CN102183797A - Ultrasonic air bubble detection device applicable to biological microtubules - Google Patents
Ultrasonic air bubble detection device applicable to biological microtubules Download PDFInfo
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- CN102183797A CN102183797A CN 201110051759 CN201110051759A CN102183797A CN 102183797 A CN102183797 A CN 102183797A CN 201110051759 CN201110051759 CN 201110051759 CN 201110051759 A CN201110051759 A CN 201110051759A CN 102183797 A CN102183797 A CN 102183797A
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Abstract
The invention discloses an ultrasonic air bubble detection device applicable to biological microtubules. The device comprises an ultrasonic signal transmitting unit, an ultrasonic probe fixing structure and an ultrasonic receiving end signal processing unit, wherein two ends of the ultrasonic probe fixing structure are fixed with an ultrasonic transmitting probe of the ultrasonic signal transmitting unit and an ultrasonic receiving probe of the ultrasonic receiving end signal processing unit respectively; and the middle part of the ultrasonic probe fixing structure is provided with a biological microtubule between the ultrasonic transmitting probe and the ultrasonic receiving probe. The device is applicable to the biological microtubules with different tube diameters, can be adapted through a straight hole switching tube during actual use, and is lower in air interference and convenient to install and detach. During ultrasonic air bubble detection, the ultrasonic signal transmitting unit adopts a 40KHZ high-frequency pulse signal, the air bubble detection accuracy and the detection threshold value can be flexibly adjusted according to an actual detection environment, and the problem of detection of liquid air bubbles in the microtubule is effectively solved.
Description
Technical field
The invention belongs to the biological detection equipment technical field, relate to a kind of bubble detection device, especially a kind of ultrasonic bubble pick-up unit that is applicable to biological microtubule.
Background technology
What life science was explored constantly continues deeply, and the biological specimen tupe of extensive, high flux, low material consumption more and more obtains people's attention.In the testing process that realizes high flux, low material consumption, the continuous pumping liquid of sample adding system, in the suction change procedure, liquid surface inside and outside pressure of moment does not wait, and is easy to generate bubble; And the existence of bubble certainly will reduce the application of sample processing accuracy.In the biochemical analysis experiment that relates to gas detection, bubble concentration is excessive, causes composition of air too much, can bring influence.In human vein when transfusion,, bubble is excessive to enter intravenous infusion needle or patient, and vein can form aeroembolism, and directly influence is detrimental to health, and then causes doctor-patient dispute and malpractice, brings unnecessary economic loss to medical institutions simultaneously.Whether the bubble detecting sensor is the key sensor device in blood collection, blood separation equipment, exist the size of air bubble and measurement air bubble to be directly connected to the life safety in real time in the monitoring bio microtubule.
At present, mainly contain the condenser type detection method, photo-electric detection method, radiographic measurement method etc. at liquid bubble detection method in the microtubule.The condenser type detection method is the passive type detection method, and its detection mode and result depend on the object to be detected relative dielectric constant, can not come the control detection precision by self parameter that changes capacitive transducer.Capacitance type sensor output impedance is big in addition, and load capacity is poor, is subject to external interference and produces wild effect.The photo-electric detection method since in the microtubule colourless transparent liquid that the degree of absorption of light and air are compared difference to the degree of absorption of light is little, the variation of photistor output voltage is very little, cause the air bubble in the microtubule to be difficult to be detected, aeroembolism in the time of can only be to transfusion blood or coloured soup in the woven hose detects, narrow application range, limitation is bigger.Radiographic measurement is installed trouble, the price height, and computing program complexity, response speed is slower.
Summary of the invention
The objective of the invention is to overcome the shortcoming of above-mentioned prior art, a kind of ultrasonic bubble pick-up unit that is applicable to biological microtubule is provided, this device is that a kind of applicability is strong, the adjustable bubble detection device of accuracy of detection and detection threshold, be applicable to the liquid bio microtubule of different tube diameters, and easy installation and removal.
