CN102205030A - Chinese medical female-benefiting and menstruation-regulating soup for treating polycystic ovary syndrome - Google Patents
Chinese medical female-benefiting and menstruation-regulating soup for treating polycystic ovary syndrome Download PDFInfo
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Abstract
The invention discloses a Chinese medical female-benefiting and menstruation-regulating soup for treating polycystic ovary syndrome. Aiming at the pathogenesis of the polycystic ovary syndrome, natural Chinese herbal medicines including Chinese yam, dangshen, medlar, bighead atractylodes rhizome, fructus psoraleae, chuanxiong rhizome, red sage root, cowherb seed, motherwort, balloonflower, lotus seed pulp, tuckahoe and semen plantaginis capable of strengthening the spleen, tonifying the kidney, regulating the flow of qi, promoting blood circulation, eliminating dampness and reducing phlegm are selected for refining the soup. By clinical tests, the total effective rate reaches 97.5%, and the soup has the advantages of stable treatment effect, low treatment cost and no obvious side effect; and the soup also has obvious treatment effects on reducing the ovary volume and reducing the occurrence of atretic follicles.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of female menstruation-regulating soup of Chinese medicine benefit for the treatment of polycystic ovary syndrome.
Background technology
Polycystic ovarian syndrome be a kind of be the syndrome of the endocrine regulation of feature with persistence anovulation, excessive androgen or insulin resistant, be the common endocrinopathy of women and cause dysgenesia mostly that its sickness rate accounts for the women of child-bearing age's 5%-10%.Clinically should disease many because of menoxenia, the infertile prescription on individual diagnosis.Research in recent years recognizes that extensively there is insulin resistant in various degree in the women of polycystic ovarian syndrome, and the insulin resistant hyperinsulinemia that occurs together causes many clinical symptoms, and is too high as the androgen level, reproduction is disorderly, metabolism disorder, acne, hirsutism etc.Suffer from the women's arteriosclerosis of polycystic ovarian syndrome and the risk factor increase of cardiovascular disease incidence owing to there is insulin resistant.Polycystic ovarian syndrome is one of infertile principal element of young married woman.Be by the not normal a kind of syndrome that produces of menstrual regulation, this class patient has infrequent menstruation or amenorrhea, infertile, hirsutism and obesity, and bilateral ovaries is the capsule increase.
At present, the Therapeutic Method of polycystic ovarian syndrome mainly contains western medicine, operative treatment and treatment by Chinese herbs, and it is big that western medicine exists side effect, and specific aim is poor, can not regulate prescription according to the variation of the state of an illness; The operative treatment wound is big, and the patient is not easy to accept, and treatment cost height, and it is little that treatment by Chinese herbs has side effect, the low advantage of treatment cost, but existing treatment by Chinese herbs all exist take effect slow, the unfavorable problem of therapeutic effect.
Summary of the invention
The purpose of this invention is to provide a kind of female menstruation-regulating soup of Chinese medicine benefit for the treatment of polycystic ovary syndrome, at the pathogeny of polycystic ovary syndrome, the natural Chinese medicinal herb of selected tonifying speen and tonifying kidney, vital energy regualting and blood circulation-promoting, drying dampness to eliminate phlegm forms.
The objective of the invention is to be achieved through the following technical solutions, the female menstruation-regulating soup of Chinese medicine benefit of this treatment polycystic ovary syndrome is made by following parts by weight of Chinese traditional medicine: Rhizoma Dioscoreae 9-15 part, Radix Codonopsis 5-9 part, Fructus Lycii 9-15 part, Rhizoma Atractylodis Macrocephalae 5-9 part, Fructus Psoraleae 10-15 part, Rhizoma Chuanxiong 12-19 part, Radix Salviae Miltiorrhizae 5-9 part, Semen Vaccariae 9-15 part, Herba Leonuri 9-15 part, Radix Platycodonis 5-9 part, Semen Nelumbinis 9-15 part, Poria 7-12 part, Semen Plantaginis 7-12 part.
