CN104984479A - System and method for inhibiting metamorphic cells by using electron collision - Google Patents
System and method for inhibiting metamorphic cells by using electron collision Download PDFInfo
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- CN104984479A CN104984479A CN201510247391.1A CN201510247391A CN104984479A CN 104984479 A CN104984479 A CN 104984479A CN 201510247391 A CN201510247391 A CN 201510247391A CN 104984479 A CN104984479 A CN 104984479A
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Abstract
The invention discloses a system and method for inhibiting metamorphic cells by using electron collision. A metamorphic cell inhibiting system collision arrow comprises a voltage-regulating and rectifying circuit, a frequency regulating and controlling circuit, a waveform transformation circuit, and a multistage amplification circuit. The voltage-regulating and rectifying circuit is an oscillating circuit. Current in the voltage-regulating and rectifying circuit is converted into low-voltage unidirectional pulse current. The frequency regulating and controlling circuit converts intermediate-frequency power into a low-frequency pulse electron flow. The waveform transformation circuit converts negative unidirectional pulse current into unidirectional square wave current. The multistage amplification circuit amplifies voltage and discharging is carried out by a nichrome electrode needle. A high-energy displacement electron field is emitted by an emitting disc and is conducted to the whole body of a patient via air, hydrogen, and water molecules, and finally enters various systems and organs of the patient. An electric field with a specific intensity and frequency is designed in order to inhibit the formation of a spindle of the uncontrollable metamorphic cells in a mitosis process, thereby promoting the death of the metamorphic cells in the mitosis process. Normal cells are not influenced in the electric field.
Description
Technical field
The present invention relates to the technical field that specific cell suppresses, particularly relate to the head-on collision of a kind of electronics to the suppression system of specific cell and suppressing method.
Background technology
From the 80's of 20th century, electric pulse is widely used at biological and medical field, as killing microorganisms, cell fusion, gene transfection, treatment of cancer etc.In treatment of cancer, a kind of method with fastest developing speed is electrochemotherapy.Its cardinal principle is that electric field can make cell membrane that instantaneous perforation occurs to the effect of cell, thus by cancer therapy drug as bleomycin is delivered in cell.Although electrochemotherapy decreases the drug dose of patient to a great extent, fundamentally do not break away from the toxic and side effects of medicine to patient itself.The development of electroporation provides probability then for treatment of cancer without medicine.Impulse waveform, pulsewidth, the isoparametric adjustable extent of electric field intensity of electric pulse have been widened in electrotechniical development, and electric field intensity can reach hundreds of kilovolt/cm, and pulsewidth shortens to nanosecond by traditional microsecond, Millisecond.The response of cell to electric pulse depends on that electric pulse field parameter is as electric field intensity, pulse width etc.When electric field intensity is 0.1 ~ 1 kV, when pulsewidth is 100 μ s, electric pulse can make cell generation electroporation, and namely under electric pulse effect, cell membrane produces temporary micropore, permeability increases, and is easy in cell, transmit medicine, genetic material, protein and other macromole.These micropores can automatically be closed again after electric pulse effect, and therefore electroporation is a reversible process.When electric field intensity be MV/cm, pulsewidth reach 10 ns level time, electric field then can walk around cell membrane affects intracellular signal transduction and born of the same parents' inner structure, and this process is called endocellular electricity process.At present, electroporation is applied to electrochemotherapy, and in born of the same parents, electric treatment is then for regulating the structure and fuction of cell interior to provide possibility.Between both, so whether also there is other bioelectrical effect? answer is affirmative.
Along with electrotechniical development, researcheres can apply higher electric field intensity and narrower pulsewidth to cell.Successively occurred that electric field intensity is 10 ~ 100 kV/cm, pulsewidth is less than nanosecond pulsed electric field, ultra-short wave pulse electric field, the submicrosecond high intense pulsed electric field of 1 μ s.Compared with traditional electroporation, these electric pulse energy inducing cells produce diverse bioelectrical effect, i.e. endocellular electricity process.According to the description of Buescher etc., born of the same parents' inner cell organ film, nuclear membrane can be made to occur to bore a hole and the electric pulse that membrane permeability is increased need possess following feature: the charging interval being 1. less than born of the same parents' inner cell organ film pulse rise time; 2. pulsewidth is greater than the charging interval of organelle film and is less than charging interval of cell membrane; 3. electric field intensity can make the charging complete in pulse applying process of organelle film.This process is called as endocellular electricity process.
As previously mentioned, during electroporation, cell is counted as a circuit equivalent model, and cell membrane is electric capacity, and Cytoplasm is conductance.And in the electric pulse induced endocellular electricity process of more short pulse duration, intracellular membrane structure and organelle film and nuclear membrane just must take in.Wherein cell membrane and organelle film are electric capacity, the Cytoplasm that can lead and nucleus protoplasm are conductance, endocellular electricity process has the feature making born of the same parents' inner cell organ generation electroporation, therefore can be used for a series of physiological effect in inducing cell as the calcium ion release in cellular calcium storehouse, gene expression variation, DNA and core conformational change etc.
Based on above-mentioned theory with put into practice conclusion, utilize electric field be used for suppress the division of specific cell, thus suppress the diffusion of cancer just to become possibility.
Summary of the invention
For the weak point existed in above-mentioned technology, the invention provides the head-on collision of a kind of practical, respond well electronics to the suppression system of specific cell and suppressing method.