The objective of the invention is to solve by the following technical programs:
This ultrasonic bubble pick-up unit that is applicable to biological microtubule comprises ultrasonic signal transmitter unit, ultrasonic probe fixed sturcture and ultrasound wave receiving end signal processing unit; The two ends of described ultrasonic probe fixed sturcture are fixed with the ultrasonic emitting probe of ultrasonic signal transmitter unit and the ultrasound wave receiving transducer of ultrasound wave receiving end signal processing unit respectively, and the middle part of described ultrasonic probe fixed sturcture is provided with biological microtubule between described ultrasonic emitting probe and ultrasound wave receiving transducer; Described ultrasonic signal transmitter unit produces the high-frequency ultrasonic signal, the biological microtubule of transmission, ultrasonic signal is through producing decay, described ultrasound wave receiving end signal processing unit receiving attenuation signal behind the bubble, and feeble signal amplified shaping filter, analog-to-digital conversion process.
Above-mentioned ultrasonic signal transmitter unit adopts AT89C51 single-chip microcomputer and phase inverter 74LS04 to produce the 40KHZ pulse voltage; The output terminal of described phase inverter 74LS04 is connected with described ultrasonic emitting probe.
Above-mentioned ultrasound wave receiving end signal processing unit comprises AD620 operational amplifier, second-order filter circuit, AD7810 modulus conversion chip and the AT89C51 single-chip microcomputer that connects successively, and described AT89C51 single-chip microcomputer is connected with external register.
Above-mentioned ultrasonic probe fixed sturcture comprises adjacent transmitting probe fixed block and receiving transducer fixed block, is connected with the conversion pipe between described transmitting probe fixed block and the receiving transducer fixed block, and described biological microtubule passes the conversion pipe; Described transmitting probe fixed block internal fixation has the ultrasonic emitting probe, and described receiving transducer fixed block internal fixation has the ultrasound wave receiving transducer; The output terminal of described ultrasonic emitting probe communicates with an end of described conversion pipe, and the input end of described ultrasound wave receiving transducer communicates with the other end of conversion pipe.
Above-mentioned transmitting probe fixed block and receiving transducer fixed block adopt pvc material processing.
Above-mentioned ultrasonic emitting probe or receiving transducer fixed block include a piezoelectric ceramic metal shell, are fixed with wafer resonance inclined-plane, piezoelectric chip and piezoelectric chip pin in the described piezoelectric ceramic metal shell successively; The input end on described wafer resonance inclined-plane is connected with the output terminal of described piezoelectric chip; Described piezoelectric chip pin is connected on the described piezoelectric chip.
The present invention has following beneficial effect:
Ultrasonic probe fixed sturcture of the present invention is applicable to the biological microtubule of different tube diameters, during actual the use, can transfer by the straight hole crossover connection, and air interference simultaneously is less, easy installation and removal.During ultrasonic bubble detects, can make the ultrasonic signal transmitter unit adopt the 40KHZ high-frequency pulse signal, bubble accuracy of detection and detection threshold can efficiently solve the detection of liquid bubble in the microtubule according to actual detected environment flexible.
Description of drawings
Fig. 1 ultrasonic bubble pick-up unit system diagram;
The biological microtubule mounting structure of Fig. 2 ultrasound wave figure;
Fig. 3 ultrasound wave is installed sonde configuration figure;
Fig. 4 ultrasound wave receiving end signal.
Wherein: 1, transmitting probe fixed block; 2, biological microtubule; 3, conversion pipe; 4, receiving transducer fixed block; 5, piezoelectric ceramic metal shell; 6, piezoelectric chip pin; 7, install and fix the hole; 8, wafer resonance inclined-plane; 9, biological microtubule hole; 10, straight hole is installed; 11, piezoelectric ceramic wafer.
Embodiment
Below in conjunction with accompanying drawing the present invention is done and to describe in further detail:
As shown in Figure 1: a kind of ultrasound wave sensing device that is adapted to biological microtubule bubble detection, this device comprises ultrasonic signal transmitter unit, ultrasonic probe fixed sturcture and ultrasound wave receiving end signal processing unit.The two ends of ultrasonic probe fixed sturcture are fixed with the ultrasonic emitting probe of ultrasonic signal transmitter unit and the ultrasound wave receiving transducer of ultrasound wave receiving end signal processing unit respectively, and the middle part of ultrasonic probe fixed sturcture is provided with biological microtubule between ultrasonic emitting probe and ultrasound wave receiving transducer; The ultrasonic signal transmitter unit adopts single-chip microcomputer to produce pulse voltage and drives piezoelectric ceramic wafer, emission high frequency ultrasound pulse signal, ultrasonic signal is propagated by the ultrasonic probe fixed sturcture, the biological microtubule of transmission, ultrasonic signal is through producing decay behind the bubble, ultrasound wave receiving end signal processing unit receiving attenuation signal, and feeble signal amplified shaping filter, analog-to-digital conversion process, and then finish bubble size and volume detection.
