CN102128809B - Surface plasma resonance sensor chip assembly and cylindrical prism chip - Google Patents
Surface plasma resonance sensor chip assembly and cylindrical prism chip Download PDFInfo
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- CN102128809B CN102128809B CN2010100342706A CN201010034270A CN102128809B CN 102128809 B CN102128809 B CN 102128809B CN 2010100342706 A CN2010100342706 A CN 2010100342706A CN 201010034270 A CN201010034270 A CN 201010034270A CN 102128809 B CN102128809 B CN 102128809B
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Abstract
The invention discloses a surface plasma resonance (SPR) sensor chip assembly and a cylindrical prism chip. The SPR sensor chip assembly comprises an integrated cylindrical prism chip, a flow pool and a flow pool cover, wherein two lateral surfaces of the cylindrical prism chip are symmetrical concentric cylindrical surfaces serving as an incidence surface and an emergence surface of detection light respectively; the upper surface of the cylindrical prism chip is a reflection surface, and the axis lines of the incidence and emergence cylindrical surfaces are on the reflection surface of the cylindrical prism chip; and the flow pool is pressed on the upper part of the reflection surface of the integrated cylindrical prism chip by the flow pool cover. The SPR sensor chip assembly greatly improves the detection precision and the detection efficiency of an SPR sensor, and can be widely applied in the fields of biological pathological examination, life science research, organic chemistry, food safety, medicament detection and the like. In addition, the whole assembly is processed by adopting an optical plastic injection molding technology, so the assembly is suitable for batch production and the cost is reduced.
Description
Technical field
The present invention relates to the sensor chip technical field, refer to especially a kind of surface plasma resonance (SPR) sensor chip assembly and cylinder prism chip.
Background technology
Surface plasma body resonant vibration (SPR) technology is very rapidly technology of development in recent years.The principle of surface plasma body resonant vibration is electronics or the electric density collective oscillation effect of propagating along the metal surface.When the incident angle of the polarized light of incident satisfied certain condition, intensity of reflected light was minimum, and the angle of this moment becomes resonance angle.When the material concentration on golden film surface changed, its resonance angle changed, and by analyzing the variation of resonance angle, can carry out original position, harmless and unmarked detection to the combination of biomolecule.Therefore the SPR detection technique has become the important means that intermolecular interaction is analyzed, particularly in the research field of bio-molecular interaction, has become the important research instrument of Biochemical Lab.And sensor chip directly has influence on the development of SPR detection technique as the core component of SPR detection technique.
The chip structure of spr sensor is referring to shown in Figure 1 and shown in Figure 2 at present.Wherein, prism shown in Figure 1 is the prism wedge chip, and Fig. 2 is cylinder prism chip.Existing SPR detector generally comprises scanning light source 211, wedge shape or cylinder prism 212, SPR chip (comprising glass sheet 130 and golden film 131), reaction tank 214 and detecting device 215, and detecting device is the Scan Architecture part of SPR detector.
The SPR chip comprises glass sheet 130, is coated with golden film 131 on the glass sheet, and the laser that scanning light source 211 penetrates is by wedge shape or 212 couplings of cylinder prism, and the free electron that causes in the golden film produces surface plasma.At some incident angle laser resonance effect can occur, cause the laser energy of incident to be absorbed, so that occur a resonance absorbing peak-SPR spectrum on the prism bottom surface on incident angle and the reflectivity optical curve.Because SPR spectrum peak incident angle effects on surface variations in refractive index is responsive, and variations in refractive index is directly proportional with the material concentration of golden film surface conjunction, therefore with detecting device 215 (for example: photodetector) the continuous monitoring surface plasma body resonant vibration absorption peak intermolecular reaction kinetics process of detection of biological in time just over time.Spr sensor is that the slide by plating single-point or multiple spot gold film is that SPR chip and reaction tank consist of.
