CN102178894B - Plaster and preparation method of plaster - Google Patents
Plaster and preparation method of plaster Download PDFInfo
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- CN102178894B CN102178894B CN201110106764A CN201110106764A CN102178894B CN 102178894 B CN102178894 B CN 102178894B CN 201110106764 A CN201110106764 A CN 201110106764A CN 201110106764 A CN201110106764 A CN 201110106764A CN 102178894 B CN102178894 B CN 102178894B
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Abstract
The invention discloses a plaster and a preparation method of the plaster. The crude drugs of the plaster include: 55-65g of Strychnos, 85-95g of radi of x clematidis, 40-50g of frankincense, 40-50g of myrrh, 25-35g of dragon's blood, 40 -50g of angelica, 25-35g of pseudo-ginseng, 45-55g of Ligusticum wallichii, 45-55g of Rhizoma Wenyujin Concisum, 40-50g of safflower, 45-55g of Processed Radix Aconiti, 45-55g of Processed Radix Aconiti Kusnezoffii, 55-65g of ephedra, 85-95g of cassia twig, 35-45g of notopterygium root, 35-45g of radix angelicae pubescentis, 55-65g of garden balsam stem, 45-55g of lycopodium clavatum, 35-45g of Rhizoma Drynariae, 45-55g of radix dipsaci, 45-55g of Eupolyphaga, 25-35g of scorpio, 40-50g of lumbricus, 40-50g of pangolin, 40-50g of Asarum and 15-25g of borneol. The formula is unique, the production method is simple and the curative effect is notable.
Description
Technical field
The present invention relates to a kind of externally applied ointment and preparation method thereof, be specifically related to a kind of by the plurality of Chinese material process, have blood circulation promoting and blood stasis dispelling, dredge the meridian passage, reducing swelling and alleviating pain function plaster and preparation method thereof.
Background technology
Prolapse of lumbar intervertebral disc is clinically one of comparatively common waist illness, is commonly encountered diseases, the frequently-occurring disease of orthopedics department.This disease is sent out in person between twenty and fifty well, with living habit and working environment much relations is arranged also, and mostly clinical manifestation is flank pain, lower limb radiating pain, waist moving obstacle, scoliosis sight, feeling of numbness etc., and tcm diagnosis is: qi depression to blood stasis, wind and cold wet, suffer from a deficiency of the kidney.
Hyperosteogeny is a kind of frequently-occurring disease, commonly encountered diseases, and pilosity is born in middle age or the old people more than 45 years old, and the male is more than the women, and active heavy worker of waist commonly used and athlete are prone to suffer from this disease, are most commonly in joints such as knee joint, hip, lumbar vertebra, cervical vertebra, elbow.Often occur clinically that lumbar vertebra and lumbar soft tissue are ached, distending pain, stiff and tired sense, even it is limited to bend over.The traditional Chinese medical science thinks that after the middle age, deficiency of the liver and kindey, QI and blood are gradually empty; Weakened defensive QI, rheumatism cold-evil takes advantage of a weak point in opponent's defence and invades, and causes stagnation of QI-blood, fights and ties in neck muscles and bones; Passages through which vital energy circulates is obstructed, and muscles and bones muscle loses in the warm of QI and blood and causes with moistening foster, advocates expelling wind and cold, relaxes through the collateral dredging eliminating impediment.
The arthritis knuckle inflammation is a kind of common chronic disease, by the arthritis pathological changes that inflammation, infection, wound or other factors cause, belongs to rheumatism subject disease, commonly osteoarthritis and rheumatoid arthritis.The traditional Chinese medical science is thought " wind-cold damp pathogen, numbness resistance passages through which vital energy circulates causes passages through which vital energy circulates obstructed, stagnation of QI and blood may bring about pain " for the traditional theory of arthritis treatment, so treatment by Chinese herbs generally is with expelling wind and cold, spasmolytic collateral dredging, activating blood circulation to dissipate blood stasis is a purpose.
Aseptic necrosis of femoral head is one of common osteoarthritis.The traditional Chinese medical science think with femur head necrosis pathological changes relation the closest for liver,spleen,kidney three dirty.The kidney being the origin of congenital constitution, and main bone is given birth to marrow, and the strong then marrow of kidney fills, and marrow completely then bone is hard.Otherwise then the marrow dry bones withers, and loses the regeneration capacity of application.The liver governing tendons store blood, with the kidney homology, Liang Zangrong declines together, if liver gets involved, store blood mistake department can not the normal regulating blood volume, " heart master blood, liver Tibetans, the people moves and then transports at warp, and the quiet then blood of people belongs to liver." if the blood transport contraband is inconsiderate, nutrition is not good, also is the key factor that causes ischemia femur head necrosis.Taste be the day after tomorrow this, all things on earth the source of vital function, make spleen be good for the stomach with, then grain rice are become thoroughly decomposed, activating QI blood is defended with the field headquarters, if taste lose strong fortune, biochemical QI and blood is passive, then muscles and bones muscle all depletion of QI with life.The cardinal symptom of femur head necrosis shows following 5 points: 1. pain, 2. ankylosis and limitation of activity etc.Determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs through the traditional Chinese medical science is to different stadium; Different syndromes and stress blood circulation promoting and blood stasis dispelling, dredging the meridian, remove the rotten and let fresh grow, join invigorating the liver and kidney, bone and muscle strengthening etc.; Thereby improve the interior environment of body; For the generation of bone newly provides material base, promote the regeneration of blood vessel and side to prop up circulation foundation, promote the generation of new bone.
Traumatic injury is a kind of disease common in the daily life, is main with soft tissue injury often.Many during treatment with the medicated wine external application, change the blood blood stasis dispelling, reducing swelling and alleviating pain.