The suppression system of a kind of electronics head-on collision of the present invention to specific cell, is made up of the electric field formed in head-on collision arrow;
Cell comprises cell membrane, Cytoplasm and nucleus, in fission process, need a kind of specific proteins, these protein free-floating in Cytoplasm, these special protein are the parts of carrying a large amount of electric charge in human body, prophase of cell division, nuclear division, Chromosomal arrangement is in cell, those protein materials are by three-dimensional sequence, end points is connected, form chain, hereditary material will be connected further, then these hereditary materials are pulled to two cells from a cell, Here it is, and a cancer cell division generates the process of two, two become four, then the tumor increased without limitation,
Cancerous cell is placed in the cavity of head-on collision arrow, transmitting is coiled downward electron emission and is formed electric field, if electric field is uniform, active force round about can cause charged molecule to be parallel to the motion of direction of an electric field discontinuously, and when electric field frequency is enough high, these molecular motions can be slowed down, for dipole, because the charged cathode of its molecule is separated with anode, it just can match with direction of an electric field, and holding position is constant; Comprise all charged molecules of dipole, then all can move to the direction that electric field density is high in uneven AC field; In common Unseparated Cell, electric field is uniform substantially, and therefore, charged molecule and the clean electric field force suffered by dipole produce motion hardly; And for the specific cell of fast division, in mitosis telophase, because a point dehiscence furrow splits two daughter cells, forming narrow Cytoplasm connects, and near connecting portion, electric field is uneven, polar molecule just can bradykinesia;
The effect of spindle in mitosis is evenly distributed in two daughter cells by the daughter chromosome after copying, in this process, small polar molecule-tubulin polymerization is in strip subunit and extends in the hereditary material of cell central array, and is combined with chromosome; Do not carrying out in mitotic cell, although electric field is uniform, but microtubule subunit can be arranged in parallel according to direction of an electric field, the electric field force acted on cell subunit stops them to arrive the orientation realized needed for polymerization, therefore abnormal long-time stopping can occurring mitosis; Tubulin causes polymerization obstacle that microtubule formation will be caused to be obstructed because being subject to enough strong electric field force; All can there is spindle and form obstacle in all cells, spend the cell of mitosis metaphase, its cell membrane splits starting to hang, and two daughter chromosome are pulled to cell the two poles of the earth, in the fission process of mitosis final step kytoplasm, divide dehiscence furrow finally to be formed, and two cells are finally separated completely; And this narrow cell membrane junction just produces one and the distinct hourglass-like inhomogeneous field of Unseparated Cell, in cytokinesis process, the position that electric field density is the highest is positioned at the center of narrow positions, in the case, the field intensity concentrated causes all electric charges and dipole are subject to the effect of unidirectional electrical field force and are moved to a point dehiscence furrow; In cell, polar molecule and dipole, move towards a point dehiscence furrow because being subject to the impact of enough strong electric field force, and this will cause the disorder of intracellular structure, produce cytoclasis effect, and then specific cell division is suppressed;
This specific cell suppresses system head-on collision arrow to comprise operation screen, voltage regulating rectification circuit, frequency control circuit, waveform translation circuit, electric current commutating circuit and multistage amplifier circuit, voltage regulating rectification circuit is oscillating circuit, low pressure unidirectional pulse electric current is transformed into through alternating current in 220V alternating current access voltage regulating rectification circuit, medium frequency electric is transformed into low frequency pulse current by frequency control circuit, by waveform translation circuit, unidirectional pulse electric current is converted to unidirectional square wave current again, last multistage amplifier circuit by Current amplifier, and goes out to be delivered to entire patient from transmitting hair updo; 12V voltage always through 8 grades of amplifications, is boosted to 50000-80000V by multistage amplifier circuit; Operation screen is electrically connected with each circuit respectively, and controls each circuit, and described multistage amplifier circuit is contained in the multistage enlarged cavity on electronics head-on collision arrow side;
This specific cell suppresses the parameters index in system operation as follows:
Frequency is one of important parameter affecting waveform electric field therapeutic effect, be less than the DeGrain of 1kHz electric field, though there is stimulation, but will soon disappear, high-frequency electric field more than MHz level can produce heat effect, large to patient body side effect, this specific cell suppresses the frequency continuously adjustabe of system, and shake frequently frequency-tuning range covers 0.9Hz-520.2Hz;
Direction of an electric field affects the effect of electric field to cell, when direction of an electric field is consistent with cell division direction of principal axis, lethality is maximum, and single one direction treatment can not bring about tangible results, this system takes the electric field turning effort in turn of multi-direction number, and the angle between multi-direction electric field is 45 ~ 90 °;
The ambient temperature of this system is 5 DEG C-40 DEG C, relative humidity is less than or equal to 80%, system maximum output voltage is 24V, the peak value of output voltage is 28V, and rated load impedance is 800, and the individual pulse maximum output energy of electrode is 0.45mJ, time set scope is 60s-360s, after arriving setup times, automatically cut off treatment and export, and sound, light prompting;
The battery lead plate of this system is nichrome electrode needle, wherein nickel element mass fraction is 55%-60%, chromium element mass fraction is 20%-30%, battery lead plate profile is strip flat board or bent plate, energising wiring hole is had at the two ends of plate electrode plate, the battery lead plate of bent plate comprises two side plates and a top board, two side plates and top board are integrated the ∏ shape bending plate of formation, at the base plate respectively having an outside bending below of biside plate, its longitudinal profile is handle-shaped, nichrome electrode needle is stretched out from battery lead plate top board, the diameter of alloy electrode pin is 3-5mm, spacing between adjacent alloys electrode needle is 20-40mm.
Wherein, voltage regulating rectification circuit is made up of automatic coupling voltage regulator, frequency control circuit is made up of frequency modulator, the outfan of automatic coupling voltage regulator is electrically connected with the input of frequency modulator, from outfan, electric current is delivered to waveform translation circuit after frequency modulator regulation and control frequency, through the compound action of multidirectional circuit and amplifying circuit, head-on collision electronics electric field is transmitted into entire patient from battery lead plate.