During detection, at first the SPR chip that is coated with sample on the gold-plated film is fitted tightly runner one side at reaction tank, golden film is inclusive among the runner, consists of the biochemical reaction passage; Then chip is fitted on the bottom surface of cylinder prism.In order to reduce the reflection of the catadioptric interface that cylinder prism bottom surface and surface of glass slide consist of, before fitting, to be coated with cedar oil, because the refractive index of the refractive index of cedar oil and cylinder prism and slide approaches, can reduce the reflective light intensity of this reflecting interface, incident light is coupled on the golden film as much as possible.When measuring, scanning light source rotates within the specific limits, and detecting device receives the SPR reaction signal along with scanning light source rotates.
Yet present this spr sensor chip has following deficiency:
When measuring, need light source and detecting device to cooperate and rotate, this requirement to process and assemble is very high, add to drive motor that light source and detecting device rotate and the precision of leading screw itself is limit, whole system be difficult to reach high precision; Every detection once just needs light source and detecting device to-and-fro movement once in addition, and detection efficiency is low, is difficult to apply in clinical detection.
Operating process is loaded down with trivial details, and is very high to experimenter's operative technique requirement.In building the process of spr sensor, chip will be through twice applying: once be and the applying of reaction tank, fit improper, can cause the reaction tank leakage, perhaps chip is damaged; Be that reaction tank is fitted on the cylinder prism bottom surface with chip for the second time, in this process, be coated with by rule of thumb an amount of cedar oil, oil be coated with too much very few or discontinuity all can have a negative impact to scanning light beam.
Prism and slide all adopt glass material, and processing charges is higher, are unfavorable for large-scale commercial production.
Summary of the invention
In view of this, in order to improve accuracy of detection and detection efficiency, the present invention proposes a kind of sensor chip assembly and cylinder prism chip.
Based on above-mentioned purpose a kind of surface plasma resonant sensor chip assembly provided by the invention, comprising: integrated cylinder prism chip, Liu Chi and Liu Chigai;
The two sides of described cylinder prism chip are symmetrical concentric circles cylinder, and respectively as the plane of incidence and the exit facet that detect light, this detects light can be cylindrical beam of light; The upper surface of cylinder prism chip is for detecting the reflection of light face, can produce equally spaced diffuse reflection isolation strip by Shooting Technique at this reflecting surface, then be coated with golden film at this reflecting surface, to form a plurality of detecting positions independent of each other, the axial line of the described plane of incidence and exit facet is on this reflecting surface of cylinder prism chip;
Described stream pond is pressed in the reflecting surface top of described integrated cylinder prism chip by described stream Chi Gai.
Preferably, the reflecting surface at cylinder prism chip described in this sensor chip assembly is the plane.
Preferably, have the hole in the position directly over described detecting position of stream Chi Gai described in this sensor chip assembly.
Preferably, be injection molded by optical plastic at cylinder prism chip described in this sensor chip assembly.
Preferably, the bottom surface at cylinder prism chip described in this sensor chip assembly is the plane.
Preferably, the combination between cylinder prism chip described in this sensor chip assembly and stream pond adopts the ultrasonic soldering mode.
Preferably, the stream in the pond of stream described in this sensor chip assembly is single channel or hyperchannel.
Preferably, the pond of stream described in the described sensor chip assembly is silica gel material.
Based on above-mentioned purpose, the present invention also provides a kind of cylinder prism chip that is applied to the surface plasma resonant sensor chip assembly, and described cylinder prism chip is integrated; The two sides of described cylinder prism chip are symmetrical concentric circles cylinder, and respectively as the plane of incidence and the exit facet that detect light, this detects light can be cylindrical beam of light; The upper surface of cylinder prism chip is for detecting the reflection of light face, can produce equally spaced diffuse reflection isolation strip by Shooting Technique at this reflecting surface, then be coated with golden film at this reflecting surface, to form a plurality of detecting positions independent of each other, the axial line of the described plane of incidence and exit facet is on this reflecting surface of cylinder prism chip.
Preferably, the reflecting surface at cylinder prism chip described in this cylinder prism chip is the plane.
Preferably, be injection molded by optical plastic at cylinder prism chip described in this cylinder prism chip.
Preferably, the bottom surface at cylinder prism chip described in this cylinder prism chip is the plane.