Based on above basic structure of the present invention, below describe the ultrasonic bubble pick-up unit that this is applicable to biological microtubule in detail by specific embodiment:
In preferred embodiment of the present invention, the ultrasonic signal transmitter unit adopts AT89C51 single-chip microcomputer and phase inverter 74LS04 to produce the 40KHZ pulse voltage; The output terminal of phase inverter 74LS04 is connected with the ultrasonic emitting probe.Ultrasound wave receiving end signal processing unit comprises AD620 operational amplifier, second-order filter circuit, AD7810 modulus conversion chip and the AT89C51 single-chip microcomputer that connects successively, and wherein the AT89C51 single-chip microcomputer connects external register.
As shown in Figure 2: ultrasonic probe fixed sturcture of the present invention comprises adjacent transmitting probe fixed block 1 and receiving transducer fixed block 4, and transmitting probe fixed block 1 and receiving transducer fixed block 4 adopt pvc material processing.Wherein be connected with conversion pipe 3 between transmitting probe fixed block 1 and the receiving transducer fixed block 4, biological microtubule 2 passes conversion pipe 3.Transmitting probe fixed block 1 internal fixation has the ultrasonic emitting probe, and receiving transducer fixed block internal fixation has the ultrasound wave receiving transducer; The output terminal of ultrasonic emitting probe communicates with an end of conversion pipe 3, and the input end of ultrasound wave receiving transducer communicates with the other end of conversion pipe 3.Referring to Fig. 3, ultrasonic emitting probe or receiving transducer fixed-block-architecture (FBA) that the present invention is arranged in transmitting probe fixed block 1 or the receiving transducer fixed block 4 are identical, include a piezoelectric ceramic metal shell 5, be fixed with wafer resonance inclined-plane 8, piezoelectric chip 11 and piezoelectric chip pin 6 in the piezoelectric ceramic metal shell 5 successively; The input end on wafer resonance inclined-plane 8 is connected with the output terminal of piezoelectric chip 11; Piezoelectric chip pin 6 is connected on the piezoelectric chip 11, and wherein piezoelectric chip pin 6 and piezoelectric chip 11 are (as the Fig. 3) that fix by the insulation fixed block that is arranged in the piezoelectric ceramic metal shell 5.Piezoelectric ceramic metal shell 5 is fixed on fixed block inside by the mounting hole 7 that is arranged in transmitting probe fixed block 1 or the receiving transducer fixed block 4, be vertically installed with installation straight hole 10 at transmitting probe fixed block 1 or receiving transducer fixed block 4 front portions, this installation straight hole 10 is to be used for installing conversion pipe 3, the two ends of conversion pipe 3 communicate respectively at the resonance of the wafer in the fixed block of two ends inclined-plane 8, the inner port that straight hole 10 is installed is a horn shape, its angle as shown in FIG., become 63 degree, the horn shape just in time hydraucone with wafer resonance inclined-plane 8 is relative.Formed one and pass the biological microtubule hole 9 that straight hole 10 is installed between transmitting probe fixed block 1 or receiving transducer fixed block 4 front end faces, biological microtubule 2 passes from biological microtubule hole 9, and utilizes PDMS that biological microtubule hole 9 is sealed degasification.