Wherein, this suppression system also comprises power circuit; Described power circuit comprises 12V rechargeable battery and booster circuit, and described 12V rechargeable battery is electrically connected with described waveform translation circuit and multistage amplifier circuit.
Wherein, the direction rotation per second of described electronics head-on collision electric field 1 time, direction of rotation is counterclockwise.
The invention discloses the suppressing method of a kind of electronics head-on collision to specific cell, concrete practice is in the work process of head-on collision arrow;
First, cancerous cell is placed in the cavity of head-on collision arrow, transmitting is coiled downward electron emission and is formed electric field, if electric field is uniform, active force round about can cause charged molecule to be parallel to the motion of direction of an electric field discontinuously, when electric field frequency is enough high, these molecular motions can be slowed down, for dipole, because the charged cathode of its molecule is separated with anode, it just can match with direction of an electric field, and holding position is constant; Comprise all charged molecules of dipole, then all can move to the direction that electric field density is high in uneven AC field; In common Unseparated Cell, electric field is uniform substantially, and therefore, charged molecule and the clean electric field force suffered by dipole produce motion hardly; And for the specific cell of fast division, in mitosis telophase, because a point dehiscence furrow splits two daughter cells, forming narrow Cytoplasm connects, and near connecting portion, electric field is uneven, polar molecule just can bradykinesia;
Cell comprises cell membrane, Cytoplasm and nucleus, in fission process, need a kind of specific proteins, these protein free-floating in Cytoplasm, these special protein are the parts of carrying a large amount of electric charge in human body, prophase of cell division, nuclear division, Chromosomal arrangement is in cell, those protein materials are by three-dimensional sequence, end points is connected, form chain, hereditary material will be connected further, then these hereditary materials are pulled to two cells from a cell, Here it is, and a cancer cell division generates the process of two, two become four, then the tumor increased without limitation,
The effect of spindle in mitosis of carrying this kind of protein is evenly distributed in two daughter cells by the daughter chromosome after copying, in this process, small polar molecule-tubulin polymerization is in strip subunit and extends in the hereditary material of cell central array, and is combined with chromosome; Do not carrying out in mitotic cell, although electric field is uniform, but microtubule subunit can be arranged in parallel according to direction of an electric field, the electric field force acted on cell subunit stops them to arrive the orientation realized needed for polymerization, therefore abnormal long-time stopping can occurring mitosis; Tubulin causes polymerization obstacle that microtubule formation will be caused to be obstructed because being subject to enough strong electric field force; All can there is spindle and form obstacle in all cells, spend the cell of mitosis metaphase, its cell membrane splits starting to hang, and two daughter chromosome are pulled to cell the two poles of the earth, in the fission process of mitosis final step kytoplasm, divide dehiscence furrow finally to be formed, and two cells are finally separated completely; And this narrow cell membrane junction just produces one and the distinct hourglass-like inhomogeneous field of Unseparated Cell, in cytokinesis process, the position that electric field density is the highest is positioned at the center of narrow positions, in the case, the field intensity concentrated causes all electric charges and dipole are subject to the effect of unidirectional electrical field force and are moved to a point dehiscence furrow; In cell, polar molecule and dipole, move towards a point dehiscence furrow because being subject to the impact of enough strong electric field force, and this will cause the disorder of intracellular structure, produce cytoclasis effect, and then specific cell division is suppressed;
The circuit adjustment mode of this specific cell suppressing method is, low pressure unidirectional pulse electric current is transformed into through alternating current in 220V alternating current access head-on collision arrow voltage regulating rectification circuit, medium frequency electric is transformed into low frequency pulse current by frequency control circuit, by waveform translation circuit, unidirectional pulse electric current is converted to unidirectional square wave current again, last multistage amplifier circuit by Current amplifier, and goes out to be delivered to entire patient from transmitting hair updo;
Parameters index in this specific cell suppressing method head-on collision arrow running is as follows:
Frequency is one of important parameter affecting waveform electric field therapeutic effect, be less than the DeGrain of 1kHz electric field, though there is stimulation, but will soon disappear, high-frequency electric field more than MHz level can produce heat effect, large to patient body side effect, this specific cell suppresses the frequency continuously adjustabe of system, and shake frequently frequency-tuning range covers 0.9Hz-520.2Hz;
Direction of an electric field affects the effect of electric field to cell, when direction of an electric field is consistent with cell division direction of principal axis, lethality is maximum, and single one direction treatment can not bring about tangible results, this system takes the electric field turning effort in turn of multi-direction number, and the angle between multi-direction electric field is 45 ~ 90 °;
The ambient temperature of operation the method is 5 DEG C-40 DEG C, relative humidity is less than or equal to 80%, head-on collision arrow maximum output voltage is 24V, the peak value of output voltage is 28V, and rated load impedance is 800, and the individual pulse maximum output energy of electrode is 0.45mJ, time set scope is 60s-360s, after arriving setup times, automatically cut off treatment and export, and sound, light prompting;
The battery lead plate of this head-on collision arrow is nichrome battery lead plate, wherein nickel element mass fraction is 55%-60%, chromium element mass fraction is 20%-30%, battery lead plate profile is strip flat board or bent plate, energising wiring hole is had at the two ends of plate electrode plate, the nickel chromium triangle battery lead plate of bent plate comprises two side plates and a top board, two side plates and top board are integrated the ∏ shape bending plate of formation, at the base plate respectively having an outside bending below of biside plate, its longitudinal profile is handle-shaped, base plate has electric wiring hole, steel mesh is provided with in the cavity of battery lead plate, steel mesh is weaved into by nichrome wire, the diameter of alloy wire is 3-5mm, spacing between adjacent alloys line is 20-40mm, the overall dimensions of steel mesh and the size of battery lead plate adapt.
