolithic subpackage, obtains antibacterial dressing for promoting wound healing.
Embodiment 2:
The first step, by cotton-shaped hygrometric state Bacterial cellulose pretreatment, adds 90 ℃ of 1% potassium hydroxide aqueous slkalis insulation 3h after rinsing, then neutralizes with acetum, then uses deionized water wash until neutral;
Second step, the AgNO3 silver salt solution that first step products therefrom is placed in to 0.008mol/L floods, then isolated by filtration obtains decorating film, again with after deionized water wash, under mechanical agitation condition, add boron potassium cyanide reduction silver ion, under room temperature, react 6 hours, rinsing product also removes 70% moisture in system;
The 3rd step, adopting concentration is that 2.5% hyaluronic acid carries out after immersion treatment second step products therefrom, removes in system 70% moisture, adds 2%1-(3-dimethylamino-propyl)-3-ethyl carbodiimide cross-linking agent, reacts 24h in the time of 30 ℃.
The 4th step, by the 3rd step product isolated by filtration, with after deionized water wash 3 times again with alcoholic solution washing 1 time, remove moisture and ethanol.
The 5th step, is coated with polysiloxanes viscose as dressing skin at chitosan film, by smooth the 4th step product, is scattered in uniformly dressing skin, is combined with each other;
The 6th step, makes product cutting by the 5th step, adopts Co 60 to carry out sterilizing after monolithic subpackage, obtains antibacterial dressing for promoting wound healing.
Embodiment 3:
The first step, by cotton-shaped hygrometric state Bacterial cellulose pretreatment, adds 90 ℃ of 10% sodium hydroxide aqueous slkalis insulation 3h after rinsing, then neutralizes with acetum, then uses deionized water wash until neutral;
Second step, the AgNO3 silver salt solution that first step products therefrom is placed in to 0.008mol/L floods, then isolated by filtration obtains decorating film, again with after deionized water wash, under mechanical agitation condition, add boron Cyanogran. reduction silver ion, under room temperature, react 6 hours, rinsing product also removes 70% moisture in system;
The 3rd step, adopting concentration is that 2.5% hyaluronic acid carries out after immersion treatment second step products therefrom, removes in system 70% moisture, adds 2% carbodiimides cross-linking agent, reacts 18h in the time of 40 ℃.
The 4th step, by the 3rd step product isolated by filtration, with after deionized water wash 3 times again with alcoholic solution washing 1 time, remove moisture and ethanol.
The 5th step, is coated with polysiloxanes viscose as dressing skin at bacteria cellulose film, by smooth the 4th step product, is scattered in uniformly dressing skin, is combined with each other;
The 6th step, makes product cutting by the 5th step, adopts Co 60 to carry out sterilizing after monolithic subpackage, obtains antibacterial dressing for promoting wound healing.
Embodiment 4:
The first step, by cotton-shaped hygrometric state Bacterial cellulose pretreatment, adds 90 ℃ of 10% sodium carbonate aqueous slkalis insulation 3h after rinsing, then neutralizes with acetum, then uses deionized water wash until neutral;
Second step, the 2 ethyl hexanoic acid silver silver salt solution that first step products therefrom is placed in to 0.006mol/L floods, then isolated by filtration obtains decorating film, again with after deionized water wash, under mechanical agitation condition, add formaldehyde reduction silver ion, under room temperature, react 6 hours, rinsing product also removes 50% moisture in system;
The 3rd step, adopting concentration is that 3.0% hyaluronic acid carries out after immersion treatment second step products therefrom, remove in system 70% moisture, add 5%1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride cross-linking agent, in the time of 50 ℃, react 8h.
The 4th step, by the 3rd step product isolated by filtration, with after deionized water wash 3 times again with alcoholic solution washing 1 time, remove moisture and ethanol.
