CN102210835A - Traditional Chinese medicine for treating coronary disease - Google Patents
Traditional Chinese medicine for treating coronary disease Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for treating a coronary disease, which is prepared from the plant Chinese herbal medicines as raw materials: prepared rhizome of rehmannia, dogwood, desertliving cistanche, radix aconiti praeparata, ginseng, radix ophiopogonis, cassia twig, angelica sinensis, radix astragali, radix salviae miltiorrhizae, sandalwood, ligusticum wallichii, radix scrophulariae, root of rehmannia, hawthorn, honeysuckle, amomum fruit and the like. The medicine disclosed by the invention is used for treating the coronary disease, has the curative effect of strengthening the body resistance and removing roots of diseases, and recovering body resistance and removing evil; the medicine takes a point of nursing kidney functions as the central loop of a therapy, and also pays attention to coordination of functions of organs, such as kidney, heart, liver, spleen and the like so as to nourish kidney-yin, warm lower body, benefit qi and enrich the blood, remove blood stasis and clear away hot heat, thereby reducing fat, resisting coagulation, reducing blood viscosity, dissolving thrombus, and also modifying endothelium functions of the blood vessels, removing vasospasm, resisting arteriosclerosis and stabilizing easily-broken plaques; in addition, the traditional Chinese medicine has double treatment functions on the pathological changes of blood and blood vessels and can be used for effectively treating the diseases of the cardiovascular system.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of coronary heart disease, being specifically related to a kind of is the Chinese medicine of the treatment coronary heart disease made of raw material with the vegetable Chinese herbal medicine.
Background technology
Coronary heart disease is the abbreviation of coronary atherosclerotic heart disease, being meant the blood vessel of supplying with the heart nutrient substance--serious atherosis or spasm takes place in coronary artery, make coronary stricture or obstruction, and the obliteration that causes of thrombosis, cause a kind of heart disease of myocardial ischemia-anoxemia or infraction, also claim ischemic heart desease.Coronary heart disease is the common type that atherosclerosis causes organ lesion, is the commonly encountered diseases of harm middle-aged and elderly people health, and presents the rejuvenation tendency.The reason that arteria coronaria narrows down is: the blood fat in the blood is too high for a long time, cholesterol accumulates over a long period is deposited on the inner membrance of coronary artery tube chamber, form ground pattern speckle, make the coarse of original slick inner membrance change, softish tube wall becomes stiff, on this basis, disruptive platelet is also condensed and is adhered to, so just as being stopped up by mud in the river course, coronary lumen is narrowed down, even entirely shut.Arteria coronaria smooth even entirely shut causes blood supply of cardiac muscle bad, and cardiac muscle can not get the nutrition of blood and necrosis is called myocardial infarction, and this is the most serious performance of coronary heart disease.In case myocardium large tracts of land infarction can not be eliminated again fast, people's life also just is through with so.Modern medicine is divided into two classes substantially to cardiopathic treatment means under the guidance of this theory: one is to use medicine to comprise blood vessel dilating class medicine and thrombolytic fat melting class medicine; The 2nd, support, bypass surgery.In the treatment of coronary heart disease, intervene operation and bypass surgery all belong to the wound treatment, and postoperative complication has a strong impact on patient's body health simultaneously.These methods are effective rescuing the sexual stage significant particularly in the treatment to the cardiac.But the precipitation once more that but can not solve rubbish such as vascular lipids from the source forms new speckle, causes blood vessel restenosis, obstruction, the problem of the not smooth chronic illness recurrence of blood supply of cardiac muscle.
Many in the new Chinese medicine of Shang Shi treatment angina pectoris in recent years with blood circulation promoting and blood stasis dispelling, the regulating QI to relieve pain therapy is main, as DIAOXINXUE KANG, the Radix Salviae Miltiorrhizae oral liquid, FUFANG DANSHEN JIAONANG, XINTONGKOU PIAN, BUXINQI KOUFUYE, grow the heart-yin oral liquid, disclosed treatment cardiovascular disease Chinese medicine preparation or the like among QI invigorating oral liquid and the patent documentation CN 1244372C, and clinical research shows: it is year high common etiology and pathogenesis of people that the heart is suffered from a deficiency of the kidney weak, singly executing promoting blood circulation by removing blood stasis is in fear of just hindering, and if with " nourishing kidney is nourished heart " Yu among, both anti-fraud of just hindering, can strengthen cardiorenal function again, more help blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of viewpoint that meets differentiation of tcm, realizes the Chinese medicine of the treatment coronary heart disease of nourishing YIN warming YANG.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
A kind of Chinese medicine for the treatment of coronary heart disease, the medicament of making by the former medicine of following weight parts:
25～50 parts in Radix Rehmanniae Preparata, 10～25 parts of Fructus Corni, 15～30 parts of Herba Cistanches, 5～20 parts of gun additioners, 5～15 parts of Radix Ginsengs, 15～25 parts of Radix Ophiopogonis, 2.5～10 parts of Fructus Schisandrae Chinensis, 5～15 parts of Ramulus Cinnamomi, 5～10 parts in Radix Glycyrrhizae, 10～25 parts of Radix Angelicae Sinensis, 15～50 parts of the Radixs Astragali, 15～50 parts of Radix Salviae Miltiorrhizaes, 1.5～5 parts in Lignum Santali Albi, 5～10 parts of Fructus Amomis, 5～15 parts of Rhizoma Chuanxiongs, 10～20 parts of Fructus Crataegis, 15～25 parts of Flos Lonicerae, 15～25 parts of Radix Scrophulariaes, 15～50 parts in the Radix Rehmanniae.