Wherein, circuit in voltage regulating rectifier process is provided by automatic coupling voltage regulator, circuit in frequency regulation process is made up of frequency modulator, the outfan of automatic coupling voltage regulator is electrically connected with the input of frequency modulator, from outfan, electric current is delivered to waveform translation circuit after frequency modulator regulation and control frequency, through the compound action of multidirectional circuit and amplifying circuit, head-on collision electronics electric field is transmitted into entire patient from battery lead plate.
Wherein, this suppressing method also needs power circuit support; Described power circuit comprises 12V rechargeable battery and booster circuit, and described 12V rechargeable battery is electrically connected with described waveform translation circuit and multistage amplifier circuit.
Wherein, the direction rotation per second of described electronics head-on collision electric field 1 time, direction of rotation is counterclockwise.
The invention has the beneficial effects as follows:
Compared with prior art, the electric field of a kind of certain strength of design and frequency is passed through in electronics head-on collision of the present invention to the suppression system of specific cell, thus the specific cell suppressing split speed fast is in the formation carrying out spindle in mitosis process, thus the apoptosis of induced fission phase cell.This system is that the treatment of cancer provides a kind of new thinking.Cancer cell-apoptosis in the electric field, but normal structure can not be influenced, while killing and wounding specific cell, so just ensure that the function of normal structure.
This suppressing method belongs to high-energy physics therapy, completely painless, also can not produce negative interaction, the security problem of quality of life that solves patient well in cancer treatment procedure.
Accompanying drawing explanation
Fig. 1 is the structure chart of the electronics head-on collision arrow used in native system;
Fig. 2 is the circuit connection diagram in the suppression system of electronics head-on collision specific cell;
Fig. 3 is specific cell without the normal condition schematic diagram in electric field environment;
Fig. 4 mitosis initial stage schematic diagram that is specific cell in without electric field environment;
Fig. 5 schematic diagram mitosis metaphase that is specific cell in without electric field environment;
Fig. 6 mitosis telophase that is specific cell in without electric field environment schematic diagram;
Fig. 7 is specific cell mitosis initial stage schematic diagram under native system running status;
Fig. 8 be specific cell under native system running status mitosis metaphase schematic diagram;
Fig. 9 is the amplifying circuit schematic diagram in the suppression system of electronics head-on collision specific cell;
Figure 10 is the 5th embodiment Liao sedate 2010 pathologic finding reports;
Figure 11 is the 5th embodiment Liao sedate 2011 CT examination reports;
Figure 12 is the CT diagnosis report list that the 6th embodiment prunus mume (sieb.) sieb.et zucc. is expanded 2010;
Figure 13 is the CT diagnosis report list after the 6th embodiment prunus mume (sieb.) sieb.et zucc. expands therapeutic trial in 2011;
Figure 14 is that the 6th embodiment prunus mume (sieb.) sieb.et zucc. expands the blood sample report 1 after the treatment of electronics head-on collision arrow in 2011;
Figure 15 is that the 6th embodiment prunus mume (sieb.) sieb.et zucc. expands the blood sample report 2 after the treatment of electronics head-on collision arrow in 2011.
Mitotic specific cell is carried out at apoptosis telophase of cell division in suppression system of the present invention.
Main element symbol description is as follows:
10, transmitting dish 11, operation screen
12, multistage enlarged cavity.
Detailed description of the invention
In order to more clearly state the present invention, below in conjunction with accompanying drawing, the present invention is further described.
First embodiment
The suppression system of a kind of electronics head-on collision of the present invention to specific cell, as shown in Figure 1, is made up of the electric field formed in head-on collision arrow;
Refer to Fig. 3-6, cell comprises cell membrane, Cytoplasm and nucleus, in fission process, need a kind of specific proteins, these protein free-floating in Cytoplasm, these special protein are the parts of carrying a large amount of electric charge in human body, prophase of cell division, nuclear division, Chromosomal arrangement is in cell, those protein materials are by three-dimensional sequence, end points is connected, form chain, hereditary material will be connected further, then these hereditary materials are pulled to two cells from a cell, Here it is, and a cancer cell division generates the process of two, two become four, then the tumor increased without limitation,
Consult Fig. 7-8 further, cancerous cell is placed in the cavity of head-on collision arrow, transmitting dish 10 downwards electron emission forms electric field, if electric field is uniform, active force round about can cause charged molecule to be parallel to the motion of direction of an electric field discontinuously, when electric field frequency is enough high, these molecular motions can be slowed down, for dipole, because the charged cathode of its molecule is separated with anode, it just can match with direction of an electric field, and the constant i.e. state shown in Fig. 7 in holding position; Comprise all charged molecules of dipole, then all can move to the direction that electric field density is high in uneven AC field; In common Unseparated Cell, electric field is uniform substantially, and therefore, charged molecule and the clean electric field force suffered by dipole produce state as shown in Figure 8 of moving hardly; And for the specific cell divided fast, in mitosis telophase, because a point dehiscence furrow splits two daughter cells, form narrow Cytoplasm to connect, near connecting portion, electric field is uneven, and polar molecule just can bradykinesia, cannot split into complete cell just apoptosis at all;
