CN102128809A - Surface plasma resonance sensor chip assembly and cylindrical prism chip - Google Patents
Surface plasma resonance sensor chip assembly and cylindrical prism chip Download PDFInfo
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- CN102128809A CN102128809A CN2010100342706A CN201010034270A CN102128809A CN 102128809 A CN102128809 A CN 102128809A CN 2010100342706 A CN2010100342706 A CN 2010100342706A CN 201010034270 A CN201010034270 A CN 201010034270A CN 102128809 A CN102128809 A CN 102128809A
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Abstract
The invention discloses a surface plasma resonance (SPR) sensor chip assembly and a cylindrical prism chip. The SPR sensor chip assembly comprises an integrated cylindrical prism chip, a flow pool and a flow pool cover, wherein two lateral surfaces of the cylindrical prism chip are symmetrical concentric cylindrical surfaces serving as an incidence surface and an emergence surface of detection light respectively; the upper surface of the cylindrical prism chip is a reflection surface, and the axis lines of the incidence and emergence cylindrical surfaces are on the reflection surface of the cylindrical prism chip; and the flow pool is pressed on the upper part of the reflection surface of the integrated cylindrical prism chip by the flow pool cover. The SPR sensor chip assembly greatly improves the detection precision and the detection efficiency of an SPR sensor, and can be widely applied in the fields of biological pathological examination, life science research, organic chemistry, food safety, medicament detection and the like. In addition, the whole assembly is processed by adopting an optical plastic injection molding technology, so the assembly is suitable for batch production and the cost is reduced.
Description
Technical field
The present invention relates to the sensor chip technical field, be meant a kind of surface plasma resonance (SPR) sensor chip assembly and cylinder prism chip especially.
Background technology
Surface plasma body resonant vibration (SPR) technology is development in recent years technology very rapidly.The principle of surface plasma body resonant vibration is electronics or the electric density collective oscillation effect of propagating along the metal surface.When the incident angle of incident polarized light satisfies certain condition, the intensity of reflected light minimum, the angle of this moment becomes resonance angle.When the material concentration on golden film surface changed, its resonance angle changed, and by analyzing the variation of resonance angle, can carry out original position, harmless and unmarked detection to the combination of biomolecule.Therefore the SPR detection technique has become the important means that intermolecular interaction is analyzed, particularly in the research field of bio-molecular interaction, has become the important research instrument of Biochemical Lab.And sensor chip directly has influence on the development of SPR detection technique as the core component of SPR detection technique.
The chip structure of spr sensor is referring to shown in Figure 1 and shown in Figure 2 at present.Wherein, prism shown in Figure 1 is the prism wedge chip, and Fig. 2 is a cylinder prism chip.Existing SPR detector generally comprises scanning light source 211, wedge shape or cylinder prism 212, SPR chip (comprising glass sheet 130 and golden film 131), reaction tank 214 and detecting device 215, and detecting device is the Scan Architecture part of SPR detector.
The SPR chip comprises glass sheet 130, is coated with golden film 131 on the glass sheet, and the laser that scanning light source 211 penetrates is by wedge shape or 212 couplings of cylinder prism, and the free electron that causes in the golden film produces surface plasma.At some incident angle laser resonance effect can take place, cause the laser energy of incident to be absorbed, make a resonance absorbing peak-SPR spectrum to occur on the incident angle and reflectivity optical curve on the prism bottom surface.Because SPR spectrum peak incident angle is to surperficial variations in refractive index sensitivity, and variations in refractive index is directly proportional with the material concentration of golden film surface combination, therefore with detecting device 215 (for example: the continuous monitoring surface plasma body resonant vibration absorption peak intermolecular reaction kinetics process of detection of biological in time just over time photodetector).Spr sensor is that the slide by plating single-point or multiple spot gold film is that SPR chip and reaction tank constitute.
During detection, at first fit tightly runner one side at reaction tank with having wrapped on the gold-plated film by the SPR chip of sample, golden film is inclusive among the runner, constitutes the biochemical reaction passage; Chip is fitted on the bottom surface of cylinder prism then.In order to reduce the reflection of the catadioptric interface that cylinder prism bottom surface and surface of glass slide constitute, before fitting, to be coated with cedar oil, because of the refractive index of the refractive index of cedar oil and cylinder prism and slide approaching, can reduce the reflective light intensity of this reflecting interface, incident light is coupled on the golden film as much as possible.When measuring, scanning light source rotates within the specific limits, and detecting device receives the SPR reaction signal along with scanning light source rotates.