The 5th step, is coated with hydrogel as dressing skin at bacteria cellulose film, by smooth the 4th step product, is scattered in uniformly dressing skin, is combined with each other;
The 6th step, makes product cutting by the 5th step, adopts Co 60 to carry out sterilizing after monolithic subpackage, obtains antibacterial dressing for promoting wound healing.
Embodiment 5:
The first step, by cotton-shaped hygrometric state Bacterial cellulose pretreatment, adds 90 ℃ of 5% potassium sodium carbonate solution insulation 3h after rinsing, then neutralizes with acetum, then uses deionized water wash until neutral;
Second step, the AgNO3 silver salt solution that first step products therefrom is placed in to 0.01mol/L floods, then isolated by filtration obtains decorating film, again with after deionized water wash, under mechanical agitation condition, add ascorbic acid reduction silver ion, under room temperature, react 6 hours, rinsing product also removes 60% moisture in system;
The 3rd step, adopting concentration is that 4.0% hyaluronic acid carries out after immersion treatment second step products therefrom, removes in system 70% moisture, adds 4% carbodiimides cross-linking agent, reacts 8h in the time of 60 ℃.
The 4th step, by the 3rd step product isolated by filtration, with after deionized water wash 3 times again with alcoholic solution washing 1 time, remove moisture and ethanol.
The 5th step, is coated with hydrogel as dressing skin at bacteria cellulose film, by smooth the 4th step product, is scattered in uniformly dressing skin, is combined with each other;
The 6th step, makes product cutting by the 5th step, adopts Co 60 to carry out sterilizing after monolithic subpackage, obtains antibacterial dressing for promoting wound healing.
Embodiment 6:
The first step, by cotton-shaped hygrometric state Bacterial cellulose pretreatment, adds 90 ℃ of 5% potassium hydroxide solutions insulation 3h after rinsing, then neutralizes with acetum, then uses deionized water wash until neutral;
Second step, the AgNO3 silver salt solution that first step products therefrom is placed in to 0.01mol/L floods, then isolated by filtration obtains decorating film, again with after deionized water wash, under mechanical agitation condition, add ascorbic acid reduction silver ion, under room temperature, react 6 hours, rinsing product also removes 60% moisture in system;
The 3rd step, adopting concentration is that 5.0% hyaluronic acid carries out after immersion treatment second step products therefrom, removes in system 60% moisture, adds 4% carbodiimides cross-linking agent, reacts 1h in the time of 80 ℃.
The 4th step, by the 3rd step product isolated by filtration, with after deionized water wash 3 times again with alcoholic solution washing 1 time, remove moisture and ethanol.
The 5th step, being coated with hydrogel as dressing skin containing paraffin paper, by smooth the 4th step product, is scattered in dressing skin uniformly, is combined with each other;
The 6th step, makes product cutting by the 5th step, adopts Co 60 to carry out sterilizing after monolithic subpackage, obtains antibacterial dressing for promoting wound healing.
Embodiment 7:
The first step, by cotton-shaped hygrometric state Bacterial cellulose pretreatment, adds 90 ℃ of 5% sodium hydroxide solutions insulation 3h after rinsing, then neutralizes with acetum, then uses deionized water wash until neutral;
Second step, the AgNO3 silver salt solution that first step products therefrom is placed in to 0.03mol/L floods, then isolated by filtration obtains decorating film, again with after deionized water wash, under mechanical agitation condition, add ascorbic acid reduction silver ion, under room temperature, react 6 hours, rinsing product also removes 70% moisture in system;
The 3rd step, adopting concentration is that 4.0% hyaluronic acid carries out after immersion treatment second step products therefrom, removes in system 70% moisture, adds 4% carbodiimides cross-linking agent, reacts 3h in the time of 70 ℃.
The 4th step, by the 3rd step product isolated by filtration, with after deionized water wash 3 times again with alcoholic solution washing 1 time, remove moisture and ethanol.
The 5th step, is coated with hydrogel as dressing skin at polyethylene film, by smooth the 4th step product, is scattered in uniformly dressing skin, is combined with each other;
The 6th step, makes product cutting by the 5th step, adopts Co 60 to carry out sterilizing after monolithic subpackage, obtains antibacterial dressing for promoting wound healing.
