CN102166327A - Preparation method of Chinese medicine for treating liver-stagnation spleen-deficiency hyperthyroidism - Google Patents
Preparation method of Chinese medicine for treating liver-stagnation spleen-deficiency hyperthyroidism Download PDFInfo
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Abstract
The invention relates to a preparation method of a Chinese medicine for treating liver-stagnation spleen-deficiency hyperthyroidism, and belongs to the technical field of preparation methods of Chinese medicines. At present, the liver-stagnation spleen-deficiency hyperthyroidism is treated by western medicines such as thyroid hormones, but medicamentous hyperthyroidism symptoms such as palpitation, tachycardia, finger tremor, hidrosis, emaciation and the like can be caused by overdose. In the technical scheme, the method comprises the following steps of: soaking the following 22 Chinese medicines: bupleurum, nutgrass galingale rhizome, costustoot, combined spicebush root, tangerine peel, green tangerine peel, immature bitter orange, officinal magnolia bark, villous amomum fruit, grosvener siraitia, caragana root, rush-brown crotalaria, kelp, seaweed, ark shell, clamshell, costazia bone, tabasheer, bamboo shavings, trichosanthes kirilowii maxim, unibract fritillary bulb and common hongfennel root in water, decocting over slow fire, filtering, and removing dregs to obtain liquid medicine, namely the Chinese medicine for treating the liver-stagnation spleen-deficiency hyperthyroidism. The invention has the advantages that the Chinese medicine has small toxic and side effects, the curative effect is lasting and the liver-stagnation spleen-deficiency hyperthyroidism is difficult to relapse after oral administration, and adverse reactions caused by the western medicines are prevented.
Description
Technical field
The present invention relates to the Chinese medicinal preparation method technical field, is a kind of Chinese medicinal preparation method for the treatment of the liver-depression and spleen-insufficiency type hyperthyroidism more specifically.
Background technology
At present treatment liver-depression and spleen-insufficiency type hyperthyroidism generally adopts: 1. thyroxin treatment: dosage is excessive to take place that cardiopalmus, tachycardia, finger are trembled, hyperhidrosis, medicine hyperthyroidism symptom such as become thin.Heart rate disorder, heart failure etc. will appear in the old people.2. propylthiouracil: the maculopapule prurigo can occur, accompany General Symptoms simultaneously, as heating.Rarer is urticaria sample erythra, vasculitis, arthralgia, the reaction of lupus erythematosus pattern, stasis jaundice, Chinese herbal medicine virus hepatitis, lymphadenitis and multiple product serous cavity inflammation.The most serious is agranulocytosis.
Summary of the invention
For overcoming above-mentioned shortcoming, the objective of the invention is to invent a kind of Chinese medicinal preparation method for the treatment of the liver-depression and spleen-insufficiency type hyperthyroidism.1, definition: the liver-depression and spleen-insufficiency type hyperthyroidism is because the one group common endocrinopathy of thyroxin due to too much can be caused by multiple reason.Account for the overwhelming majority with diffuse goiter companion hyperthyroidism and nodular thyroid goiter accompanied with thyroid hyperthyroidism clinically, the person all seldom sees due to the other reasons.2, the cause of disease and etiopathogenesis: diffuse goiter accompanies the hyperthyroid cause of disease not illustrate fully as yet.Think that in the past it may be the reason that causes primary disease that the regulatory function imbalance of hypothalamic-pituitary-thyroid axis causes the TSH of pituitary supersecretion.But discover that in recent years the TSH concentration in the liver-depression and spleen-insufficiency type hyperthyroidism patient blood is not more or less than normal even can survey; The cell hypertrophy not of secretion TSH has degradation phenomena on the contrary in this patient's the hypophysis; Antepituitary hypofunction and HPX patient also have this patient of generation; Using throtropin releasing hormone fails to stimulate this group patient's blood TSH concentration to raise.The pathology of liver-depression and spleen-insufficiency type hyperthyroidism is: thyroid anthorisma in various degree, and vasodilation in the body of gland, hypertrophy, blood is annotated with plentifully.The acinus epithelial hyperplasia, become column by normal cube, bubble wall hypertrophy is folded into papillae and stretches in the alveolar lumen, colloid reduces in the acinus, big amount lymphocyte and plasmocyte infiltrating are arranged in the stroma, the whole body lymphoid tissue comprises lymphadenosis in spleen and the thymus, and blood lymphocyte also increases, and has reflected the pathologic basis relevant with autoimmune.