Yet present this spr sensor chip has following deficiency:
When measuring, need light source and detecting device to cooperate and rotate, this requirement to process and assemble is very high, add to drive motor that light source and detecting device rotate and the precision of leading screw itself is limit, total system be difficult to reach high precision; Every in addition detection once just needs light source and detecting device to-and-fro movement once, and detection efficiency is low, is difficult in the clinical detection to apply.
Operating process is loaded down with trivial details, and is very high to experimenter's operative technique requirement.In building the process of spr sensor, chip will be through twice applying: once be and the applying of reaction tank, it is improper to fit, and can cause the reaction tank leakage, perhaps chip breakage; Be that reaction tank is fitted on the cylinder prism bottom surface with chip for the second time, in this process, be coated with an amount of cedar oil by rule of thumb, oil is coated with too much very fewly or discontinuity all can have a negative impact to scanning light beam.
Prism and slide all adopt glass material, and processing charges is higher, are unfavorable for large-scale commercial production.
Summary of the invention
In view of this, in order to improve accuracy of detection and detection efficiency, the present invention proposes a kind of sensor chip assembly and cylinder prism chip.
Based on above-mentioned purpose a kind of surface plasma resonant sensor chip assembly provided by the invention, comprising: incorporate cylinder prism chip, Liu Chi and Liu Chigai;
The two sides of described cylinder prism chip are symmetrical concentric circles cylinder, respectively as the plane of incidence and the exit facet that detect light; The upper surface of cylinder prism chip is for detecting the reflection of light face, and the axial line of the described plane of incidence and exit facet is on this reflecting surface of cylinder prism chip;
Described stream pond is pressed in the reflecting surface top of described integrated cylinder prism chip by described stream Chi Gai.
Preferably, be the plane at the reflecting surface of cylinder prism chip described in this sensor chip assembly, be coated with golden film on the reflecting surface.
Preferably, at the reflecting surface of cylinder prism chip described in this sensor chip assembly equally spaced diffuse reflection array that distributes, form a plurality of detecting positions independent of each other.
Preferably, have the hole in the position directly over described detecting position of stream Chi Gai described in this sensor chip assembly.
Preferably, be injection molded at cylinder prism chip described in this sensor chip assembly by optical plastic.
Preferably, the bottom surface at cylinder prism chip described in this sensor chip assembly is the plane.
Preferably, the combination between cylinder prism chip described in this sensor chip assembly and stream pond adopts the ultrasonic soldering mode.
Preferably, the stream in the pond of stream described in this sensor chip assembly is single channel or hyperchannel.
Preferably, the pond of stream described in the described sensor chip assembly is a silica gel material.
Based on above-mentioned purpose, the present invention also provides a kind of cylinder prism chip that is applied to the surface plasma resonant sensor chip assembly, and described cylinder prism chip is integrated; The two sides of described cylinder prism chip are symmetrical concentric circles cylinder, respectively as the plane of incidence and the exit facet that detect light; The upper surface of cylinder prism chip is for detecting the reflection of light face, and the axial line of the described plane of incidence and exit facet is on this reflecting surface of cylinder prism chip.
Preferably, be the plane at the reflecting surface of cylinder prism chip described in this cylinder prism chip, be coated with golden film on the reflecting surface.
Preferably, at the reflecting surface of cylinder prism chip described in this cylinder prism chip equally spaced diffuse reflection array that distributes, form a plurality of detecting positions independent of each other.
Preferably, be injection molded at cylinder prism chip described in this cylinder prism chip by optical plastic.
Preferably, the bottom surface at cylinder prism chip described in this cylinder prism chip is the plane.