Described medicine is any one in oral solutions, powder, tablet, the capsule.
The preparation method of described oral solutions is: with total raw material by medicine: the Capacity Ratio of water is that soaked 0.5 hour at least 1:2～4, adds suitable quantity of water again and decocts 0.5～2 hour, considers and goes behind the medicinal residues sterile preservation or sterile filling to get final product.
Described medicaments preparation method is: with total raw material by medicine: the Capacity Ratio of water is that soaked 0.5 hour at least 1:2～10, adding suitable quantity of water again decocted 0.5～2 hour, the elimination medicinal residues, under negative pressure, cryogenic condition clarifying Chinese medicine leachate being concentrated into the Bomi degree is more than 80%, make dry powder (temperature of spout≤100 ℃) by powder spraying apparatus, in dry powder, make tablet or capsule again behind the absorb fillers.
Described medicaments preparation method is: be mixed in proportion after each former medicine is ground to form fine powder, and cross 100～200 mesh sieves, be powder, or powder compaction is become tablet, or powder incapsulated make capsule.
The present invention has actively useful effect:
1. dialectical medication and composition principle
Coronary heart disease belongs to the thoracic obstruction, cardiopalmus, angina pectoris category, and clinical manifestation is diseases such as severe palpitation, irregularly intermittent and regularly intermittent pulse, angina pectoris, tired unable, sensation of oppression over the chest with shortness of breath or irritated sweating.About this sick pathogeny, the inventor thinks, in people's life nature, six climate exopathogens (wind, cold, summer-heat, wet, dry, fire) arranged outward, in seven emotions (happiness, anger, melancholy, think of, compassion, shy, fear) are arranged; Between each internal organs of human body internal environment, and internal environment and external environment under the mutual equilibrated state, just can keep normal physiological activity only in mutual coordination, shows as healthy sign; If disequilibrium, disorder of movement of QI will make healthy energy impaired between the inside of human body internal organs, positive QI-insufficiency is then invaded in the exopathogen, and disease generates, promptly so-called " healthy energy deposit in, heresy can not be done ", " institute of heresy gathers, its gas must void "; Find six kinds of cards of cardiovascular diseases marquis (stagnation of heart-blood, cold coagulation heart arteries and veins, essential resistance of turbid phlegm, heart deficiency of the kidney yin, deficiency of heart-YANG and kidney-YANG in the clinical treatment practice for many years, insufficiency of heart-QI is weak) in, heart deficiency of the kidney yin, deficiency of heart-YANG and kidney-YANG, insufficiency of heart-QI weak person are in the majority, this be because deficiency of the kidney yin, kidney yin can not on help in the heart, then heart-yang rising, the heart must not be pacified; Deficiency of the kidney yin, liver lose and nourish, and cause excessive rising of liver-YANG again, liver-wind stirring up internally, and conscience is all high, and with the passing of time fire-transformation causes the blood depletion thickness.Insufficiency of kidney-YANG, kidney yang can not be gone up replenishing vital QI with drugs of warm nature in the heart, and then heart-yang is not prosperous; Insufficiency of kidney-YANG can make hypoactivity of spleen-YANG again, and fortuneization is unable, forms deficiency of both the heart and spleen; A little less than the insufficiency of heart-QI, agitate the dynamics of blood operation to reduce, speed slows down, and flow reduces.Slowly under the situation, materials such as the lipid in the blood, cholesterol very easily are deposited on blood vessel, and intravascular space is narrowed down at this hyperlipidemia, flow velocity, the artery-clogging inner chamber cause myocardial ischemia to form the thoracic obstruction, and the whole body blood vessel also will inevitably be impaired, especially cerebrovascular impaired after, easily cause apoplexy.In view of the above, in treatment and angiocardiopathy preventing, should with the kidney key link, each is dirty to pay attention to conditioning kidney conscience spleen lung, makes it to coordinate coexistence and co-prosperity.
Coronary heart disease pathogenesis complexity, existing weakened body resistance one side has the one side of the domination of pathogen again.Weakened body resistance one side comprises a little less than heart deficiency of the kidney yin, deficiency of heart-YANG and kidney-YANG, the insufficiency of heart-QI; The one side of the domination of pathogen comprises that qi depression to blood stasis, pyretic toxicity join the army.In view of coronary heart disease pathogenesis complexity, the card of deficient and excessive syndromes appearing together, non-folk prescription can be controlled.According to the principle of " disease being not cured by odd-prescription should be treated by even-prescription a, side does not go then to answer it ", the inventor adopts nourishing kidney yin, warm Yuanyang, benefiting QI and nourishing blood, blood circulation promoting and blood stasis dispelling, removing summer-heat blood poison, regulating QI to relieve pain for many years, and all methods are combined into medicine of the present invention, and curative effect is rather good.
