CN102188655A - Molecular Chinese patent medicine for inhibiting defects of Lifei tablets and syndromes of pulmonary tuberculosis - Google Patents

Abstract

The invention relates to a molecular Chinese patent medicine for inhibiting defects of Lifei tablets and syndromes of pulmonary tuberculosis complications (HIV, diabetes, asthma and pneumoconiosis). The medicine is characterized in that the active components of the preparation are suitable for treating clinical symptoms and are in line with medicinal functions, and have the functions of antianaphylaxis, anti-hypoxia, anti-malaria, anti-tumor, immunoloregulation, intelligence development and organ damage resistance. Compared with the existing medicine for treating the diseases, the medicine of the invention has the advantages that: first, the medicine has clear components that are easy to form clinical combination therapy, and also provides scientific basis for optimization (technology and dosage form) and quality control; second, the medicine has a reduced cost and improved drug efficacy; third, combination of the active components of the preparation and a medicament composition for treating pulmonary tuberculosis specified by WTO can enhance the therapeutic effect and reduce the toxicity of the medicament composition; fourth, with a low treatment cost, the medicine reduces the economic burden of the country; fifth, the exhaust gas and herb residue are recyclable as sheet materials and medicinal plants can be used as ornamental plants, thus the added value of the project is raised and environmental pollution is reduced; sixth, the preparation is in line with the ideal medication standards provided by WTO, and is a molecular Chinese patent medicine applicable for treatment and prevention; seventh, the medicine saves land resources.

Description

The molecule Chinese patent medicine that suppresses LIFEI PIAN defective and the concurrent syndrome of pulmonary tuberculosis

One. technical field

The present invention relates to the field of Chinese medicines, specifically, relate to the molecule Chinese patent medicine that suppresses LIFEI PIAN defective and pulmonary tuberculosis and concurrent (HIV, diabetes, asthma and pneumoconiosis) syndrome.

Two. background technology

Along with increasing of environmental pollution, HIV, diabetes, pneumoconiosis and asthmatic patient, the tuberculosis epidemic situation is gone up, and China is one of the high burden of 22 tuberculosis in whole world country, also is simultaneously to pollute in the world that China has 13 in 20 the most serious cities.At present this disease of control adopts the medicine combination (isoniazid, rifampicin, arsenic carboxamide dihydrochloride, ethambutol, streptomycin) of WTO regulation, and its side effect is: treatment time is long, easily drug resistance, produce and be still a world medicine difficult problem at present what environment produced pollution, medical expense height, pulmonary tuberculosis complication (HIV, diabetes, asthma and pneumoconiosis).

Though LIFEI PIAN has obtained certain curative effect at the treatment pulmonary tuberculosis cough, because self-defect has limited its development.One of defective. market price confusion-with the every box price of standard is the highest and minimumly differ tens times; Two. become to be hard to tell and cause clinical misuse, misuse, medical treatment cost is improved, share, cardiac glycoside poisoning-arrhythmia and conduction block easily take place as Radix Glycyrrhizae, Concha Ostreae and Bulbus Lilii in the LIFEI PIAN and Western medicine cardiac tonic ...; Three. quality instability (Shanghai public research/development platform pulmonary tuberculosis experiment prove); Four. its technology (extract, concentrate, drying) is removed as immunomodulating, anti-compositions such as (pulmonary tuberculosis, asthma, HIV virus, allergy, pneumoconiosis, malaria) a large amount of effective active compositions, causes the wasting of resources, environmental pollution; Five. the tablet poor solubility, be difficult in the body absorb, cause the medical material utilization rate low.

Therefore people seek a kind of better method, break through above-mentioned bottleneck, and be free from side effects, the Chinese patent medicine of taking convenience.

Three. summary of the invention

I find through the practice of for many years market, clinically Chinese patent medicine am used lack of standardization, through wrong and misuse commonly used, medical treatment cost am improved, the reason that causes be become to be hard to tell-mechanism is unclear, LIFEI PIAN is exactly one of them.