From above as can be seen, sensor chip assembly provided by the invention and cylinder prism chip, the cylinder prism of SPR chip and SPR instrument is combined into an integral body replaces original prism of SPR instrument and slide with integrated cylinder prism chip, thereby cancel the operation that original spr sensor need be fitted with the cylinder prism, make and use the SPR instrument of this device will no longer need prism, fundamentally simplified clinical manipulation.Also remove simultaneously the catadioptric interface between cylinder prism bottom surface and the slide, make the cylinder prism become as a whole with slide, thereby eliminate unnecessary reflection and veiling glare interference that the interface between cylinder prism and the slide produces, help to improve the quality of detection signal; The present invention adopts cylinder prism chip, and the characteristics of cylinder prism are that two sides are the concentric circles cylinder, utilize the cylinder light beam as detection light source, can cover bigger measurement range, no longer need rotatable parts, the defective of having avoided traditional light source scanning mode to bring.
Further be set to single channel or hyperchannel by flowing the pond, this stream pond is flowed Chi Gai and is pressed on the integrated cylinder prism chip, weld together with ultrasonic bond, thereby constituted a complete cylinder prism chip and stream pond incorporate SPR sensing chip assembly, do not needed scanning to get final product the multiple biochemical reaction of a plurality of samples of parallel detection.
Sensor chip assembly of the present invention and cylinder prism chip can be widely used in the biology pathological examination, fields such as life science, organic chemistry, food security, drug test.All components adopts the optical plastic injection molding technology to process in addition, is fit to produce in batches, reduces cost.
Description of drawings
Fig. 1 is a prior art wedge shape cylinder prism chip structure synoptic diagram;
Fig. 2 is a prior art cylinder prism chip structure synoptic diagram;
Fig. 3 A is an embodiment of the invention cylinder prism chip stereo external view;
Fig. 3 B is an embodiment of the invention cylinder prism chip xsect optical principle synoptic diagram;
Fig. 3 C is embodiment of the invention cylinder prism chip profile and optical principle synoptic diagram;
Fig. 4 is the decomposing schematic representation of embodiment of the invention cylinder prism chip stream pond incorporate SPR sensing chip assembly;
Fig. 5 is an embodiment of the invention cylinder prism chip assembly three-dimensional appearance view;
Fig. 6 is the measuring principle synoptic diagram of embodiment of the invention SPR chip assembly;
The measured drawing that Fig. 7 obtains for the SPR sensing chip assembly with the embodiment of the invention;
Fig. 8 is the decomposing schematic representation of another embodiment of cylinder prism chip of the present invention and stream pond incorporate SPR sensing chip assembly;
Fig. 9 is the decomposing schematic representation of the third embodiment of cylinder prism chip of the present invention and stream pond incorporate SPR sensing chip assembly;
Figure 10 is the stream synoptic diagram in silica gel stream pond among the embodiment among Fig. 9;
Figure 11 is the schematic cross-section of embodiment of the invention cylinder light beam.
Embodiment
The present invention is in order to overcome the defective design cylinder prism chip of prior art, prism and slide is made into be structure as a whole.The two sides of described cylinder prism chip are symmetrical concentric circles cylinder, respectively as the plane of incidence and the exit facet that detect light; The upper surface of cylinder prism chip is a reflecting surface, and the axial line of incident and outgoing cylinder is on this reflecting surface of cylinder prism chip.This integrated cylinder prism chip is to be formed by the gold-plated film of optical plastic cylinder prism.Like this, the plane of incidence, reflecting surface, exit facet have just constituted the light path system of surface plasma resonance.The measurement range of cylinder prism chip is big, can cover most biological respinse, compares efficient height, precision height with traditional beam flying metering system.
On this basis, a kind of spr sensor chip assembly provided by the invention comprises: incorporate cylinder prism chip, Liu Chi and Liu Chigai; Wherein, the two sides of described cylinder prism chip are symmetrical concentric circles cylinder, respectively as the plane of incidence and the exit facet that detect light; The upper surface of cylinder prism chip is a reflecting surface, and the axial line of incident and outgoing cylinder is on this reflecting surface of cylinder prism chip; Described stream pond is pressed in the reflecting surface top of described integrated cylinder prism chip by described stream Chi Gai.
The present invention adopts cylinder prism chip, and the characteristics of cylinder prism are that two sides are the concentric circles cylinder, utilize the cylinder light beam as detection light source, can cover bigger measurement range, no longer need rotatable parts, the defective of having avoided traditional light source scanning mode to bring; Reflecting surface on the cylinder prism chip is produced equally spaced diffuse reflection array by Shooting Technique.Gold-plated film on reflecting surface promptly forms a plurality of independently detecting positions again.Place the stream pond on the reflecting surface of cylinder prism chip, in order to pass through biological respinse liquid.This stream pond is pressed on the catoptron gold film by a stream Chi Gai, with ultrasonic bond gland is welded on the cylinder prism chip.A complete cylinder prism chip and stream pond incorporate SPR sensing chip assembly have so just been constituted.