Clinical manifestation: poke, companion's extremity sleepiness, sighing frequently is breathed hard, and the decreased food intake body is thin, pale complexion, thin fur, weak pulse is unable.Blood test: (1) thyroxine and free thyroxine increase.(2) thyroid suction iodine test is increased.(3) trilute and free triiodothyronine increase.(4) the former amino acid of anti-triiodo thyroid increases.
Its technical scheme is: get Radix Bupleuri 9 weight portions, Rhizoma Cyperi 12 weight portions, the Radix Aucklandiae 9 weight portions, the Radix Linderae 9 weight portions, Pericarpium Citri tangerinae 9 weight portions, Pericarpium Citri Reticulatae Viride 3 weight portions, Fructus Aurantii Immaturus 12 weight portions, Cortex Magnoliae Officinalis 10 weight portions, Fructus Amomi 3 weight portions, Fructus Momordicae 12 weight portions, Radix Caraganae Sinicae 12 is reaffirmed part, Herba Crotalariae Ferrugineae 9 weight portions, Thallus Laminariae (Thallus Eckloniae) 12 weight portions, Sargassum 12 weight portions, Concha Arcae 6 weight portions, Concha Meretricis seu Cyclinae 6 weight portions, Pumex 9 weight portions, Concretio Silicea Bambusae 6 weight portions, Caulis Bambusae In Taenia 12 weight portions, Fructus Trichosanthis 9 weight portions, Bulbus Fritillariae Cirrhosae 6 weight portions and Radix Peucedani 9 weight portions, at above 22 flavor Chinese medicines, place 1200 ml waters to soak 35 minutes, slow fire is fried 32 minutes then, filter and remove residue gets 520 milliliters of medicinal liquids, is the Chinese medicine of treatment liver-depression and spleen-insufficiency type hyperthyroidism.
The advantage of this invention is: it is little to make herbal toxic effect simple, that make, and behind oral this Chinese medicine, curative effect is lasting, is difficult for bounce-back, and medicine has avoided using the untoward reaction that Western medicine produces in the digestive tract good absorbing.And can make the liver-depression and spleen-insufficiency type hyperthyroidism obtain curing or taking a turn for the better.Radix Bupleuri, Rhizoma Cyperi, the Radix Aucklandiae, the Radix Linderae, Pericarpium Citri tangerinae, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Fructus Amomi, this 9 flavor medical instrument has dispersing the stagnated live-QI to relieve the stagnation of QI, the effect of regulating QI to relieve pain.Wherein: Radix Bupleuri again can dispelling wind and heat pathogens, the clearing gallbladder preventing the attack (or recurrence) of malaria; Rhizoma Cyperi again can regulating menstruation; The Radix Aucklandiae again can circulation of qi promoting, invigorating the stomach and promoting digestion; The Radix Linderae again can warming kidney for dispelling cold; Pericarpium Citri tangerinae again can drying dampness to eliminate phlegm, spleen invigorating; Pericarpium Citri Reticulatae Viride again can dispelling the stagnated QI, long-pendingization of loosing is stagnant; Fructus Aurantii Immaturus again can the dispelling the stagnated QI removing food stagnancy, remove painful abdominal mass; Cortex Magnoliae Officinalis again can removing dampness, warming middle-JIAO, lowering the adverse QI to relieve asthma; Fructus Amomi again can the stomach warming preventing or arresting vomiting, wet spleen antidiarrheal; Fructus Amomi Rotundus again can removing dampness disappear painful abdominal mass, stomach warming preventing or arresting vomiting.This 9 flavor medicine plays main therapeutical effect, so be monarch drug in the process of treatment liver-depression and spleen-insufficiency type hyperthyroidism.Fructus Momordicae, Radix Caraganae Sinicae, Herba Crotalariae Ferrugineae, Thallus Laminariae (Thallus Eckloniae), Sargassum, Concha Arcae, Concha Meretricis seu Cyclinae, Pumex, Concretio Silicea Bambusae, Caulis Bambusae In Taenia, Fructus Trichosanthis, Bulbus Fritillariae Cirrhosae.This 12 flavor medical instrument has clearing away lung-heat to relieve cough, cooling blood for hemostasis, and the intestine moistening of promoting the production of body fluid, the spleen invigorating eliminating dampness by diuresis, blood circulation and channel