All sides' such as medicine of the present invention acquisition dihuang drink, SHENGMAI SAN, Ramuli Cinnamomi and Glycyrrhizae Decoction, shenfu decoction, Radix Angelicae Sinensis decoction for tonifying blood, Radix Salviae Miltiorrhizae drink, SIMIAOYONGAN TANG, Zengye Tang length, and add to simplify to cut out in conjunction with long-term clinical experience and form.Medicine of the present invention is with the Fructus Corni of the Radix Rehmanniae Preparata of sweet temperature and the acid temperature benefiting kidney-YIN that matches; The invigorating kidney-YANG of Herba Cistanches temperature, the Radix Aconiti Lateralis Preparata that compatibility is hot, first down with replenishing vital QI with drugs of warm nature, the merits that medicine-feeding four flavors can be played tonifying both YIN and YANG; SHENGMAI SAN, with tonifying the lung, the prosperous then all dirty gas of lung qi is all prosperous with the sweet temperature supplementing QI for promoting the production of body fluid of its Radix Ginseng, the source of sweet cold yin nourishing moisturizing Radix Ophiopogonis, the trimethyl gallic acid temperature is astringed the lung and is promoted the production of body fluid, entirely can supplementing QI for promoting the production of body fluid, astringing YIN to stop sweating; Shenfu decoction invigorate vital energy and reinforce the heart tonifying YANG, warm promoting blood circulation are often done heart infarction, the first aid side of the heart failure; Ramulus Cinnamomi, Radix Glycyrrhizae warming and activating heart-YANG are specially controlled the cardiopalmus of deficiency of heart-YANG; Radix Angelicae Sinensis decoction for tonifying blood, with the gas of Radix Astragali spleen reinforcing lung, as a means of biochemistry, Chinese Angelica blood replonishing is promoted blood circulation, and plays the merit of qi-supplementing, blood-engendering; Radix Salviae Miltiorrhizae drink in the side, the Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, pain relieving and the non-impairment of QI-blood, Lignum Santali Albi, the pain relieving of Fructus Amomi warming middle-JIAO to promote flow of QI, this medicine three flavors, the property of medicine is gentle, QI and blood and controlling, but both blood stasis dispelling promoting the circulation of QI to relieve pain, be again the good recipe of the obstruction of qi in the chest and cardialgia of the cold disease retardance of treatment, hypofunction of YANG QI in chest, more join Rhizoma Chuanxiong, Fructus Crataegi blood circulation promoting and blood stasis dispelling, analgesic effect is better; Flos Lonicerae, Radix Scrophulariae agree Radix Angelicae Sinensis without prior consultation, Radix Glycyrrhizae is SIMIAOYONGAN TANG, but heat-clearing and toxic substances removing, promoting blood circulation and stopping pain join live painstaking effort, nourishing heart powder of Radix Salviae Miltiorrhizae again and become silted up, cure pained its merit of more seeing.
Clinical diagnosis is among the patient of coronary disease, and the trouble glycosuria patient that holds concurrently is many, and diabetes make coronary heart disease increase the weight of conversely, in treatment coronary heart disease, must pay attention to the control of diabetes, the Radix Astragali, the Radix Rehmanniae, Radix Scrophulariae, Radix Salviae Miltiorrhizae in the side, modern medicine study all has good hypoglycemic activity.Moreover, patients with coronary heart disease particularly the aged coronary heart disease patient double to suffer from constipation person many, the constipation serious disease that concerning common people, is nothing, but be a mortal malady concerning patients with coronary heart disease, because constipation makes difficult defecation, when straining at stool, the cardiac pressure load increases, and brings out the heart infarction sudden death easily, for taking this problem into account, the Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis constitute Zengye Tang in the side, merit promote the production of body fluid moisturize, loosening bowel to relieve constipation.
The pharmacological effect of each crude drug of distinguishing the flavor of:
Radix Rehmanniae Preparata, sweet, tepor.Return liver, kidney channel.The yin nourishing of enriching blood, life essence-filling, marrow-benefitting.Radix Rehmanniae Preparata can significantly suppress liver hemorrhagic necrosis kitchen range and simple necrosis; To the hyperlipemia that high lipid food causes, the hepatic vein hemorrhage that fatty liver and rat endotoxin cause all has the thrombotic effect of inhibition; To the activation of plasminogen, be antithrombotic mechanism of action.
Fructus Corni, sour, puckery, tepor.Return liver, kidney channel.Liver and kidney tonifying, essence astringing and desertion stemming.Be used for vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating collapse.Interior-heat is quenched one's thirst.The anti-stress ability of Fructus Corni energy enhancing body improves mice anoxia enduring, anti-fatigue ability, memory reinforcing.Fructus Corni can improve SOD activity in the erythrocyte, to anti peroxidation of lipid.Its ethanol extract also has effect for reducing blood fat, can reduce serum triglycerides, content of cholesterol, arteriosclerosis.
Herba Cistanches is returned through sweet, salty temperature.Return kidney, large intestine channel.Kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation." Bencao Jingshu ": the key medicine of nourishing kidney replenishing vital essence and blood, the invigorating middle warmer of sweet energy heat extraction, acid can be gone into liver, the nourishing kidney of salty energy, the kidney liver is cloudy, and cloudy gas is grown, and then the consumptive fever of the five internal organs is from moving back the spontaneous recovery of penis invasion by pathogenic cold burning pain.
Gun additioner, suffering, big heat, poisonous.Go into the heart, spleen, kidney channel.Recuperating depleted YANG and rescuing the patient from collapse, warming the interior is by trembling with fear antalgic.Contain multiple alkaloid: hypaconitine (Hypa-conitine), aconitine (Aconitine), mesaconitine (Mesaconitine), talaisamine (Talatisamine), chuan-wu base A and chuan-wu base B etc.