Can find out from above, sensor chip assembly provided by the invention and cylinder prism chip, the cylinder prism of SPR chip and SPR instrument is combined into an integral body replaces the original prism of SPR instrument and slide with integrated cylinder prism chip, thereby cancel the operation that original spr sensor need to be fitted with the cylinder prism, so that use the SPR instrument of this device will no longer need prism, fundamentally simplified clinical manipulation.Also remove simultaneously the catadioptric interface between cylinder prism bottom surface and the slide, make the cylinder prism become as a whole with slide, thereby eliminate unnecessary reflection and veiling glare interference that the interface between cylinder prism and the slide produces, help to improve the quality of detection signal; The present invention adopts cylinder prism chip, and the characteristics of cylinder prism are that two sides are the concentric circles cylinder, utilize cylindrical beam of light as detection light source, can cover larger measurement range, no longer need rotatable parts, the defective of having avoided traditional light source scanning mode to bring.
Further be set to single channel or hyperchannel by flowing the pond, this stream pond is flowed Chi Gai and is pressed on the integrated cylinder prism chip, weld together with ultrasonic bond, thereby consisted of a complete cylinder prism chip and stream pond integrated SPR sensing chip assembly, do not needed scanning to get final product the multiple biochemical reaction of a plurality of samples of parallel detection.
Sensor chip assembly of the present invention and cylinder prism chip can be widely used in the biology pathological examination, the fields such as life science, organic chemistry, food security, drug test.All components adopts the optical plastic injection molding technology to process in addition, is fit to batch production, reduces cost.
Description of drawings
Fig. 1 is prior art wedge shape cylinder prism chip structure schematic diagram;
Fig. 2 is prior art cylinder prism chip structure schematic diagram;
Fig. 3 A is embodiment of the invention cylinder prism chip stereo external view;
Fig. 3 B is embodiment of the invention cylinder prism chip xsect optical principle schematic diagram;
Fig. 3 C is embodiment of the invention cylinder prism chip profile and optical principle schematic diagram;
Fig. 4 is the decomposing schematic representation of embodiment of the invention cylinder prism chip stream pond integrated SPR sensing chip assembly;
Fig. 5 is embodiment of the invention cylinder prism chip assembly three-dimensional appearance view;
Fig. 6 is the measuring principle schematic diagram of embodiment of the invention SPR chip assembly;
The measured drawing that Fig. 7 obtains for the SPR sensing chip assembly with the embodiment of the invention;
Fig. 8 is the decomposing schematic representation of another embodiment of cylinder prism chip of the present invention and stream pond integrated SPR sensing chip assembly;
Fig. 9 is the decomposing schematic representation of the third embodiment of cylinder prism chip of the present invention and stream pond integrated SPR sensing chip assembly;
Figure 10 is the stream schematic diagram in silica gel stream pond among the embodiment among Fig. 9;
Figure 11 is the schematic cross-section of embodiment of the invention cylindrical beam of light.
Embodiment
The present invention is in order to overcome the faultiness design cylinder prism chip of prior art, prism and slide is made into be structure as a whole.The two sides of described cylinder prism chip are symmetrical concentric circles cylinder, respectively as the plane of incidence and the exit facet that detect light; The upper surface of cylinder prism chip is reflecting surface, and the axial line of incident and outgoing cylinder is on this reflecting surface of cylinder prism chip.This integrated cylinder prism chip is to be formed by the gold-plated film of optical plastic cylinder prism.Like this, the plane of incidence, reflecting surface, exit facet have just consisted of the light path system of surface plasma resonance.The measurement range of cylinder prism chip is large, can cover most biological respinse, compares with traditional beam flying metering system, and efficient is high, precision is high.
On this basis, a kind of spr sensor chip assembly provided by the invention comprises: integrated cylinder prism chip, Liu Chi and Liu Chigai; Wherein, the two sides of described cylinder prism chip are symmetrical concentric circles cylinder, respectively as the plane of incidence and the exit facet that detect light; The upper surface of cylinder prism chip is reflecting surface, and the axial line of incident and outgoing cylinder is on this reflecting surface of cylinder prism chip; Described stream pond is pressed in the reflecting surface top of described integrated cylinder prism chip by described stream Chi Gai.