Further the cylinder prism chip reflecting surface of this sensor chip assembly equally spaced diffuse reflection array that distributes forms multichannel detecting position independent of each other, and the contrast height makes to distinguish completely between detecting position and the background.Thereby avoid occurring the measurement result of mistake.Bag can have been improved detection efficiency to the parallel independent detection of the biological respinse of each detecting position by different probe on detecting position.
Further the stream pond of this sensor chip assembly is divided into single channel or multichannel, use single channel stream pond, can detect the multiple biological respinse of a sample, when using hyperchannel stream pond, multiple biological respinse that can a plurality of samples of parallel detection has improved detection efficiency greatly.
Further the combination between the cylinder prism chip of this sensor chip assembly and the stream pond adopts the ultrasonic soldering mode, consists of an integral device after the welding.
Further the material of this sensor chip assembly is an optical plastic, adopts the Shooting Technique one-shot forming, is easy to realize suitability for industrialized production, thereby reduces cost greatly.
For making the purpose, technical solutions and advantages of the present invention clearer, below in conjunction with specific embodiment, and with reference to accompanying drawing, the present invention is described in more detail.
Fig. 3 A, 3B, 3C are profile and the optical principle synoptic diagram thereof of a kind of embodiment of cylinder prism chip of the present invention.Wherein, Fig. 3 A is an embodiment of the invention cylinder prism chip assembly three-dimensional appearance view; Fig. 3 B is an embodiment of the invention cylinder prism chip assembly xsect optical principle synoptic diagram; Fig. 3 C is embodiment of the invention cylinder prism chip assembly profile and optical principle synoptic diagram.
Detection light source is utilized cylinder light beam 111, enters cylinder prism chip via incident cylinder 11, is reflection on the golden film 12 at the prismatic reflection face, via 15 outgoing of outgoing cylinder, forms outgoing cylinder light beam 112.The plane of incidence 11 of cylinder prism and exit facet 15 are symmetrical concentric circles cylinder, and reflecting surface 12 is a level crossing, the axis of incident and outgoing cylinder on level crossing, gold-plated film on the level crossing.Like this, incident cylinder 11, mirror surface are the light path system that golden film 12, outgoing cylinder 15 have just constituted surface plasma resonance.Cylinder light beam 111 can cover a bigger sensing range, does not need to rotate, and can cover different types of biological respinse, has improved detection efficiency and precision.In the present embodiment, the xsect of cylinder light beam 111 is referring to Figure 11 shows that rectangle.
The reflecting surface of cylinder prism chip is coated with golden film 12, adopts special process at plated film front-reflection face, produces equally spaced diffuse reflection isolation strip 14, and each detecting position 121 is separated in the diffuse reflection isolation strip, sets up detecting position independent of each other.Cylinder prism chip has 26 detecting positions in the present embodiment, and bag is by different probe on each detecting position, and a fluid injection can 26 kinds of biochemical reactions of parallel detection.
Fig. 4 and Fig. 5 are the structural representations of cylinder prism chip of the present invention and a kind of embodiment of stream pond incorporate SPR sensing chip assembly.
Fig. 4 is the exploded view of this cylinder prism chip and stream pond incorporate SPR sensing chip assembly.This assembly comprises: incorporate cylinder prism chip 1, silica gel stream pond 2, stream pond lid 3.On silica gel stream pond 2, one or more passage is arranged.Stream pond 2 covers on the detecting position 121 of integrated cylinder prism chip, and detected sample flows into from liquid injection hole 21, flows out from fluid hole 22.Detect the dressing probe combination on sample and the detecting position, instrument just can detect the biological respinse in the sample.The single current pond can be arranged to, i.e. passage, or multithread pond, the i.e. passage of one or more in stream pond 2.Use the single current pond, can detect the multiple biological respinse of a sample, when using the multithread pond, can detect the multiple biological respinse of a plurality of samples simultaneously, improved detection efficiency greatly.
