CN102132938B - Citric acid-lauric acid monoglyceryl ester microemulsion and preparation method thereof - Google Patents
Citric acid-lauric acid monoglyceryl ester microemulsion and preparation method thereof Download PDFInfo
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- CN102132938B CN102132938B CN 201110069259 CN201110069259A CN102132938B CN 102132938 B CN102132938 B CN 102132938B CN 201110069259 CN201110069259 CN 201110069259 CN 201110069259 A CN201110069259 A CN 201110069259A CN 102132938 B CN102132938 B CN 102132938B
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Abstract
The invention relates to a citric acid-lauric acid monoglyceryl ester microemulsion and a preparation method thereof. The citric acid-lauric acid monoglyceryl ester microemulsion is characterized in that the microemulsion system comprises the following components in parts by weight: 4-10 parts of lauric acid monoglyceryl ester, 4-10 parts of surfactant, 7-15 parts of cosurfactant, 2-5 parts of citric acid and 8-18 parts of distilled water. The preparation method comprises the steps: preparing all the components in required proportion; and putting the prepared components in a container and mixing evenly; treating with ultrasonic weave for 25-35 minutes at the temperature of 25 DEG C to finally obtain the citric acid-lauric acid monoglyceryl ester microemulsion. The invention has the advantages that the water solubility and the anticorrosion effect of the lauric acid monoglyceryl ester are improved, and the citric acid with synergism and bacteriostatic effect is dissolved into the microemulsion system, thereby improving the bacteriostatic effect of the microemulsion.
Description
Technical field
The present invention relates to a kind of microemulsion anticorrisive agent of food-grade, especially relate to a kind of citric acid-lauric acid monoglyceryl ester microemulsion and preparation method thereof.
Background technology
Microemulsion is the transparent or semitransparent system of You Heshui (salt solution) and exhibiting high surface activating agent and the spontaneous formation of cosurfactant (being generally middle short chain alcohol).The decentralized photo particle radius of microemulsion is very little, is generally 1～100nm scope, through high speed centrifugation lamination does not occur, is thermodynamic stable system.Because microemulsion is the different material of carrying dissolubility simultaneously, and might develop the system of available water infinite dilution, therefore be very suitable for solving the dissolving of the different Compositional antiseptic agent of dissolubility and use a difficult problem.
Existing lauric monoglyceride (GML) has good anti-corrosion function, a kind of safety, efficiently, broad spectrum antimicrobicide, its antibacterial effect is not affected by pH, be better than sorbic acid, benzoic acid, acid anticorrisive agent and the paraben preservatives such as dehydrogenation acid esters, but diversity and complexity owing to putrefactive microorganisms in the food, use single anticorrisive agent often to be difficult to the corrosion-resistanting fresh-keeping effect that reaches desirable, the lauric monoglyceride fusing point is high simultaneously, poorly water-soluble is (such as 25 ℃, solubility only has 0.3mg/mL during pH=7.0), so that GML is difficult to effectively its antisepsis of performance in production application, so antiseptic effect is unsatisfactory.
Summary of the invention
Technical problem to be solved by this invention provides a kind of the water-soluble of lauric monoglyceride of not only having improved, strengthen its preservative efficacy, the citric acid solubilising that will have again the Synergistic bacteriostasis advances citric acid-lauric acid monoglyceryl ester microemulsion of microemulsion system and preparation method thereof.
The present invention solves the problems of the technologies described above the technical scheme that adopts: a kind of citric acid-lauric acid monoglyceryl ester microemulsion, and this microemulsion system is comprised of following component and parts by weight: lauric monoglyceride 4-10 part; Surfactant 4-10 part; Cosurfactant 7-15 part; Citric acid 2-5 part; Distilled water 8-18 part.
This microemulsion system is comprised of following component and parts by weight: 4 parts of lauric monoglycerides; 6 parts in surfactant; 7 parts of cosurfactants; 3 parts of citric acids; 12 parts of distilled water.
Described surfactant adopts Tween-20.Tweens is a based food surfactant of relatively commonly using, and the microemulsion system ratio that contains tween is easier to form between the single-phase water dilution zone, and without liquid crystalline phase, two-phase section is also obviously less; The HLB value of polysorbas20 is 16.7 in the Tweens, is that hydrophily is the strongest, a kind of tween that the solubilising oil mass is maximum.
Described cosurfactant adopts ethanol.Alcohol has changed spontaneous curvature and the elasticity of surfactant interface film.Ethanol as a kind of food-grade short chain alcohol, can change the polarity of polarity and nonpolar phase, improves the elasticity at interface and the stability of destroying liquid crystalline phase.