invigorating, vanishing sputum and dispelling knot, eliminating phlegm and softening indurated mass, blood stasis-eliminating and stagnation-dissipating, removing heat from the lung and dissipating phlegm, the clearing away phlegm dissipating depression of QI, relieving epigastric distention and reducing the stagnation, the effect of carbuncle is treated in detumescence.Wherein: " south of the Five Ridges gather medicinal herbs record " record, Fructus Momordicae " reason phlegm-fire cough and lean pork are fried in shallow oil soup and obeyed it "; " Guangxi Chinese medicinal herbal " record, Fructus Momordicae " cough-relieving heat clearing away, removing heat from blood intestine moistening.Control cough, the dry gastric heat constipation of blood etc." the salty-cold matter of Thallus Laminariae (Thallus Eckloniae) is sliding, act on identically with Sargassum and stronger, the two is the principal agent of the strongly fragrant spleen-deficient hyperthyroidism for the treatment of the liver also with heightening the effect of a treatment.Modern medicine study confirms: Thallus Laminariae (Thallus Eckloniae) contains potassium iodide, alginic acid, mannitol and ferrum, calcium etc.According to pharmacological research, the main pharmacological of Sargassum and Thallus Laminariae (Thallus Eckloniae) is because it contains iodine compound.After iodide are absorbed into tissue and blood, except that the osmotic pressure effect of general electrolyte, the absorption of pathological product and inflammatory exudate can be promoted again, and the tissue collapse and the dissolving of morbid state can be made.Iodine also can temporarily suppress the metabolism rate of hyperthyroidism simultaneously, and makes its sx.So the heat clearing away of the cold energy of Concha Meretricis seu Cyclinae, but salty softening the hard mass are the wart eliminating stagnation that can disappear.In a word, Fructus Momordicae, Radix Caraganae Sinicae, Herba Crotalariae Ferrugineae, Thallus Laminariae (Thallus Eckloniae), Sargassum, Concha Arcae, Concha Meretricis seu Cyclinae, Pumex, Concretio Silicea Bambusae, Caulis Bambusae In Taenia, Fructus Trichosanthis, Bulbus Fritillariae Cirrhosae, this 12 flavor medicine can be assisted principal agent performance therapeutical effect in the process of treatment liver-depression and spleen-insufficiency type hyperthyroidism, so be ministerial drug.Radix Peucedani: bitter, hot, be slightly cold.Go into lung meridian.The expectorant of energy sending down the abnormal ascending QI, dispelling wind-heat are specially gone into lung meridian, and because of lung occupies the part of the body cavity above the diaphragm housing the heart and lungs, the up through focus of all medicines of energy rate is so be adjuvant.Radix Bupleuri, Rhizoma Cyperi, the Radix Aucklandiae, the Radix Linderae, Pericarpium Citri tangerinae, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Fructus Amomi, Fructus Momordicae, Radix Caraganae Sinicae, Herba Crotalariae Ferrugineae, Thallus Laminariae (Thallus Eckloniae), Sargassum, Concha Arcae, Concha Meretricis seu Cyclinae, Pumex, Concretio Silicea Bambusae, Caulis Bambusae In Taenia, Fructus Trichosanthis, Bulbus Fritillariae Cirrhosae, Radix Peucedani.More than 22 herbal medicines, compatibility is used, having the effect of dispersing the stagnated live-QI to relieve the stagnation of QI, regulating QI to relieve pain, invigorating the spleen and replenishing QI, clearing away lung-heat to relieve cough, cooling blood for hemostasis, the intestine moistening of promoting the production of body fluid, spleen invigorating eliminating dampness by diuresis, blood circulation and channel invigorating, dissipating phlegm and resolving masses, eliminating phlegm and softening indurated mass, blood stasis-eliminating and stagnation-dissipating, removing heat from the lung and dissipating phlegm, clearing away phlegm dissipating depression of QI, relieving epigastric distention and reducing the stagnation, detumescence treatment carbuncle, is the optimum formula of treatment liver-depression and spleen-insufficiency type hyperthyroidism.Radix Bupleuri: little hardship, little