CN102188499A - Ganoderma liver-protection tea and preparation method thereof - Google Patents
Ganoderma liver-protection tea and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of health-care products, and in particular relates to a ganoderma liver-protection tea and a preparation method thereof. The preparation method of the ganoderma liver-protection tea comprises the steps of: crushing, mixing, stirring, pelletizing and drying ganoderma capense, ganoderma sinense, ganoderma lucidum karst and raw ganoderma lucidum spore powder to obtain pure ganoderma tea particles, and then spraying traditional Chinese medicine extract on the surface of the pure ganoderma tea particles for drying, thus obtaining the ganoderma liver-protection tea. The ganoderma liver-protection tea adds various traditional Chinese medicinal materials for tonifying and nourishing the liver into raw ganoderma, thus having the obvious effect of protecting the liver; when being supplied for patients with different types of hepatopathy for long-term drinking, the ganoderma liver-protection tea can be cooperative with the conventional hepatopathy drugs so as to protect the liver, degrade enzyme, prevent and treat diseases, and has an obvious curative effect especially on chronic hepatitis, chronic active hepatitis earlier-cirrhosis. The ganoderma liver-protection tea has no toxic and side effects, can be conveniently administrated, and is suitable for long-term administration by patients.
Description
Technical field
The invention belongs to field of health care products, relate to a kind of Ganoderma tea liver-protecting tea and preparation method thereof.
Background technology
Chronic hepatitis B is a kind of worldwide disease that is caused by hepatitis B virus (HBV).Developing country's sickness rate height, according to statistics, the asymptomatic hepatitis B virus carriers in the whole world (HBsAg carrier) surpasses 2.8 hundred million, and China accounts for 1.3 hundred million.Most asymptomatic, wherein 1/3 clinical manifestation that hepatic injury occurs.There is hepatitis B patient 3,000 ten thousand in China at present.The characteristics of hepatitis B are that onset is more slow, and are more common with subclinical type and chronic type.The easy chronicity of non-icteric type HBsAg lasting masculin person.Primary disease mainly contacts with property by blood, mother and baby and propagates.
The target of chronic hepatitis B treatment is a long term inhibition or eliminate HBV to greatest extent, alleviates necrosis of hepatocyte inflammation and hepatic fibrosis, delays and stops progression of disease, reduce and prevent that the liver mistake is compensatory, the generation of liver cirrhosis, hepatocarcinoma and complication thereof.The medicine of at present clinical anti-HBV treatment is mainly nucleoside (acid) analog, as lamivudine, adefovir ester, Entecavir etc.Adefovir ester is 5 ' the no ring analogues of single phosphoric acid deoxidation vidarabine.Clinical trial shows that oral adefovir ester can obviously suppress HBV-DNA and duplicate, and its resistant rate and virus variation rate are lower, needing to be particularly suitable for the chronic hepatitis B patient of long-term prescription.But be subjected to the restriction of its kidney toxic and side effects, the dosage of FDA approval treatment chronic hepatitis B only is 1/3 of early-stage Study dosage.Therefore, the anti-HBV effect of adefovir ester also is restricted, and shows as the HBV-DNA response rate is lower than lamivudine etc. and other nucleoside (acid) class medicine.The Chinese medicine chronic hepatitis B often has many target spots, multipath comprehensive effect, anti-HBV and liver protecting therapy special effect.Therefore, the present stage expert recommends the Chinese and western medicine drug combination, for improve response rate, shorten antiviral course of treatment, the generation and recurrence and the raising clinical efficacies etc. that reduce the drug resistance variation all have positive effect.
Ganoderma claims Ganoderma lucidum seu Japonicum, Ganoderma, ZHICAO, Herba mesonae chinensis, Ganoderma again, originate in east Asia, China distributes the widest in Jiangxi, and Ganoderma is treasured medical material as the Chinese tradition that has thousands of years medicinal histories, possesses very high medical value, modern pharmacology through scientific research institution's many decades studies confirm that Ganoderma is for strengthening body immunity, blood sugar regulation, controlling blood pressure, auxiliary tumor chemoradiotherapy, hepatoprotective, aspects such as hypnotic all have significant curative effect.
Herba Ecliptae is the herb of feverfew Eclipta prostrata, because when crumpling its stem and leaf, the juice of visible black color flows out, so cry " Herba Ecliptae " again, different name is Nanjing grass, Alternanthera sessilis (L.) DC. again.Herba Ecliptae, nature and flavor are sweet, sour, cold, and the effect of good liver and kidney tonifying is arranged, and are the traditional Chinese medical science liver-nourishing kidney-boosting, cooling blood for hemostasis medicine commonly used.Multiple due to all diseases of Light-headedness, odontoseisis, aching pain in waist and back, flaccidity and weakness of the lower limbs due to the hepatic and renal YIN deficiency and the heat in blood gone out blood disorder good efficacy is arranged.