One of the object of the invention is exactly: in the searching, the common language of doctor trained in Western medicine, suppress the LIFEI PIAN defective, create high effect nontoxic, definite ingredients and quality controllable modern molecule Chinese patent medicine.

Another one purpose of the present invention is exactly: medicine combination (isoniazid, rifampicin, arsenic carboxamide dihydrochloride, ethambutol, streptomycin) curative effect that a kind of WTO of enhancing regulation is provided, lower the toxic and side effects of this drug regimen and the medicine for the treatment of pulmonery tuberculosis complication (HIV, diabetes, asthma and pneumoconiosis) syndrome, this medicine can effectively improve actual cure rate, at a specified future date do not have bounce-back, and have no side effect.

Four. research method

Utilize molecular biology and Measurement for Biochemistry research LIFEI PIAN prescription pluses and minuses, and propose solution.

LIFEI PIAN is made up of the Radix Stemonae, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium Eriobotryae, Bulbus Lilii, Cordyceps, Gecko powder, Fructus Schisandrae Chinensis, Concha Ostreae, Radix Glycyrrhizae nine flavor medical materials, and their effect is as follows:

The Radix Stemonae: [meridian distribution of property and flavor] sweet in the mouth, hardship, slightly warm in nature.Return lung meridian.

[effect cures mainly] nourishing the lung to arrest cough, new chronic cough is coughed, pertussis, consumptive disease is coughed; Anti HIV-1 virus; Antibiotic.

(1) Miao ethnic group: reducing the asthenic fever, cough-relieving, pulmonary tuberculosis, cough.

(2) Bouyei: treatment pneumonia

The Pseudobulbus Bletillae (Rhizoma Bletillae): [property of medicine return through] bitter in the mouth, sweet, puckery, cold nature.Attach to the lung and stomach meridians.

[function with cure mainly] astringing to arrest bleeding, detumescence and promoting granulation; Cure mainly spitting of blood, haematemesis, pneumosilicosis, warm malaria, eliminating inflammation and expelling toxin, appetizing, epidemic disease flu, dyspepsia, gallbladder disease, treatment pulmonary tuberculosis (Wa, the Dai nationality, the Yi nationality, distributed over Yunnan, Sichuan and Guizhou, the Yao nationality, De'ang nationality, Jingpo Nationality, Bai nationality, the Dong nationality, Tujia); Anti HIV-1 virus; Antibiotic.

Folium Eriobotryae: [property of medicine] bitter in the mouth, little suffering, cold nature.Attach to the lung and stomach meridians.

[function with cure mainly] clearing away lung-heat to relieve cough, regulating the stomach and sending down the abnormal ascending QI is quenched the thirst.Cure mainly the cough due to lung-heat, deficiency of YIN chronic cough, hemoptysis, haematemesis, gastropyretic vomiting, treatment pulmonary tuberculosis (Mulao), infectious hepatitis (Miao ethnic group); Anti HIV-1 virus; Antibiotic.

Bulbus Lilii: [property of medicine] sweet in the mouth, little hardship, cold nature.GUIXIN, lung meridian.

[function and main energy] nourishing YIN and moistening the lung cough-relieving, clearing away heart-fire for tranquillization, the function of invigorating the spleen and replenishing QI.Cure mainly the lung-heat impairment of YIN, or the coughing of lung-dryness syndrome due to deficiency of YIN, pulmonary tuberculosis, haematemesis, spitting of blood and fidgets due to deficiency palpitation with fear, insomnia and dreamful sleep; Anti AIDS virus; Antibiotic.

Cordyceps: [property of medicine] sweet in the mouth, salty, digestion back sweet in the mouth, warm in nature, effect is moistened and is softened.

[function with cure mainly] nourishing and fit keeping function, tonifying YANG is mended smart, invigorating the lung and the kidney.Cure mainly many sick, the pneumonopathy of body void, bronchitis, kidney fire lose, stop blooding, reduce phlegm, chronic consumptive disease cough, hemoptysis sweating due to debility etc., pulmonary tuberculosis, anemia weakness, refreshing essence stomachache, vomiting, regurgitation, inappetence, bones and muscles pain etc., punish-old year chronic bronchitis, pulmonary tuberculosis, diseases such as emphysema and pneumonia.