The present invention adopts cylinder prism chip, and the characteristics of cylinder prism are that two sides are the concentric circles cylinder, utilize cylindrical beam of light as detection light source, can cover larger measurement range, no longer need rotatable parts, the defective of having avoided traditional light source scanning mode to bring; Reflecting surface on the cylinder prism chip is produced equally spaced diffuse reflection array by Shooting Technique.Gold-plated film on reflecting surface namely forms a plurality of independently detecting positions again.Place the stream pond on the reflecting surface of cylinder prism chip, in order to pass through biological respinse liquid.This stream pond is pressed on the catoptron gold film by a stream Chi Gai, with ultrasonic bond gland is welded on the cylinder prism chip.A complete cylinder prism chip and stream pond integrated SPR sensing chip assembly have so just been consisted of.
Further the cylinder prism chip reflecting surface of this sensor chip assembly equally spaced diffuse reflection array that distributes forms multichannel detecting position independent of each other, and contrast is high, so that distinguish thoroughly between detecting position and the background.Thereby avoid occurring the measurement result of mistake.At the coated different probe of detecting position, can to the parallel independent detection of the biological respinse of each detecting position, improve detection efficiency.
Further the stream pond of this sensor chip assembly is divided into single channel or multichannel, use single channel stream pond, can detect the multiple biological respinse of a sample, when using hyperchannel stream pond, multiple biological respinse that can a plurality of samples of parallel detection has improved detection efficiency greatly.
Further the combination between the cylinder prism chip of this sensor chip assembly and the stream pond adopts the ultrasonic soldering mode, consists of an integral device after the welding.
Further the material of this sensor chip assembly is optical plastic, adopts the Shooting Technique one-shot forming, is easy to realize suitability for industrialized production, thereby greatly reduces cost.
For making the purpose, technical solutions and advantages of the present invention clearer, below in conjunction with specific embodiment, and with reference to accompanying drawing, the present invention is described in more detail.
Fig. 3 A, 3B, 3C are profile and the optical principle schematic diagram thereof of a kind of embodiment of cylinder prism chip of the present invention.Wherein, Fig. 3 A is embodiment of the invention cylinder prism chip assembly three-dimensional appearance view; Fig. 3 B is embodiment of the invention cylinder prism chip assembly xsect optical principle schematic diagram; Fig. 3 C is embodiment of the invention cylinder prism chip assembly profile and optical principle schematic diagram.
Detection light source is utilized cylindrical beam of light 111, enters cylinder prism chip via incident cylinder 11, is golden film 12 reflections at the prismatic reflection face, via 15 outgoing of outgoing cylinder, forms outgoing cylindrical beam of light 112.The plane of incidence 11 of cylinder prism and exit facet 15 are symmetrical concentric circles cylinder, and reflecting surface 12 is level crossing, the axis of incident and outgoing cylinder on level crossing, gold-plated film on the level crossing.Like this, incident cylinder 11, mirror surface are the light path system that golden film 12, outgoing cylinder 15 have just consisted of surface plasma resonance.Cylindrical beam of light 111 can cover a larger sensing range, does not need to rotate, and can cover different types of biological respinse, has improved detection efficiency and precision.In the present embodiment, the xsect of cylindrical beam of light 111 is referring to Figure 11 shows that rectangle.
The reflecting surface of cylinder prism chip is coated with golden film 12, adopts special process at plated film front-reflection face, produces equally spaced diffuse reflection isolation strip 14, and each detecting position 121 is separated in the diffuse reflection isolation strip, sets up detecting position independent of each other.The present embodiment central column face prism chip has 26 detecting positions, and at the coated different probe of each detecting position, a fluid injection can 26 kinds of biochemical reactions of parallel detection.
Fig. 4 and Fig. 5 are the structural representations of cylinder prism chip of the present invention and a kind of embodiment of stream pond integrated SPR sensing chip assembly.