The course of work of the present invention is as follows:
The single-chip microcomputer of ultrasonic signal transmitter unit produces pulse voltage, by piezoelectric chip pin 6 driving piezoelectric ceramic wafers 11, makes it produce resonance, and ultrasonic beam converges by the hydraucone of wafer resonance inclined-plane 8 and installation straight hole 10, in straight hole, propagate,
The single-chip microcomputer of ultrasonic signal transmitter unit produces pulse voltage (pulse voltage can be selected 40KHZ), utilize the anti-phase reinforcement voltage signal of 74LS04 phase inverter and drive piezoelectric ceramic wafer 11 by piezoelectric chip pin 6, make it produce resonance, ultrasonic beam converges by the hydraucone of wafer resonance inclined-plane 8 and installation straight hole 10, after in straight hole, propagating, pulse signal sees through the installation straight hole 10 of biological microtubule 2 backs to the other end, when arriving the ultrasound wave receiving element, the ultrasound wave receiving element adopts the AD620 operational amplifier to amplify and utilizes second-order filter circuit to carry out filter shape, the AD620 operational amplifier is as the high-precision meter amplifier, only need with an external resistor, just can be provided with that adjustable extent is wide to reach 1～1000 amplifier gain, adopt the AD7810 modulus conversion chip that the ultrasound wave received signal is converted to digital quantity signal, ultrasound wave is transmitted in the gas in liquid, energy can be decayed, and amplitude diminishes; Utilize the AT89C51 single-chip microcomputer that deamplification is handled, judge the definite bubble detection threshold of amplitude size, and the result is kept at external register, as shown in Figure 4.
Claims (6)
1. a ultrasonic bubble pick-up unit that is applicable to biological microtubule is characterized in that: comprise ultrasonic signal transmitter unit, ultrasonic probe fixed sturcture and ultrasound wave receiving end signal processing unit; The two ends of described ultrasonic probe fixed sturcture are fixed with the ultrasonic emitting probe of ultrasonic signal transmitter unit and the ultrasound wave receiving transducer of ultrasound wave receiving end signal processing unit respectively, and the middle part of described ultrasonic probe fixed sturcture is provided with biological microtubule between described ultrasonic emitting probe and ultrasound wave receiving transducer; Described ultrasonic signal transmitter unit produces the high-frequency ultrasonic signal, the biological microtubule of transmission, ultrasonic signal is through producing decay, described ultrasound wave receiving end signal processing unit receiving attenuation signal behind the bubble, and feeble signal amplified shaping filter, analog-to-digital conversion process.
2. the ultrasonic bubble pick-up unit that is applicable to biological microtubule according to claim 1 is characterized in that: described ultrasonic signal transmitter unit adopts AT89C51 single-chip microcomputer and phase inverter 74LS04 to produce the 40KHZ pulse voltage; The output terminal of described phase inverter 74LS04 is connected with described ultrasonic emitting probe.
3. the ultrasonic bubble pick-up unit that is applicable to biological microtubule according to claim 1, it is characterized in that: ultrasound wave receiving end signal processing unit comprises AD620 operational amplifier, second-order filter circuit, AD7810 modulus conversion chip and the AT89C51 single-chip microcomputer that connects successively, and described AT89C51 single-chip microcomputer is connected with external register.
4. the ultrasonic bubble pick-up unit that is applicable to biological microtubule according to claim 1, it is characterized in that: described ultrasonic probe fixed sturcture comprises adjacent transmitting probe fixed block (1) and receiving transducer fixed block (4), be connected with conversion pipe (3) between described transmitting probe fixed block (1) and the receiving transducer fixed block (4), described biological microtubule (2) passes conversion pipe (3); Described transmitting probe fixed block (1) internal fixation has the ultrasonic emitting probe, and described receiving transducer fixed block internal fixation has the ultrasound wave receiving transducer; The output terminal of described ultrasonic emitting probe communicates with an end of described conversion pipe (3), and the input end of described ultrasound wave receiving transducer communicates with the other end of conversion pipe (3).
5. the ultrasonic bubble pick-up unit that is applicable to biological microtubule according to claim 4 is characterized in that: described transmitting probe fixed block (1) and receiving transducer fixed block (4) adopt pvc material processing.
6. according to claim 1 or the 4 described ultrasonic bubble pick-up units that are applicable to biological microtubule, it is characterized in that: described ultrasonic emitting probe or receiving transducer fixed block include a piezoelectric ceramic metal shell (5), are fixed with wafer resonance inclined-plane (8), piezoelectric chip (11) and piezoelectric chip pin (6) in the described piezoelectric ceramic metal shell (5) successively; The input end on described wafer resonance inclined-plane (8) is connected with the output terminal of described piezoelectric chip (11); Described piezoelectric chip pin (6) is connected on the described piezoelectric chip (11).