Tibetan medicine-pulmonary tuberculosis; Anti HIV-1 virus; Antibiotic.

Gecko: [property of medicine] salty in the mouth, property is flat.Return lung, kidney channel.

[function with cure mainly] kidney tonifying tonifying the lung, Dingchuan antitussive, cure mainly deficiency of both the lung and kidney asthma and cough, cough due to consumptive disease, spitting of blood, impotence due to deficiency of the kidney, seminal emission, frequent micturition, quench one's thirst, promote the production of body fluid and bring down a fever, promote the production of body fluid and bring down a fever; Anti-anti HIV-1 virus; Antibiotic.

Fructus Schisandrae Chinensis: [property of medicine] sour in the mouth, property is flat.Gui Jing: go into lung, kidney channel.

[function with cure mainly] improve blood circulation, emesis rush down, aid digestion.Cure mainly cold and heat and have loose bowels, vomiting singultus, myasthenia of limbs, dyspnea, hypertension etc.; Support lung, appetizing; Astringe the lung, nourishing kidney is promoted the production of body fluid, and receives antiperspirant, arresting seminal emission.Control the deficiency of the lung and breath with cough, xerostomia is done thirsty, spontaneous perspiration, and night sweat, impairment caused by overstrain is won tired, chronic diarrhea, chronic dysentery.Vomiting singultus, myasthenia of limbs, dyspnea is controlled the deficiency of the lung and is breathed with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat; Anti HIV-1 virus; Antibiotic.

Concha Ostreae: [property of medicine] salty in the mouth, puckery,, cold nature.Return liver, kidney channel.

[function with cure mainly] suppressing the hyperactive liver and subsiding YANG, tranquillization with heavy prescription, hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating.Cure mainly vertigo and tinnitus, palpitation with fear insomnia, scrofula goiter, scar abdominal mass mass in the abdomen, spontaneous sweating, resolving phlegm and softening hard masses, removing damp-heat.End heart temper pain, under the dysentery; The xenon abdominal mass that disappears is amassed piece, wart disease tuberculosis; Anti HIV-1 virus, antibiotic.

Radix Glycyrrhizae: [property of medicine] sweet in the mouth, return through: go into spleen, stomach, lung meridian.

[function with cure mainly] clearing and antitussive eliminates the phlegm, and quenches one's thirst.Cure mainly pneumonopathy, tracheitis, disorders of meridian, vomiting, laryngopharyngeal diseases, weakness of the spleen and stomach, dry pharynx, dry cough.

[Radix Glycyrrhizae is clinical]: (1) treatment pulmonary tuberculosis and use the Radix Glycyrrhizae preparation when using antituberculosis drugs, to or the patient that sb.'s illness took a turn for the worse not good through antituberculosis drugs thing therapeutic effect for a long time, can receive better curative effect; Anti HIV-1 virus; Antibiotic.

(2) treatment thrombocytopenia purpura.

Mel (Radix Stemonae and Pi leaf processed with honey with): [property of medicine] sweet in the mouth, property is flat. return spleen, lung, large intestine advance through.

[function with cure mainly] is born in heat, opens obstruction, the dampness supplementing the brain, and strong muscle is good for flesh, nourishes the body. relieving cough and asthma, loosening bowel to relieve constipation.Cure mainly raw property or lymphatic temperament disease, asthenia universalis is had a guilty conscience, the deficiency of the lung, insufficiency of stomach, deficiency of the liver, cough and asthma, intestinal obstruction etc.; Tonify deficiency is moisturized, pain relieving, and detoxifcation cures mainly dry cough without phlegm, the dryness of the intestine constipation.

Five. result of study and analysis thereof

1. this project and the relative analysis of western medical treatment method:

Acquired immune deficiency syndrome (AIDS): the western medical treatment method is that WTO therapeutic scheme and " cocktail " are treated this medicine combination, to liver, kidney, etc. organ injury and cholesterol and the rising of blood glucose sugar, spiritual class disease etc., the said preparation active component has compositions such as polysaccharide, cordycepin, and the treatment cost is low.