The Radix Polygoni Multiflori is done, i.e. Radix Polygoni Multiflori Preparata is mixed Radix Polygoni Multiflori to dry after the steaming with the Semen sojae atricolor liquor and is used as medicine, bitter in the mouth, sweet, puckery, warm in nature flat, energy invigorating the liver and kidney, benefiting essence-blood, black beard and hair, bone and muscle strengthening are used for blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body void etc.
Herba Scutellariae Barbatae, property suffering, hardship, cold, return lung, liver, kidney channel, heat-clearing and toxic substances removing, blood stasis dispelling diuresis.Be used for furuncle swelling toxin, laryngopharynx swelling and pain, venom falls and pounces on the pain of injury, edema, jaundice.
Summary of the invention
The objective of the invention is above-mentioned deficiency, a kind of Ganoderma liver-protecting tea with good hepatoprotective effect is provided at prior art.
Another object of the present invention provides the preparation method of this Ganoderma liver-protecting tea.
Purpose of the present invention can be achieved through the following technical solutions:
A kind of Ganoderma liver-protecting tea, this Ganoderma liver-protecting tea is to prepare by the following method:
(1) by multistage pulverizing with dry Ganoderma capenseD.A.Reid, Ganoderma sinense Zhao Xu et Zhang, Ganoderma lucidum (Leyss. Ex Fr.) Karst. raw material pulverize separately is to the flocculence of crossing 20～30 mesh sieves;
(2) get Ganoderma lucidum (Leyss. Ex Fr.) Karst. 1.5～3 weight portions of pulverizing, Ganoderma capenseD.A.Reid 2.5～3.5 weight portions, Ganoderma sinense Zhao Xu et Zhang 4.0～6.0 weight portions, former powder 0.7～1.0 weight portion of Ganoderma spore powder, mix: forward stirred 2～5 minutes, oppositely stirred 2～5 minutes again; Repeat 4～10 circulations;
(3), stirred 8～15 minutes to the water that wherein adds 5～9 weight portions successively; Add the water of 2～4 weight portions, stirred 8～15 minutes; Add the water of 2～4 weight portions, stirred 8～15 minutes; Add the water of 2～4 weight portions, stirred 8～15 minutes; Add the water of 2～4 weight portions, stirred 8～15 minutes;
(4) the final gained material of step (3) is carried out pelletize, obtaining particle diameter is the pure Ganoderma tea pellet of 4～5mm;
(5) by following program pure Ganoderma tea pellet is dried and dosing: 1. close dehumidifying baking 3-4 hour, rise to 78-82 ℃ until oven temperature; 2. beginning to rehearse wets toasted 20～40 minutes, dropped to 65-70 ℃ until oven temperature; 3. close dehumidifying baking 4-5 hour, reach 100 ℃ up to temperature; 4. take out the Ganoderma tea pellet, add 1～2 parts by weight of Chinese traditional medicine extracting solution with spray pattern; 5. close dehumidifying and continue baking 0.5～1.5 hour, beginning to rehearse wet baking 15～45 minutes reaches 75-80 ℃ to temperature, closes dehumidifying and is baked to 115～120 ℃, keeps temperature to continue baking 40-50 minute; Described Chinese medicine extraction liquid prepares by the following method: with Herba Ecliptae 0.8～1.2Kg, the Radix Polygoni Multiflori is done 0.8～1.2Kg, and Herba Scutellariae Barbatae 0.8～1.2Kg mixes, be divided into two parts, be packaged in respectively in the ripe medicated bag and put into boiling machine, add water to 16L, big fire was endured 90 minutes, and little fire is ripe in 13L.
The former powder of described Ganoderma spore powder is selected from the former powder of Ganoderma sinense Zhao Xu et Zhang spore powder, the former powder of Ganoderma lucidum (Leyss. Ex Fr.) Karst. spore powder or the former powder of Ganoderma sinense Zhao Xu et Zhang spore powder and the mixing spore powder former powder of the former powder of Ganoderma lucidum (Leyss. Ex Fr.) Karst. spore powder with arbitrary proportion mixing gained.