Radix Ginseng, property is flat, sweet in the mouth, little hardship, tepor.Return spleen, lung meridian.Strongly invigorating primordial QI, multiple arteries and veins takes off invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the Fructus Alpiniae Oxyphyllae of calming the nerves admittedly.Radix Ginseng has protective effect to cardiac muscle.The ginsenoside can reduce mice brain and myocardium lactic acid content under the severe depletion of oxygen situation, cardiac muscle cAMP/cGMP ratio in the time of recovering anoxia, and the effect that has protection heart muscle capillary endotheliocyte and alleviate mitochondrial injury.
Radix Ophiopogonis, sweet, little hardship is slightly cold.GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Be used for dryness of the lung dry cough.The chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, the dryness of the intestine constipation; Pharyngeal diphtheria.Infraction back myocardial nutritional flow amount is increased, and the myocardial cell of hypoxic-ischemic comparatively fast obtains to repair and protection, causes the release of myocardium cGMP and cAMP to reduce, thereby reduces the content in the blood plasma, and both are restored balance by ratio.
Fructus Schisandrae Chinensis, temperature; Sour, sweet; Return lung, the heart, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Fructus Schisandrae Chinensis has vasodilative effect.Schizandrin, schisandrin C, deoxyschisandrin etc. shrink for stripped Canis familiaris L. Mesenteric artery all inhibitory action, can increase arteries and veins Mus isolated heart and anesthesia Canis familiaris L. coronary flow.Fructus Schisandrae Chinensis helps histiocytic oxygen exchange, can produce protective effect to heart tissue, also palmic rate and relieve hypertension gently.
Ramulus Cinnamomi, hot, sweet, temperature.GUIXIN, lung, urinary bladder channel.The diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Blood vessel dilating is regulated blood circulation, makes blood flow to body surface, strengthens the Herba Ephedrae perspiration.
Radix Glycyrrhizae, property is flat, and sweet in the mouth is returned 12 warps.Detoxifcation arranged, eliminate the phlegm, pain relieving, spasmolytic be so that pharmacological action such as anticancer.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Radix Angelicae Sinensis, warm in nature, hide sweet, hot.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Radix Angelicae Sinensis can improve hypercoagulability in the body, adjusts blood lipid metabolism, cholesterol reducing.
The Radix Astragali, property is sweet, tepor.Return lung, spleen, liver, kidney channel.There are benefiting QI for strengthening the superficies, arresting sweating to take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.The Radix Astragali can strengthen myocardial contraction, and coronary artery dilating improves myocardial blood flow and myocardial metabolism, improves superoxide dismutase activity, lowers lipid peroxide contents, thereby alleviates the damage that free radical causes.
Radix Salviae Miltiorrhizae, hardship is slightly cold.GUIXIN, Liver Channel.Promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.Radix Salviae Miltiorrhizae energy blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, the mind calming that nourishes blood can increase the coronary heart disease blood flow, improves myocardial contraction, and does not increase the myocardial ischemia amount, promotes the reallocation of side Zhi Xunhuan and blood flow.
Lignum Santali Albi, suffering, temperature.Return spleen, stomach, the heart, lung meridian.The circulation of qi promoting warming middle-JIAO, the appetizing pain relieving.Be used for QI stagnated by cold, chest pain, stomachache, stomachache lack of appetite; Coronary heart disease, angina pectoris.
Fructus Amomi, acrid in the mouth, warm in nature.Return spleen channel, stomach warp, kidney channel." the medical center bun is wanted ": the profit kidney, tonifying liver is mended the gate of vitality, and taste, relieving stagnation.
Rhizoma Chuanxiong, suffering, temperature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.Be used to pacify nerve, positive wind syndrome of head headache, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Rhizoma Chuanxiong can be expanded smooth muscle, microcirculation improvement, and anticoagulant, anti-aggregation are arranged, and the blood pressure lowering by the expansion peripheral vessel.
Fructus Crataegi, sour in the mouth, sweet, slightly warm in nature.Return spleen, stomach, Liver Channel.Appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, the circulation of qi promoting of reducing phlegm.Be used for carnivorous stagnate long-pending, lump in the abdomen, abdominal distention feeling of fullness, the stasis of blood resistance stomachache, phlegm retention, have loose bowels, discharging fresh blood stool etc.Fructus Crataegi can significantly reduce serum cholesterol and triglyceride, effectively prevents and treats atherosclerosis; Fructus Crataegi can also play heart tonifying and prevent anginal effect by strengthening myocardial contraction, increase cardiac output, coronary artery dilator blood vessel, coronary blood flow increasing, reduction myocardial oxygen consumption etc.In addition, the total flavones in the Fructus Crataegi has the effect of blood vessel dilating and lasting blood pressure lowering.
Flos Lonicerae, sweet, cold.Attach to the lung and stomach meridians.Effect: heat-clearing and toxic substances removing.Has effect for reducing blood fat.
Radix Scrophulariae, sweet in the mouth, hardship, salty; Cold nature.Return lung, stomach, kidney channel.Pathogenic warmth is joined the army, the pericardium that caves in, and maculae caused by violent heat pathogen, constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus are hindered in consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin.
The Radix Rehmanniae, sweet, cold.GUIXIN, liver, kidney channel.Clearing away heat and cooling blood, yin nourishing is promoted the production of body fluid.Be used for calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis is sent out the speckle dermexanthesis.