Embodiment 8:
The first step, by cotton-shaped hygrometric state Bacterial cellulose pretreatment, adds 90 ℃ of 1% sodium hydroxide solutions insulation 3h after rinsing, then neutralizes with acetum, then uses deionized water wash until neutral;
Second step, the AgNO3 silver salt solution that first step products therefrom is placed in to 0.04mol/L floods, then isolated by filtration obtains decorating film, again with after deionized water wash, under mechanical agitation condition, add ascorbic acid reduction silver ion, under room temperature, react 6 hours, rinsing product also removes 70% moisture in system;
The 3rd step, adopting concentration is that 1.0% hyaluronic acid carries out after immersion treatment second step products therefrom, removes in system 70% moisture, adds 2%N, N-dicyclohexyl carbodiimide cross-linking agent reacts 3h in the time of 80 ℃.
The 4th step, by the 3rd step product isolated by filtration, with after deionized water wash 3 times again with alcoholic solution washing 1 time, remove moisture and ethanol.
The 5th step, is coated with soft adhesion heat melten gel as dressing skin at polyethylene film, by smooth the 4th step product, is scattered in uniformly dressing skin, is combined with each other;
The 6th step, makes product cutting by the 5th step, adopts Co 60 to carry out sterilizing after monolithic subpackage, obtains antibacterial dressing for promoting wound healing.
By reference to the accompanying drawings, can be found out by film-making, can prepare with this understanding the uniform silver particles of 2nm.The present invention is passing through Bacterial cellulose molecule and silver ion coordination, by reducing agent reduce that silver ion prepares that particle diameter is little, after the nanometer silver that is evenly distributed, adopt chemical crosslink technique, the hyaluronic acid with wound repair effect is connect and propped up on Bacterial cellulose molecule, form Bacterial cellulose/hyaluronic acid and carry silver-colored compound system.Bacterial cellulose/hyaluronic acid carries silver composite material and can be used for the fields such as antibacterial heal-promoting medical dressing.
Claims (7)
1. a preparation method for antibacterial dressing for promoting wound healing, is characterized in that comprising the following steps:
The first step, will join heat treated in aqueous slkali after cotton-shaped hygrometric state Bacterial cellulose rinsing, then neutralizes with acid solution, then uses deionized water wash until neutral;
Second step, is placed in silver salt solution by first step products therefrom and floods, and then isolated by filtration obtains decorating film, then with after deionized water wash, adds reducing agent and react under stirring condition, then rinsing products therefrom remove moisture;
The 3rd step, adopts hyaluronic acid solution to carry out after immersion treatment second step products therefrom, dewaters and adds cross-linking agent, then Bacterial cellulose and hyaluronic acid solution is carried out to cross-linking reaction, makes Bacterial cellulose and hyaluronic acid composite;
The 4th step, by the 3rd step product isolated by filtration, with washing with alcoholic solution after deionized water wash, removes moisture and ethanol again;
The 5th step, is coated with high viscose as dressing skin at the high-elastic property non-woven fabrics back side, by smooth the 4th step product, be scattered in dressing skin uniformly, make it to be combined with each other with dressing skin;
The 6th step, makes product cutting by the 5th step, after monolithic subpackage, adopts cobalt
60carry out sterilizing, obtain antibacterial dressing for promoting wound healing.
2. the preparation method of antibacterial dressing for promoting wound healing according to claim 1, it is characterized in that: in the first step, Bacterial cellulose is that dynamic fermentation legal system is standby, aqueous slkali is one or more the mixing of sodium hydroxide, potassium hydroxide, sodium carbonate, and alkaline concentration is 1%-4%.
