CN102114227B - Pharmaceutical composition for treating hepatitis B and cirrhosis - Google Patents
Pharmaceutical composition for treating hepatitis B and cirrhosis Download PDFInfo
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- CN102114227B CN102114227B CN201110036505XA CN201110036505A CN102114227B CN 102114227 B CN102114227 B CN 102114227B CN 201110036505X A CN201110036505X A CN 201110036505XA CN 201110036505 A CN201110036505 A CN 201110036505A CN 102114227 B CN102114227 B CN 102114227B
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Abstract
The invention discloses a pharmaceutical composition for treating hepatopathy, which is a preparation prepared by the following active pharmaceutical ingredients in portions by weight: 3-5 portions of black nightshade herb, 2-3 portions of common scouring rush herb, 4-8 portions of wild buckwheat rhizome, 3-5 portions of Indian kalimeris herb, 2-5 portions of zedoary, 3-5 portions of carrageen, 3-5 portions of Indian rorippa herb, 3-5 portions of lightyellow sophora root, 3-5 portions of virgate wormwood herb, 3-8 portions of coix seed and 3-5 portions of sinkiang arnebia root. The pharmaceutical composition can effectively inhibit virus replication, convert hepatitis B e-antigen and hepatitis B virus (DNA: deoxyribonucleic acid) gene polymerase to be negative within 40 weeks, effectively treat hepatitis B, further reduce the liver fibrosis level, improve the organic disorder in liver and spleen, increase the seralbumin, quickly reduce the liver functional seroenzyme, restore liver functions, have a good effect of protecting the liver, and effectively treat viral hepatitis and cirrhosis; and the pharmaceutical composition particularly has significant treatment effect for the hepatitis B and the cirrhosis after various types of the hepatitis.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition of treating hepatitis B, liver cirrhosis.Belong to drug world.
Background technology
Liver is a digestive gland maximum in the digestion, is the human metabolic vitals of realizing.But,, make the incidence rate of hepatic disease significantly rise along with factors such as environmental pollution are on the rise, the dietetic life custom is bad.At present, common hepatopathy has viral hepatitis, hepatocarcinoma, fatty liver, alcoholic liver, liver cirrhosis etc.
Hepatitis B is one of common viral hepatitis, can propagate through modes such as blood, mother and baby, damaged skin and property contacts, and also be common chronic infectious disease.According to The World Health Organization (WHO), chronic hepatitis B accounts in the global top ten disease cause of the death the 7th, and wherein 30% hepatitis B patient develops into liver cirrhosis and hepatocarcinoma the most at last, and only China is annual just has 300,000 people to die from the disease that hepatitis B virus infection causes.At present, adopt nucleoside analog and interferon that hepatitis B and hepatitis B virus carriers are treated more.Wherein, The normal nucleoside analog that uses draws that the miaow husband is fixed, adefovirdipivoxil fat, Entecavir, Sebivo, tenofovir ester etc., and its overall security and toleration are good, but can rare, the rare serious adverse reaction of generation in clinical practice; Like renal insufficiency, myositis, rhabdomyolysis, lactic acidosis etc.; In case and drug withdrawal, most of patient's hepatitis B virus DNA polymerase parameter bounce-back, higher before the ratio that the has treatment.
Liver cirrhosis is a kind of common chronic hepatopathy, and patient's liver is carrying out property, diffusivity, fibrous lesions.Modern clinical research is thought; The cause of disease that causes liver cirrhosis has multiple; According to the different causes of disease, can liver cirrhosis be divided into viral hepatitis liver cirrhosis, alcoholic cirrhosis, parasitic liver cirrhosis, metabolic liver cirrhosis, LADA liver cirrhosis, poisonous substance and drug induced liver cirrhosis, nutritional cirrhosis etc.To the treatment of liver cirrhosis, unsuitable Drug abuse, otherwise can increase burden of liver increases the weight of the state of an illness, and present stage mainly is to combine with Diet Therapy through Drug therapy, from balanced nutrients, improve aspects such as liver function, anti-hepatic fibrosis and set about.At present, also there is not specific drug to liver cirrhosis and hepatic ascites.
Under the Western medicine situation not good to hepatitis B, liver cirrhosis therapeutic effect, people begin to turn one's attention to Chinese medicine.At present, be that the effectively new drug of treatment hepatic disease is sought on the basis with the theory of Chinese medical science, become the new direction of current medical personnel's research.