Fig. 6 is the measuring principle figure of SPR chip assembly.As shown in the figure, a branch of cylinder light beam 111 enters through the plane of incidence of cylinder prism chip, reflection on the golden film 12 that reflecting surface plated, and some light transmission reflecting surface gold film 12 surface, react in conjunction with SPR takes place with the probe on the golden film 12, the folded light beam that has spr signal after the reaction is through the outgoing cylinder and be incident upon on the projection screen 4, bright dark fringe appears on the projection screen, each bright fringes is represented a detecting position, bright fringes comprises a complete SPR resonance spectrum, the resonance spectrum curve is also shown in Figure 6, and resonance spectrum is the distribution curve of the SPR resonance in the measurement range.By analyzing the peak 41 of resonance spectrum, obtain the SPR resonant angle, resonant angle is the angle of resonance spectrum peak correspondence.Referring to shown in Figure 7, be the measured drawing that obtains with SPR sensing chip assembly of the present invention, have 26 bright lines among the figure, represent 26 detecting positions, the length of bright line is represented the sensing range of cylinder prism, and detecting position is separated by concealed wire each other, and concealed wire is the detecting position isolation strip, make between the detecting position separately, do not interact.SPR among figure reaction occurs in the position, lower middle, each detecting position bag quilt be with a kind of probe, so form the blanking bar of a level.
Fig. 8, Fig. 9 are the structural representation of embodiment in of the present invention other two.
As shown in Figure 8, as the another kind of embodiment of cylinder prism chip of the present invention and stream pond incorporate SPR sensing chip assembly, this sensor device comprises cylinder prism chip 5, silica gel stream pond 2 and chip lid 3.Described cylinder prism chip is a chip that contains 52 detecting positions, and the quantity of detecting position can be expanded arbitrarily as required.
As shown in Figure 9, the third embodiment as cylinder prism chip of the present invention and stream pond incorporate SPR sensing chip assembly, this sensor device comprises cylinder prism chip 1, silica gel stream pond 6 and chip lid 3, and 6 streams independent of each other are contained in described silica gel stream pond 6.This chip assembly can detect 6 samples simultaneously.Equally, can as required silica gel be flowed the pond expands arbitrarily.The planar structure of stream is referring to shown in Figure 10 in the stream pond 6, and wherein sequence number 61～66 is respectively stream 1～6.But thereby 6 passages of parallel detection.
The whole device collection chip of SPR sensing chip assembly of the present invention, cylinder prism, reaction tank are single device, with high flux SPR detection, multichannel reaction channel, functions such as device Fast Installation are incorporated on the device, not only simplified clinical manipulation greatly, and reduced cost, for SPR equipment is walked out the laboratory, cleared away obstacle as conventional medical institutions detection means, SPR equipment has been played conclusive effect in clinical medical popularization.
Above-described specific embodiment is specific embodiments of the invention only, is not limited to the present invention, and is within the spirit and principles in the present invention all, any modification of being made, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (14)
1. a surface plasma resonant sensor chip assembly is characterized in that, comprising: incorporate cylinder prism chip, Liu Chi and Liu Chigai;
The two sides of described cylinder prism chip are symmetrical concentric circles cylinder, respectively as the plane of incidence and the exit facet that detect light; The upper surface of cylinder prism chip is for detecting the reflection of light face, and the axial line of the described plane of incidence and exit facet is on this reflecting surface of cylinder prism chip;
Described stream pond is pressed in the reflecting surface top of described integrated cylinder prism chip by described stream Chi Gai.
2. sensor chip assembly according to claim 1 is characterized in that, the reflecting surface of described cylinder prism chip is the plane, is coated with golden film on the reflecting surface.
3. sensor chip assembly according to claim 1 and 2 is characterized in that, the reflecting surface of the described cylinder prism chip equally spaced diffuse reflection array that distributes forms a plurality of detecting positions independent of each other.
4. sensor chip assembly according to claim 3 is characterized in that, described stream Chi Gai position directly over described detecting position has the hole.
5. sensor chip assembly according to claim 1 is characterized in that, described cylinder prism chip is injection molded by optical plastic.
6. sensor chip assembly according to claim 1 is characterized in that, the bottom surface of described cylinder prism chip is the plane.
7. sensor chip assembly according to claim 1 is characterized in that, the combination between described cylinder prism chip and the stream pond adopts the ultrasonic soldering mode.