The preparation method of Ganoderma tea of the present invention comprises the steps:
(1) by multistage pulverizing with dry Ganoderma capenseD.A.Reid, Ganoderma sinense Zhao Xu et Zhang, Ganoderma lucidum (Leyss. Ex Fr.) Karst. raw material pulverize separately is to the flocculence of crossing 20～30 mesh sieves;
(2) get Ganoderma lucidum (Leyss. Ex Fr.) Karst. 1.5～3 weight portions of pulverizing, Ganoderma capenseD.A.Reid 2.5～3.5 weight portions, Ganoderma sinense Zhao Xu et Zhang 4.0～6.0 weight portions, former powder 0.7～1.0 weight portion of Ganoderma spore powder, mix: forward stirred 2～5 minutes, oppositely stirred 2～5 minutes again; Repeat 4～10 circulations;
(3), stirred 8～15 minutes to the water that wherein adds 5～9 weight portions successively; Add the water of 2～4 weight portions, stirred 8～15 minutes; Add the water of 2～4 weight portions, stirred 8～15 minutes; Add the water of 2～4 weight portions, stirred 8～15 minutes; Add the water of 2～4 weight portions, stirred 8～15 minutes;
(4) the final gained material of step (3) is carried out pelletize, obtaining particle diameter is the pure Ganoderma tea pellet of 4～5mm;
(5) by following program pure Ganoderma tea pellet is dried and dosing: 1. close dehumidifying baking 3-4 hour, rise to 78-82 ℃ until oven temperature; 2. beginning to rehearse wets toasted 20～40 minutes, dropped to 65-70 ℃ until oven temperature; 3. close dehumidifying baking 4-5 hour, reach 100 ℃ up to temperature; 4. take out the Ganoderma tea pellet, add 1～2 parts by weight of Chinese traditional medicine extracting solution with spray pattern; 5. close dehumidifying and continue baking 0.5～1.5 hour, beginning to rehearse wet baking 15～45 minutes reaches 75-80 ℃ to temperature, closes dehumidifying and is baked to 115～120 ℃, keeps temperature to continue baking 40-50 minute; Described Chinese medicine extraction liquid prepares by the following method: with Herba Ecliptae 0.8～1.2Kg, the Radix Polygoni Multiflori is done 0.8～1.2Kg, and Herba Scutellariae Barbatae 0.8～1.2Kg mixes, be divided into two parts, be packaged in respectively in the ripe medicated bag and put into boiling machine, add water to 16L, big fire was endured 90 minutes, and little fire is ripe in 13L.
The former powder of described Ganoderma spore powder is the former powder of Ganoderma sinense Zhao Xu et Zhang spore powder, the former powder of Ganoderma lucidum (Leyss. Ex Fr.) Karst. spore powder or the former powder of Ganoderma sinense Zhao Xu et Zhang spore powder and the mixing spore powder former powder of the former powder of Ganoderma lucidum (Leyss. Ex Fr.) Karst. spore powder with arbitrary proportion mixing gained.
Beneficial effect of the present invention:
1, Ganoderma tea of the present invention is selected Ganoderma capenseD.A.Reid for use, Ganoderma sinense Zhao Xu et Zhang, the spore powder of Ganoderma lucidum (Leyss. Ex Fr.) Karst. and Ganoderma sinense Zhao Xu et Zhang and Ganoderma lucidum (Leyss. Ex Fr.) Karst. is as raw material, the Ganoderma material effective component content that has overcome single variety is uneven, the defective that the part effective content is very few, give full play to the complementary advantage of different Ganoderma effects, enlarged the indication scope of Ganoderma tea.Be aided with kinds of traditional Chinese medicines on this basis with tonification nourishing the liver, make the Ben Lingzhi liver-protecting tea have outstanding hepatoprotective effect, offer dissimilar hepatopath's long-term drink, can be collaborative with the liver disease medicine of routine, the liver protecting and ALT lowering is prevented and cured diseases, and especially chronic hepatitis, chronic active hepatitis early stage liver cirrhosis is had significant curative effect.And this Ganoderma liver-protecting tea is without any side effects, and taking convenience is suitable for the patient and takes for a long time.
2, the Herba Ecliptae in the Ganoderma liver-protecting tea of the present invention, the Radix Polygoni Multiflori do, Herba Scutellariae Barbatae etc. is used as medicine with the extracting solution form, have overcome directly with the medical material defective that effective ingredient is difficult to discharge when brewing of being used as medicine.
3, to select pure Ganoderma and Chinese herbal medicine for use be raw material to Ganoderma liver-protecting tea granule of the present invention, do not add any adjuvant in the preparation process, make powder by distinctive technology, wherein the former powder of Ganoderma spore powder with breaking cellular wall not substitutes the binding agent of pharmaceutic adjuvant as pelletize, original noncohesive Ganoderma stem and cap feedstock production are become Ganoderma powder (tea granule), be convenient to packing, carry and brew.
5, Ganoderma liver-protecting tea of the present invention only contains the moisture of Ganoderma raw material and Chinese medicine extract and minute quantity, does not contain the sweeting agent that sucrose etc. is not suitable for diabetic to take, is suitable for comprising that all groups of diabetic drink.