3. the preparation method of antibacterial dressing for promoting wound healing according to claim 1, it is characterized in that: in second step, silver salt is silver nitrate or 2 ethyl hexanoic acid silver, the consumption mass ratio of silver salt and Bacterial cellulose is 0.01: 1-0.1: 1, the time of reacting under stirring condition is 2-6 hour, and reducing agent is one or more mixing of ascorbic acid solution, boron potassium cyanide, boron Cyanogran., formaldehyde.
4. the preparation method of antibacterial dressing for promoting wound healing according to claim 1, is characterized in that: in the 3rd step, hyaluronic acid solution concentration is 0.05-5.0%, and hyaluronan molecule amount is 10
5-10
7, cross-linking agent is Carbodiimides, the 0.5-5% that the consumption of cross-linking agent is cellulose amount, and reaction temperature is 20-80 ℃, response time 1-24h.
5. the preparation method of antibacterial dressing for promoting wound healing according to claim 1, is characterized in that: in the 4th step, be 1-5 time with the number of times of deionized water wash, with the number of times of alcoholic solution washing be 1-3 time.
6. the preparation method of antibacterial dressing for promoting wound healing according to claim 1, is characterized in that: in the 5th step, high-elastic property non-woven fabrics can be bacteria cellulose film, chitosan film, polyethylene film or contains paraffin paper.
7. the preparation method of antibacterial dressing for promoting wound healing according to claim 1, is characterized in that: the high viscose in the 5th step is polysiloxanes, hydrogel or soft adhesion heat melten gel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010139908.2A CN102210884B (en) | 2010-04-07 | 2010-04-07 | Preparation method of antibacterial dressing for promoting wound healing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010139908.2A CN102210884B (en) | 2010-04-07 | 2010-04-07 | Preparation method of antibacterial dressing for promoting wound healing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102210884A CN102210884A (en) | 2011-10-12 |
| CN102210884B true CN102210884B (en) | 2014-05-14 |
Family
ID=44742567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010139908.2A Expired - Fee Related CN102210884B (en) | 2010-04-07 | 2010-04-07 | Preparation method of antibacterial dressing for promoting wound healing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102210884B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102357258B (en) * | 2011-10-27 | 2014-02-05 | 上海美宝生命科技有限公司 | Preparation method of dressing for treating burn combined with moist burn cream |
| CN103480028B (en) * | 2012-06-12 | 2015-05-13 | 钟春燕 | Bacterial cellulose composite dressing |
| CN103990171B (en) * | 2014-05-26 | 2016-01-13 | 北京鼎瀚恒海生物科技发展有限公司 | A kind of based composite dressing for medical use and preparation method thereof |
| CN104874015B (en) * | 2015-06-05 | 2017-06-16 | 四川大学 | A kind of bacteria cellulose dressing with antibacterial bacteriostatic function and preparation method and application |
| CN108904530B (en) * | 2018-08-03 | 2021-04-23 | 安徽省银锂子生物科技发展有限公司 | Nano-silver bactericidal hemostatic composition |
| CN109568651B (en) * | 2018-12-24 | 2020-02-21 | 苏州榭睿迦医疗科技发展有限公司 | Long-acting liquid dressing |
| CN110694095A (en) * | 2019-10-23 | 2020-01-17 | 北京幸福益生再生医学科技有限公司 | Regenerated silicon mineral material skin repair patch and preparation method thereof |
| CN113750286B (en) * | 2021-09-30 | 2022-11-29 | 振德医疗用品股份有限公司 | Skin wound covering film and preparation method thereof |
| CN113980185B (en) * | 2021-12-13 | 2023-09-15 | 河南汇博医疗股份有限公司 | Amorphous silver-containing long-acting antibacterial hydrogel dressing with photocrosslinking curing function and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4772419A (en) * | 1985-03-01 | 1988-09-20 | Pharmacia Ab | Shaped article and processes for its preparation |
| CN101264335A (en) * | 2008-05-07 | 2008-09-17 | 东华大学 | Bacteria cellulose membrane containing silver chloride nano particle and preparation and application thereof |