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| CN 201110051759 CN102183797A (en) | 2011-03-04 | 2011-03-04 | Ultrasonic air bubble detection device applicable to biological microtubules |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104905382A (en) * | 2015-06-05 | 2015-09-16 | 华南理工大学 | Variable-frequency ultrasound-assisted dough freezing method and device |
| CN105527986A (en) * | 2015-12-11 | 2016-04-27 | 成都翰道科技有限公司 | Intelligent aerator control system based on two-stage filter circuit |
| CN107742753A (en) * | 2017-09-08 | 2018-02-27 | 侬泰轲（昆山）检测科技有限公司 | A kind of encapsulating structure of battery, method for packing and detection method |
| CN108132299A (en) * | 2018-03-06 | 2018-06-08 | 杭州森威传感科技有限公司 | A kind of air bubble sensor and method for bubble in signal piping |
| CN109085247A (en) * | 2018-06-27 | 2018-12-25 | 中国计量大学 | A kind of acoustic contrast agent cavitation bubble group resonance state measurement method |
| WO2020062273A1 (en) * | 2018-09-30 | 2020-04-02 | 深圳迈瑞生物医疗电子股份有限公司 | Ultrasonic probe |
| CN111905174A (en) * | 2020-08-07 | 2020-11-10 | 成都威力生生物科技有限公司 | Dialysis pipeline bubble detection circuit |
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| CN200987792Y (en) * | 2005-12-20 | 2007-12-12 | 重庆圣德利医疗器械研究有限公司 | Ultrasonic air monitor for blood purifying equipment |
| CN101189509A (en) * | 2005-06-03 | 2008-05-28 | 弗雷泽纽斯医疗保健德国有限公司 | Method and device for monitoring a flow of liquid for the presence of air by means of ultrasound |
| CN101766854A (en) * | 2008-12-29 | 2010-07-07 | 北京谊安医疗系统股份有限公司 | Bubble detection device for infusion pipeline |
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2011
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| CN101189509A (en) * | 2005-06-03 | 2008-05-28 | 弗雷泽纽斯医疗保健德国有限公司 | Method and device for monitoring a flow of liquid for the presence of air by means of ultrasound |
| CN200987792Y (en) * | 2005-12-20 | 2007-12-12 | 重庆圣德利医疗器械研究有限公司 | Ultrasonic air monitor for blood purifying equipment |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104905382A (en) * | 2015-06-05 | 2015-09-16 | 华南理工大学 | Variable-frequency ultrasound-assisted dough freezing method and device |
| CN104905382B (en) * | 2015-06-05 | 2018-04-13 | 华南理工大学 | A kind of method and device of variable-frequency ultrasound auxiliary freezing flour-dough |
| CN105527986A (en) * | 2015-12-11 | 2016-04-27 | 成都翰道科技有限公司 | Intelligent aerator control system based on two-stage filter circuit |
| CN107742753A (en) * | 2017-09-08 | 2018-02-27 | 侬泰轲（昆山）检测科技有限公司 | A kind of encapsulating structure of battery, method for packing and detection method |
| CN108132299A (en) * | 2018-03-06 | 2018-06-08 | 杭州森威传感科技有限公司 | A kind of air bubble sensor and method for bubble in signal piping |
| CN109085247A (en) * | 2018-06-27 | 2018-12-25 | 中国计量大学 | A kind of acoustic contrast agent cavitation bubble group resonance state measurement method |
| CN109085247B (en) * | 2018-06-27 | 2020-10-30 | 中国计量大学 | Ultrasonic contrast agent cavitation bubble group resonance state measurement method |
| WO2020062273A1 (en) * | 2018-09-30 | 2020-04-02 | 深圳迈瑞生物医疗电子股份有限公司 | Ultrasonic probe |
| CN111905174A (en) * | 2020-08-07 | 2020-11-10 | 成都威力生生物科技有限公司 | Dialysis pipeline bubble detection circuit |
| CN111905174B (en) * | 2020-08-07 | 2023-07-28 | 成都威力生生物科技有限公司 | Dialysis pipeline bubble detection circuit |
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Application publication date: 20110914 |