Function with cure mainly
Medicine of the present invention is used for the treatment of coronary heart disease, tool consolidates mark, the multiple effect of just removing heresy, and it is to be the key link of treatment to nurse one's health renal function, pays attention to the coordination of function of internal organs such as kidney, the heart, liver, spleen simultaneously, kidney yin must be grown, down first warm, QI and blood must be mended, congestion must be separated, pyretic toxicity can be clear, not only can the blood fat reducing anticoagulant, blood viscosity lowering, thrombus, can also improve vascular endothelial function, remove vasospasm, arteriosclerosis is stablized vulnerable plaque; Blood, vascular lesion are had the double treatment effect, can treat cardiovascular system diseases effectively.
3. disease is diagnosed and criterion of therapeutical effect
" traditional Chinese medical science disease diagnosis criterion of therapeutical effect " according to State Administration of Traditional Chinese Medicine's issue on June 28th, 1994 carries out the judgement of disease diagnosis and criterion of therapeutical effect.
Inventor's recent two decades successively receives thousands of name persons of seing patients, and wherein remains with 1129 people of complete case history archive record, male 748 people wherein, women 381 people.Age is 40～55 years old person 175 people, 56～65 years old person 597 people, person 357 people more than 66 years old.Among 1129 persons of seing patients, the shortest person of the course of disease more than 80 day, elder reaches 15 years.
To person's of seing patients oral " protect kidney protect the heart soup " water decoction, every day potion, one month is a course of treatment, a general patient's subjective symptoms course of treatment is obviously improved, Most patients reaches three to four courses of treatment cures or produce effects.Clinical manifestation before and after the detailed observed and recorded patient treatment of period in a medicine as finding untoward reaction, is taked respective handling.The viewing duration other drug stops without exception.Clinical curative effect analysis sees Table 1, and the clinical total effective rate of this prescription reaches 96.14% as can be known from table, and does not find that during treating this medicament has obvious toxic and side effects.
Table 1 TCM Syndrome Type and clinical curative effect analysis
The specific embodiment
1 one kinds of Chinese medicines for the treatment of coronary heart disease of embodiment, make by following former medicine:
Radix Rehmanniae Preparata 35g, Fructus Corni 20g, Herba Cistanches 25g, gun additioner 15g, Radix Ginseng 10g, Radix Ophiopogonis 20g, Fructus Schisandrae Chinensis 6g, Ramulus Cinnamomi 10g, Radix Glycyrrhizae 8g, Radix Angelicae Sinensis 18g, Radix Astragali 35g, Radix Salviae Miltiorrhizae 40g, Lignum Santali Albi 3.5g, Fructus Amomi 7g, Rhizoma Chuanxiong 10g, Fructus Crataegi 15g, Flos Lonicerae 20g, Radix Scrophulariae 20g, Radix Rehmanniae 35g.
The raw material that more than is one pair of medicament constitutes (during batch process, each component enlarges in proportion), with it by medicine: the Capacity Ratio of water is that 1:2 soaked 1.5 hours, adding suitable quantity of water again decocted 1 hour, consider and remove medicinal residues, obtain medicinal liquid 150 mL, the sealing fill of sterilization back gets final product.Divide early, middle and late three clothes, each 50mL, one month is a course of treatment.
2 one kinds of Chinese medicines for the treatment of coronary heart disease of embodiment, make by following former medicine:
Radix Rehmanniae Preparata 25g, Fructus Corni 10g, Herba Cistanches 15g, gun additioner 5g, Radix Ginseng 5g, Radix Ophiopogonis 15g, Fructus Schisandrae Chinensis 2.5g, Ramulus Cinnamomi 5g, Radix Glycyrrhizae 5g, Radix Angelicae Sinensis 10g, Radix Astragali 15g, Radix Salviae Miltiorrhizae 15g, Lignum Santali Albi 1.5g, Fructus Amomi 5g, Rhizoma Chuanxiong 5g, Fructus Crataegi 10g, Flos Lonicerae 15g, Radix Scrophulariae 15g, Radix Rehmanniae 15g.
The raw material that more than is one pair of powder constitutes, and moisture many former medicine lyophilizations such as Radix Angelicae Sinensis, Fructus Crataegi are pulverized again, and each former medicine that water content is low directly is ground into fine powder, and crosses 150 mesh sieves, promptly makes powder.Every day, early, middle and late taking 3 times obeyed crude drug in whole fine powder 6～12g at every turn, and one month is a course of treatment.
3 one kinds of Chinese medicines for the treatment of coronary heart disease of embodiment, make by following former medicine:
Radix Rehmanniae Preparata 50g, Fructus Corni 25g, Herba Cistanches 30g, gun additioner 20g, Radix Ginseng 15g, Radix Ophiopogonis 25g, Fructus Schisandrae Chinensis 10g, Ramulus Cinnamomi 15g, Radix Glycyrrhizae 10g, Radix Angelicae Sinensis 25g, Radix Astragali 50g, Radix Salviae Miltiorrhizae 50g, Lignum Santali Albi 5g, Fructus Amomi 10g, Rhizoma Chuanxiong 15g, Fructus Crataegi 20g, Flos Lonicerae 25g, Radix Scrophulariae 25g, Radix Rehmanniae 50g.