Described cosurfactant is the mixture that ethanol and propane diols form, and the weight ratio of ethanol and propane diols is 4: 3 in the described mixture.When low wash water, the mixed liquor of ethanol and propane diols is conducive to form hydrophobic surfactant interface film, so that increase between low water district microemulsion region; When high water amount, surfactant interface film hydrophily is stronger, and therefore in this microemulsion system, the adding of propane diols can increase the micro emulsion area in low water district, is conducive to the formation of microemulsion system.
A kind of preparation method of citric acid-lauric acid monoglyceryl ester microemulsion, preparation process is as follows: after placing glass container to mix lauric monoglyceride 4-10 part, surfactant 4-10 part, cosurfactant 7-15 part, citric acid 2-5 part, distilled water 8-18 part by weight, be under 25 ℃ the condition in temperature, ultrasonic wave is processed 25-35min, namely obtains citric acid-lauric acid monoglyceryl ester microemulsion.
A kind of preparation method of citric acid-lauric acid monoglyceryl ester microemulsion, preparation process is as follows: by weight with 4 parts of lauric monoglycerides; 6 parts in surfactant; 7 parts of cosurfactants; 3 parts of citric acids; After 12 parts of distilled water place glass container to mix, be that ultrasonic wave is processed 25-35min, namely obtains citric acid-lauric acid monoglyceryl ester microemulsion under 25 ℃ the condition in temperature.
Described surfactant adopts Tween-20.
Described cosurfactant adopts ethanol.
Described cosurfactant is the mixture that ethanol and propane diols form, and the weight ratio of ethanol and propane diols is 4: 3 in the described mixture.
Compared with prior art, the invention has the advantages that: a kind of citric acid-lauric acid monoglyceryl ester microemulsion of the present invention and preparation method thereof, by selecting surfactant and cosurfactant, composition and ratio reasonable in design, solubilising advances to have the citric acid of collaborative fungistatic effect simultaneously, the citric acid for preparing-lauric monoglyceride microemulsion system had both solved the problem of lauric monoglyceride poorly water-soluble, successful solubilising advances to have the citric acid of collaborative fungistatic effect again, realize the dual stack of the composite and microemulsified of bacteriostatic activity, greatly strengthened its preservative efficacy, and this preparation method operates simple and easy, with low cost, be applied to foods and cosmetics, can play anticorrosion, mildew-resistant, the effect that extends the shelf life has improved corrosion-resistanting fresh-keeping effect.
The specific embodiment
Below in conjunction with embodiment the present invention is described in further detail.
Embodiment 1
A kind of citric acid-lauric acid monoglyceryl ester microemulsion of the present invention, this microemulsion system is comprised of following component and parts by weight: 4 parts of lauric monoglycerides; 6 parts in surfactant; 7 parts of cosurfactants; 3 parts of citric acids; 12 parts of distilled water, its Raw lauric monoglyceride is provided by Hangzhou health derived food Co., Ltd, and monoester content is more than 90%, and concrete preparation method is as follows:
By weight with 4 parts of lauric monoglycerides; 6 parts in surfactant; 7 parts of cosurfactants; 3 parts of citric acids; After 12 parts of distilled water place flat-bottomed glass test tube to mix, be that ultrasonic wave is processed 30min, namely obtains citric acid-lauric acid monoglyceryl ester microemulsion, this microemulsion system clear homogeneous under 25 ℃ the condition in temperature.
In this specific embodiment, surfactant is selected Tween-20; Cosurfactant selects ethanol and propane diols to mix by weight 4: 3 ratio.
Citric acid of the present invention-lauric monoglyceride prescription micro emulsion product is carried out stability analysis: with micro emulsion at room temperature 4000g rotating speed centrifugal treating 15min be separated; 25 ℃ of preservations were not separated in 1 month yet, had good stability.
Embodiment 2
A kind of citric acid-lauric acid monoglyceryl ester microemulsion of the present invention, this microemulsion system is comprised of following component and parts by weight: lauric monoglyceride is 10 parts of oil phases; 10 parts in surfactant; 15 parts of cosurfactants; 5 parts of citric acids; 18 parts of distilled water, its Raw lauric monoglyceride is provided by Hangzhou health derived food Co., Ltd, and monoester content is more than 90%, and concrete preparation method is as follows:
Be after 18 parts of 10 parts of oil phases, 10 parts in surfactant, 15 parts of cosurfactants, 5 parts of citric acids, distilled water place flat-bottomed glass test tube to mix by weight with lauric monoglyceride, be under 25 ℃ the condition in temperature, ultrasonic wave is processed 35min, namely obtain citric acid-lauric acid monoglyceryl ester microemulsion, this microemulsion system clear homogeneous.
In this specific embodiment, surfactant is selected Tween-20; Cosurfactant is selected ethanol.
Citric acid of the present invention-lauric monoglyceride prescription micro emulsion product is carried out stability analysis: with micro emulsion at room temperature 4000g rotating speed centrifugal treating 15min be separated; 25 ℃ of preservations were not separated in 1 month yet, had good stability.