The specific embodiment
Embodiment 1
(1) by two grade pulverization with dry Ganoderma capenseD.A.Reid, Ganoderma sinense Zhao Xu et Zhang, Ganoderma lucidum (Leyss. Ex Fr.) Karst. raw material pulverize separately is to the flocculence of crossing 30 mesh sieves;
(2) get the Ganoderma lucidum (Leyss. Ex Fr.) Karst. 2Kg of pulverizing, Ganoderma capenseD.A.Reid 3Kg, Ganoderma sinense Zhao Xu et Zhang 5Kg, the former powder 0.8Kg of Ganoderma spore powder adds blender, mixes: forward stirred 3 minutes, oppositely stirred 3 minutes again; Repeat 6 circulations;
(3), stirred 10 minutes to the water that wherein adds 5Kg successively; Add the water of 2Kg, stirred 10 minutes; Add the water of 2Kg, stirred 10 minutes; Add the water of 2Kg, stirred 10 minutes; Add the water of 2Kg, stirred 10 minutes;
(4) the final gained material of step (3) is carried out pelletize, obtaining particle diameter is the pure Ganoderma tea pellet of 4～5mm;
(5) by following program pure Ganoderma tea pellet is dried and dosing: 1. close dehumidifying and toasted about 3 hours, rise to 78-82 ℃ until oven temperature; 2. beginning to rehearse wets toasted 30 minutes, dropped to 65-70 ℃ until oven temperature; 3. close dehumidifying and toasted about 5 hours, reach 100 ℃ up to temperature; 4. take out the Ganoderma tea pellet, add the Chinese medicine extraction liquid of 1Kg with spray pattern; 5. close dehumidifying and continue baking 0.5 hour, beginning to rehearse wet baking 15 minutes reaches 75-80 ℃ to temperature, closes dehumidifying and is baked to 115～120 ℃, keeps temperature to continue about 40 minutes of baking.Wherein, Chinese medicine extraction liquid prepares by the following method: with Herba Ecliptae 1Kg, the Radix Polygoni Multiflori is done 1Kg, and Herba Scutellariae Barbatae 1Kg mixes, and is divided into two parts, is packaged in respectively in the ripe medicated bag and puts into boiling machine, adds water to 16L, and big fire was endured 90 minutes, and little fire is ripe in 13L.
Embodiment 2
(1) by two grade pulverization with dry Ganoderma capenseD.A.Reid, Ganoderma sinense Zhao Xu et Zhang, Ganoderma lucidum (Leyss. Ex Fr.) Karst. raw material pulverize separately is to the flocculence of crossing 30 mesh sieves;
(2) get the Ganoderma lucidum (Leyss. Ex Fr.) Karst. 1.5Kg of pulverizing, Ganoderma capenseD.A.Reid 2.5Kg, Ganoderma sinense Zhao Xu et Zhang 4.0Kg, the former powder 0.7Kg of Ganoderma spore powder adds blender, mixes: forward stirred 5 minutes, oppositely stirred 5 minutes again; Repeat 4 circulations;
(3), stirred 8 minutes to the water that wherein adds 6Kg successively; Add the water of 3Kg, stirred 8 minutes; Add the water of 3Kg, stirred 8 minutes; Add the water of 3Kg, stirred 8 minutes; Add the water of 3Kg, stirred 8 minutes;
(4) the final gained material of step (3) is carried out pelletize, obtaining particle diameter is the pure Ganoderma tea pellet of 4～5mm;
(5) by following program pure Ganoderma tea pellet is dried and dosing: 1. close dehumidifying and toasted about 3 hours, rise to 78-82 ℃ until oven temperature; 2. beginning to rehearse wets toasted 30 minutes, dropped to 65-70 ℃ until oven temperature; 3. close dehumidifying and toasted about 5 hours, reach 100 ℃ up to temperature; 4. take out the Ganoderma tea pellet, add the Chinese medicine extraction liquid of 2Kg with spray pattern; 5. close dehumidifying and continue baking 0.5 hour, beginning to rehearse wet baking 15 minutes reaches 75-80 ℃ to temperature, closes dehumidifying and is baked to 115～120 ℃, keeps temperature to continue about 40 minutes of baking; Described Chinese medicine extraction liquid prepares by the following method: with Herba Ecliptae 0.8Kg, the Radix Polygoni Multiflori is done 0.8Kg, and Herba Scutellariae Barbatae 0.8Kg mixes, and is divided into two parts, is packaged in respectively in the ripe medicated bag and puts into boiling machine, adds water to 16L, and big fire was endured 90 minutes, and little fire is ripe in 13L.