The raw material that more than is one pair of Chinese patent medicine constitutes.During preparation, with total raw material by medicine: the Capacity Ratio of water is that 1:3 soaks 1h at least, add suitable quantity of water again and decoct 2h, the elimination medicinal residues, under negative pressure, cryogenic condition clarifying Chinese medicine leachate being concentrated into the Bomi degree is more than 75%, make dry powder (temperature of spout≤100 ℃) by powder spraying apparatus, in dry powder, add being pressed into tablet (above be conventional Chinese drug preparation technique) behind an amount of medical starch again.Take every day 3 times (early, middle and late), obey 4～6 (be equivalent to crude drug in whole 8～12g), one month is a course of treatment at every turn.
4 one kinds of Chinese medicines for the treatment of coronary heart disease of embodiment, make by following former medicine:
Radix Rehmanniae Preparata 40g, Fructus Corni 15g, Herba Cistanches 20g, gun additioner 10g, Radix Ginseng 8g, Radix Ophiopogonis 18g, Fructus Schisandrae Chinensis 7g, Ramulus Cinnamomi 12g, Radix Glycyrrhizae 6g, Radix Angelicae Sinensis 22g, Radix Astragali 40g, Radix Salviae Miltiorrhizae 35g, Lignum Santali Albi 2g, Fructus Amomi 8g, Rhizoma Chuanxiong 12g, Fructus Crataegi 17g, Flos Lonicerae 18g, Radix Scrophulariae 22g, Radix Rehmanniae 40g.Preparation and instructions of taking are with embodiment 1.
5 one kinds of Chinese medicines for the treatment of coronary heart disease of embodiment, make by following former medicine:
Radix Rehmanniae Preparata 30g, Fructus Corni 15g, Herba Cistanches 16g, gun additioner 8g, Radix Ginseng 6g, Radix Ophiopogonis 16g, Fructus Schisandrae Chinensis 3g, Ramulus Cinnamomi 7g, Radix Glycyrrhizae 8g, Radix Angelicae Sinensis 12g, Radix Astragali 17g, Radix Salviae Miltiorrhizae 16g, Lignum Santali Albi 3g, Fructus Amomi 6g, Rhizoma Chuanxiong 6g, Fructus Crataegi 12g, Flos Lonicerae 16g, Radix Scrophulariae 16g, Radix Rehmanniae 17g.Preparation and instructions of taking are with embodiment 1.
6 one kinds of Chinese medicines for the treatment of coronary heart disease of embodiment, make by following former medicine:
Radix Rehmanniae Preparata 45g, Fructus Corni 24g, Herba Cistanches 28g, gun additioner 18g, Radix Ginseng 14g, Radix Ophiopogonis 24g, Fructus Schisandrae Chinensis 9g, Ramulus Cinnamomi 13g, Radix Glycyrrhizae 9g, Radix Angelicae Sinensis 23g, Radix Astragali 45g, Radix Salviae Miltiorrhizae 48g, Lignum Santali Albi 4.5g, Fructus Amomi 9g, Rhizoma Chuanxiong 14g, Fructus Crataegi 18g, Flos Lonicerae 24g, Radix Scrophulariae 24g, Radix Rehmanniae 45g.Preparation and instructions of taking are with embodiment 1.
7 one kinds of Chinese medicines for the treatment of coronary heart disease of embodiment, make by following former medicine:
Radix Rehmanniae Preparata 30g, Fructus Corni 22g, Herba Cistanches 18g, gun additioner 20g, Radix Ginseng 7g, Radix Ophiopogonis 23g, Fructus Schisandrae Chinensis 3g, Ramulus Cinnamomi 15g, Radix Glycyrrhizae 7g, Radix Angelicae Sinensis 24g, Radix Astragali 18g, Radix Salviae Miltiorrhizae 45g, Lignum Santali Albi 1.5g, Fructus Amomi 8g, Rhizoma Chuanxiong 6g, Fructus Crataegi 12g, Flos Lonicerae 24g, Radix Scrophulariae 16g, Radix Rehmanniae 42g.Preparation and instructions of taking are with embodiment 2.
8 one kinds of Chinese medicines for the treatment of coronary heart disease of embodiment, make by following former medicine:
Radix Rehmanniae Preparata 48g, Fructus Corni 11g, Herba Cistanches 28g, gun additioner 6g, Radix Ginseng 13g, Radix Ophiopogonis 16g, Fructus Schisandrae Chinensis 9g, Ramulus Cinnamomi 5g, Radix Glycyrrhizae 9g, Radix Angelicae Sinensis 12g, Radix Astragali 48g, Radix Salviae Miltiorrhizae 16g, Lignum Santali Albi 4g, Fructus Amomi 6g, Rhizoma Chuanxiong 14g, Fructus Crataegi 18g, Flos Lonicerae 16g, Radix Scrophulariae 24g, Radix Rehmanniae 18g.Preparation and instructions of taking are with embodiment 3.
9 one kinds of Chinese medicines for the treatment of coronary heart disease of embodiment, make by following former medicine:
Radix Rehmanniae Preparata 26g, Fructus Corni 12g, Herba Cistanches 29g, gun additioner 9g, Radix Ginseng 12g, Radix Ophiopogonis 19g, Fructus Schisandrae Chinensis 8g, Ramulus Cinnamomi 8g, Radix Glycyrrhizae 8g, Radix Angelicae Sinensis 23g, Radix Astragali 38g, Radix Salviae Miltiorrhizae 46g, Lignum Santali Albi 2.5g, Fructus Amomi 6g, Rhizoma Chuanxiong 7g, Fructus Crataegi 13g, Flos Lonicerae 22g, Radix Scrophulariae 19g, Radix Rehmanniae 28g.Preparation and instructions of taking are with embodiment 3.