Above-mentioned disease can adopt external medication also can adopt the endo-medicine treatment when treatment, and endo-medicine is generally anti-inflammatory analgesic class medicine, and like indometacin, ibuprofen etc., analgesic effect is strong, and antiinflammatory and anti rheumatism action are also stronger.But general anti-inflammatory analgesic class medicine can not be taken the long period and these methods of clinical practice can only the alleviating pain symptom, can't play the effect of radical cure, and oral medicine is very big to liver, kidney, gastrointestinal damage, and therefore, Dressed plaster is reasonable Therapeutic Method.Plaster external application stimulating acupoint can " wind dispelling cold ", " and QI and blood ", " strengthening bone and muscle ", and the medicine focus of going directly is more rapid-action than oral drugs, and has no side effect.Now, the plaster of selling on the market comes with some shortcomings, and perhaps only is that therapeutic domain is narrow to a certain disease, and perhaps therapeutic effect is slow, the course of treatment is long, perhaps costs an arm and a leg, and these deficiencies have been brought very big inconvenience to patient.
Summary of the invention
The present invention provides a kind of plaster in order to overcome the deficiency of prior art, and it can blood circulation promoting and blood stasis dispelling, dredge the meridian passage, reducing swelling and alleviating pain, is mainly used in treatment prolapse of lumbar intervertebral disc, hyperosteogeny, arthritis, aseptic necrosis of femoral head and traumatic injury.
The present invention also provides the method for preparing of this plaster.
Generally, diseases such as prolapse of lumbar intervertebral disc, hyperosteogeny, arthritis, aseptic necrosis of femoral head and traumatic injury are all followed pain, swelling phenomenon, and the traditional Chinese medical science thinks that blood circulation promoting and blood stasis dispelling, dredging the meridian are the keys of treatment pain, and general rule is not bitterly.The inventor is through research for many years; Drug effect to each Chinese crude drug; Summed up the prescription that can treat prolapse of lumbar intervertebral disc, hyperosteogeny, arthritis, aseptic necrosis of femoral head and traumatic injury disease, this prescription can be made into plaster and is affixed on the affected part, and is rapid-action; Healing time is short and price is suitable, is easy to be extended and applied.Its concrete technical scheme is following:
A kind of plaster is characterized in that being made up of following crude drug:
Semen Strychni 55-65g, Radix Clematidis 85-95g, Olibanum (system) 40-50g, Myrrha (processed) 40-50g, Sanguis Draxonis 25-35g, Radix Angelicae Sinensis 40-50g; Radix Notoginseng 25-35g, Rhizoma Chuanxiong 45-55g, Rhizoma Wenyujin Concisum 45-55g, Flos Carthami 40-50g, Radix Aconiti Preparata 45-55g; Radix Aconiti Kusnezoffii Preparata 45-55g, Herba Ephedrae 55-65g, Ramulus Cinnamomi 85-95g, Rhizoma Et Radix Notopterygii 35-45g, Radix Angelicae Pubescentis 35-45g; Herba speranskiae tuberculatae 55-65g, Herba Lycopodii 45-55g, Rhizoma Drynariae 35-45g, Radix Dipsaci 45-55g, Eupolyphaga Seu Steleophaga 45-55g; Scorpio 25-35g, Pheretima 40-50g, Squama Manis (big gun) 40-50g, Herba Asari 40-50g, Borneolum Syntheticum 15-25g.
Further, the preferred following crude drug of above-mentioned ointment:
Semen Strychni 65g, Radix Clematidis 95g, Olibanum (system) 50g, Myrrha (processed) 50g, Sanguis Draxonis 30g, Radix Angelicae Sinensis 45g, Radix Notoginseng 30g; Rhizoma Chuanxiong 55g, Rhizoma Wenyujin Concisum 40g, Flos Carthami 45g, Radix Aconiti Preparata 45g, Radix Aconiti Kusnezoffii Preparata 45g, Herba Ephedrae 65g, Ramulus Cinnamomi 95g; Rhizoma Et Radix Notopterygii 40g, Radix Angelicae Pubescentis 40g, Herba speranskiae tuberculatae 55g, Herba Lycopodii 45g, Rhizoma Drynariae 45g, Radix Dipsaci 55g; Eupolyphaga Seu Steleophaga 45g, Scorpio 25g, Pheretima 50g, Squama Manis (big gun) 50g, Herba Asari 40g, Borneolum Syntheticum 15g.
Further, the preferred following crude drug of above-mentioned ointment:
Semen Strychni 58-62g, Radix Clematidis 88-92g, Olibanum (system) 43-46g, Myrrha (processed) 43-46g, Sanguis Draxonis 28-32g, Radix Angelicae Sinensis 43-48g; Radix Notoginseng 28-33g, Rhizoma Chuanxiong 48-53g, Rhizoma Wenyujin Concisum 48-53g, Flos Carthami 42-47g, Radix Aconiti Preparata 48-52g; Radix Aconiti Kusnezoffii Preparata 48-52g, Herba Ephedrae 58-62g, Ramulus Cinnamomi 88-92g, Rhizoma Et Radix Notopterygii 38-42g, Radix Angelicae Pubescentis 38-42g; Herba speranskiae tuberculatae 58-63g, Herba Lycopodii 48-53g, Rhizoma Drynariae 38-42g, Radix Dipsaci 48-52g, Eupolyphaga Seu Steleophaga 48-52g; Scorpio 28-32g, Pheretima 43-48g, Squama Manis (big gun) 43-48g, Herba Asari 43-48g, Borneolum Syntheticum 18-22g.
Further, the most preferably following crude drug of above-mentioned ointment:
Semen Strychni 60g, Radix Clematidis 90g, Olibanum (system) 45g, Myrrha (processed) 45g, Sanguis Draxonis 30g, Radix Angelicae Sinensis 45g, Radix Notoginseng 30g; Rhizoma Chuanxiong 50g, Rhizoma Wenyujin Concisum 50g, Flos Carthami 45g, Radix Aconiti Preparata 50g, Radix Aconiti Kusnezoffii Preparata 50g, Herba Ephedrae 60g, Ramulus Cinnamomi 90g; Rhizoma Et Radix Notopterygii 40g, Radix Angelicae Pubescentis 40g, Herba speranskiae tuberculatae 60g, Herba Lycopodii 50g, Rhizoma Drynariae 40g, Radix Dipsaci 50g; Eupolyphaga Seu Steleophaga 50g, Scorpio 30g, Pheretima 45g, Squama Manis (big gun) 45g, Herba Asari 45g, Borneolum Syntheticum 20g.