8. sensor chip assembly according to claim 1 is characterized in that, the stream in described stream pond is single channel or hyperchannel.
9. sensor chip assembly according to claim 1 is characterized in that, described stream pond is a silica gel material.
10. a cylinder prism chip that is applied to the surface plasma resonant sensor chip assembly is characterized in that, described cylinder prism chip is integrated; The two sides of described cylinder prism chip are symmetrical concentric circles cylinder, respectively as the plane of incidence and the exit facet that detect light; The upper surface of cylinder prism chip is for detecting the reflection of light face, and the axial line of the described plane of incidence and exit facet is on this reflecting surface of cylinder prism chip.
11. cylinder prism chip according to claim 10 is characterized in that the reflecting surface of described cylinder prism chip is the plane, is coated with golden film on the reflecting surface.
12., it is characterized in that the reflecting surface of the described cylinder prism chip equally spaced diffuse reflection array that distributes forms a plurality of detecting positions independent of each other according to claim 10 or 11 described cylinder prism chips.
13. cylinder prism chip according to claim 10 is characterized in that, described cylinder prism chip is injection molded by optical plastic.
14. cylinder prism chip according to claim 10 is characterized in that the bottom surface of described cylinder prism chip is the plane.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010100342706A CN102128809B (en) | 2010-01-19 | 2010-01-19 | Surface plasma resonance sensor chip assembly and cylindrical prism chip |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010100342706A CN102128809B (en) | 2010-01-19 | 2010-01-19 | Surface plasma resonance sensor chip assembly and cylindrical prism chip |
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| CN102128809A true CN102128809A (en) | 2011-07-20 |
| CN102128809B CN102128809B (en) | 2013-01-02 |
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| CN2010100342706A Expired - Fee Related CN102128809B (en) | 2010-01-19 | 2010-01-19 | Surface plasma resonance sensor chip assembly and cylindrical prism chip |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104321638A (en) * | 2012-06-01 | 2015-01-28 | 日东电工株式会社 | SPR sensor cell and SPR sensor |
| CN107843577A (en) * | 2017-09-21 | 2018-03-27 | 丁利 | A kind of integrated glass prism component for surface plasmon resonance detecting system |
| CN107843558A (en) * | 2017-09-21 | 2018-03-27 | 丁利 | A kind of prism-type surface plasma resonance spectrometer angle modulated mechanism |
| CN110567919A (en) * | 2019-09-17 | 2019-12-13 | 华中科技大学 | Beam scanning type SPR sensor and use method thereof |
| CN114166755A (en) * | 2021-10-18 | 2022-03-11 | 北京英柏生物科技有限公司 | Flow path plate and surface plasma resonance detection device with same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1246686C (en) * | 2003-10-14 | 2006-03-22 | 清华大学 | High-sensitivity surface plasma resonance detector with multiple total reflection |
| CN101576491A (en) * | 2008-05-09 | 2009-11-11 | 南开大学 | Array surface plasma resonant sensor chip based on binary optical device |
| CN101556248B (en) * | 2009-05-18 | 2011-03-30 | 中国科学院长春应用化学研究所 | Method for detecting time resolution of surface plasma resonance spectroscopy |
-
2010
- 2010-01-19 CN CN2010100342706A patent/CN102128809B/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104321638A (en) * | 2012-06-01 | 2015-01-28 | 日东电工株式会社 | SPR sensor cell and SPR sensor |
| US9470631B2 (en) | 2012-06-01 | 2016-10-18 | Nitto Denko Corporation | SPR sensor cell and SPR sensor |
| CN107843577A (en) * | 2017-09-21 | 2018-03-27 | 丁利 | A kind of integrated glass prism component for surface plasmon resonance detecting system |
| CN107843558A (en) * | 2017-09-21 | 2018-03-27 | 丁利 | A kind of prism-type surface plasma resonance spectrometer angle modulated mechanism |
| CN110567919A (en) * | 2019-09-17 | 2019-12-13 | 华中科技大学 | Beam scanning type SPR sensor and use method thereof |
| CN114166755A (en) * | 2021-10-18 | 2022-03-11 | 北京英柏生物科技有限公司 | Flow path plate and surface plasma resonance detection device with same |
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| CN102128809B (en) | 2013-01-02 |
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