10 1 kinds of Chinese medicines for the treatment of coronary heart disease of embodiment, make by following former medicine:
Radix Rehmanniae Preparata 38g, Fructus Corni 18g, Herba Cistanches 27g, gun additioner 11g, Radix Ginseng 11g, Radix Ophiopogonis 17g, Fructus Schisandrae Chinensis 5.5g, Ramulus Cinnamomi 7g, Radix Glycyrrhizae 7g, Radix Angelicae Sinensis 11g, Radix Astragali 32g, Radix Salviae Miltiorrhizae 42g, Lignum Santali Albi 4.5g, Fructus Amomi 7.5g, Rhizoma Chuanxiong 7g, Fructus Crataegi 12g, Flos Lonicerae 17g, Radix Scrophulariae 18g, Radix Rehmanniae 25g.Preparation and instructions of taking are with embodiment 1.
11 1 kinds of Chinese medicines for the treatment of coronary heart disease of embodiment, make by following former medicine:
Radix Rehmanniae Preparata 32g, Fructus Corni 14g, Herba Cistanches 22g, gun additioner 14g, Radix Ginseng 7g, Radix Ophiopogonis 19g, Fructus Schisandrae Chinensis 3g, Ramulus Cinnamomi 9g, Radix Glycyrrhizae 7g, Radix Angelicae Sinensis 13g, Radix Astragali 28g, Radix Salviae Miltiorrhizae 26g, Lignum Santali Albi 2g, Fructus Amomi 6g, Rhizoma Chuanxiong 7g, Fructus Crataegi 13g, Flos Lonicerae 17g, Radix Scrophulariae 16g, Radix Rehmanniae 28g.Preparation and instructions of taking are with embodiment 1.
12 1 kinds of Chinese medicines for the treatment of coronary heart disease of embodiment, make by following former medicine:
Radix Rehmanniae Preparata 47g, Fructus Corni 23g, Herba Cistanches 27g, gun additioner 17g, Radix Ginseng 13g, Radix Ophiopogonis 22g, Fructus Schisandrae Chinensis 8g, Ramulus Cinnamomi 13g, Radix Glycyrrhizae 8g, Radix Angelicae Sinensis 23g, Radix Astragali 43g, Radix Salviae Miltiorrhizae 44g, Lignum Santali Albi 4g, Fructus Amomi 8g, Rhizoma Chuanxiong 14g, Fructus Crataegi 19g, Flos Lonicerae 24g, Radix Scrophulariae 22g, Radix Rehmanniae 41g.Preparation and instructions of taking are with embodiment 1.
Only enumerate some concrete case explanations in recent years below:
Case 1 Zhao's generation method, the man, 55 years old, Jian Tou township, Xincai County, Henan Province Zhao Tang village peasant, suffered from coronary heart disease in 1987, repeatedly go to provincial capital how home large hospital diagnosis and treatment not see that obvious curative effects is arranged, the inventor that comes locates to go to a doctor in June, 1989, gives clothes embodiment the Chinese medicine of 1 described treatment coronary heart disease, (one month is a course of treatment after continuous two courses of treatment, down together), symptom is eliminated, and visits and does not have recurrence in 2 years.
Case 2 Ma Jinlong, the man, 41 years old, Xincai County, Henan Province Zhuan Jiren diagnoses out trouble coronary heart disease in October, 2000, introduces the inventor to locate to go to a doctor April calendar year 2001 through the people, give clothes embodiment the Chinese medicine of 2 described treatment coronary heart disease, after serveing on nearly two courses of treatment, symptom is eliminated fully, visits and does not have recurrence in 2 years.
Case 3 Xu Guohuas, man, 60 years old, Sun Zhao township, Xincai County, Henan Province government functionary, diagnose out trouble coronary heart disease in August, 2005, seeks medical advice in many ways, and it is countless to spend, all there is not obvious curative effects, invention place of coming is gone to a doctor in February, 2008, gives clothes embodiment the Chinese medicine of 3 described treatment coronary heart disease, serve on more than two after the course of treatment, symptom is eliminated fully, visits 2 and does not have recurrence.
Case 4 Zhao's generation beautiful jades, woman, 63 years old, the machine-operated retired cadre in Xincai County, Henan Province, December in 2005 burst on the 25th heart infarction, the inventor that comes locates to go to a doctor, and the Chinese medicine of giving clothes embodiment 4 described treatment coronary heart disease is after two and half courses of treatment, through check, the heart infarction symptom is eliminated fully, visits and does not have recurrence in 2 years.
Case 5 Xu Guohuas, man, 69 years old, oak town and country, Xincai County, Henan Province Chen Lou people from village, diagnose out trouble coronary heart disease in March, 2004, and the diagnosis and treatment of seeking medical advice everywhere in several years fail to take effect, costly, come out of admiration for a famous person in June, 2006 inventor place sees the doctor for treatment, and gives clothes embodiment the Chinese medicine of 5 described treatment coronary heart disease, serve on three courses of treatment after, subjective symptoms is eliminated, and visits and does not have recurrence in 3 years.
Case fearful mountain of 6 generations, the man, nineteen twenty-seven gives birth to, and Xincai County, Henan Province secondary school teachers is checked during one's late 30s and is diagnosed as coronary heart disease, though seek medical advice everywhere, still often outbreak, ill history reaches decades.The inventor that comes out of admiration for a famous person in June, 2005 locates to go to a doctor, and gives clothes embodiment the Chinese medicine of 6 described treatment coronary heart disease, and after 8 courses of treatment, the check disease is eliminated, and does not show effect over 5 years again.