Preferably, the female menstruation-regulating soup of the Chinese medicine of this treatment polycystic ovary syndrome benefit is made by following parts by weight of Chinese traditional medicine: 12 parts of Rhizoma Dioscoreaes, 7 parts of Radix Codonopsis, 12 parts of Fructus Lycii, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 13 parts of Fructus Psoraleaes, 15 parts of Rhizoma Chuanxiongs, 7 parts of Radix Salviae Miltiorrhizaes, 12 parts of Semen Vaccariae, 12 parts of Herba Leonuris, 7 parts of Radix Platycodoniss, 12 parts of Semen Nelumbinis, 9 parts in Poria, 9 parts of Semen Plantaginiss.
Get above each medicine, add an amount of water, middle routinely drug-decocting method is made decoction.
Rhizoma Dioscoreae, Radix Codonopsis, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae, Fructus Psoraleae invigorating kidney qi in the side, nourishing the liver and kidney, the YIN nourishing benefit is smart, reaches the merit of tonifying speen and tonifying kidney; Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Semen Vaccariae, the unobstructed blood vessels of Herba Leonuri promote that blood is capable, have the promoting the circulation of blood dissipating blood stasis, the promoting blood circulation to restore menstrual flow function; Radix Platycodonis, Semen Nelumbinis, Poria, Semen Plantaginis lung qi dispersing promoting the circulation of QI, invigorating the spleen and benefiting QI, stomach function regulating eliminating dampness by diuresis, clearing away heat and promoting diuresis.
Clinical data
1, the physical data case is selected to go to a doctor in PCOS patient's 80 examples of my institute's specialized department for sterility outpatient service from year June in June, 2003-2008, is divided into treatment group and matched group at random, and 40 examples are organized in treatment, matched group 40 examples.Treatment group age 24-37 year, 26 routine hypomenorrhea, menstrual cycle 45d-6 month; 17 routine amenorrheas, infertile time 2-9, average 3.6 years.Matched group age 25-38 year, 25 routine hypomenorrhea, menstrual cycle 44d-6 month; 15 routine amenorrheas, infertile time 2-10, average 3.5 years.Two groups of patient's physical data there was no significant differences (P＞0.05) have comparability.
2, more than diagnostic criteria (1) hypomenorrhea or amenorrhea half a year; (2) lutropin/follicule-stimulating hormone (FSH)＞2.5; (3) ultrasound diagnosis finds that ovary has polycystic change, atretic follicle number＞8; (4) obesity; (5) acne; (6) hirsutism; (7) basal body temperature is single-phase or the two-phase that is not true to type.Meet (1)～(3), and possess more than 2 in (4)～(7) and can be diagnosed as PCOS.
3, Therapeutic Method treatment group. get the female menstruation-regulating soup of benefit of the present invention, took medicine in hemorrhage the 4th day from menstrual cycle or withdrawal, 1 dose/d, serve on 10d, 1 time/month, serveing on 3 months is 1 course of treatment, treats 1～3 course of treatment altogether.Matched group: (every contains 0.15mg desogestrel and 0.03mg ethinylestradiol from the 1st day oral marvelon tablet of menstrual cycle, Holland Ou Jianong company product), 1/d, serve on drug withdrawal behind the 21d, treat that next menstrual cycle worked the clothes that continue on the 1st day, added Chloramiphene 100mg/d on the 5th day in the 3rd menstrual cycle, altogether 5d.
4, two groups of patients of observation index all begin to follow up a case by regular visits to after the 3rd menstrual cycle medication finishes 1 month, carry out the observation and the detection of every index.(1) basal body temperature; (2) menstrual cycle; (3) maximum cross section area of ultrasound diagnosis ovary and vesicle number, wherein treatment group basal body temperature is two-phase person in menstrual cycle capable once more B ultrasonic check in the 9th～11 day, basal body temperature is single-phase person to be checked after 3 courses of treatment of treatment by Chinese herbs once more, observe maximum cross section area of ovary and follicle number (follicle with diameter 2～8mm as the counting object), all patients check by same B ultrasonic instrument and the same doctor.