Fig. 4 is the exploded view of this cylinder prism chip and stream pond integrated SPR sensing chip assembly.This assembly comprises: integrated cylinder prism chip 1, silica gel stream pond 2, stream pond lid 3.In silica gel stream pond 2 one or more passage is arranged.Stream pond 2 covers on the detecting position 121 of integrated cylinder prism chip, and detected sample flows into from liquid injection hole 21, flows out from fluid hole 22.Detect the dressing probe combination on sample and the detecting position, instrument just can detect the biological respinse in the sample.The single current pond can be arranged to, i.e. passage, or multithread pond, the i.e. passage of one or more in stream pond 2.Use the single current pond, can detect the multiple biological respinse of a sample, when using the multithread pond, can detect simultaneously the multiple biological respinse of a plurality of samples, greatly improved detection efficiency.
Fig. 6 is the measuring principle figure of SPR chip assembly.As shown in the figure, a branch of cylindrical beam of light 111 enters through the plane of incidence of cylinder prism chip, the golden film 12 that plates at reflecting surface reflects, and some light transmission reflecting surface gold film 12 surface, react in conjunction with SPR occurs with the probe on the golden film 12, reaction is passed through the outgoing cylinder with the folded light beam of spr signal afterwards and is incident upon on the projection screen 4, bright dark fringe appears on the projection screen, each bright fringes represents a detecting position, bright fringes comprises a complete SPR resonance spectrum, the resonance spectrum curve is also shown in Figure 6, and resonance spectrum is the distribution curve of the SPR resonance in the measurement range.By analyzing the peak 41 of resonance spectrum, obtain the SPR resonant angle, resonant angle is angle corresponding to resonance spectrum peak.Referring to shown in Figure 7, be the measured drawing that obtains with SPR sensing chip assembly of the present invention, have 26 bright lines among the figure, represent 26 detecting positions, the length of bright line represents the sensing range of cylinder prism, and detecting position is separated by concealed wire each other, and concealed wire is the detecting position isolation strip, so that separate between the detecting position, do not interact.SPR reaction among the figure occurs in the position, lower middle, and what each detecting position was coated is the same probe, therefore forms the blanking bar of a level.
Fig. 8, Fig. 9 are the structural representation of embodiment in of the present invention other two.
As shown in Figure 8, as the another kind of embodiment of cylinder prism chip of the present invention and stream pond integrated SPR sensing chip assembly, this sensor device comprises cylinder prism chip 5, silica gel stream pond 2 and chip lid 3.Described cylinder prism chip is a chip that contains 52 detecting positions, and the quantity of detecting position is arbitrary extension as required.
As shown in Figure 9, the third embodiment as cylinder prism chip of the present invention and stream pond integrated SPR sensing chip assembly, this sensor device comprises cylinder prism chip 1, silica gel stream pond 6 and chip lid 3, and 6 streams independent of each other are contained in described silica gel stream pond 6.This chip assembly can detect 6 samples simultaneously.Equally, can as required silica gel be flowed the pond arbitrary extension.The planar structure of stream is referring to shown in Figure 10 in the stream pond 6, and wherein sequence number 61～66 is respectively stream 1～6.But thereby 6 passages of parallel detection.
The whole device collection chip of SPR sensing chip assembly of the present invention, cylinder prism, reaction tank are single device, with high flux SPR detection, multichannel reaction channel, the Function Integration Mechanisms such as device Fast Installation are on a device, not only simplified greatly clinical manipulation, and reduced cost, for SPR equipment is walked out the laboratory, cleared away obstacle as conventional medical institutions detection means, SPR equipment has been played conclusive effect in clinical medical popularization.
Above-described specific embodiment is specific embodiments of the invention only, is not limited to the present invention, and is within the spirit and principles in the present invention all, any modification of making, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (11)
1. a surface plasma resonant sensor chip assembly is characterized in that, comprising: integrated cylinder prism chip, Liu Chi and Liu Chigai;
The two sides of described cylinder prism chip are symmetrical concentric circles cylinder, and as the plane of incidence and the exit facet that detect light, this detection light is cylindrical beam of light respectively; The upper surface of cylinder prism chip is for detecting the reflection of light face, produce equally spaced diffuse reflection isolation strip by Shooting Technique at this reflecting surface, then be coated with golden film at this reflecting surface, to form a plurality of detecting positions independent of each other, the axial line of the described plane of incidence and exit facet is on this reflecting surface of cylinder prism chip;
Described stream pond is pressed in the reflecting surface top of described integrated cylinder prism chip by described stream Chi Gai.