The effect of spindle in mitosis is evenly distributed in two daughter cells by the daughter chromosome after copying, in this process, small polar molecule-tubulin polymerization is in strip subunit and extends in the hereditary material of cell central array, and is combined with chromosome; Do not carrying out in mitotic cell, although electric field is uniform, but microtubule subunit can be arranged in parallel according to direction of an electric field, the electric field force acted on cell subunit stops them to arrive the orientation realized needed for polymerization, therefore abnormal long-time stopping can occurring mitosis; Tubulin causes polymerization obstacle that microtubule formation will be caused to be obstructed because being subject to enough strong electric field force; All can there is spindle and form obstacle in all cells, spend the cell of mitosis metaphase, its cell membrane splits starting to hang, and two daughter chromosome are pulled to cell the two poles of the earth, in the fission process of mitosis final step kytoplasm, divide dehiscence furrow finally to be formed, and two cells are finally separated completely; And this narrow cell membrane junction just produces one and the distinct hourglass-like inhomogeneous field of Unseparated Cell, in cytokinesis process, the position that electric field density is the highest is positioned at the center of narrow positions, in the case, the field intensity concentrated causes all electric charges and dipole are subject to the effect of unidirectional electrical field force and are moved to a point dehiscence furrow; In cell, polar molecule and dipole, move towards a point dehiscence furrow because being subject to the impact of enough strong electric field force.This will cause the disorder of intracellular structure, produce cytoclasis effect, and then specific cell division is suppressed;
Please consult Fig. 1 further, Fig. 2 and Fig. 9, this specific cell suppresses system head-on collision arrow to comprise operation screen 11, voltage regulating rectification circuit, frequency control circuit, waveform translation circuit, electric current commutating circuit and multistage amplifier circuit, voltage regulating rectification circuit is oscillating circuit, low pressure unidirectional pulse electric current is transformed into through alternating current in 220V alternating current access voltage regulating rectification circuit, medium frequency electric is transformed into low frequency pulse current by frequency control circuit, by waveform translation circuit, unidirectional pulse electric current is converted to unidirectional square wave current again, last multistage amplifier circuit is by Current amplifier, and send from transmitting dish 10 and be delivered to entire patient, 12V voltage always through 8 grades of amplifications, is boosted to 50000-80000V by multistage amplifier circuit, operation screen 11 is electrically connected with each circuit respectively, and controls each circuit, and described multistage amplifier circuit is contained in the multistage enlarged cavity 12 on electronics head-on collision arrow side,
This specific cell suppresses the parameters index in system operation as follows:
Frequency is one of important parameter affecting waveform electric field therapeutic effect, be less than the DeGrain of 1kHz electric field, though there is stimulation, but will soon disappear, high-frequency electric field more than MHz level can produce heat effect, large to patient body side effect, this specific cell suppresses the frequency continuously adjustabe of system, and shake frequently frequency-tuning range covers 0.9Hz-520.2Hz;
Direction of an electric field affects the effect of electric field to cell, when direction of an electric field is consistent with cell division direction of principal axis, lethality is maximum, and single one direction treatment can not bring about tangible results, this system takes the electric field turning effort in turn of multi-direction number, and the angle between multi-direction electric field is 45 ~ 90 °;
The ambient temperature of this system is 5 DEG C-40 DEG C, relative humidity is less than or equal to 80%, system maximum output voltage is 24V, the peak value of output voltage is 28V, and rated load impedance is 800, and the individual pulse maximum output energy of electrode is 0.45mJ, time set scope is 60s-360s, after arriving setup times, automatically cut off treatment and export, and sound, light prompting;
The battery lead plate of this system is nichrome electrode needle, wherein nickel element mass fraction is 55%-60%, chromium element mass fraction is 20%-30%, battery lead plate profile is strip flat board or bent plate, energising wiring hole is had at the two ends of plate electrode plate, the battery lead plate of bent plate comprises two side plates and a top board, two side plates and top board are integrated the ∏ shape bending plate of formation, at the base plate respectively having an outside bending below of biside plate, its longitudinal profile is handle-shaped, nichrome electrode needle is stretched out from battery lead plate top board, the diameter of alloy electrode pin is 3-5mm, spacing between adjacent alloys electrode needle is 20-40mm.
In the present embodiment, voltage regulating rectification circuit is made up of automatic coupling voltage regulator, frequency control circuit is made up of frequency modulator, the outfan of automatic coupling voltage regulator is electrically connected with the input of frequency modulator, from outfan, electric current is delivered to waveform translation circuit after frequency modulator regulation and control frequency, through the compound action of multidirectional circuit and amplifying circuit, head-on collision electronics electric field is transmitted into entire patient from battery lead plate.
In the present embodiment, this suppression system also comprises power circuit; Described power circuit comprises 12V rechargeable battery and booster circuit, and described 12V rechargeable battery is electrically connected with described waveform translation circuit and multistage amplifier circuit.
In the present embodiment, the direction rotation per second of described electronics head-on collision electric field 1 time, direction of rotation is counterclockwise.
Second embodiment
For the test of GBM disease patient
Patient is GBM recurrence, and they once accepted operation, the radiotherapy of high strength and First-line chemotherapy, and then they have failed, and tumor still recurs.
First group accepts second-line chemotherapy, and contrast does not meet subject patient completely, and expection can extend one times of survival life-span;
Second group, only accept the treatment of oncotherapy electric field, two combination radiotherapy group are the same with oncotherapy electric field treatment group life expectancy, but the matched group importantly accepting electronics head-on collision arrow does not suffer the side effect of any chemotherapy, there is no pain, do not infect, do not feel sick and diarrhoea, constipation or fatigue, these possible symptoms.
3rd embodiment
The clinical research for the treatment of diabetic foot
Dong so-and-so, female, 58 years old, 15 years diabetes medical histories (II type), in July calendar year 2001, find two lower limb acroanesthesia, there is vesicle sample ulcer in double-legged toe, spreads gradually, and black hole appears in right crus of diaphragm little finger of toe, suppurates more than, can not walk, three or four toe necrosis.Right lower limb is numb, and doctor advocates to do high amputation operation.Patient accepts the treatment of electronics colliding technique, adopts inhalation, blows pouring method, any medicine of stopping using.After two months, hematuria sugar is normal.Through treatment in three months, right lower extremity healing rehabilitation, the complication caused because of diabetes also disappeared completely.Pay a return visit patient after 1 year, all are normal.