5, curative effect determinate standard (1) recovery from illness: the menstrual cycle rule, basal body temperature is two-phase, ovary＜1/4 uterine volume, atretic follicle number＜3, or become pregnant successfully.(2) produce effects: basal body temperature is two-phase, 1h/fsh＜2.5 or ovary＜1/4 uterine volume, and the maximum cross section area of ovary is dwindled and follicle decreased number＞1/2.(3) effective: basal body temperature is the two-phase that is not true to type, and low temperature prolongs mutually or high temperature has fluctuation mutually, the maximum cross section area of ovary dwindle and follicle decreased number＞1/3 and≤1/2.(4) invalid: symptom unit improves or increases the weight of.
6, after therapeutic outcome treatment three courses of treatment, clinical statistics: treatment group 23 examples of fully recovering, produce effects 11 examples, effective 5 examples, invalid 1 example, total effective rate 97.5%; Average menstrual cycle is (55 ± 40) d before taking medicine; 23 its basal body temperatures of routine patient of recovery from illness all transfer typical two-phase to, wherein treat 1 normal (28～36d) persons, 8 example of the menstrual cycle recovery course of treatment, treat 2 normal (27～29d) persons, 9 examples of the menstrual cycle recovery course of treatment, treat 3 the course of treatment menstrual cycle recover normal (30d) person 6 examples, wherein 6 examples have among the fertility claimer 5 examples become pregnant.Matched group 10 examples (menstrual cycle become rule) of fully recovering, produce effects 10 examples (menstrual cycle 40～50d, basal body temperature is shown with ovulation, and autonomous menstrual onset is arranged), effective 9 examples, invalid 11 examples (amenorrhea once more after the drug withdrawal), total effective rate 72.5%.Two groups of patient's total effective rate comparing differences have statistical significance (p＜0.05).
The variation of ultrasound diagnosis ovary and follicle before and after the treatment group treatment: have 30 routine patients all to accept the bilateral ovaries ultrasound diagnosis before and after taking medicine in the treatment group, the result shows that maximum cross section area of treatment front and back ovary and follicle number all have significant change, and difference has statistical significance (p＜0.05).
The specific embodiment
Embodiment one: get Rhizoma Dioscoreae 12g, Radix Codonopsis 7g, Fructus Lycii 12g, Rhizoma Atractylodis Macrocephalae 7g, Fructus Psoraleae 13g, Rhizoma Chuanxiong 15g, Radix Salviae Miltiorrhizae 7g, Semen Vaccariae 12g, Herba Leonuri 12g, Radix Platycodonis 7g, Semen Nelumbinis 12g, Poria 9g, Semen Plantaginis 9g.More than each medicine, add an amount of water, routinely in drug-decocting method make decoction.
Embodiment two: get Rhizoma Dioscoreae 15g, Radix Codonopsis 5g, Fructus Lycii 9g, Rhizoma Atractylodis Macrocephalae 9g, Fructus Psoraleae 10g, Rhizoma Chuanxiong 12g, Radix Salviae Miltiorrhizae 5g, Semen Vaccariae 15g, Herba Leonuri 9g, Radix Platycodonis 5g, Semen Nelumbinis 9g, Poria 12g, Semen Plantaginis 7g.More than each medicine, add an amount of water, routinely in drug-decocting method make decoction.
Embodiment three: get Rhizoma Dioscoreae 9g, Radix Codonopsis 9g, Fructus Lycii 15g, Rhizoma Atractylodis Macrocephalae 5g, Fructus Psoraleae 15g, Rhizoma Chuanxiong 19g, Radix Salviae Miltiorrhizae 9g, Semen Vaccariae 9g, Herba Leonuri 15g, Radix Platycodonis 9g, Semen Nelumbinis 15g, Poria 7g, Semen Plantaginis 12g.More than each medicine add an amount of water, routinely in drug-decocting method make decoction.