Embodiment 3
(1) by two grade pulverization with dry Ganoderma capenseD.A.Reid, Ganoderma sinense Zhao Xu et Zhang, Ganoderma lucidum (Leyss. Ex Fr.) Karst. raw material pulverize separately is to the flocculence of crossing 30 mesh sieves;
(2) get the Ganoderma lucidum (Leyss. Ex Fr.) Karst. 3.0Kg of pulverizing, Ganoderma capenseD.A.Reid 3.5Kg, purple clever 6.0Kg, the former powder 1Kg of Ganoderma spore powder adds blender, mixes: forward stirred 2 minutes, oppositely stirred 2 minutes again; Repeat 8 circulations;
(3), stirred 15 minutes to the water that wherein adds 7Kg successively; Add the water of 4Kg, stirred 15 minutes; Add the water of 4Kg, stirred 15 minutes; Add the water of 4Kg, stirred 15 minutes; Add the water of 4Kg, stirred 15 minutes;
(4) the final gained material of step (3) is carried out pelletize, obtaining particle diameter is the pure Ganoderma tea pellet of 4～5mm;
(5) by following program pure Ganoderma tea pellet is dried and dosing: 1. close dehumidifying and toasted about 4 hours, rise to 78-82 ℃ until oven temperature; 2. beginning to rehearse wets toasted 40 minutes, dropped to 65-70 ℃ until oven temperature; 3. close dehumidifying and toasted about 5 hours, reach 100 ℃ up to temperature; 4. take out the Ganoderma tea pellet, add the Chinese medicine extraction liquid of 1.5Kg with spray pattern; 5. close dehumidifying and continue baking 1.5 hours, beginning to rehearse wet baking 45 minutes reaches 75-80 ℃ to temperature, closes dehumidifying and is baked to 115～120 ℃, keeps temperature to continue about 50 minutes of baking; Described Chinese medicine extraction liquid prepares by the following method: with Herba Ecliptae 1.2Kg, the Radix Polygoni Multiflori is done 1.2Kg, and Herba Scutellariae Barbatae 1.2Kg mixes, and is divided into two parts, is packaged in respectively in the ripe medicated bag and puts into boiling machine, adds water to 16L, and big fire was endured 90 minutes, and little fire is ripe in 13L.
Embodiment 4
1 physical data
Three group of 60 example adopts the principle of contrast at random to be divided into observation group, 1 group of contrast and matched group 2 each 36 example.In observation group's 20 examples, male's 12 examples, women's 8 examples; 18～53 years old age, average (33.78 ± 5.24) year; The course of disease 0.6～31 year, average (15.31 ± 12.80) year.Contrast in 1 group of 20 example male's 11 examples, women's 9 examples; 19～60 years old age, average (36.10 ± 5.92) year; The course of disease 0.7～38 year, average (15.62 ± 13.16) year.Contrast in 2 group of 20 example male's 10 examples, women's 10 examples; 18～57 years old age, average (34.55 ± 4.32) year; The course of disease 0.7～35 year, average (16.38 ± 15.07) year.Data comparing differences such as three groups of sexes, age, the course of disease there are no significant meaning (P＞0.05) has comparability.
2 diagnostic criterias
Draft [1] according to the diagnostic criteria that the prevention and treatment for chronic hepatitis B guide of formulation is united in December, 2005 China lemology branch of medical association, hepatopathy credit meeting, the positive history of hepatitis B or HBsAg is promptly arranged above 6 months, existing HBsAg and (or) the still positive person of HBV-DNA, diagnosable is chronic HBV infection.
(the hepatopathy credit meeting of [1] Chinese Medical Association, the Chinese hepatopathy magazine of lemology branch prevention and treatment for chronic hepatitis B guide [J], 2005,13 (12): 881-891.)
3 include standard in
(1) meets the diagnostic criteria of above-mentioned chronic hepatitis B; (2) HBeAg positive person; (3) course of disease was above 6 months; (4) HBV-DNA＞105copies/m; 2～10 times in l (5) the ALT normal value upper bound, TB il is less than 2 times of normal value.
4 exclusion standards
(1) the negative chronic hepatitis B person of HBeAg; (2) HBV virus variation or drug resistance person; (3) merge HCV, HDV the infected; (4) lose compensatory liver cirrhosis person; (5) hepatocarcinoma and autoimmune liver disease person.
5 Therapeutic Method
5.1 contrast 1 group: adopt adefovir ester (trade name: He Weili, Britain Glaxo Wellcome company) 10mg, every day 1 time, for oral administration.Be 48 weeks the course of treatment.
5.2 contrast 2 groups: on the basis of 1 group of treatment of contrast, the pure Ganoderma tea of 10g every day, boiled water brews, when tea-drinking is used.Be 48 weeks the course of treatment.Pure Ganoderma tea is that the Chinese medicine extraction liquid that adds in the present embodiment 1 such as is replaced by at quality water, and other technologies are constant to be made.
5.3 observation group: on the basis of 1 group of treatment of contrast, 10g Ganoderma liver-protecting tea every day (embodiment 1 preparation), boiled water brews, when tea-drinking is used.Be 48 weeks the course of treatment.
6 observation of curative effect
6.1 measure indexs such as liver function index (ALT), hepatitis B virus index and HBV-DNA respectively before and after three groups of treatments of observation index.By comparing indexs such as ALT normalization rate, HB eAg negative conversion rate and HBV-DNA negative conversion rate with overall merit.
6.2 statistical method carries out data analysis with the SPSS13.0 statistical software, measurement data is described with average plus-minus standard deviation, and paired data adopts t check, the relatively employing x of rate
2Check.