2. sensor chip assembly according to claim 1 is characterized in that, the reflecting surface of described cylinder prism chip is the plane.
3. sensor chip assembly according to claim 2 is characterized in that, described cylinder prism chip is injection molded by optical plastic.
4. sensor chip assembly according to claim 3 is characterized in that, the bottom surface of described cylinder prism chip is the plane.
5. sensor chip assembly according to claim 1 is characterized in that, the combination between described cylinder prism chip and the stream pond adopts the ultrasonic soldering mode.
6. sensor chip assembly according to claim 1 is characterized in that, the stream in described stream pond is single channel or hyperchannel.
7. sensor chip assembly according to claim 1 is characterized in that, described stream pond is silica gel material.
8. a cylinder prism chip that is applied to the surface plasma resonant sensor chip assembly is characterized in that, described cylinder prism chip is integrated; The two sides of described cylinder prism chip are symmetrical concentric circles cylinder, and as the plane of incidence and the exit facet that detect light, this detection light is cylindrical beam of light respectively; The upper surface of cylinder prism chip is for detecting the reflection of light face, produce equally spaced diffuse reflection isolation strip by Shooting Technique at this reflecting surface, then be coated with golden film at this reflecting surface, to form a plurality of detecting positions independent of each other, the axial line of the described plane of incidence and exit facet is on this reflecting surface of cylinder prism chip.
9. cylinder prism chip according to claim 8 is characterized in that, the reflecting surface of described cylinder prism chip is the plane.
10. cylinder prism chip according to claim 9 is characterized in that, described cylinder prism chip is injection molded by optical plastic.
11. cylinder prism chip according to claim 10 is characterized in that the bottom surface of described cylinder prism chip is the plane.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010100342706A CN102128809B (en) | 2010-01-19 | 2010-01-19 | Surface plasma resonance sensor chip assembly and cylindrical prism chip |
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| CN2010100342706A CN102128809B (en) | 2010-01-19 | 2010-01-19 | Surface plasma resonance sensor chip assembly and cylindrical prism chip |
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| CN102128809B true CN102128809B (en) | 2013-01-02 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5946330B2 (en) | 2012-06-01 | 2016-07-06 | 日東電工株式会社 | SPR sensor cell and SPR sensor |
| CN107843577B (en) * | 2017-09-21 | 2020-05-15 | 丁利 | Integrated prism assembly for surface plasma sub-resonance detection system |
| CN107843558B (en) * | 2017-09-21 | 2020-05-15 | 丁利 | Angle modulation mechanism of prism type surface plasma resonance spectrometer |
| CN110567919A (en) * | 2019-09-17 | 2019-12-13 | 华中科技大学 | Beam scanning type SPR sensor and use method thereof |
| CN114166755B (en) * | 2021-10-18 | 2022-12-09 | 北京英柏生物科技有限公司 | Flow path plate and surface plasma resonance detection device with same |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1529147A (en) * | 2003-10-14 | 2004-09-15 | 清华大学 | High-sensitivity surface plasma resonance detector with multiple total reflection |
| CN101556248A (en) * | 2009-05-18 | 2009-10-14 | 中国科学院长春应用化学研究所 | Method for detecting time resolution of surface plasmon resonance spectroscopy |
| CN101576491A (en) * | 2008-05-09 | 2009-11-11 | 南开大学 | Array surface plasma resonant sensor chip based on binary optical device |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1529147A (en) * | 2003-10-14 | 2004-09-15 | 清华大学 | High-sensitivity surface plasma resonance detector with multiple total reflection |
| CN101576491A (en) * | 2008-05-09 | 2009-11-11 | 南开大学 | Array surface plasma resonant sensor chip based on binary optical device |
| CN101556248A (en) * | 2009-05-18 | 2009-10-14 | 中国科学院长春应用化学研究所 | Method for detecting time resolution of surface plasmon resonance spectroscopy |
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