The present invention also provides the method for preparing of above-mentioned plaster, it is characterized in that comprising the following steps:
(1) Herba Ephedrae, Herba Asari and Ramulus Cinnamomi water are decocted twice, the consumption of water be drug dose the 3-5 quality doubly, merge filtrating twice, filtrating is concentrated into thick paste;
(2) Olibanum, Myrrha, Sanguis Draxonis and Borneolum Syntheticum are pulverized separately respectively; Scorpio, Radix Notoginseng, Squama Manis, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Pheretima and Eupolyphaga Seu Steleophaga mix to be pulverized, and the medical material after the pulverizing mixes with above-mentioned thick paste, processes soft material; With the soft material cold drying, be ground into fine powder again;
(3) 12 flavors such as remaining 12 flavor medicine all the other Rhizoma Wenyujin Concisum are given as one thinks fit cataclasm, in pot, add Oleum Sesami, then will cataclasm medicine to put into Oleum Sesami fried to withered black, filter, remove slag and stay oil, oil continues to refine to dripping into pearl;
(4) in the good oil of refining, add Plumbum preparatium, stir the back and receive cream, cream is soaked in releasing fire-toxin in the cold water;
(5) after the immersion, cream is taken out,, add the fine powder that finally makes in the step (2), stir, share on cloth, promptly get plaster with the slow fire fusing.
In the above-mentioned method for preparing, in the step (1), decocted 2 hours for the first time, decocted 1 hour for the second time; Being concentrated into temperature is 60 ℃, and relative density is the thick paste of 1.4-1.45;
In the above-mentioned method for preparing, in the step (2), each medicine is crushed to the 80-100 order.
In the above-mentioned method for preparing, in the step (3), the consumption of edible vegetable oil be 12 flavor medical material total amounts the 4-4.5 quality doubly.
In the above-mentioned method for preparing, in the step (4), the consumption of Plumbum preparatium is the 40-51wt% of vegetable oil.
In the above-mentioned method for preparing, in the step (4), be 4-10 days with the water-immersed time of cream, general 4-5 days summer, general 7-10 days winter.
The usage of medicine of the present invention and consumption: external, clean illing skin with Rhizoma Zingiberis Recens, it is softening that plaster is heated, and is affixed on the affected part.But the anemia of pregnant woman prohibits subsides waist and abdominal part.
The onset after general one day of this ointment, 1-3 the recovery from illness course of treatment whenever changed medicine one time at a distance from 7 days, and general 1 month is a course of treatment.
Adopt 26 flavor Chinese medicine medical materials in the present invention's prescription altogether, the effect of each medicine material is following:
Semen Strychni: nature and flavor are bitter, temperature; Very toxic; Gui Jing returns liver, spleen channel; Effect, removing obstruction in the collateral to relieve pain, mass dissipating and swelling eliminating.
Radix Clematidis: nature and flavor are hot, salty, temperature; Gui Jing returns urinary bladder channel; Effect, expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.
Olibanum: nature and flavor are arduous, temperature; Gui Jing goes into the heart, liver, spleen channel; Effect, regulating qi and activating blood, analgesic therapy chases after poison.
Myrrha: another name, myrrh (" detailed outline "), bright Myrrha " national Chinese herbal medicine compilation ", nature and flavor are bitter, and suffering is flat; Gui Jing goes into the heart, liver; Effect, the blood blood stasis removing that looses, subduing swelling and relieving pain.
Sanguis Draxonis: nature and flavor, sweet, salty, flat; Gui Jing, GUIXIN, Liver Channel; Effect, removing blood stasis and relieving pain, hemostasia and promoting granulation.
Radix Angelicae Sinensis: nature and flavor, sweet, hot, temperature; Gui Jing returns liver, the heart, spleen channel; Effect is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Radix Notoginseng: nature and flavor, sweet, little hardship, temperature; Gui Jing returns liver, stomach warp; Effect, dissipating blood stasis hemostasis, subduing swelling and relieving pain.
Rhizoma Chuanxiong: nature and flavor, suffering, temperature; Gui Jing returns liver, gallbladder, pericardium channel; Effect, blood-activating and qi-promoting, wind-expelling pain-stopping.
Rhizoma Wenyujin Concisum: nature and flavor, hot, bitter, temperature; Gui Jing returns liver, spleen channel; Effect, removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.
Flos Carthami: nature and flavor, suffering, temperature; Gui Jing, GUIXIN, Liver Channel; Effect, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.
Radix Aconiti Preparata: nature and flavor, hot, bitter, heat, poisonous; Gui Jing, GUIXIN, liver, kidney, board warp; Effect, expelling wind and removing dampness, antalgic.
Radix Aconiti Kusnezoffii Preparata: nature and flavor are hot, bitter, heat; Poisonous; Gui Jing, GUIXIN, liver,kidney,spleen warp; Effect, expelling wind and removing dampness, antalgic.
Herba Ephedrae: nature and flavor, hot, little hardship, temperature; Gui Jing returns lung, urinary bladder channel; Effect, diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.
Ramulus Cinnamomi: nature and flavor, hot, sweet, temperature; Gui Jing, GUIXIN, lung, urinary bladder channel; Effect, diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.
Rhizoma Et Radix Notopterygii: nature and flavor, hot, bitter, temperature; Gui Jing returns bladder, kidney channel; Effect, cold expelling dispels the wind, dehumidifying, pain relieving.
Radix Angelicae Pubescentis: nature and flavor, hot, bitter, tepor; Gui Jing returns kidney, urinary bladder channel; Effect, expelling wind and removing dampness, numbness relieving and pain relieving.
Herba speranskiae tuberculatae: different name, perennial root common vetch (" important forage cultivating "), the bean seedling that falls, mountain Semen Pisi sativi, mountain bean seedlings, perennial root wild vetch, bean bowl bowl, waterlogging bean seedling (" homemade forage grass "), mountain Semen sojae atricolor (" the northeast medicine is planted will "), Herba Viciae Amoenae, wild vetch (" Jilin Chinese herbal medicine "); Nature and flavor are sweet, flat, nontoxic; Effect, wind-damp dispelling is invigorated blood circulation, Shujin, pain relieving.