Asthma: the doctor trained in Western medicine method is antibiotic (antibiotic), antiinflammatory (hormone), reduce phlegm and anti-asthmatic, antiallergic, oxygen uptake, and its side effect is organ injury such as liver, kidney, stomach, and hormone easily causes osteoporosis, treatment cost height; And active component has anti-filial piety and breathes heavily compositions such as disease effect (antibiotic-alkaloid, antiinflammatory-tannin, reduce phlegm and anti-asthmatic-volatile oil, antiallergic-saponin, immunomodulating-protein, anti-liver injury-organic acid, anti-injury of kidney-flavonoid, anti-gastric injury-polysaccharide, anti-bone injury-flavonoid) class in the said preparation, and the treatment cost is low.

Pneumoconiosis: the western medical treatment method is antitussive, pain relieving, calm the nerves, aid digestion, enhance immunity, oxygen uptake etc., and side effect is to organ injury such as liver, kidneys, treatment cost height; The said preparation active component have (pulmonary fibrosis resistant-polysaccharide, immunomodulating-protein, anti-hypoxia-alkaloid, antitussive-volatile oil, anti-heart damage-polysaccharide, hepatic injury-organic acid, injury of kidney-flavonoid, aid digestion-polysaccharide, calm the nerves-saponins, analgesia-volatile oil) etc. composition, the treatment cost is low.

Diabetes: the western medical treatment method is blood sugar lowering, insulin, side effect to liver, kidney, etc. organ injury and irritated treatment cost height; The said preparation active component has compositions such as alkaloids, and the treatment cost is low.

Depression and psychosis: doctor trained in Western medicine method: antidepressant, sleep peacefully, organ injury, blurred vision, allergy, xerostomia, constipation, osteoporosises etc. such as side effect headache, ECG change, dysmnesia, (blood pressure, blood glucose, blood fat) rising, leukopenia, liver, kidney are the quality cost height; The said preparation active component has the i.e. composition such as (antidepressant-alkaloid, calm the nerves-saponins, analgesia-volatile oil, anti-heart damage-polysaccharide, hepatic injury-organic acid, injury of kidney-flavonoid, aid digestion-polysaccharide, bone injury-alkaloid, Fructus Alpiniae Oxyphyllae-polysaccharide, anti-hypoxia-alkaloid, blood sugar lowering-alkaloid, blood fat reducing-saponins, leukocyte increasing-polysaccharide, antiallergic-volatile oil, anti-stress-protein) class of psychosis and depressed effect, and it is low to treat cost.

One of 2. optimize prescription:. the Cordyceps in the LIFEI PIAN prescription is made into the Cordyceps militaris of artificial implantation, cordycepin content in the Cordyceps militaris is higher than tens times of traditional Cordyceps, polysaccharide 12.8mg/100g in it, and traditional Cordyceps only is 7mg/100g, because cordycepin has treating pulmonery tuberculosis, antibiotic, antiinflammatory, HIV-I resisting type virus, regulates immunity, antiallergic, resists (liver, stomach) damage, antiviral etc.; Cordyceps polysaccharide has anti-HIV, treating pulmonery tuberculosis, adjusting immunity, anti-organ injury, blood sugar lowering, enhancing bone marrow hematogenesis function, the blood oxygen ability etc. that improves, the price per kilogram is wild to differ tens times with the artificial implantation price, so its anti-HIV, pulmonary tuberculosis, liver, renal function and blood sugar decreasing effect strengthen; Two. the Concha Ostreae in the LIFEI PIAN is made Concha Ostreae (calcined) into, be because the Concha Ostreae (calcined) composition be convenient to fried active ingredient; Three. the Radix Stemonae makes the sweet Radix Stemonae into, because pulmonary tuberculosis cough is a dry cough, sweet Radix Stemonae nourishing the lung to arrest cough function ratio Radix Stemonae is strong, and the treating pulmonery tuberculosis of the sweet Radix Stemonae, antiallergic, anti-(organs such as liver, kidney) damaging action are stronger than Radix Stemonae simultaneously; Four. ursolic acid content increases behind the Folium Eriobotryae processed with honey, and treating pulmonery tuberculosis, HIV, liver, renal function strengthen, and promptly product cost reduces, and curative effect improves.

