CN102139005A - Medicine for treating cardiovascular and cerebrovascular diseases - Google Patents
Medicine for treating cardiovascular and cerebrovascular diseases Download PDFInfo
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- CN102139005A CN102139005A CN2011100844571A CN201110084457A CN102139005A CN 102139005 A CN102139005 A CN 102139005A CN 2011100844571 A CN2011100844571 A CN 2011100844571A CN 201110084457 A CN201110084457 A CN 201110084457A CN 102139005 A CN102139005 A CN 102139005A
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Abstract
The invention relates to a medicine for treating cardiovascular and cerebrovascular diseases, and belongs to the technical field of traditional Chinese medicines. The invention aims at providing the medicine for treating the cardiovascular and cerebrovascular diseases, which has small side effect and obvious therapeutic effect. The invention discloses the medicine for treating the cardiovascular and cerebrovascular diseases, which is characterized in that: the medicine is prepared from the following pharmaceutical raw materials in parts by weight: 800 parts of ginkgo leaves, 500 parts of radix paeoniae alba, 500 parts of liquorice, 500 parts of witloof, 200 parts of radix notoginseng, 100 parts of lychee seeds and 100 parts of lumbricus. The medicine has the following beneficial effects: a pharmaceutical composition in the invention has small side effect and obvious therapeutic effect; when the medicine is adopted, the experimental carotid artery thrombosis time of a rat can be obviously prolonged, and the platelet aggregation of the rat can be obviously inhibited; and the medicine has the obvious therapeutic effects of resisting thrombosis, and treating thrombotic diseases, ischemic cardiovascular and cerebrovascular diseases, blood circulation obstacles and the like.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of cardiovascular and cerebrovascular disease, belong to the Chinese medicine technical field.
Background technology
Cardiovascular and cerebrovascular disease is meant that sclerosis takes place for heart and arteries and the heart ischemia that causes or hemorrhage disease, comprises that coronary heart disease, angina pectoris, hypertension, arrhythmia, myocardial infarction, cerebral infarction wait indefinitely.Cardiovascular and cerebrovascular disease is known as the No.1 killer who threatens human health always, and hypertension, hyperlipidemia, coronary heart disease, diabetes become " pestilence in epoch ".Show that according to relevant investigation report the people that China dies from cardiovascular and cerebrovascular disease every year has more than 300 ten thousand, account for 50% of the annual total death toll of China, and the people 75% who survives disability in various degree, 4% is heavy residual.In recent years, the cardiovascular and cerebrovascular disease sickness rate is the trend that rises year by year, and particularly its morbidity and dead age are rejuvenation trend day by day, and how effectively control also just causes people's great attention.
At present, the treatment cardiovascular and cerebrovascular disease generally adopt Western medicine to treat, but curative effect is unsatisfactory, takes medicine for a long time and can bring certain dependency.
Summary of the invention
The object of the present invention is to provide a kind of medicine with toxic and side effects treatment cardiovascular and cerebrovascular disease little, evident in efficacy.
The invention discloses a kind of medicine for the treatment of cardiovascular and cerebrovascular disease, it is characterized in that making: 800 parts of Folium Ginkgos, 500 parts of the Radix Paeoniae Albas, 500 parts in Radix Glycyrrhizae, 500 parts of Herba Cichoriis, 200 parts of Radix Notoginseng, 100 parts of Semen Litchis, 100 parts of Pheretimas by the medicinal raw material of following weight portion.
Preparation method: Pheretima is cut into chunks, add in the boiled water of 8-10 times of weight with other crude drug, boiling 3-5 hour, filter out filtering residue, concentrated filtrate becomes dry extract, pulverize, can make clinically arbitrary or pharmaceutically acceptable dosage form, be applied to the patient of this treatment of needs in the mode of oral or parenteral.During oral administration, can be made into oral normal release dosage form, sustained-release and controlled release dosage form, granule etc.
The preparation of above-mentioned all pharmaceutical compositions can adopt the conventional method production in the existing pharmaceutical field, can add pharmaceutically acceptable carrier when needing.
Folium Ginkgo: the effect of protection capillary permeability, coronary artery dilator, recovery arteries elasticity, nourishing brain cell and other organ, and the peculiar effect that makes blood matter in tremulous pulse, peripheral vessel, the blood capillary and cholesterol keep normal level in addition.
Radix Paeoniae Alba: formal name used at school Paeonia sterniana Fletcher in Journ has coronary artery dilator, the effect of bringing high blood pressure down.
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm.
Herba Cichorii: have heat-clearing and toxic substances removing, inducing diuresis to remove edema, effect such as be good for the stomach.
Radix Notoginseng: dissipating blood stasis hemostasis, subduing swelling and relieving pain.
Semen Litchi: the dry mature seed for sapindaceous plant Fructus Litchi Litchi chinensis Sonn has promoting QI to circulate and dispersing the agglomeration of the pathogens, cold relieving analgesic effect.
Pheretima: clearing heat for calming endogenous wind, lung heat clearing Dingchuan, inducing diuresis for treating stranguria syndrome.
Beneficial effect: pharmaceutical composition toxic and side effects of the present invention is little, evident in efficacy, medicine of the present invention can significant prolongation rat experiment carotid artery thrombus formation time, significantly suppress the rat platelet coagulation, suppressing platelet aggregation, antithrombotic forms and the treatment thrombotic disease, the treatment ischemic cardio cerebrovascular diseases, and there is significant curative effect aspects such as treatment blood flow circulatory disturbance.
The specific embodiment
The invention discloses a kind of medicine for the treatment of cardiovascular and cerebrovascular disease, it is characterized in that making: 800 parts of Folium Ginkgos, 500 parts of the Radix Paeoniae Albas, 500 parts in Radix Glycyrrhizae, 500 parts of Herba Cichoriis, 200 parts of Radix Notoginseng, 100 parts of Semen Litchis, 100 parts of Pheretimas by the medicinal raw material of following weight portion.