Herba Lycopodii: nature and flavor, property mildly bitter flavor, suffering, temperature; Gui Jing returns the liver,spleen,kidney warp; Effect, expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.
Rhizoma Drynariae: nature and flavor are bitter, temperature; Gui Jing returns kidney, Liver Channel; Effect, the kidney invigorating bone strengthening continues and hinders pain relieving.
Radix Dipsaci: nature and flavor, bitter, hot, tepor; Gui Jing returns liver, kidney channel; Effect, invigorating the liver and kidney, bone and muscle strengthening, continuous folding is hindered, and ends metrorrhagia.
Eupolyphaga Seu Steleophaga: another name, Eupolyphaga Seu Steleophaga, eupolyphaga, DIWUGUI 、 female ground beetle; Nature and flavor are salty, cold; Slightly poisonous; Gui Jing returns Liver Channel; Function cures mainly, removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.
Scorpio: nature and flavor, suffering, flat; Poisonous; Gui Jing returns Liver Channel; Effect, endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.
Pheretima: nature and flavor are salty, cold; Gui Jing returns liver, spleen, urinary bladder channel; Effect, the heat clearing away arresting convulsion, collateral dredging is relievingd asthma, diuresis.
Squama Manis: nature and flavor are salty, be slightly cold; Gui Jing returns liver, stomach warp; Effect, the stimulating milk secretion of stimulating the menstrual flow, detumescence and apocenosis, expel wind to dredge collateral.
Herba Asari: nature and flavor, suffering, temperature; Gui Jing, GUIXIN, lung, kidney channel; Effect, expelling wind and cold, understand things pain-stopping, warming the lung to resolve fluid-retention; Borneolum Syntheticum: nature and flavor, hot, bitter, cold; Effect, the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.
Plaster is a pith in motherland's medical science, is one of five big pharmaceutical dosage forms.Externally applied plaster can not only be treated some surgical disease, and has treating both the principal and secondary aspects of a disease, characteristics easy to use.About the record of plaster, be shown in the earliest in the classic medical science works such as medical literature Huangdi's Internal Classics, Shennong's Herbal, Difficult Classic.The Eastern Han Dynasty cures holy Zhang Zhongjing and in " Treatise on Febrile and Miscellaneous Disease ", says: extremity just feel heavily stagnant, promptly guide the expiration and inspiration acupuncture, a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease therapies should be practised to clear the nine orifices.The a large amount of plaster prescriptions and the mechanism of curing the disease have all been put down in writing in the books such as " Later Han Dynasty's book medicine,divination,and similar arts passes ", Compendium of Material Medica.This reliable, the easy to use and carry dosage form that has curative effect is paid attention to and widespread usage by the working people at all times.Its permeability is strong, directly goes into disease institute, and it is lasting to act on, and curative effect is reliable, is not that cloth cream is comparable with other exterior-applied formulation, the panacea of the orthopedics department of still can yet be regarded as so far.
The fill a prescription marrow of inheriting tradition patch therapy of the present invention, several clinical for many years experiences adopt blood circulation promoting and blood stasis dispelling, and expelling wind and cold is treated the famous and precious medicine that numbness relieves the pain and is formed.The Semen Strychni temperature is bitter in the side, dispersing swelling and dissipating binds, and inducing menstruation to relieve menalgia is used for treating swelling and pain by traumatic injury, rheumatoid arthritis stubborn.Radix Clematidis has the effect of expelling wind and removing dampness inducing menstruation to relieve menalgia, is monarch drug.Olibanum, Myrrha, Sanguis Draxonis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Notoginseng, Rhizoma Wenyujin Concisum, Flos Carthami promoting blood circulation to remove blood stasis, circulation of qi promoting loose and stagnate reducing swelling and alleviating pain; Radix Aconiti, Radix Aconiti Kusnezoffii, Herba Ephedrae, Ramulus Cinnamomi, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Herba speranskiae tuberculatae, Herba Lycopodii expelling wind and dampness, promoting the flow of QI in the collateral by warming the meridian is ministerial drug altogether.Rhizoma Drynariae, Radix Dipsaci invigorating the liver and kidney, bone and muscle strengthening, continuous muscle pain relieving; Eupolyphaga Seu Steleophaga, Squama Manis, Scorpio, Pheretima expel wind to dredge collateral, the detumescence dampness removing, removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones is adjuvant drug altogether.Herba Asari, the pain relieving of Borneolum Syntheticum transdermal are messenger drug altogether.
Generally speaking; The present invention adopts unique prescription; Each compatibility of drugs is precise and appropriate in the prescription, and effect is collaborative, is suitable for patient's body acupuncture point or affected part; The effect of borrowing the dredge the meridian passage of the path of meridians with the performance medicine, row to stagnate blood stasis dispelling, deep, the expelling wind and cold of having one's ideas straightened out, promoting blood circulation and stopping pain can be used for treatment of conditions such as prolapse of lumbar intervertebral disc, hyperosteogeny, arthritis, aseptic necrosis of femoral head, traumatic injury.Be affixed on the affected part during use and get final product, pain relieving is rapid, and healing time is short, rapid-action, have no side effect, reasonable price.
Method for preparing of the present invention is simple, and easy operating, gained plaster meet each item regulation (appendix IP of Chinese Pharmacopoeia version in 2000) relevant under the plaster item, can directly be used for the affected part, and be rapid-action.
The specific embodiment
Further set forth through the present invention of specific embodiment degree below, should be understood that, following explanation only is in order to explain the present invention, its particular content not to be limited.