6.3 three groups of ALT normalization rates and HBeAg, HBV-DNA negative conversion rate be (seeing Table 1) relatively
Table 1
| Group | n | ALT normalization rate (%) | The HBeAg negative conversion rate | The HBV-DNA negative conversion rate |
| Observation group | 20 | 34(90.8) △ | 17(45.7) * | 33(90.1) * |
| Contrast 1 group | 20 | 30(81.5) | 9(26.4) | 24(67.3) |
| Contrast 2 groups | 20 | 31(85.2) △ | 11(30.0) △ | 27(74.8) △ |
Annotate: compare for 1 group with contrast, △ represents P＞0.05,
*Expression P＜0.05.
6.4 untoward reaction
Treating 1 group has 2 examples slight nonspecific symptom to occur, as weak, poor appetite, diarrhoea, erythra etc., all gives after the anti symptom treatment symptom and alleviates gradually or disappear.Other 2 groups any untoward reaction all do not occur.
This clinical observation result shows, adefovir ester coupling Ganoderma liver-protecting tea treatment of the present invention HB eAg positive chronic hepatitis B, aspect HBeAg and the HBV-DNA negative conversion rate synergism is being arranged all, curative effect obviously is better than single adefovir ester of using, and can significantly reduce even eliminate and take the untoward reaction that nucleoside medicine brings, improve patient's compliance and quality of life, but ALT normal again aspect, 1 group of curative effect no significant difference of observation group and contrast.The adefovir ester treatment interim coupling of HBeAg positive chronic hepatitis B Ganoderma liver-protecting tea of the present invention, can increase the reply sensitivity of chronic hepatitis B patient to adefovir ester, help the serology conversion of HBeAg, reach reduction drug resistance and aberration rate with this, improve the curative effect of antiviral therapy, reach the purpose of long term inhibition hepatitis B virus duplication.
Embodiment 5
1 ordinary circumstance: select hospital outpatient to confirm as patient's 100 examples of chronic active hepatitis B, early stage liver cirrhosis.Observation group's 50 examples, male 35 examples, women 15 examples, 24～69 years old age, average 38.7 years old, the course of disease 3～28 years, average 5.8 years.Matched group 50 examples, male 33 examples, women 17 examples, 27～71 years old age, average 32.5 years old, the course of disease 2～26 years, average 5.3 years.
2 cases are selected: all patients who meets following several, and as observing case.(1) meeting clinical diagnosis according to " viral hepatitis is prevented and treated scheme " of the national viral hepatitis meeting revision in nineteen ninety Shanghai the 6th time is chronic active hepatitis and HBSAg positive person; (2) platelet count＜80,000 mm
3(3) protein electrophoresis r＞23%; (4) splenomegaly, B ultrasonic show spleen thick＞touch spleen under 4.0cm or the rib.
3 Therapeutic Method: matched group and the patient of observation group give western medicine simultaneously: Hepatitis B virus vaccine 30g intramuscular injection January once, glucuronolatone sheet 0.2g, 3 times on the one, oral, vitamin C 3 times on the 0.2%,, persantin 25mg, 3 times on the one, levamisole 25mg, 3 times on the one, observation group is on the basis of western medicine, 10g Ganoderma liver-protecting tea every day (embodiment 1 preparation), boiled water brews, when tea-drinking is used.3 months is a course of treatment, generally takes medicine 2 courses of treatment.
4 detect index: biochemistry detection (comprising ALT, AST, platelet, protein electrophoresis), hepatic fibrosis detects (comprising HA, PCIII, LN).
5 curative effect determinate standards: with reference to " viral hepatitis curative effect determinate standard (trying) " chronic active hepatitis curative effect determinate standard of internal medicine hepatopathy Professional Committee of All-China Association of Traditional Chinese Medicine Tianjin in 1991 meeting formulation.
6 efficacy results
6.1 medicine is to the influence of biochemistry detection index: see Table 2.
Change conditions (meansigma methods ± standard deviation) before and after the treatment of table 2 biochemical indicator
Annotate: compare with matched group: △ represents P＜0.01; △ △ represents P＜0.05; △ △ △ represents P＞0.05.
See Table 3 6.2 hepatic fibrosis is detected the influence of index.
Table 3 hepatic fibrosis detects index change conditions (meansigma methods ± standard deviation)
Annotate: compare with matched group: △ represents P＜0.01; △ △ represents P＜0.05
6.3 condition of illness sign situation of change: see Table 4.
Compare before and after the treatment of table 4 symptom and sign
6.4 the curative effect synthetic determination sees Table 5.
Table 5 clinical efficacy synthetic determination
| Clinical cure | Produce effects | Take a turn for the better | Invalid | Total effective rate | |
| The n=50 of observation group | 4(8.0) | 21(42.0) | 20(40.0) | 5(10.0) | 90 |
| Matched group n=50 | 2(4.0) | 17(34.0) | 16(32.0) | 15(30.0) | 70 |
Annotate: compare P＜0.05 with matched group.