4th embodiment
King so-and-so, female, 60 years old, suffers from psoriasis more than 40 year, though through in many ways not stopping treatment, always recurrent exerbation, patient has lost treatment confidence.In March, 2006, accept electronics head-on collision treatment, 16 hours every days, through bimestrial treatment, be discharged from hospitals upon recovery.Treatments period, without the need to diet control.Pay a return visit patient, all are normal so far, without recurrence.
5th embodiment
Consult Figure 10-11, Liao so-and-so, man, 27 years old, in May, 2010 moved in Hospital of Southern Medical University, was fusiformis by om observation to its stomach thing oncocyte that swells, intensive; Slight atypia, karyokinesis, as 4 ~ 7/50HPP, is diagnosed as low potential malignancy gastrointestinal stromal tumors (GISTs).The CT examination report display carried out in June, 2011, see a huge mass shape occupancy focus between liver stomach, polishing is owed at edge, and form is irregular, and size is about about 12.2*9.3*10cm.Stomach and pancreas cause form tube wall by pushing displacement, and focus is charged into forward in abdomen antetheca subcutaneous layer of fat and also locally protruded from body surface; Demarcate unclear with coat of the stomach and surrounding intestinal tube, demarcate with rear pancreas and still can distinguish.Focus density unevenness, major part is in soft-tissue density, and interior visible number is located low density area and is dispersed in point, the fine and close shadow of strip; The large portion of enhanced ct scans focus slightly strengthens, and in it, low density area contrast obviously.CT diagnosis and impression are occupying lesion between liver stomach, in conjunction with considering during clinical disease that mesenchymoma probability is large.Due to the intestines and stomach mesenchymoma, therefore dare not perform an operation always.Use the ECT electronics of the Kang Xin Science and Technology Ltd. arrow that clashes to treat in March, 2013, to treat with power supply through the head-on collision of this electronics head-on collision electronics of three days of arrow and feel good, after proceed trimestral treatment, the intestines and stomach mesenchymoma removes substantially, is discharged from hospitals upon recovery.Treatments period, without the need to diet control.Pay a return visit patient, all are normal so far, without recurrence.
Specific embodiment six
Consult Figure 12-15 further, prunus mume (sieb.) sieb.et zucc. so-and-so, female, 41 years old, in November, 2010 carried out the inspection of chest Enhanced CT at attached Beijing Tumour Hospital of Capital University of Medical Sciences treatments period, report display, and thorax is symmetrical, and vertical diaphragm is placed in the middle.Trachea and bronchi lobares et segmentales unobstructed.Two pulmonary branches trachea vascular bundle increases, disorder of walking, the visible tuberosity shadow of superior lobe of right lung, and edge is rough, visible multiple burr, and and pleural adhesion, density is comparatively even, has no obvious strengthening after enhancing; Middle lobe of right lung, left lung tongue section visible patch shape shade, ground glass shadow.In vertical diaphragm, two hilus pulumonis and right supraclavicular fossa be shown in several small lymph node.Heart, trunk form, size no abnormality seen.The plump adhesion of upper right pleura limitation, right side oblique segmentation thickens, and thoracic cavity and pericardium have no obvious hydrops.Spleen increases, Da Bagelei unit.Diagnostic result is upper right pulmonary carcinoma, two lung inflammation, vertical diaphragm and two hilus pulumonis, the several small lymph node display of right supraclavicular fossa, right side pleura localized thickening, splenomegaly.The ECT electronics of Kang Xin Science and Technology Ltd. head-on collision arrow is used to carry out usability treatment in February, 2011, again carry out chest Enhanced CT, result is diagnosed as, and upper right pulmonary carcinoma slightly reduces than front focus, reduce to some extent before the multiple small lymph node display comparatively of vertical diaphragm, right side pleura localized thickening.After proceed trimestral treatment, right upper lung carninomatosis stove reduces rapidly, is discharged from hospitals upon recovery.Treatments period, without the need to diet control.Pay a return visit patient, all are normal so far, without recurrence.
So the present invention effectively can play the division suppressing specific cell, simultaneously without any side effects.Although current electronics of the present invention head-on collision can only use as independently therapy system the suppression system of specific cell and suppressing method, but, through further studying, more clinical trial, native system and method are combined with traditional method and treat, will have broad prospects.
Be only several specific embodiment of the present invention above, but the present invention is not limited thereto, the changes that any person skilled in the art can think of all should fall into protection scope of the present invention.