Ointment of the present invention is an effective ingredient with Semen Strychni, Radix Clematidis, Olibanum (system), Myrrha (processed), Sanguis Draxonis, Radix Angelicae Sinensis, Radix Notoginseng, Rhizoma Chuanxiong, Rhizoma Wenyujin Concisum, Flos Carthami, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Herba Ephedrae, Ramulus Cinnamomi, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Herba speranskiae tuberculatae, Herba Lycopodii, Rhizoma Drynariae, Radix Dipsaci, Eupolyphaga Seu Steleophaga, Scorpio, Pheretima, Squama Manis (big gun), Herba Asari, this 20 Six-element medicine of Borneolum Syntheticum, and various medical materials all can have been bought in market.The present invention adopts unified method for preparing to prepare plaster, can be when practical application according to the consumption of different each medical materials of needs conversion, and its concrete method for preparing is following:
1, get Herba Ephedrae, Herba Asari and Ramulus Cinnamomi, the decocte with water secondary, 2 hours for the first time, the 2nd time 1 hour, the consumption of water be drug dose the 3-5 quality doubly, preferred 3 times, decoct the back and merge twice filtrating, filtrating is concentrated into the thick paste of 1.4-1.45 (60 ℃);
2, then, Olibanum, Myrrha, Sanguis Draxonis and Borneolum Syntheticum are crushed to the 80-100 order respectively separately, to be easy to absorption; Scorpio, Radix Notoginseng, Squama Manis, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Pheretima and Eupolyphaga Seu Steleophaga are mixed; Be ground into 80-100 purpose fine powder,, process soft material medicine and the above-mentioned thick paste mix homogeneously after pulverizing; Soft material is dry at low temperatures, is ground into 80-100 purpose fine powder again;
3,12 flavor medicines such as remaining Rhizoma Wenyujin Concisum are given as one thinks fit cataclasm, in pot, add this 12 flavor medicine quality 4-4.5 Oleum Sesami doubly, then will cataclasm medicine put into that oil is fried to be filtered to withered black, remove slag and stay oil, oil continues to refine to dripping into pearl;
4, will refine in the good oil and add Plumbum preparatium, the addition of Plumbum preparatium is the 40-51wt% of vegetable oil, stirs the back and receives cream, and cream is soaked in releasing fire-toxin in the cold water, soak time 4-10 days, wherein soaked summer 4-5 days, and soaked winter 7-10 days;
5, after the immersion, cream is taken out,, add the fine powder that finally makes in the step 2, stir, share on cloth, promptly get plaster with the slow fire fusing.
Embodiment 1
Adopt method for preparing externally applied ointment of the present invention, the prescription of said plaster is: Semen Strychni 60g, Radix Clematidis 90g, Olibanum (system) 45g, Myrrha (processed) 45g, Sanguis Draxonis 30g; Radix Angelicae Sinensis 45g, Radix Notoginseng 30g, Rhizoma Chuanxiong 50g, Rhizoma Wenyujin Concisum 50g, Flos Carthami 45g, Radix Aconiti Preparata 50g; Radix Aconiti Kusnezoffii Preparata 50g, Herba Ephedrae 60g, Ramulus Cinnamomi 90g, Rhizoma Et Radix Notopterygii 40g, Radix Angelicae Pubescentis 40g; Herba speranskiae tuberculatae 60g, Herba Lycopodii 50g, Rhizoma Drynariae 40g, Radix Dipsaci 50g, Eupolyphaga Seu Steleophaga 50g; Scorpio 30g, Pheretima 45g, Squama Manis (big gun) 45g, Herba Asari 45g, Borneolum Syntheticum 20g.
Embodiment 2
Adopt method for preparing externally applied ointment of the present invention, the prescription of said plaster is: Semen Strychni 58g, Radix Clematidis 88g, Olibanum (system) 46g, Myrrha (processed) 46g, Sanguis Draxonis 32g; Radix Angelicae Sinensis 48g, Radix Notoginseng 28g, Rhizoma Chuanxiong 48g, Rhizoma Wenyujin Concisum 48g, Flos Carthami 47g, Radix Aconiti Preparata 52g; Radix Aconiti Kusnezoffii Preparata 52g, Herba Ephedrae 58g, Ramulus Cinnamomi 92g, Rhizoma Et Radix Notopterygii 42g, Radix Angelicae Pubescentis 38g; Herba speranskiae tuberculatae 58g, Herba Lycopodii 53g, Rhizoma Drynariae 42g, Radix Dipsaci 48g, Eupolyphaga Seu Steleophaga 48g; Scorpio 32g, Pheretima 43g, Squama Manis (big gun) 48g, Herba Asari 48g, Borneolum Syntheticum 22g.
Embodiment 3
Adopt method for preparing externally applied ointment of the present invention, the prescription of said plaster is: Semen Strychni 55g, Radix Clematidis 95g, Olibanum (system) 46g, Myrrha (processed) 43g, Sanguis Draxonis 25g; Radix Angelicae Sinensis 48g, Radix Notoginseng 25g, Rhizoma Chuanxiong 55g, Rhizoma Wenyujin Concisum 55g, Flos Carthami 40g, Radix Aconiti Preparata 50g; Radix Aconiti Kusnezoffii Preparata 52g, Herba Ephedrae 62g, Ramulus Cinnamomi 92g, Rhizoma Et Radix Notopterygii 38g, Radix Angelicae Pubescentis 42g; Herba speranskiae tuberculatae 55g, Herba Lycopodii 55g, Rhizoma Drynariae 38g, Radix Dipsaci 52g, Eupolyphaga Seu Steleophaga 45g; Scorpio 32g, Pheretima 40g, Squama Manis (big gun) 48g, Herba Asari 43g, Borneolum Syntheticum 18g.
Embodiment 4
Semen Strychni 65g, Radix Clematidis 95g, Olibanum (system) 50g, Myrrha (processed) 50g, Sanguis Draxonis 30g, Radix Angelicae Sinensis 45g, Radix Notoginseng 30g; Rhizoma Chuanxiong 55g, Rhizoma Wenyujin Concisum 40g, Flos Carthami 45g, Radix Aconiti Preparata 45g, Radix Aconiti Kusnezoffii Preparata 45g, Herba Ephedrae 65g, Ramulus Cinnamomi 95g; Rhizoma Et Radix Notopterygii 40g, Radix Angelicae Pubescentis 40g, Herba speranskiae tuberculatae 55g, Herba Lycopodii 45g, Rhizoma Drynariae 45g, Radix Dipsaci 55g; Eupolyphaga Seu Steleophaga 45g, Scorpio 25g, Pheretima 50g, Squama Manis (big gun) 50g, Herba Asari 40g, Borneolum Syntheticum 15g.