Be difficult for becoming in the hepatic tissue pathology inspection under the situation of routine examination of chronic hepatitis and Patients with Cirrhosis After Hepatitis, clinical observation in recent years finds that HA, PCIII, LN can reflect the hepatic fibrosis active state, as the observation index of anti-fibrosis medicine curative effect.The chronic active hepatitis early stage liver cirrhosis is all with in various degree hepatic fibrosis, this from hepatic fibrosis detect index such as HA, PCIII, LN all is higher than normal value, also confirmed.Above result shows, Ganoderma liver-protecting tea of the present invention can make serum liver fibrosis detection index be significant decline, wherein more obvious with HA, PCIII improvement, P＜0.01 this medicine of prompting has certain inhibitory action to the liver fibrosis process of chronic active hepatitis early stage liver cirrhosis.Aspect the clinical symptoms sign improves, this research has been screened six of pain in the hepatic region, abdominal distention, weak, tooth epistaxis blood, splenomegaly, liver palm spider angiomas to common, meaningful symptoms sign clinically, emphasis is observed, the result shows that Ganoderma liver-protecting tea of the present invention all improves significantly to preceding four aspects, and its effective percentage is all above 80%.
In addition, Ganoderma liver-protecting tea of the present invention reaches 90% at the comprehensive therapeutic effect effective percentage of treatment chronic active hepatitis, early stage liver cirrhosis, is better than matched group, and both compare, and notable difference is arranged, P＜0.05.Conclusion: the Ganoderma liver-protecting tea be applied to clinical it can obviously improve the hepatopathy symptom, recover liver function, promote that albumen is synthetic, suppress hepatic fibrosis index, the treatment of chronic active hepatitis early stage liver cirrhosis to be had synergism with the Western medicine coupling.
Claims (4)
1. Ganoderma liver-protecting tea is characterized in that this Ganoderma liver-protecting tea is to prepare by the following method:
(1) by multistage pulverizing with dry Ganoderma capenseD.A.Reid, Ganoderma sinense Zhao Xu et Zhang, Ganoderma lucidum (Leyss. Ex Fr.) Karst. raw material pulverize separately is to the flocculence of crossing 20～30 mesh sieves;
(2) get Ganoderma lucidum (Leyss. Ex Fr.) Karst. 1.5～3 weight portions of pulverizing, Ganoderma capenseD.A.Reid 2.5～3.5 weight portions, Ganoderma sinense Zhao Xu et Zhang 4.0～6.0 weight portions, former powder 0.7～1.0 weight portion of Ganoderma spore powder, mix: forward stirred 2～5 minutes, oppositely stirred 2～5 minutes again; Repeat 4～10 circulations;
(3), stirred 8～15 minutes to the water that wherein adds 5～9 weight portions successively; Add the water of 2～4 weight portions, stirred 8～15 minutes; Add the water of 2～4 weight portions, stirred 8～15 minutes; Add the water of 2～4 weight portions, stirred 8～15 minutes; Add the water of 2～4 weight portions, stirred 8～15 minutes;
(4) the final gained material of step (3) is carried out pelletize, obtaining particle diameter is the pure Ganoderma tea pellet of 4～5mm;
(5) by following program pure Ganoderma tea pellet is dried and dosing: 1. close dehumidifying baking 3-4 hour, rise to 78-82 ℃ until oven temperature; 2. beginning to rehearse wets toasted 20～40 minutes, dropped to 65-70 ℃ until oven temperature; 3. close dehumidifying baking 4-5 hour, reach 100 ℃ up to temperature; 4. take out the Ganoderma tea pellet, add 1～2 parts by weight of Chinese traditional medicine extracting solution with spray pattern; 5. close dehumidifying and continue baking 0.5～1.5 hour, beginning to rehearse wet baking 15～45 minutes reaches 75-80 ℃ to temperature, closes dehumidifying and is baked to 115～120 ℃, keeps temperature to continue baking 40-50 minute; Described Chinese medicine extraction liquid prepares by the following method: with Herba Ecliptae 0.8～1.2Kg, the Radix Polygoni Multiflori is done 0.8～1.2Kg, and Herba Scutellariae Barbatae 0.8～1.2Kg mixes, be divided into two parts, be packaged in respectively in the ripe medicated bag and put into boiling machine, add water to 16L, big fire was endured 90 minutes, and little fire is ripe in 13L.
2. Ganoderma according to claim 1 is protected heart tea, it is characterized in that the former powder of described Ganoderma spore powder is selected from the former powder of Ganoderma sinense Zhao Xu et Zhang spore powder, the former powder of Ganoderma lucidum (Leyss. Ex Fr.) Karst. spore powder or the former powder of Ganoderma sinense Zhao Xu et Zhang spore powder and the mixing spore powder former powder of the former powder of Ganoderma lucidum (Leyss. Ex Fr.) Karst. spore powder with arbitrary proportion mixing gained.