Claims (8)
1. the suppression system of electronics head-on collision to specific cell, is characterized in that, is made up of the high electric field formed in head-on collision arrow;
Cell comprises cell membrane, Cytoplasm and nucleus, in fission process, need a kind of specific proteins, these protein free-floating in Cytoplasm, these special protein are the parts of carrying a large amount of electric charge in human body, prophase of cell division, nuclear division, Chromosomal arrangement is in cell, those protein materials are by three-dimensional sequence, end points is connected, form chain, hereditary material will be connected further, then these hereditary materials are pulled to two cells from a cell, Here it is, and a cancer cell division generates the process of two, two become four, then the tumor increased without limitation,
Cancerous cell is placed in the cavity of head-on collision arrow, transmitting is coiled downward electron emission and is formed electric field, if electric field is uniform, active force round about can cause charged molecule to be parallel to the motion of direction of an electric field discontinuously, and when electric field frequency is enough high, these molecular motions can be slowed down, for dipole, because the charged cathode of its molecule is separated with anode, it just can match with direction of an electric field, and holding position is constant; Comprise all charged molecules of dipole, then all can move to the direction that electric field density is high in uneven AC field; In common Unseparated Cell, electric field is uniform substantially, and therefore, charged molecule and the clean electric field force suffered by dipole produce motion hardly; And for the specific cell of fast division, in mitosis telophase, because a point dehiscence furrow splits two daughter cells, forming narrow Cytoplasm connects, and near connecting portion, electric field is uneven, polar molecule just can bradykinesia;
The effect of spindle in mitosis is evenly distributed in two daughter cells by the daughter chromosome after copying, in this process, small polar molecule-tubulin polymerization is in strip subunit and extends in the hereditary material of cell central array, and is combined with chromosome; Do not carrying out in mitotic cell, although electric field is uniform, but microtubule subunit can be arranged in parallel according to direction of an electric field, the electric field force acted on cell subunit stops them to arrive the orientation realized needed for polymerization, therefore abnormal long-time stopping can occurring mitosis; Tubulin causes polymerization obstacle that microtubule formation will be caused to be obstructed because being subject to enough strong electric field force; All can there is spindle and form obstacle in all cells, spend the cell of mitosis metaphase, its cell membrane splits starting to hang, and two daughter chromosome are pulled to cell the two poles of the earth, in the fission process of mitosis final step kytoplasm, divide dehiscence furrow finally to be formed, and two cells are finally separated completely; And this narrow cell membrane junction just produces one and the distinct hourglass-like inhomogeneous field of Unseparated Cell, in cytokinesis process, the position that electric field density is the highest is positioned at the center of narrow positions, in the case, the field intensity concentrated causes all electric charges and dipole are subject to the effect of unidirectional electrical field force and are moved to a point dehiscence furrow; In cell, polar molecule and dipole, move towards a point dehiscence furrow because being subject to the impact of enough strong electric field force, and this will cause the disorder of intracellular structure, produce cytoclasis effect, and then specific cell division is suppressed;
This specific cell suppresses system head-on collision arrow to comprise operation screen, voltage regulating rectification circuit, frequency control circuit, waveform translation circuit, electric current commutating circuit and multistage amplifier circuit, voltage regulating rectification circuit is oscillating circuit, low pressure unidirectional pulse electric current is transformed into through alternating current in 220V alternating current access voltage regulating rectification circuit, medium frequency electric is transformed into low frequency pulse current by frequency control circuit, by waveform translation circuit, unidirectional pulse electric current is converted to unidirectional square wave current again, last multistage amplifier circuit is by Current amplifier, and go out to be delivered to entire patient from transmitting hair updo, operation screen is electrically connected with each circuit respectively, and each circuit is controlled, described multistage amplifier circuit is contained in the multistage enlarged cavity on electronics head-on collision arrow side,
This specific cell suppresses the parameters index in system operation as follows:
Frequency is one of important parameter affecting waveform electric field therapeutic effect, be less than the DeGrain of 1kHz electric field, though there is stimulation, but will soon disappear, high-frequency electric field more than MHz level can produce heat effect, large to patient body side effect, this specific cell suppresses the frequency continuously adjustabe of system, and shake frequently frequency-tuning range covers 0.9Hz-520.2Hz;
Direction of an electric field affects the effect of electric field to cell, when direction of an electric field is consistent with cell division direction of principal axis, lethality is maximum, and single one direction treatment can not bring about tangible results, this system takes the electric field turning effort in turn of multi-direction number, and the angle between multi-direction electric field is 45 ~ 90 °;
The ambient temperature of this system is 5 DEG C-40 DEG C, relative humidity is less than or equal to 80%, system maximum output voltage is 24V, the peak value of output voltage is 28V, and rated load impedance is 800, and the individual pulse maximum output energy of electrode is 0.45mJ, time set scope is 60s-360s, after arriving setup times, automatically cut off treatment and export, and sound, light prompting;
The battery lead plate of this system is nichrome electrode needle, wherein nickel element mass fraction is 55%-60%, chromium element mass fraction is 20%-30%, battery lead plate profile is strip flat board or bent plate, energising wiring hole is had at the two ends of plate electrode plate, the battery lead plate of bent plate comprises two side plates and a top board, two side plates and top board are integrated the ∏ shape bending plate of formation, at the base plate respectively having an outside bending below of biside plate, its longitudinal profile is handle-shaped, nichrome electrode needle is stretched out from battery lead plate top board, the diameter of alloy electrode pin is 3-5mm, spacing between adjacent alloys electrode needle is 20-40mm.
2. the suppression system of electronics head-on collision according to claim 1 to specific cell, it is characterized in that, voltage regulating rectification circuit is made up of automatic coupling voltage regulator, frequency control circuit is made up of frequency modulator, the outfan of automatic coupling voltage regulator is electrically connected with the input of frequency modulator, from outfan, electric current is delivered to waveform translation circuit after frequency modulator regulation and control frequency, through the compound action of multidirectional circuit and amplifying circuit, head-on collision electronics electric field is transmitted into entire patient from battery lead plate.
3. the suppression system of electronics head-on collision according to claim 1 to specific cell, it is characterized in that, this suppression system also comprises power circuit; Described power circuit comprises 12V rechargeable battery and booster circuit, and described 12V rechargeable battery is electrically connected with described waveform translation circuit and multistage amplifier circuit.
4. the suppression system of electronics head-on collision according to claim 1 to specific cell, is characterized in that, the direction rotation per second of described electronics head-on collision electric field 1 time, direction of rotation is counterclockwise, high energy is assembled and produces metal Luminous Ring.