Summary of the invention
Technical scheme of the present invention has provided a kind of pharmaceutical composition of treating hepatopathy, and it is the preparation that is prepared from following raw materials by weight proportions:
Rhizoma Fagopyri Dibotryis 4-8 part, Herba Solani Nigri 3-5 part, Rhizoma Curcumae 2-5 part, Herba Equiseti Hiemalis 2-3 part, Herba Kalimeridis 3-5 part, Pelvetia siliquosa Tseng et C. F. Chang 3-5 Fen 、 Herba Rorippae 3-5 part, Radix Sophorae Flavescentis 3-5 part, Herba Artemisiae Scopariae 3-5 part, Semen Coicis 3-8 part, Radix Arnebiae (Radix Lithospermi) 3-5 part.
Further preferably, it is the preparation that is prepared from following raw materials by weight proportions:
8 parts of Rhizoma Fagopyri Dibotryiss, 5 parts of Herba Solani Nigris, 5 parts of Rhizoma Curcumae, 3 parts of Herba Equiseties Hiemalis, 5 parts of Herba Kalimeridis, Pelvetia siliquosa Tseng et C. F. Chang 35 parts of Fen 、 Herba Rorippae, 4 parts of Radix Sophorae Flavescentiss, 4 parts of Herba Artemisiae Scopariaes, 8 parts of Semen Coiciss, 3 parts of Radix Arnebiae (Radix Lithospermi)s.
Wherein, described preparation is an oral formulations pharmaceutically commonly used.
Wherein, described oral formulations is decoction, powder, pill, granule, tablet, oral liquid or drop pill.
The present invention also provides a kind of method for preparing above-mentioned pharmaceutical composition, and it is characterized in that: it is implemented as follows:
(1) get the crude drug of recipe quantity, pulverize, the powder of getting it filled is subsequent use; Or
(2) get the crude drug of recipe quantity, add water or organic solvent extraction, the active component that extracts gained is subsequent use;
(3) get the medicated powder of step (1) gained or the active component of step (2) gained, add adjuvant or complementary composition pharmaceutically commonly used, prepare through the conventional formulation method.
The present invention also provides the above-mentioned purposes of pharmaceutical composition in the medicine of preparation treatment hepatitis B.
Further, described medicine is the medicine of treating acute or chronic hepatitis B.
The present invention also provides the above-mentioned purposes of pharmaceutical composition in the medicine of preparation treatment liver cirrhosis.
Further, described medicine is the medicine of treatment posthepatitic cirrhosis.
The present invention also provides the above-mentioned purposes of pharmaceutical composition in the medicine of preparation the liver protecting and ALT lowering.
Rhizoma Fagopyri Dibotryis in the drug regimen raw material of the present invention is the dry rhizome of polygonaceae plant Rhizoma Fagopyri Dibotryis Fagopyrum dibotrys (D.Don) Hara, little suffering, puckery, cold.Return lung meridian, heat-clearing and toxic substances removing, the evacuation of pus blood stasis dispelling is used to treat lung abscess, and measles pneumonia is dense swollen around the tonsil.Herba Solani Nigri is the herb of Solanaceae nightshade Herba Solani Nigri Solanumnigrum L..Bitter in the mouth, cold in nature, slightly poisonous.Heat-clearing and toxic substances removing, promoting blood circulation and detumescence.Cure mainly furuncle, carbuncle, erysipelas, osteopatia sprain, cough, edema.Rhizoma Curcumae, the dry rhizome of zingiberaceous plant Rhizoma Curcumae Curcuma phaeocaulisVal., Guangxi zedoary Curcuma kwangsiensis S.G.Lee et C.F.Liang or RADIX CURCUMAE Curcuma wenyujin Y.H.Chen et C.Ling.Hot, bitter, temperature.Return liver, spleen channel.The circulation of qi promoting removing blood stasis, the removing food stagnancy pain relieving.Yong Yu mass in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.The Herba Equiseti Hiemalis is the herb of Equisetaceae plant Herba Equiseti Hiemalis Equisetum hiemale L..The property sweet temperature mildly bitter flavor flat nontoxic.Function cures mainly wind-dispelling heat-dissipating, expelling pathogenic factors from muscles, nebula removing.Control order and give birth to nebula, epiphora induced by wind, discharging fresh blood stool laryngalgia, carbuncle.Pelvetia siliquosa Tseng et C. F. Chang has another name called chondrus ocellatus Holmes, is the frond of the plant chondrus ocellatus Holmes Chondrus ocellatusHolm. of China fir algae section, and sweet in the mouth, salty is cold in nature.Heat-clearing and toxic substances removing, the stomach function regulating relieving constipation cures mainly the flu cold and heat, mumps, laryngopharynx swelling and pain, traumatic injury, gastralgia, dryness of the intestine constipation.Herba Rorippae is the herb of Shi