Embodiment 5
Adopt method for preparing externally applied ointment of the present invention, the prescription of said plaster is: Semen Strychni 65g, Radix Clematidis 85g, Olibanum (system) 40g, Myrrha (processed) 50g, Sanguis Draxonis 28g; Radix Angelicae Sinensis 40g, Radix Notoginseng 28g, Rhizoma Chuanxiong 48g, Rhizoma Wenyujin Concisum 53g, Flos Carthami 50g, Radix Aconiti Preparata 45g; Radix Aconiti Kusnezoffii Preparata 48g, Herba Ephedrae 58g, Ramulus Cinnamomi 88g, Rhizoma Et Radix Notopterygii 45g, Radix Angelicae Pubescentis 35g; Herba speranskiae tuberculatae 58g, Herba Lycopodii 48g, Rhizoma Drynariae 45g, Radix Dipsaci 55g, Eupolyphaga Seu Steleophaga 48g; Scorpio 35g, Pheretima 48g, Squama Manis (big gun) 43g, Herba Asari 50g, Borneolum Syntheticum 15g.
Embodiment 6
Adopt method for preparing externally applied ointment of the present invention, the prescription of said plaster is: Semen Strychni 62g, Radix Clematidis 92g, Olibanum (system) 43g, Myrrha (processed) 43g, Sanguis Draxonis 28g; Radix Angelicae Sinensis 43g, Radix Notoginseng 32g, Rhizoma Chuanxiong 53g, Rhizoma Wenyujin Concisum 53g, Flos Carthami 42g, Radix Aconiti Preparata 48g; Radix Aconiti Kusnezoffii Preparata 48g, Herba Ephedrae 62g, Ramulus Cinnamomi 88g, Rhizoma Et Radix Notopterygii 38g, Radix Angelicae Pubescentis 42g; Herba speranskiae tuberculatae 63g, Herba Lycopodii 48g, Rhizoma Drynariae 38g, Radix Dipsaci 52g, Eupolyphaga Seu Steleophaga 52g; Scorpio 28g, Pheretima 48g, Squama Manis (big gun) 43g, Herba Asari 43g, Borneolum Syntheticum 18g.
Embodiment 7
Adopt method for preparing externally applied ointment of the present invention, the prescription of said plaster is: Semen Strychni 59g, Radix Clematidis 91g, Olibanum (system) 44g, Myrrha (processed) 45g, Sanguis Draxonis 29g; Radix Angelicae Sinensis 44g, Radix Notoginseng 31g, Rhizoma Chuanxiong 52g, Rhizoma Wenyujin Concisum 52g, Flos Carthami 43g, Radix Aconiti Preparata 49g; Radix Aconiti Kusnezoffii Preparata 49g, Herba Ephedrae 61g, Ramulus Cinnamomi 89g, Rhizoma Et Radix Notopterygii 39g, Radix Angelicae Pubescentis 41g; Herba speranskiae tuberculatae 62g, Herba Lycopodii 49g, Rhizoma Drynariae 39g, Radix Dipsaci 51g, Eupolyphaga Seu Steleophaga 51g; Scorpio 29g, Pheretima 47g, Squama Manis (big gun) 47g, Herba Asari 44g, Borneolum Syntheticum 19g.
Embodiment 8
Adopt method for preparing externally applied ointment of the present invention, the prescription of said plaster is: Semen Strychni 61g, Radix Clematidis 89g, Olibanum (system) 45g, Myrrha (processed) 44g, Sanguis Draxonis 31g; Radix Angelicae Sinensis 47g, Radix Notoginseng 29g, Rhizoma Chuanxiong 49g, Rhizoma Wenyujin Concisum 49g, Flos Carthami 46g, Radix Aconiti Preparata 51g; Radix Aconiti Kusnezoffii Preparata 51g, Herba Ephedrae 59g, Ramulus Cinnamomi 91g, Rhizoma Et Radix Notopterygii 41g, Radix Angelicae Pubescentis 39g; Herba speranskiae tuberculatae 59g, Herba Lycopodii 52g, Rhizoma Drynariae 41g, Radix Dipsaci 49g, Eupolyphaga Seu Steleophaga 49g; Scorpio 33g, Pheretima 44g, Squama Manis (big gun) 44g, Herba Asari 47g, Borneolum Syntheticum 21g.
Embodiment 9
Adopt method for preparing externally applied ointment of the present invention, the prescription of said plaster is: Semen Strychni 58g, Radix Clematidis 92g, Olibanum (system) 43g, Myrrha (processed) 40g, Sanguis Draxonis 35g; Radix Angelicae Sinensis 43g, Radix Notoginseng 32g, Rhizoma Chuanxiong 45g, Rhizoma Wenyujin Concisum 45g, Flos Carthami 47g, Radix Aconiti Preparata 52g; Radix Aconiti Kusnezoffii Preparata 55g, Herba Ephedrae 55g, Ramulus Cinnamomi 95g, Rhizoma Et Radix Notopterygii 42g, Radix Angelicae Pubescentis 38g; Herba speranskiae tuberculatae 65g, Herba Lycopodii 48g, Rhizoma Drynariae 35g, Radix Dipsaci 48g, Eupolyphaga Seu Steleophaga 55g; Scorpio 28g, Pheretima 43g, Squama Manis (big gun) 50g, Herba Asari 40g, Borneolum Syntheticum 22g.
Embodiment 10
Adopt method for preparing externally applied ointment of the present invention, the prescription of said plaster is: Semen Strychni 62g, Radix Clematidis 88g, Olibanum (system) 50g, Myrrha (processed) 46g, Sanguis Draxonis 32g; Radix Angelicae Sinensis 50g, Radix Notoginseng 35g, Rhizoma Chuanxiong 53g, Rhizoma Wenyujin Concisum 48g, Flos Carthami 42g, Radix Aconiti Preparata 48g; Radix Aconiti Kusnezoffii Preparata 45g, Herba Ephedrae 65g, Ramulus Cinnamomi 85g, Rhizoma Et Radix Notopterygii 35g, Radix Angelicae Pubescentis 45g; Herba speranskiae tuberculatae 63g, Herba Lycopodii 45g, Rhizoma Drynariae 42g, Radix Dipsaci 45g, Eupolyphaga Seu Steleophaga 52g; Scorpio 25g, Pheretima 50g, Squama Manis (big gun) 40g, Herba Asari 48g, Borneolum Syntheticum 20g.