Embodiment 3
A kind of citric acid-lauric acid monoglyceryl ester microemulsion of the present invention, this microemulsion system is comprised of following component and parts by weight: lauric monoglyceride is 6 parts of oil phases; 4 parts in surfactant; 8 parts of cosurfactants; 2 parts of citric acids; 8 parts of distilled water, its Raw lauric monoglyceride is provided by Hangzhou health derived food Co., Ltd, and monoester content is more than 90%, and concrete preparation method is as follows:
Be 6 parts of oil phases by weight with lauric monoglyceride; 4 parts in surfactant; 8 parts of cosurfactants; 2 parts of citric acids; After 8 parts of distilled water place flat-bottomed glass test tube to mix, be that ultrasonic wave is processed 25min, namely obtains citric acid-lauric acid monoglyceryl ester microemulsion, this microemulsion system clear homogeneous under 25 ℃ the condition in temperature.
In this specific embodiment, surfactant is selected Tween-20; Cosurfactant selects user's ethanol and propane diols to mix by weight 4: 3 ratio.
Citric acid of the present invention-lauric monoglyceride prescription micro emulsion product is carried out stability analysis: with micro emulsion at room temperature 4000g rotating speed centrifugal treating 15min be separated; 25 ℃ of preservations were not separated in 1 month yet, had good stability.
Contrast test
Control group 1
Lauric monoglyceride among the embodiment 1 is replaced with distilled water, be about to Tween-20, ethanol, propane diols, citric acid and distilled water by weight 6: 4: 3: mix at 3: 16, be that ultrasonic wave is processed 30min, obtains mixed liquor A under 25 ℃ the condition in temperature.
Control group 2
Citric acid in the enforcement group is replaced with distilled water, be about to lauric monoglyceride, ethanol, propane diols, Tween-20 and distilled water by weight 4: 4: 3: mix at 6: 15, under the condition of 25 ℃ of temperature, ultrasonic wave is processed 30min, obtains mixed liquid B.
The microemulsion of 1 group of embodiment, control group 1, control group 2 is carried out the bacteriostatic test contrast, result of the test is as follows, 1 group of embodiment, control group 1 and control group 2 the staphylococcus minimum inhibitory concentration is respectively 100 μ g/ml, 4000 μ g/ml and 150 μ g/ml, illustrate that the citric acid solubilising is advanced the lauric monoglyceride microemulsion system has preferably collaborative antibacterial synergistic effect.
The bacteriostatic agents such as citric acid-lauric acid monoglyceryl ester microemulsion of the present invention and existing sorbic acid, nisin Nisin, Sodium Benzoate, sodium dehydroacetate, p-hydroxybenzoate and control group 1, control group 2 are compared staphylococcic minimum inhibitory concentration MIC (μ g/mL), as shown in the following Table 1:
Table 1 bacteriostatic agent is to staphylococcic minimum inhibitory concentration MIC (μ g/mL)
Annotate: test strain is that preservation is separated in University Of Ningbo food biotechnology laboratory
By above result as can be known, citric acid-lauric acid monoglyceryl ester microemulsion of the present invention advances the lauric monoglyceride microemulsion system with the citric acid solubilising and has preferably collaborative antibacterial synergistic effect, and this its fungistatic effect of citric acid-lauric acid monoglyceryl ester microemulsion good water solubility obviously is better than the bacteriostatic agents such as existing sorbic acid, nisin Nisin, Sodium Benzoate, sodium dehydroacetate, p-hydroxybenzoate.
Claims (2)
1. the citric acid-lauric acid monoglyceryl ester microemulsion as food grade preservative is characterized in that this microemulsion system is comprised of following component and parts by weight: 4 parts of lauric monoglycerides; 6 parts of Tween-20s; 4 parts of ethanol; 3 parts of propane diols; 3 parts of citric acids; 12 parts of distilled water.
2. the preparation method of the citric acid-lauric acid monoglyceryl ester microemulsion as food grade preservative claimed in claim 1 is characterized in that preparation process is as follows: by weight with 4 parts of lauric monoglycerides; 6 parts of Tween-20s; 4 parts of ethanol; 3 parts of propane diols; 3 parts of citric acids; After 12 parts of distilled water place glass container to mix, be that ultrasonic wave is processed 25-35min, namely obtains citric acid-lauric acid monoglyceryl ester microemulsion under 25 ℃ the condition in temperature.
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| CN110199994A (en) * | 2019-06-18 | 2019-09-06 | 曾婷 | A kind of disinfectant and preparation method thereof, application, feed addictive |
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| CN112056312A (en) * | 2020-08-04 | 2020-12-11 | 西北农林科技大学 | Salmonella disinfectant and its preparation method |
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