| CN101509025A (en) * | 2009-03-20 | 2009-08-19 | 武汉科技学院 | Method of preparing bacteria cellulose composite material |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11322808A (en) * | 1998-05-11 | 1999-11-26 | Mitsubishi Chemical Corp | Crosslinked hyaluronic acid sponge material and its production |
-
2010
- 2010-04-07 CN CN201010139908.2A patent/CN102210884B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4772419A (en) * | 1985-03-01 | 1988-09-20 | Pharmacia Ab | Shaped article and processes for its preparation |
| CN101264335A (en) * | 2008-05-07 | 2008-09-17 | 东华大学 | Bacteria cellulose membrane containing silver chloride nano particle and preparation and application thereof |
| CN101509025A (en) * | 2009-03-20 | 2009-08-19 | 武汉科技学院 | Method of preparing bacteria cellulose composite material |
Non-Patent Citations (2)
| Title |
|---|
| 四川省生物医学工程学会,2009,第26卷(第5期), * |
| 孙东平,杨加志,李骏,周伶俐,于俊伟.载银细菌纤维素抗菌敷料的制备及其抗菌性能的研究.《生物医学工程学杂志》.四川大学华西医院 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102210884A (en) | 2011-10-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102210884B (en) | Preparation method of antibacterial dressing for promoting wound healing | |
| CN102961777B (en) | Method for preparing porous compound type high permeability absorption hemostasis coating with modified nano-crystalline cellulose | |
| CN110354295B (en) | Photo-thermal conversion material and preparation method thereof | |
| CN100411690C (en) | Bacteriostatic porous polyelectrolyte material and its prepn process | |
| CN103356692B (en) | A kind of composite antibacterial gel and preparation method thereof | |
| CN103834050A (en) | Method for preparing gelatin/nano-silver/chitosan derivative composite film | |
| CN102850598B (en) | Alginate-gelatin-carboxymethylcellulose sodium blend membrane, and preparation and application thereof | |
| CN106975101B (en) | Nano-silver composite collagen medical dressing and preparation method thereof | |
| CN104906623B (en) | A kind of cellulose-based dressings and its preparation method and application | |
| CN101816802B (en) | Chitosan-based medical dressing | |
| CN103990171B (en) | A kind of based composite dressing for medical use and preparation method thereof | |
| CN114000349B (en) | Alginate-encapsulated bacterial cellulose composite photothermal antibacterial medical dressing and preparation method thereof | |
| CN109731121A (en) | A kind of preparation method of the cellulose containing mesoporous silicon oxide and chitosan combine dressing | |
| CN113144270A (en) | Preparation method of photo-thermal sensitive composite bacterial cellulose antibacterial dressing | |
| CN101879324A (en) | Method for preparing chitosan-based composite dressing for medical use | |
| CN103480034A (en) | Irradiation crosslinked chitosan/gelatin/polyvinyl alcohol hydrogel dressing as well as preparation method and application thereof | |
| CN103083711B (en) | Chitosan-iodine composite biological medical film and preparation method thereof | |
| CN103638551A (en) | Preparation method for chitosan 6-OH immobilized cyclodextrin included tea tree oil thermo-sensitive hydrogel | |
| CN104606710B (en) | A kind of preparation method of high antibiotic property alginate dressing | |
| CN103386143B (en) | Chitosan-iodine composite biological medical film and preparation method thereof | |
| CN103394117B (en) | Self-adhesive type composite active carbon fiber dressing and preparation method thereof | |
| CN107177980B (en) | Contact wound dressing and preparation method thereof | |
| CN109529099B (en) | Double-network chitosan enzyme-loaded hydrogel dressing based on three-dimensional printing technology and preparation method thereof | |
| CN107185026B (en) | Preparation method of medical konjac glucomannan antibacterial dressing | |
| CN116376123A (en) | Injectable glucan-based hydrogel, glucan-based hydrogel loaded with paris polyphylla saponin I, and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140514 Termination date: 20180407 |