CN102125731A

CN102125731A - Fully-automatic photodynamic laser therapeutic system

Info

Publication number: CN102125731A
Application number: CN2011100653235A
Authority: CN
Inventors: 李彬清; 李纯
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-03-18
Filing date: 2011-03-18
Publication date: 2011-07-20

Abstract

The invention discloses photodynamic equipment for treating tumors and cell hyperactive proliferation diseases, which is modularly designed and consists of a host computer, a node laser system, an image acquisition and analysis system, a bus communication controller, a universal mechanical movement platform, an optical fiber system, an automatic spray medicine administration system and a sensor system. The function of the equipment is to perform in-vitro or interventional irradiation treatment on tumors together with a photosensitizer. Compared with the prior art, the equipment effectively combines an image processing technique, a laser technique and a photosensitizer biochemical reaction process, and therefore can conduct a treatment function and well isolate doctors and patients to prevent treatment cross infection.

Description

Full-automatic light power laser therapeutic system

Technical field

The present invention relates to a kind of benign tumor (cutaneous diseases: nevus flammeus, psoriasis, acne, day photosensitiveness keratinization, scleroderma etc. that is applied to; Ophthalmic diseases: the choroidal neovascularization that fundus macular degeneration and other reasons cause; Digestive system disease: Barrett esophagus, esophageal varicosis, colon telangiectasis etc.; Condyloma acuminatum etc.) and malignant tumor (skin and subcutaneous tissue malignant tumor: scale cancer, basal cell carcinoma, malignant melanoma, Kaposi sarcoma, Bowen disease, eczematoid carcinoma (Paget disease), metastatic carcinoma of skin etc. infectious disease:; Tumor of head and neck: carcinoma of tongue, lip cancer, laryngeal carcinoma, nasopharyngeal carcinoma, vocal cords and almond body tumor etc.; Tumor of bronchus; Digestive tract tumor: the esophageal carcinoma, gastric cancer, hepatocarcinoma, cancer of pancreas, cancerous stricture, tumor post-operation recurrence etc.; Gynecological tumor: carcinoma vulvae, cervical cancer; The cerebral tumor: treat in the art of glioma, metastatic encephaloma; Urinary system tumor: bladder tumor, carcinoma of prostate, carcinoma of penis etc.; Ophthalmology tumor: optic nerve blastoma, eye socket, bulbar conjunctiva malignant tumor etc.); and cellular abnormality enlivens the special-purpose medical apparatus and instruments system of target tissue diagnosis, the treatment in hypertrophy class disease treatment field; belong to biochemical technology, microelectric technique, computer software, automatization and control a multi-field bonded innovative technology, be used for the target cell of clinical experiment and treatment implementation process and organizational diagnosis, target tissue is demarcated and optical dynamic therapy.

Background technology

Tumor (Tumor) be body under various carcinogenic factor effects, some cells of local organization lose the normal regulation to its growth on gene level, cause its clonal abnormality hypertrophy and the neoplasm that forms.Generally tumor is divided into optimum and pernicious two big classes.All malignant tumor are generically and collectively referred to as cancer (cancer).Tumor is genopathy in itself.All-environment and hereditary carcinogenic factor causes the DNA infringement with collaborative or sequential mode, thereby activate proto-oncogene and (or) the deactivation tumor suppressor gene, add the apoptosis regulator gene and (or) change of DNA-repair gene, cause the unusual of expression then, target cell is transformed.The hypertrophy that is earlier clone's property by cell transformed more, through a very long multistage evolution process, one of them clones unconfined relatively amplification, pass through addition mutation, optionally form sub-clone (heterogeneousization) with different characteristics, thereby the ability (vicious transformation) that obtains infiltration and shift forms tumor.It no matter is optimum or malignant tumor, harm to human body all has: (1) is blocked and compressing: this point is similar with benign tumor, but the obstruction of malignant tumor compressing development rapidly, and degree is also high, can stop up esophagus as esophageal carcinoma cancerous protuberance, cause patient's dysphagia.(2) 26S Proteasome Structure and Function of destruction place organ: because hepatocyte is destroyed bile duct obstruction in the regulating liver-QI, can cause the general jaundice as hepatocarcinoma.(3) invasion and attack destroy adjacent organs: as the penetrable esophageal wall of the esophageal carcinoma, invade the trachea of esophagus front, form esophago-tracheal fistula; When swallowing, food falls in the trachea, and cause that the property swallowed pneumonia (4) is downright bad, hemorrhage, infect: malignant growth is rapid, cancerous tissue usually necroses because of blood supply insufficiency, if cancerous issue is invaded blood vessel, can cause bleeding, as nasopharyngeal cancer patient epistaxis (being epistaxis) is often arranged; Lung cancer patient usually merges pulmonary infection.(5) pain: because cancerous tissue compressing or infringement are neural, can cause the pain of corresponding site, all have an intense pain as advanced liver cancer, gastric cancer.In addition, after the cancer secondary infection, also can cause pain.(6) heating: the bacterial infection of the metabolite of tumor tissues, the catabolite of slough and secondary can cause the cancer patient heating, low heat in generally showing as.(7) cachexia: cachexia also has person for " dyscrasia ", is meant that body is seriously become thin, the state of unable, anemia and whole body depletion, and it is the major reason of cancer patient death.No matter be benign tumor or malignant tumor, they all belong to cellular abnormality and enliven hypertrophy class disease