3. the preparation method of the described Ganoderma tea of claim 1 is characterized in that comprising the steps:
(1) by multistage pulverizing with dry Ganoderma capenseD.A.Reid, Ganoderma sinense Zhao Xu et Zhang, Ganoderma lucidum (Leyss. Ex Fr.) Karst. raw material pulverize separately is to the flocculence of crossing 20～30 mesh sieves;
(2) get Ganoderma lucidum (Leyss. Ex Fr.) Karst. 1.5～3 weight portions of pulverizing, Ganoderma capenseD.A.Reid 2.5～3.5 weight portions, Ganoderma sinense Zhao Xu et Zhang 4.0～6.0 weight portions, former powder 0.7～1.0 weight portion of Ganoderma spore powder, mix: forward stirred 2～5 minutes, oppositely stirred 2～5 minutes again; Repeat 4～10 circulations;
(3), stirred 8～15 minutes to the water that wherein adds 5～9 weight portions successively; Add the water of 2～4 weight portions, stirred 8～15 minutes; Add the water of 2～4 weight portions, stirred 8～15 minutes; Add the water of 2～4 weight portions, stirred 8～15 minutes; Add the water of 2～4 weight portions, stirred 8～15 minutes;
(4) the final gained material of step (3) is carried out pelletize, obtaining particle diameter is the pure Ganoderma tea pellet of 4～5mm;
(5) by following program pure Ganoderma tea pellet is dried and dosing: 1. close dehumidifying baking 3-4 hour, rise to 78-82 ℃ until oven temperature; 2. beginning to rehearse wets toasted 20～40 minutes, dropped to 65-70 ℃ until oven temperature; 3. close dehumidifying baking 4-5 hour, reach 100 ℃ up to temperature; 4. take out the Ganoderma tea pellet, add 1～2 parts by weight of Chinese traditional medicine extracting solution with spray pattern; 5. close dehumidifying and continue baking 0.5～1.5 hour, beginning to rehearse wet baking 15～45 minutes reaches 75-80 ℃ to temperature, closes dehumidifying and is baked to 115～120 ℃, keeps temperature to continue baking 40-50 minute; Described Chinese medicine extraction liquid prepares by the following method: with Herba Ecliptae 0.8～1.2Kg, the Radix Polygoni Multiflori is done 0.8～1.2Kg, and Herba Scutellariae Barbatae 0.8～1.2Kg mixes, be divided into two parts, be packaged in respectively in the ripe medicated bag and put into boiling machine, add water to 16L, big fire was endured 90 minutes, and little fire is ripe in 13L.
4. Ganoderma tea according to claim 3 is characterized in that the former powder of described Ganoderma spore powder is the former powder of Ganoderma sinense Zhao Xu et Zhang spore powder, the former powder of Ganoderma lucidum (Leyss. Ex Fr.) Karst. spore powder or the former powder of Ganoderma sinense Zhao Xu et Zhang spore powder and the mixing spore powder former powder of the former powder of Ganoderma lucidum (Leyss. Ex Fr.) Karst. spore powder with arbitrary proportion mixing gained.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105145980A (en) * | 2015-09-10 | 2015-12-16 | 桂林盛兴电子科技有限公司 | Traditional Chinese medicine tea bag and preparation method thereof |
| CN105613845A (en) * | 2015-12-23 | 2016-06-01 | 安徽省霍山县轩芝缘生物科技有限公司 | Detoxifying and beautifying ganoderma lucidum tea |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1281721A (en) * | 1999-07-26 | 2001-01-31 | 李冠祥 | Chinese medicine cancer-digesting preparation and its production method |
| CN1903324A (en) * | 2005-07-29 | 2007-01-31 | 陈爱先 | Medicine composition for treating chronic hepatitis B |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1281721A (en) * | 1999-07-26 | 2001-01-31 | 李冠祥 | Chinese medicine cancer-digesting preparation and its production method |
| CN1903324A (en) * | 2005-07-29 | 2007-01-31 | 陈爱先 | Medicine composition for treating chronic hepatitis B |
Non-Patent Citations (2)
| Title |
|---|
| 《天津中医学院学报》 19960630 赵玉华 中医药免疫功能的研究 , 第2期 * |
| 《江西中医药》 19970228 匡奕璜 中医中药诊治乙型病毒性肝炎述评 第28卷, 第1期 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105145980A (en) * | 2015-09-10 | 2015-12-16 | 桂林盛兴电子科技有限公司 | Traditional Chinese medicine tea bag and preparation method thereof |
| CN105613845A (en) * | 2015-12-23 | 2016-06-01 | 安徽省霍山县轩芝缘生物科技有限公司 | Detoxifying and beautifying ganoderma lucidum tea |
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