suffering are slightly cold.Go into liver, gallbladder meridian.Evacuation is brought down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, clearing gallbladder preventing the attack (or recurrence) of malaria, elevate a turnable ladder yang-energy.Rhizoma Cyperi: hot, little hardship, little sweet, flat.Go into liver, tri-jiao channel.Regulate the flow of vital energy resolving depression, menstruction regulating and pain relieving.The Radix Aucklandiae: hot, bitter, warm.Go into spleen, stomach, large intestine, tri-jiao channel.Promoting the circulation of QI to relieve pain, invigorating the stomach and promoting digestion.The Radix Linderae: hot, warm.Go into spleen, lung, kidney, urinary bladder channel.Promoting the circulation of QI to relieve pain, warming kidney for dispelling cold.Pericarpium Citri tangerinae: hot, bitter, warm.Go into spleen, lung meridian.Drying dampness to eliminate phlegm, regulating qi-flowing for strengthening spleen.Pericarpium Citri Reticulatae Viride: bitter, hot, warm.Go into liver, gallbladder meridian.Soothing the liver dispelling the stagnated QI, long-pendingization of loosing stagnates.Fructus Aurantii Immaturus: hardship is slightly cold.Go into spleen, stomach, large intestine channel.The dispelling the stagnated QI removing food stagnancy, circulation of qi promoting removes painful abdominal mass.Cortex Magnoliae Officinalis: bitter, hot, warm.Go into spleen, stomach, large intestine channel.Circulation of qi promoting removing dampness, warming middle-JIAO to relieve pain, lowering the adverse QI to relieve asthma.Fructus Amomi: hot, warm.Go into spleen, stomach, kidney channel.Circulation of qi promoting ends carbuncle, stomach warming preventing or arresting vomiting, warming spleen and stopping diarrha.Fructus Momordicae: sweet, cold.Go into lung, spleen channel.Clearing away lung-heat to relieve cough, cooling blood for hemostasis, the intestine moistening of promoting the production of body fluid.Radix Caraganae Sinicae: bitter, hot, flat.Go into lung, spleen, Liver Channel.Clearing away lung-heat to relieve cough, spleen invigorating eliminating dampness by diuresis, blood circulation and channel invigorating.Herba Crotalariae Ferrugineae: bitter, little acid, cold.Go into lung, kidney channel.The QI invigorating of astringing the lung, kidney tonifying detumescence, clearing away heat-damp and promoting diuresis, heat-clearing and toxic substances removing.Thallus Laminariae (Thallus Eckloniae): salty, cold.Go into liver, stomach, kidney channel.Vanishing sputum and dispelling knot.Sargassum: bitter, salty, cold.Go into liver, stomach, kidney channel.Vanishing sputum and dispelling knot.Concha Arcae: sweet, salty, flat.Go into lung, stomach, liver, spleen channel.Eliminating phlegm and softening indurated mass, blood stasis-eliminating and stagnation-dissipating, relieving gastric hyperacidity to alleviate stomachache.Concha Meretricis seu Cyclinae: salty, cold.Go into lung, kidney channel.Removing heat from the lung and dissipating phlegm, hard masses softening and resolving, inducing diuresis to remove edema.Pumex: salty, cold.Go into lung meridian.Removing heat from the lung and dissipating phlegm, hard masses softening and resolving, Sal Nitri is treating stranguria.Concretio Silicea Bambusae: sweet, cold.Go into the heart, stomach, Liver Channel.Clear heat and eliminate phlegm, cool heart arresting convulsion.Caulis Bambusae In Taenia: sweet, be slightly cold.Go into lung, stomach, gallbladder meridian.The clearing away phlegm dissipating depression of QI, clearing away heat to stop vomiting.Fructus Trichosanthis: sweet, cold.Go into lung, stomach, large intestine channel.Removing heat-phlegm, relieving epigastric distention and reducing the stagnation, carbuncle, loosening bowel to relieve constipation are treated in detumescence.Bulbus Fritillariae Cirrhosae: bitter, sweet, be slightly cold.Go into the heart, lung meridian.Moistening the lung and resolving phlegm, eliminating stagnation expels the heat-evil.Radix Peucedani: bitter, hot, be slightly cold.Go into lung meridian.The sending down the abnormal ascending QI expectorant, dispelling wind-heat.