In recent years, photodynamic therapy (PDT) is applied to tumor and cellular abnormality enlivens the relevant various diseases of hypertrophy class, has obtained satisfied curative effect.Discover that photodynamic therapy can inducing antitumor and virus immunity, removes clinical simultaneously and the subclinical infection kitchen range, to enliven hypertrophy class treatment of diseases present situation significant for improving tumor and cellular abnormality.At present, domestic medical circle adopts traditional remedies about tumor-infiltrated histiocytic treatment more, be schemes such as chemotherapy, radiotherapy, thermotherapy, laser burn, freezing, excision, Chinese and western drugs partner treatment, ubiquity patient treatment misery is bigger, problems such as side effect is obvious, and treatment back relapse rate is higher, treatment cycle is long.The present invention fills up domestic industry blank, the scheme that automatization's control, light bootstrap technique and computer software image analysis technology by the advanced person and medicine combine, overcome most of problem of traditional treatment, select for oncotherapy provides new photodynamic therapy, the online record function of the video data that equipment provides is set up for medical archive fast way is provided.

Summary of the invention

1, the comprehensive laser irradiation of monobasic multipoint mode;

2, the manual double mode focusing of laser system;

3, special-purpose locked mechanism, scram button, leakproof photosystem, multiple safeties avoids high power laser light equipment to cause accidental damage;

4, calculate, adjust laser irradiation dosage and irradiation duration automatically according to affected part data information;

5, adopt the difference comparison algorithm, regulate laser irradiation power and pulse frequency automatically, the change curve of adaptive medicine in tissue;

6, each treatment progress of voice suggestion improves the equipment pre-alerting ability;

7, mobile alarm is followed the trail of in the patient treatment;

8, therapeutic process video data all time record, random time Duan Junke gathers picture, enriches clinical foundation for the foundation of pathological study information bank provides;

9, doctors and patients' high degree of isolation formula design, auto spraying formula drug-supplying system avoids operation to infect, and avoids the pleasing to the eye threat of laser, avoids expensive medicament waste;

10, doctors and patients' information adopts data base's formula management mode, and capacity is huge;

11, bus topolopy design can be carried out the increase and decrease of point of care position fast according to patient's amount of flow needs;

12, modularity upper and lower computer design, maintenance difficulties is little.

Description of drawings

As figure, accompanying drawing is system frame structure figure.The present invention is further described below in conjunction with accompanying drawing.

As shown in the figure, among the figure, the 1st, host computer management system, the 2nd, bus communication controller, the 3rd, The Cloud Terrace system, the 4,5, the 6th, camera chain, the 7,8, the 9th, node laser instrument, the 10,12, the 14th, fibre system, the 11,13, the 15th, auto spraying formula drug-supplying system.

The specific embodiment

In the drawings, 1 host computer management system, 2 bus communication controllers are connected by some communications and feed cable between the 3 The Cloud Terrace systems; 4,5,6 camera chains are carried in 3 The Cloud Terrace systems, are connected by some videos, communication and feed cable between them; 7, connect by some communications and feed cable between 8,9 node laser instrument and the 2 bus communication controllers; 7 node laser instrument are connected with 10 fibre systems, 11 auto spraying formula drug-supplying systems; 8 node laser instrument are connected with 12 fibre systems, 13 auto spraying formula drug-supplying systems; 9 node laser instrument are connected with 14 fibre systems, 15 auto spraying formula drug-supplying systems.After connecting main power, whole system will carry out initialization and whether each module connection of self check is normal, treats that doctors and patients are in place, and when entering the treatment step, main frame can carry out voice suggestion according to each step, and the operator operates according to prompting and gets final product.