Preparation method: Pheretima is cut into chunks, add in the boiled water of 8-10 times of weight with other crude drug, boiling 3-5 hour, filter out filtering residue, concentrated filtrate becomes dry extract, pulverizes, and is pressed into the granule of 10mg.
The pathology experiment
1, animal: rat.
2, experimental drug: the medicine of medicine of the present invention and commercially available treatment cardiovascular and cerebrovascular disease.
3, method: measure the rat carotid artery blood coagulation time.
Step: get the uniform rat of normal type, male and female half and half are divided into three groups at random, gastric infusion, dosage are the 3mg/kg body weight, and the medication of invention group institute is a medicine of the present invention, the medicine that 1 medication of matched group is commercially available treatment cardiovascular and cerebrovascular disease, matched group 2 is used to be distilled water.Once a day, successive administration 20 days, the last administration was cut carotid artery and is got blood after 2 hours, measured clotting time (CT) with capillary tube method.Statistical result sees the following form 1.
Table 1 clotting time contrast table
| Group | Clotting time (second) |
| The invention group | 227±31 |
| Matched group 1 | 184±19 |
| Matched group 2 | 126±45 |
Clinical trial
1, physical data: patients with coronary heart disease 100 examples, wherein male 58 examples, women 42 examples, diagnostic criteria for coronary heart disease meets WHO " about the name and the diagnostic criteria of ischemic heart desease " in 1979.
2, Therapeutic Method: the granule in the oral embodiment, three times on the one, each 5,10 days one courses of treatment, continuous two courses of treatment.
3, curative effect determinate standard:
Produce effects: chest pain, cardio palmus shape disappear substantially, and electrocardiogram demonstration ischemic state recovers normal substantially;
Effectively: chest pain, cardio palmus shape alleviate or attack times reduces, and electrocardiogram shows that myocardial ischemia improves:
Invalid: chest pain, cardio palmus shape do not have obvious improvement, and electrocardiogram shows that ischemic state does not take a favorable turn to invalid.
4, therapeutic outcome:
Produce effects 49 examples, effective 44 examples, invalid 7 examples, total effective rate 93%, as seen, medicine of the present invention has the good curing effect to cardiovascular and cerebrovascular disease.And the raw materials used Chinese medicine that is of medicine of the present invention has no side effect, and can not produce any harm to human body.
Claims (1)
1. medicine for the treatment of cardiovascular and cerebrovascular disease is characterized in that being made by the medicinal raw material of following weight portion:
800 parts of Folium Ginkgos, 500 parts of the Radix Paeoniae Albas, 500 parts in Radix Glycyrrhizae, 500 parts of Herba Cichoriis,
200 parts of Radix Notoginseng, 100 parts of Semen Litchis, 100 parts of Pheretimas.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100844571A CN102139005B (en) | 2011-04-06 | 2011-04-06 | Medicine for treating cardiovascular and cerebrovascular diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100844571A CN102139005B (en) | 2011-04-06 | 2011-04-06 | Medicine for treating cardiovascular and cerebrovascular diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102139005A true CN102139005A (en) | 2011-08-03 |
| CN102139005B CN102139005B (en) | 2012-05-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011100844571A Expired - Fee Related CN102139005B (en) | 2011-04-06 | 2011-04-06 | Medicine for treating cardiovascular and cerebrovascular diseases |
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| CN (1) | CN102139005B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435771A (en) * | 2014-10-29 | 2015-03-25 | 赵海红 | Health tea paste with nerve-soothing, heart-nourishing and qi-tonifying functions and preparation method |
| KR20190028006A (en) * | 2017-09-08 | 2019-03-18 | 안동대학교 산학협력단 | Pharmaceutical composition comprising the seed extract of litchi as an effective component for prevention or treatment of thrombosis and health functional food comprising the same |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1689632A (en) * | 2004-04-30 | 2005-11-02 | 刘文通 | Medicine for treating ischemic cardiovascular/cerebrovascular diseases |
| CN1891279A (en) * | 2005-07-06 | 2007-01-10 | 陈克治 | Capsule for treating cardio-cerebrovasular disease |
-
2011
- 2011-04-06 CN CN2011100844571A patent/CN102139005B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1689632A (en) * | 2004-04-30 | 2005-11-02 | 刘文通 | Medicine for treating ischemic cardiovascular/cerebrovascular diseases |
| CN1891279A (en) * | 2005-07-06 | 2007-01-10 | 陈克治 | Capsule for treating cardio-cerebrovasular disease |
Non-Patent Citations (2)
| Title |
|---|
| 《中西医结合心脑血管病杂志》 20030930 田文杰等 中医药对冠心病病人血小板功能影响的研究现状 535-538 1 第01卷, 第09期 2 * |
| 《医疗保健器具》 20080815 姚丰安 中药免疫治疗心脑血管病的再探与发现 66-68 1 第12卷, 第08期 2 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435771A (en) * | 2014-10-29 | 2015-03-25 | 赵海红 | Health tea paste with nerve-soothing, heart-nourishing and qi-tonifying functions and preparation method |
| KR20190028006A (en) * | 2017-09-08 | 2019-03-18 | 안동대학교 산학협력단 | Pharmaceutical composition comprising the seed extract of litchi as an effective component for prevention or treatment of thrombosis and health functional food comprising the same |
| KR102013297B1 (en) * | 2017-09-08 | 2019-08-23 | 안동대학교 산학협력단 | Pharmaceutical composition comprising the seed extract of litchi as an effective component for prevention or treatment of thrombosis and health functional food comprising the same |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102139005B (en) | 2012-05-30 |
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