Claims (2)
1. the female menstruation-regulating soup of Chinese medicine benefit for the treatment of polycystic ovary syndrome is characterized in that the female menstruation-regulating soup of Chinese medicine benefit of this treatment polycystic ovary syndrome is made by following parts by weight of Chinese traditional medicine: Rhizoma Dioscoreae 9-15 part, Radix Codonopsis 5-9 part, Fructus Lycii 9-15 part, Rhizoma Atractylodis Macrocephalae 5-9 part, Fructus Psoraleae 10-15 part, Rhizoma Chuanxiong 12-19 part, Radix Salviae Miltiorrhizae 5-9 part, Semen Vaccariae 9-15 part, Herba Leonuri 9-15 part, Radix Platycodonis 5-9 part, Semen Nelumbinis 9-15 part, Poria 7-12 part, Semen Plantaginis 7-12 part.
2. the female menstruation-regulating soup of Chinese medicine benefit of treatment polycystic ovary syndrome according to claim 1 is characterized in that the female menstruation-regulating soup of Chinese medicine benefit of this treatment polycystic ovary syndrome is made by following parts by weight of Chinese traditional medicine: 12 parts of Rhizoma Dioscoreaes, 7 parts of Radix Codonopsis, 12 parts of Fructus Lycii, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 13 parts of Fructus Psoraleaes, 15 parts of Rhizoma Chuanxiongs, 7 parts of Radix Salviae Miltiorrhizaes, 12 parts of Semen Vaccariae, 12 parts of Herba Leonuris, 7 parts of Radix Platycodoniss, 12 parts of Semen Nelumbinis, 9 parts in Poria, 9 parts of Semen Plantaginiss.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103272144A (en) * | 2013-05-24 | 2013-09-04 | 孙炳云 | Medicine for treating polycystic ovarian syndrome |
| CN104971301A (en) * | 2015-06-09 | 2015-10-14 | 林加五 | Drug for treating polycystic ovarian syndrome |
| CN108992536A (en) * | 2018-08-16 | 2018-12-14 | 南京长江医院集团有限公司 | Tiaojing Zhongzi |
| CN113599475A (en) * | 2021-09-07 | 2021-11-05 | 宁夏医科大学 | Middle-warming and kidney-tonifying composition for treating polycystic ovarian syndrome and preparation method and application thereof |
Citations (2)
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| CN1178116A (en) * | 1997-07-12 | 1998-04-08 | 迟经惠 | Medicine for tonifying yin for female |
| CN101837112A (en) * | 2010-06-30 | 2010-09-22 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for curing irregular menstrual period and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1178116A (en) * | 1997-07-12 | 1998-04-08 | 迟经惠 | Medicine for tonifying yin for female |
| CN101837112A (en) * | 2010-06-30 | 2010-09-22 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for curing irregular menstrual period and preparation method thereof |
Non-Patent Citations (2)
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| 朱丽娟等: "活血化瘀法治疗妇科疾病研究述要", 《陕西中医学院学报》, vol. 31, no. 06, 10 November 2008 (2008-11-10), pages 88 - 90 * |
| 金燕: "排卵功能障碍的中医药治疗进展", 《安徽中医学院学报》, vol. 22, no. 03, 25 June 2003 (2003-06-25), pages 62 - 64 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103272144A (en) * | 2013-05-24 | 2013-09-04 | 孙炳云 | Medicine for treating polycystic ovarian syndrome |
| CN104971301A (en) * | 2015-06-09 | 2015-10-14 | 林加五 | Drug for treating polycystic ovarian syndrome |
| CN108992536A (en) * | 2018-08-16 | 2018-12-14 | 南京长江医院集团有限公司 | Tiaojing Zhongzi |
| CN113599475A (en) * | 2021-09-07 | 2021-11-05 | 宁夏医科大学 | Middle-warming and kidney-tonifying composition for treating polycystic ovarian syndrome and preparation method and application thereof |
| CN113599475B (en) * | 2021-09-07 | 2022-07-12 | 宁夏医科大学 | Middle-warming and kidney-tonifying composition for treating polycystic ovarian syndrome and preparation method and application thereof |
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