The specific embodiment
Get Radix Bupleuri 9g, Rhizoma Cyperi 12g, Radix Aucklandiae 9g, Radix Linderae 9g, Pericarpium Citri tangerinae 9g, Pericarpium Citri Reticulatae Viride 3g, Fructus Aurantii Immaturus 12g, Cortex Magnoliae Officinalis 10g, Fructus Amomi 3g, Fructus Momordicae 12g, Radix Caraganae Sinicae 12g, Herba Crotalariae Ferrugineae 9g, Thallus Laminariae (Thallus Eckloniae) 12g, Sargassum 12g, Concha Arcae 6g, Concha Meretricis seu Cyclinae 6g, Pumex 9g, Concretio Silicea Bambusae 6g, Caulis Bambusae In Taenia 12g, Fructus Trichosanthis 9g, Bulbus Fritillariae Cirrhosae 6g and Radix Peucedani 9g, at above 22 flavor Chinese medicines, place 1200 ml waters to soak 35 minutes, slow fire is fried 32 minutes then, filter and remove residue gets 520 milliliters of medicinal liquids, is the Chinese medicine of treatment liver-depression and spleen-insufficiency type hyperthyroidism.When the treatment of the needs of patients of liver-depression and spleen-insufficiency type hyperthyroidism, medicinal liquid is warmed to 36 ℃, one time 260 milliliters, a twice-daily, three is a course of treatment, if symptom is still deposited, obeys for second course of treatment again, so that recovery from illness.
Among the patient of 317 routine liver-depression and spleen-insufficiency type hyperthyroidisms, 17～21 years old person's 1 example accounts for 0.32%; 22～39 years old person's 277 examples account for 87.38%; 40～51 years old persons, 39 examples account for 12.30%.
Among the patient of 317 routine liver-depression and spleen-insufficiency type hyperthyroidisms, treat 3～6 days cured person 2 examples, account for 0.63%; 7～8 days cured person 153 examples account for 48.26%; 9～11 days cured persons, 95 examples account for 29.97%; 12～16 days cured persons, 66 examples account for 20.82%; 17～22 days cured person 1 examples account for 0.32%.
Table one: information slip before and after the 317 routine liver-depression and spleen-insufficiency type hyperthyroidism patient
Claims (1)
1. Chinese medicinal preparation method for the treatment of the liver-depression and spleen-insufficiency type hyperthyroidism, it is characterized in that: get Radix Bupleuri 9 weight portions, Rhizoma Cyperi 12 weight portions, the Radix Aucklandiae 9 weight portions, the Radix Linderae 9 weight portions, Pericarpium Citri tangerinae 9 weight portions, Pericarpium Citri Reticulatae Viride 3 weight portions, Fructus Aurantii Immaturus 12 weight portions, Cortex Magnoliae Officinalis 10 weight portions, Fructus Amomi 3 weight portions, Fructus Momordicae 12 weight portions, Radix Caraganae Sinicae 12 is reaffirmed part, Herba Crotalariae Ferrugineae 9 weight portions, Thallus Laminariae (Thallus Eckloniae) 12 weight portions, Sargassum 12 weight portions, Concha Arcae 6 weight portions, Concha Meretricis seu Cyclinae 6 weight portions, Pumex 9 weight portions, Concretio Silicea Bambusae 6 weight portions, Caulis Bambusae In Taenia 12 weight portions, Fructus Trichosanthis 9 weight portions, Bulbus Fritillariae Cirrhosae 6 weight portions and Radix Peucedani 9 weight portions, at above 22 flavor Chinese medicines, place 1200 ml waters to soak 35 minutes, slow fire is fried 32 minutes then, filter and remove residue gets 520 milliliters of medicinal liquids, is the Chinese medicine of treatment liver-depression and spleen-insufficiency type hyperthyroidism.
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