In order to prove the therapeutic effect of ointment of the present invention, carry out following experiment
One, toxicity test
Plaster of the present invention is a kind of special effect Chinese preparation of treating hyperosteogeny, arthritis, aseptic necrosis of femoral head, traumatic injury, is example with embodiment 1 below, carries out the skin irritation test.
1, experiment material
The plaster that 1.1 medicine: embodiment 1 is made, trade name compound recipe Radix Clematidis cream.
1.2 animal: rabbit, animal housing of Heze City medicine inspecting institute provides.
2, method and result
Choose 9 of the white rabbit of adult healthy, divide three groups at random, three every group, with 24h before the administration with rabbit spinal column both sides QUMAO, the about 10cm*12cm of QUMAO area, experiment adopts consubstantiality left and right sides self to compare.Left side QUMAO district's drug of topical application 13 grams, 9.75 grams, 6.5 grams, blank is done on the right side, every rabbit sub-cage rearing.
The result: respectively at 24,48, remove behind the 72h and tried thing, naked eyes are seen and are wiped, and record receives position all not show speckle and edema, performance nonirritant.Blank side does not all have erythema and edema phenomenon in each time.
3, brief summary and discussion
The plaster of embodiment 1 is to laboratory animal skin nonirritant, and prepared plaster is to animal skin also nonirritant in other scope of the invention.
Two, zoopery
1, case source
1240 patients of this city various big hospital random choose as the drug use volunteer, wherein patients with lumbar disc herniation 320 examples, hyperosteogeny patient's 256 examples, arthritic's 224 examples, 240 of aseptic necrosis of femoral head patients, traumatic injury patient's 200 examples.Wherein, 728 of male patients, 512 of female patients, patient age be between 35-65 year, patient's mild or moderate, moderate, severe state of an illness number basically identical, state of an illness judgment basis country relevant regulations.
2, experimental technique
Patients with lumbar disc herniation is equally divided into four groups according to sex, age, the state of an illness, first group of plaster that uses embodiment 1, second group of plaster that uses embodiment 2, the 3rd group of plaster that uses embodiment 3, the 4th group of plaster that uses embodiment 4.Hyperosteogeny patient, arthritic, aseptic necrosis of femoral head patient, traumatic injury patient also divide into groups and dispenser according to the method described above.
3, application method
Clean illing skin with Rhizoma Zingiberis Recens, it is softening that plaster is heated, and is affixed on corresponding affected part, changed, and used January continuously in per 7 days one.
4, criterion
Produce effects: patient's pain significantly alleviates behind the dispenser 2-5h, and the position swelling of pasting is obviously disappeared after 3-5 days, and the state of an illness is obviously alleviated, transference cure or basic disappearances such as pain, numbness, swelling after one month;
Effectively: patient's pain relief behind the dispenser 10-15h, the position swelling of pasting is disappeared to some extent after 3-5 days, and the state of an illness is alleviated to some extent, and symptoms such as pain, numbness, swelling obviously alleviate after one month;
Invalid: behind the dispenser 10-15h, patient's pain does not have and alleviates or pain increases the weight of, and the position swelling of pasting does not have and disappears or increase the weight of to some extent after 3-5 days, and the state of an illness does not have alleviation.
5, experimental result
6, experiment conclusion
Can find out from above-mentioned experimental result; Plaster of the present invention all has good therapeutic effect to prolapse of lumbar intervertebral disc, hyperosteogeny, arthritis, aseptic necrosis of femoral head, traumatic injury; And this ointment is rapid-action; Can alleviate patient's slight illness in the short time, play the effect of activating blood circulation to dissipate blood stasis, dredge the meridian passage, reducing swelling and alleviating pain.
Plaster in all protection domains of the present invention all can play good therapeutical effect, and above-mentioned only is to have enumerated a part of experimental data, and the therapeutic effect of other embodiment is with above-mentioned similar.
Claims (10)
1. plaster of treating prolapse of lumbar intervertebral disc, hyperosteogeny, arthritis, aseptic necrosis of femoral head and traumatic injury is characterized in that being processed by following crude drug:
Semen Strychni 55-65g, Radix Clematidis 85-95g, Olibanum (processed) 40-50g, Myrrha (processed) 40-50g, Sanguis Draxonis 25-35g, Radix Angelicae Sinensis 40-50g; Radix Notoginseng 25-35g, Rhizoma Chuanxiong 45-55g, Rhizoma Wenyujin Concisum 45-55g, Flos Carthami 40-50g, Radix Aconiti Preparata 45-55g; Radix Aconiti Kusnezoffii Preparata 45-55g, Herba Ephedrae 55-65g, Ramulus Cinnamomi 85-95g, Rhizoma Et Radix Notopterygii 35-45g, Radix Angelicae Pubescentis 35-45g; Herba speranskiae tuberculatae 55-65g, Herba Lycopodii 45-55g, Rhizoma Drynariae 35-45g, Radix Dipsaci 45-55g, Eupolyphaga Seu Steleophaga 45-55g; Scorpio 25-35g, Pheretima 40-50g, Squama Manis preparata 40-50g, Herba Asari 40-50g, Borneolum Syntheticum 15-25g.
2. plaster according to claim 1 is characterized in that being processed by following crude drug:
Semen Strychni 65g, Radix Clematidis 95g, Olibanum (processed) 50g, Myrrha (processed) 50g, Sanguis Draxonis 30g, Radix Angelicae Sinensis 45g, Radix Notoginseng 30g; Rhizoma Chuanxiong 55g, Rhizoma Wenyujin Concisum 40g, Flos Carthami 45g, Radix Aconiti Preparata 45g, Radix Aconiti Kusnezoffii Preparata 45g, Herba Ephedrae 65g, Ramulus Cinnamomi 95g; Rhizoma Et Radix Notopterygii 40g, Radix Angelicae Pubescentis 40g, Herba speranskiae tuberculatae 55g, Herba Lycopodii 45g, Rhizoma Drynariae 45g, Radix Dipsaci 55g; Eupolyphaga Seu Steleophaga 45g, Scorpio 25g, Pheretima 50g, Squama Manis preparata 50g, Herba Asari 40g, Borneolum Syntheticum 15g.