Case 7 generation fine moment, the man, life in 1933, the cultural system worker that leaves one's post in Xincai County, Henan Province diagnoses out trouble coronary heart disease many years ago, cures in many ways, does not see effective in cure.The inventor that comes out of admiration for a famous person in May, 2000 locates to go to a doctor, and the Chinese medicine of giving clothes embodiment 8 described treatment coronary heart disease is after 4 courses of treatment, and symptom is eliminated, and does not recur over 10 years.
Claims (5)
1. a Chinese medicine for the treatment of coronary heart disease is characterized in that, it is to be made by the former medicine of following weight parts:
25～50 parts in Radix Rehmanniae Preparata, 10～25 parts of Fructus Corni, 15～30 parts of Herba Cistanches, 5～20 parts of gun additioners, 5～15 parts of Radix Ginsengs, 15～25 parts of Radix Ophiopogonis, 2.5～10 parts of Fructus Schisandrae Chinensis, 5～15 parts of Ramulus Cinnamomi, 5～10 parts in Radix Glycyrrhizae, 10～25 parts of Radix Angelicae Sinensis, 15～50 parts of the Radixs Astragali, 15～50 parts of Radix Salviae Miltiorrhizaes, 1.5～5 parts in Lignum Santali Albi, 5～10 parts of Fructus Amomis, 5～15 parts of Rhizoma Chuanxiongs, 10～20 parts of Fructus Crataegis, 15～25 parts of Flos Lonicerae, 15～25 parts of Radix Scrophulariaes, 15～50 parts in the Radix Rehmanniae.
2. the Chinese medicine of treatment coronary heart disease according to claim 1 is characterized in that, described medicine is any one in oral solutions, powder, tablet, the capsule.
3. the Chinese medicine of treatment coronary heart disease according to claim 2, it is characterized in that, the preparation method of described oral solutions is: with total raw material by medicine: the Capacity Ratio of water is that soaked 0.5 hour at least 1:2～4, adds suitable quantity of water again and decocts to consider after 0.5～2 hour and go medicinal residues to get final product.
4. the Chinese medicine of treatment coronary heart disease according to claim 2, it is characterized in that, described medicaments preparation method is: with total raw material by medicine: the Capacity Ratio of water is that soaked 0.5 hour at least 1:2～10, adding suitable quantity of water again decocted 0.5～2 hour, the elimination medicinal residues, under negative pressure, cryogenic condition clarifying Chinese medicine leachate being concentrated into the Bomi degree is more than 80%, make dry powder (temperature of spout≤100 ℃) by powder spraying apparatus, in dry powder, make tablet or capsule again behind the absorb fillers.
5. the Chinese medicine of treatment coronary heart disease according to claim 2 is characterized in that, described medicaments preparation method is: be mixed in proportion after each former medicine is ground to form fine powder, and mistake 100～200 mesh sieves, be powder, or powder compaction is become tablet, or powder incapsulated make capsule.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102600255A (en) * | 2012-03-29 | 2012-07-25 | 周柳池 | Coronary disease treatment capsule |
| CN103919910A (en) * | 2014-04-29 | 2014-07-16 | 山东省立医院 | Medicine for treating coronary heart disease |
| CN104189714A (en) * | 2014-09-20 | 2014-12-10 | 田丽华 | Traditional Chinese medicine capsule for treating coronary heart disease |
| CN105311538A (en) * | 2015-11-21 | 2016-02-10 | 戴淑娟 | Traditional Chinese medicine for treating cardiac insufficiency and fabrication method |
| CN115337348A (en) * | 2021-08-05 | 2022-11-15 | 中国中医药科技发展中心(国家中医药管理局人才交流中心) | Traditional Chinese medicine composition for treating heat accumulation and blood vessels |
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| CN1305483C (en) * | 2005-11-08 | 2007-03-21 | 吴家录 | Heart failure regulating Chinese medicine |
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| CN1136444A (en) * | 1995-05-22 | 1996-11-27 | 王希亚 | Medicine for curing coronary heart disease |
| CN1176814A (en) * | 1997-06-26 | 1998-03-25 | 李静 | Oral liquor for preventing and curing cerebrovascular disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102600255A (en) * | 2012-03-29 | 2012-07-25 | 周柳池 | Coronary disease treatment capsule |
| CN103919910A (en) * | 2014-04-29 | 2014-07-16 | 山东省立医院 | Medicine for treating coronary heart disease |
| CN104189714A (en) * | 2014-09-20 | 2014-12-10 | 田丽华 | Traditional Chinese medicine capsule for treating coronary heart disease |
| CN105311538A (en) * | 2015-11-21 | 2016-02-10 | 戴淑娟 | Traditional Chinese medicine for treating cardiac insufficiency and fabrication method |
| CN115337348A (en) * | 2021-08-05 | 2022-11-15 | 中国中医药科技发展中心(国家中医药管理局人才交流中心) | Traditional Chinese medicine composition for treating heat accumulation and blood vessels |
| CN115337348B (en) * | 2021-08-05 | 2023-10-24 | 中国中医药科技发展中心(国家中医药管理局人才交流中心) | Traditional Chinese medicine composition for treating heat-accumulation blood vessels |
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| CN102210835B (en) | 2013-08-21 |
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