5. the suppressing method of electronics head-on collision to specific cell, is characterized in that, concrete practice is in the work process of head-on collision arrow;
First, cancerous cell is placed in the cavity of head-on collision arrow, transmitting is coiled downward electron emission and is formed electric field, if electric field is uniform, active force round about can cause charged molecule to be parallel to the motion of direction of an electric field discontinuously, when electric field frequency is enough high, these molecular motions can be slowed down, for dipole, because the charged cathode of its molecule is separated with anode, it just can match with direction of an electric field, and holding position is constant; Comprise all charged molecules of dipole, then all can move to the direction that electric field density is high in uneven AC field; In common Unseparated Cell, electric field is uniform substantially, and therefore, charged molecule and the clean electric field force suffered by dipole produce motion hardly; And for the specific cell of fast division, in mitosis telophase, because a point dehiscence furrow splits two daughter cells, forming narrow Cytoplasm connects, and near connecting portion, electric field is uneven, polar molecule just can bradykinesia;
Cell comprises cell membrane, Cytoplasm and nucleus, in fission process, need a kind of specific proteins, these protein free-floating in Cytoplasm, these special protein are the parts of carrying a large amount of electric charge in human body, prophase of cell division, nuclear division, Chromosomal arrangement is in cell, those protein materials are by three-dimensional sequence, end points is connected, form chain, hereditary material will be connected further, then these hereditary materials are pulled to two cells from a cell, Here it is, and a cancer cell division generates the process of two, two become four, then the tumor increased without limitation,
The effect of spindle in mitosis of carrying this kind of protein is evenly distributed in two daughter cells by the daughter chromosome after copying, in this process, small polar molecule-tubulin polymerization is in strip subunit and extends in the hereditary material of cell central array, and is combined with chromosome; Do not carrying out in mitotic cell, although electric field is uniform, but microtubule subunit can be arranged in parallel according to direction of an electric field, the electric field force acted on cell subunit stops them to arrive the orientation realized needed for polymerization, therefore abnormal long-time stopping can occurring mitosis; Tubulin causes polymerization obstacle that microtubule formation will be caused to be obstructed because being subject to enough strong electric field force; All can there is spindle and form obstacle in all cells, spend the cell of mitosis metaphase, its cell membrane splits starting to hang, and two daughter chromosome are pulled to cell the two poles of the earth, in the fission process of mitosis final step kytoplasm, divide dehiscence furrow finally to be formed, and two cells are finally separated completely; And this narrow cell membrane junction just produces one and the distinct hourglass-like inhomogeneous field of Unseparated Cell, in cytokinesis process, the position that electric field density is the highest is positioned at the center of narrow positions, in the case, the field intensity concentrated causes all electric charges and dipole are subject to the effect of unidirectional electrical field force and are moved to a point dehiscence furrow; In cell, polar molecule and dipole, move towards a point dehiscence furrow because being subject to the impact of enough strong electric field force, and this will cause the disorder of intracellular structure, produce cytoclasis effect, and then specific cell division is suppressed;
The circuit adjustment mode of this specific cell suppressing method is, low pressure unidirectional pulse electric current is transformed into through alternating current in 220V alternating current access head-on collision arrow voltage regulating rectification circuit, medium frequency electric is transformed into low frequency pulse current by frequency control circuit, by waveform translation circuit, unidirectional pulse electric current is converted to unidirectional square wave current again, last multistage amplifier circuit by Current amplifier, and goes out to be delivered to entire patient from transmitting hair updo;
Parameters index in this specific cell suppressing method head-on collision arrow running is as follows:
Frequency is one of important parameter affecting waveform electric field therapeutic effect, be less than the DeGrain of 1kHz electric field, though there is stimulation, but will soon disappear, high-frequency electric field more than MHz level can produce heat effect, large to patient body side effect, this specific cell suppresses the frequency continuously adjustabe of system, and shake frequently frequency-tuning range covers 0.9Hz-520.2Hz;
Direction of an electric field affects the effect of electric field to cell, when direction of an electric field is consistent with cell division direction of principal axis, lethality is maximum, and single one direction treatment can not bring about tangible results, this system takes the electric field turning effort in turn of multi-direction number, and the angle between multi-direction electric field is 45 ~ 90 °;
The ambient temperature of operation the method is 5 DEG C-40 DEG C, relative humidity is less than or equal to 80%, head-on collision arrow maximum output voltage is 24V, the peak value of output voltage is 28V, and rated load impedance is 800, and the individual pulse maximum output energy of electrode is 0.45mJ, time set scope is 60s-360s, after arriving setup times, automatically cut off treatment and export, and sound, light prompting;
The battery lead plate of this head-on collision arrow is nichrome battery lead plate, wherein nickel element mass fraction is 55%-60%, chromium element mass fraction is 20%-30%, battery lead plate profile is strip flat board or bent plate, energising wiring hole is had at the two ends of plate electrode plate, the nickel chromium triangle battery lead plate of bent plate comprises two side plates and a top board, two side plates and top board are integrated the ∏ shape bending plate of formation, at the base plate respectively having an outside bending below of biside plate, its longitudinal profile is handle-shaped, base plate has electric wiring hole, steel mesh is provided with in the cavity of battery lead plate, steel mesh is weaved into by nichrome wire, the diameter of alloy wire is 3-5mm, spacing between adjacent alloys line is 20-40mm, the overall dimensions of steel mesh and the size of battery lead plate adapt.
6. the suppressing method of electronics head-on collision according to claim 5 to specific cell, it is characterized in that, circuit in voltage regulating rectifier process is provided by automatic coupling voltage regulator, circuit in frequency regulation process is made up of frequency modulator, the outfan of automatic coupling voltage regulator is electrically connected with the input of frequency modulator, from outfan, electric current is delivered to waveform translation circuit after frequency modulator regulation and control frequency, through the compound action of multidirectional circuit and amplifying circuit, head-on collision electronics electric field is transmitted into entire patient from battery lead plate.
7. the suppressing method of electronics head-on collision according to claim 5 to specific cell, it is characterized in that, this suppressing method also needs power circuit support; Described power circuit comprises 12V rechargeable battery and booster circuit, and described 12V rechargeable battery is electrically connected with described waveform translation circuit and multistage amplifier circuit.
8. the suppressing method of electronics head-on collision according to claim 5 to specific cell, is characterized in that, the direction rotation per second of described electronics head-on collision electric field 1 time, direction of rotation is counterclockwise.
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