3. optimization technology: Gecko is adopted the superfine powder technology, improves drug effect, saves medical material.

4.WTO the side effect of treatment pulmonary tuberculosis drug regimen is as follows:

4.1. isoniazid: peripheral neuropathy, nystagmus, hepatitis, drowsiness, lethargy, convulsions, pellagra, arthralgia, agranulocytosis, lupoid reaction, erythra, acute mental disorder, lupus erythematosus sample pulmonary lesion, pulmonary vasculitis, kidney damage.Isoniazid causes encephalopathy clinical manifestation (maincenter symptom): mental disorder, muscle spasm, tic etc., hemopoietic system (aplastic anemia, thrombocytopenia, the purple plate of anaphylaxis, granulocytopenia), the downright bad absent-mindedness of toxic epidermis disease, exfoliative dermatitis, lupus nephritis, oral lesion, neuromuscular function disorder, pulmonary infiltration eosinophilia, eye damage, cause tinnitus, auditory dysesthesia, blood sugar increasing etc.

4.2. rifampicin: gastrointestinal symptom (anorexia, feel sick, vomiting, stomachache), hepatitis, acute renal failure, shock, thrombocytopenia, erythra, " influenza syndrome (intermittent use) ", pseudomembranous colitis, pseudo-adrenal crisis, osteomalacia, pancreatitis, blood pressure increases, hemopoietic system (thrombocytopenia, hold courageous and upright anemia), cause digestive tract hemorrhage, the downright bad absent-mindedness of toxic epidermis disease, exfoliative dermatitis, the eye infringement, cause tinnitus, auditory dysesthesia, blood sugar increasing etc.

4.3. corner of the eyes carboxamide dihydrochloride: arthralgia, hepatitis, gastrointestinal symptom, erythra, sideroblast anemia, the gout that causes, allergy, heating, erythra, lymphangitis, stomatitis are weak, loss of appetite etc.

4.4. streptomycin: audition and vestibular nerve are impaired, kidney damage, erythra, lupus erythematosus, blood pressure increase, angina pectoris, nystagmus, hemopoietic system (aplastic anemia, anaphylactoid purpura), heating, lupus erythematosus sample pulmonary lesion, dizzy, youngster's ring, nausea and vomiting, youngster's infringement etc.

4.5. ethambutol: optic neuritis, erythra, arthralgia, peripheral neuropathy, exfoliative dermatitis, eye infringement etc.

5. result:

5.1 every flavor medical material all has treating pulmonery tuberculosis, anti HIV-1 virus and antibacterial action.

5.2. this project preparation active component and clinical symptoms match, effect such as have anti-(HIV virus, pulmonary tuberculosis, diabetes, asthma, pneumoconiosis), anti-(liver, kidney, stomach, bone, the heart, nerve, hemopoietic system) damage, anti-(depression, allergy, psychosis, anoxia, malaria, tumor), immunomodulating, Fructus Alpiniae Oxyphyllae, antiinflammatory, antibiotic, anti-stress, calm the nerves, thereby its active component and WTO treat pulmonary tuberculosis drug regimen synergy attenuation.

5.3 waste water in the preparation and medicinal residues are utilized (sheet material etc.) again.

5.4 because drug discovery is the starting point of original new drug research and the step with decision meaning, this achievement is fit to relate to said preparation all (technology, dosage form and adjuvants).

Six. advantage of the present invention:

1. this project is compared with LIFEI PIAN: cost reduces, and curative effect improves.

2. this project adopts Chinese exclusive method-Integrative Chinese-Western, collaborative development had both been brought into play Chinese medicine advantage efficacy enhancing and toxicity reducing, reduce the Western medicine consumption simultaneously, reduce environmental pollution, reduce this disease expense of treatment, alleviate national load-molecule Chinese medicine and meet the desirable medication standard of World Health Organization (WHO), not only be used for the treatment of, prevent, also can be used for simultaneously rehabilitation and health promotion.