3. plaster according to claim 1 is characterized in that being processed by following crude drug:
Semen Strychni 58-62g, Radix Clematidis 88-92g, Olibanum (processed) 43-46g, Myrrha (processed) 43-46g, Sanguis Draxonis 28-32g, Radix Angelicae Sinensis 43-48g; Radix Notoginseng 28-33g, Rhizoma Chuanxiong 48-53g, Rhizoma Wenyujin Concisum 48-53g, Flos Carthami 42-47g, Radix Aconiti Preparata 48-52g; Radix Aconiti Kusnezoffii Preparata 48-52g, Herba Ephedrae 58-62g, Ramulus Cinnamomi 88-92g, Rhizoma Et Radix Notopterygii 38-42g, Radix Angelicae Pubescentis 38-42g; Herba speranskiae tuberculatae 58-63g, Herba Lycopodii 48-53g, Rhizoma Drynariae 38-42g, Radix Dipsaci 48-52g, Eupolyphaga Seu Steleophaga 48-52g; Scorpio 28-32g, Pheretima 43-48g, Squama Manis preparata 43-48g, Herba Asari 43-48g, Borneolum Syntheticum 18-22g.
4. plaster according to claim 3 is characterized in that being processed by following crude drug:
Semen Strychni 60g, Radix Clematidis 90g, Olibanum (processed) 45g, Myrrha (processed) 45g, Sanguis Draxonis 30g, Radix Angelicae Sinensis 45g, Radix Notoginseng 30g; Rhizoma Chuanxiong 50g, Rhizoma Wenyujin Concisum 50g, Flos Carthami 45g, Radix Aconiti Preparata 50g, Radix Aconiti Kusnezoffii Preparata 50g, Herba Ephedrae 60g, Ramulus Cinnamomi 90g; Rhizoma Et Radix Notopterygii 40g, Radix Angelicae Pubescentis 40g, Herba speranskiae tuberculatae 60g, Herba Lycopodii 50g, Rhizoma Drynariae 40g, Radix Dipsaci 50g; Eupolyphaga Seu Steleophaga 50g, Scorpio 30g, Pheretima 45g, Squama Manis preparata 45g, Herba Asari 45g, Borneolum Syntheticum 20g.
5. a method for preparing of treating the plaster of prolapse of lumbar intervertebral disc, hyperosteogeny, arthritis, aseptic necrosis of femoral head and traumatic injury is characterized in that, crude drug is: Semen Strychni 55-65g, Radix Clematidis 85-95g, Olibanum (processed) 40-50g; Myrrha (processed) 40-50g, Sanguis Draxonis 25-35g, Radix Angelicae Sinensis 40-50g, Radix Notoginseng 25-35g, Rhizoma Chuanxiong 45-55g; Rhizoma Wenyujin Concisum 45-55g, Flos Carthami 40-50g, Radix Aconiti Preparata 45-55g, Radix Aconiti Kusnezoffii Preparata 45-55g, Herba Ephedrae 55-65g; Ramulus Cinnamomi 85-95g, Rhizoma Et Radix Notopterygii 35-45g, Radix Angelicae Pubescentis 35-45g, Herba speranskiae tuberculatae 55-65g, Herba Lycopodii 45-55g; Rhizoma Drynariae 35-45g, Radix Dipsaci 45-55g, Eupolyphaga Seu Steleophaga 45-55g, Scorpio 25-35g, Pheretima 40-50g; Squama Manis preparata 40-50g, Herba Asari 40-50g, Borneolum Syntheticum 15-25g comprises the following steps:
(1) Herba Ephedrae, Herba Asari and Ramulus Cinnamomi water are decocted twice, the consumption of water be drug dose the 3-5 quality doubly, merge filtrating twice, filtrating is concentrated into thick paste;
(2) Olibanum, Myrrha, Sanguis Draxonis and Borneolum Syntheticum are pulverized separately respectively; Scorpio, Radix Notoginseng, Squama Manis, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Pheretima and Eupolyphaga Seu Steleophaga mix to be pulverized, and the medical material after the pulverizing mixes with above-mentioned thick paste, processes soft material; With the soft material cold drying, be ground into fine powder again;
(3) give as one thinks fit remaining 12 flavor medicines cataclasm, in pot, add Oleum Sesami, then will cataclasm medicine put into that Oleum Sesami is fried to be filtered to withered black, remove slag and stay oil, oil continues to refine to dripping into pearl;
(4) in the good oil of refining, add Plumbum preparatium, stir the back and receive cream, cream is soaked in releasing fire-toxin in the cold water;
(5) after the immersion, cream is taken out,, add the fine powder that finally makes in the step (2), stir, share on cloth, promptly get plaster with the slow fire fusing.
6. method for preparing according to claim 5 is characterized in that: in the step (1), decocted 2 hours for the first time, decocted 1 hour for the second time.
7. method for preparing according to claim 5 is characterized in that: in the step (1), filtrating is condensed into the thick paste that relative density is 1.4-1.45 at 60 ℃.
8. method for preparing according to claim 5 is characterized in that: in the step (2), each medicine is crushed to the 80-100 order.
9. method for preparing according to claim 5 is characterized in that: in the step (3), the consumption of Oleum Sesami be 12 flavor medical material total amounts the 4-4.5 quality doubly; In the step (4), the consumption of Plumbum preparatium is the 40-51wt% of Oleum Sesami.
10. method for preparing according to claim 5 is characterized in that: in the step (4), be 4-10 days with the water-immersed time of cream.
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| CN201110106764A CN102178894B (en) | 2011-04-27 | 2011-04-27 | Plaster and preparation method of plaster |
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| CN104958484A (en) * | 2015-05-29 | 2015-10-07 | 马海春 | traditional Chinese medicine unguent for promoting blood circulation to remove meridian obstruction and preparing method of traditional Chinese medicine unguent |
| CN109464635A (en) * | 2019-01-09 | 2019-03-15 | 高永民 | A kind of Chinese medicinal black plaster |
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