Claims

1. an equipment is used for benign tumor (cutaneous diseases: nevus flammeus, psoriasis, acne, day photosensitiveness keratinization, scleroderma etc.; Ophthalmic diseases: the choroidal neovascularization that fundus macular degeneration and other reasons cause; Digestive system disease: Barrett esophagus, esophageal varicosis, colon telangiectasis etc.; Condyloma acuminatum) and malignant tumor (skin and subcutaneous tissue malignant tumor: scale cancer, basal cell carcinoma, malignant melanoma, Kaposi sarcoma, Bowen disease, eczematoid carcinoma (Paget disease), metastatic carcinoma of skin etc. infectious disease:; Tumor of head and neck: carcinoma of tongue, lip cancer, laryngeal carcinoma, nasopharyngeal carcinoma, vocal cords and almond body tumor etc.; Tumor of bronchus; Digestive tract tumor: the esophageal carcinoma, gastric cancer, hepatocarcinoma, cancer of pancreas, cancerous stricture, tumor post-operation recurrence etc.; Gynecological tumor: carcinoma vulvae, cervical cancer; The cerebral tumor: treat in the art of glioma, metastatic encephaloma; Urinary system tumor: bladder tumor, carcinoma of prostate, carcinoma of penis etc.; Ophthalmology tumor: optic nerve blastoma, eye socket, bulbar conjunctiva malignant tumor etc.) cellular abnormality enlivens the optical dynamic therapy of hypertrophy class disease.Equipment adopts modularized design, is made of host computer management system, node Optical Maser System, image acquisition and analytical system, bus communication controller, universal mechanical movement platform, fibre system, auto spraying formula drug-supplying system and sensing system.It is characterized in that: the host computer management system embodies the master control function, implementation information collection, output and to the control of each module; The node Optical Maser System can carry out automatically, the operation of manual switchover formula; Possess picture system, operator keep apart by picture system and Laser emission end, and human body does not contact laser, can not pass through the picture system operating equipment in the direct visual range of laser facula; Picture system can be recorded the treatment video; Equipment treatment overall process possesses voice suggestion, warning function; Auto spraying formula drug-supplying system and fibre system are worked in coordination, and receive the PC control instruction by communication cable, and these two systems are all changeable operates for manual mode.

2. equipment according to claim 1 is characterized in that: adopt light principle of dynamics treatment benign tumor (cutaneous diseases: nevus flammeus, psoriasis, acne, day photosensitiveness keratinization, scleroderma etc.; Ophthalmic diseases: the choroidal neovascularization that fundus macular degeneration and other reasons cause; Digestive system disease: Barrett esophagus, esophageal varicosis, colon telangiectasis etc.; Condyloma acuminatum) and malignant tumor (skin and subcutaneous tissue malignant tumor: scale cancer, basal cell carcinoma, malignant melanoma, Kaposi sarcoma, Bowen disease, eczematoid carcinoma (Paget disease), metastatic carcinoma of skin etc. infectious disease:; Tumor of head and neck: carcinoma of tongue, lip cancer, laryngeal carcinoma, nasopharyngeal carcinoma, vocal cords and almond body tumor etc.; Tumor of bronchus; Digestive tract tumor: the esophageal carcinoma, gastric cancer, hepatocarcinoma, cancer of pancreas, cancerous stricture, tumor post-operation recurrence etc.; Gynecological tumor: carcinoma vulvae, cervical cancer; The cerebral tumor: treat in the art of glioma, metastatic encephaloma; Urinary system tumor: bladder tumor, carcinoma of prostate, carcinoma of penis etc.; Ophthalmology tumor: optic nerve blastoma, eye socket, bulbar conjunctiva malignant tumor etc.).

3. equipment according to claim 1, it is characterized in that: the host computer management system is carried out center control to entire equipment, the input and output of full detail, the control function of each module realize on the host computer management system that all host computer management system and node Optical Maser System are isolated.

4. equipment according to claim 1, it is characterized in that: the node Optical Maser System can carry out automatically, the operation of manual switchover formula, Optical Maser System will be set spot size, movement locus and output pulses change curve under the automatic mode, carry out work according to existing plan; Under the manual mode, the spot size of laser instrument, movement locus and output pulses change curve all can artificially be controlled.

5. equipment according to claim 1 is characterized in that: possess picture system, operator keep apart by picture system and Laser emission end, carry out operated from a distance, away from the direct contact area of laser facula.

6. equipment according to claim 1, it is characterized in that: picture system has recording function, can carry out whole process to therapeutic process and record and be made into the warehouse-in archives material.

7. equipment according to claim 1 is characterized in that: equipment treatment overall process all can obtain the phonetic order prompting of main frame, and the alarm lamp flash caution is arranged.

8. equipment according to claim 1 is characterized in that: possess the mechanism that auto spraying formula drug-supplying system and fibre system cooperate, the host computer management system is controlled the operation workflow of auto spraying formula drug-supplying system and fibre system by communication cable.These two systems can be switched to manual mode and carry out manually-operated.