3. this project has the drug tolerance pulmonary tuberculosis of inhibition and concurrent (HIV, diabetes, asthma and pneumoconiosis) syndrome effect.

4. become to distinguish one from the other, safety obviously improves, and is beneficial to clinical and the Western medicine drug combination, enlarges use amount.

5. preparation level obviously improves, and stability improves, extension of validity, taking convenience.

6. for the control harmful substance lays the foundation, as the pollution of heavy metal ion, residual pesticide and other harmful substances.

7. being more suitable for the modern pharmaceutical enterprise scale produces.

8. improve medicine and in human body, absorb, strengthen drug effect, save herb resource.

9. this invention is fit to relate to all (technology, dosage form and adjuvants) of said preparation.

10. waste water in the preparation and medicinal residues are utilized-sheet material again, the plant of medical material can do ornamental plant etc., improves added value of product.

11. stability improves, extension of validity, taking convenience.

12. become to distinguish one from the other for optimize (technology, dosage form), quality control provides scientific basis.

13., promote social harmony and play positive role to suppressing LIFEI PIAN market price confusion.

14. wild cordyceps makes the Cordyceps militaris of artificial implantation into, not only curative effect improves, and has also saved land resource simultaneously.

Claims (13)

1. the present invention relates to suppress the LIFEI PIAN defective and the molecule Chinese patent medicine of pulmonary tuberculosis concurrent (HIV, diabetes, asthma and pneumoconiosis) syndrome, it is characterized in that: the active component of preparation and clinical symptoms performance and pharmic function coincide.

2. according to right 1, Cordyceps militaris, Folium Eriobotryae, the Radix Stemonae that the Cordyceps of its feature in former LIFEI PIAN prescription makes artificial implantation into change processed with honey into, promptly sweet Folium Eriobotryae, the sweet Radix Stemonae, and Concha Ostreae changes Concha Ostreae (calcined) into.

3. according to right 1,2, its feature adopts the superfine powder technology in: Gecko.

4. according to right 1,2,3, its feature is in its prescription, and every flavor medical material all has treating pulmonery tuberculosis, anti HIV-1 virus and is antibacterial action.

5. according to right 1,2,3,4, its feature is in its active component: effect such as have anti-(HIV virus, pulmonary tuberculosis, diabetes, asthma, pneumoconiosis), anti-(liver, kidney, stomach, bone, the heart, nerve, hemopoietic system) damage, anti-(depression, allergy, psychosis, anoxia, malaria, tumor), immunomodulating, Fructus Alpiniae Oxyphyllae, antiinflammatory, antibiotic, anti-stress, calm the nerves

6. according to right 1,2,3,4,5, its feature is in treating pulmonary tuberculosis drug regimen (isoniazid, rifampicin, corner of the eyes carboxamide dihydrochloride, ethambutol, streptomycin) synergy attenuation with WTO.

7. according to right 1,2,3,4,5,6, its feature is in all (technology, dosage form and adjuvants) of relating to said preparation.

8. according to right 1,2,3,4,5,6,7, its feature becomes to distinguish one from the other in preparation provides scientific basis for optimizing (technology, dosage form) and quality control.

9. according to right 1,2,3,4,5,6,7,8, its feature in preparation waste water and medicinal residues utilize again-sheet material, medical material plant can do ornamental plant etc.

10. according to right 1,2,3,4,5,6,7,8,9, its feature, lays the foundation as the pollution of heavy metal ion, residual pesticide and other harmful substances for the control harmful substance in definite ingredients.

11. according to right 1,2,3,4,5,6,7,8,9,10, its feature reduces in treatment time shortening, expense.

12. according to right 1,2,3,4,5,6,7,8,9,10,11, its feature improves in safety, is beneficial to clinical drug combination.

13. according to right 1,2,3,4,5,6,7,8,9,10,11,12, its feature improves in stability, extension of validity, taking convenience.