word Hua Ke Herba Rorippae Shu Zhi Wu Herba Rorippae Rorippa indica (L) Hiern [Sisymbrium indicum L.] and no Ban Herba Rorippae R.dubia (Pers.) Hara [R.montana (Wall.) Small].Acrid in the mouth, hardship, slightly warm in nature.Expelling phlegm for arresting cough, the cold expelling that induces sweat, detoxification and promoting urination cures mainly the cough phlegm dyspnea, cold, fever, measles is sent out not smooth thoroughly, rheumatic arthralgia, laryngopharynx swelling and pain, furuncle carbuncle, dermatitis rhus, amenorrhea, traumatic injury, jaundice, edema.Radix Sophorae Flavescentis, the dry root of leguminous plant Radix Sophorae Flavescentis Sophora.flavescens Ait., bitter in the mouth, cold in nature, GUIXIN, liver, stomach, large intestine, urinary bladder channel.Heat clearing and damp drying, parasite killing, diuresis.Be used for hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy, external treatment trichomonal vaginitis.Semen Coicis is the dry mature kernal of grass Semen Coicis Coix lacryma-jobi L.var.mayuen (Roman.) Stapf, and sweet in the mouth, light is cool in nature, spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, clearing away heat and discharging pus.Be used for edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.Herba Kalimeridis is the herb of Compositae Herba Kalimeridis platymiscium Herba Kalimeridis Kalimeris indica (L.) Sch.-Bip. [Aster indicus L.], and acrid in the mouth is cool in nature, goes into lung, liver, stomach, large intestine channel.Heat clearing and blood cooling, eliminating damp, detoxifying.Cure mainly multiple hemorrhage, malaria, jaundice, the edema stranguria with turbid discharge, the cough, pharyngalgia sore throat, acute mastitis hemorrhoid, carbuncle erysipelas, infantile malnutrition, venom.Herba Artemisiae Scopariae; The dry aerial parts of feverfew BINHAO Artemisia scoparia Waldst.et Kit. or Herba Artemisiae Scopariae Artemisia capillarisThunb., acrid in the mouth, hardship, cold nature; Return spleen, stomach, liver, gallbladder meridian; Have clearing away damp-heat, the effect of jaundice eliminating subcutaneous ulcer is used for jaundice oliguria, eczema pruritus more.Radix Arnebiae (Radix Lithospermi) is the root of comfrey lithospermum euchromum Royle Arnebia euchroma (Royle) Johnst. or arnebia guttata Bunge Arnebia guttata Bunge.Sweet in the mouth, salty, cold in nature, go into the heart, Liver Channel.Removing heat from blood is invigorated blood circulation, the detoxifcation rash.Be used for that heat in blood poison is contained, purple black, the measles without adequate eruption of macule, skin infection, eczema, burn due to hot liquid or fire.
Hepatitis B belongs to " the work addiction of liver " in " interior warp " contained " addictions of the five internal organs ".Pharmaceutical composition of the present invention is guidance with the traditional Chinese medical science " The liver and the kidney have a common source " theory, with " letter, just, test, honest and clean " be policy, fill a prescription.Be monarch with Rhizoma Fagopyri Dibotryis removing pathogenic heat from blood and toxic substance from the body, expelling wind and removing dampness in the side; With Herba Solani Nigri heat-clearing and toxic substances removing, mass dissipating and swelling eliminating is minister; With Rhizoma Curcumae circulation of qi promoting removing blood stasis is assistant; Can go into foot with the Herba Equiseti Hiemalis and faint the moon, few positive blood system evacuation liver-heat for making, the full side of set 11 flavor medicine synergism reach the purpose of treatment " the work addiction of liver ", have the effect of stronger removing pathogenic heat from blood and toxic substance from the body, depressed liver-energy dispersing and function of gallbladder promoting, removing damp-heat.
Pharmaceutical composition of the present invention can effectively suppress virus replication, and hepatitis B great three positive E antigen and hepatitis B virus (DNA) gene pyramiding enzyme are turned out cloudy, and effectively treats hepatitis B; And can reduce the hepatic fibrosis level; Improve liver, spleen organic disorder, the rising serum albumin reduces the liver function sero-enzyme fast; Recovering liver function; Have good hepatoprotective effect, can effectively treat viral hepatitis and liver cirrhosis, especially have notable therapeutic effect to hepatitis B and various posthepatitic cirrhosis.
The specific embodiment
The preparation of embodiment 1 pharmaceutical composition pill of the present invention
Depletion Semen Fagopyri Esculenti 8g, Herba Solani Nigri 5g, Rhizoma Curcumae 5g, Herba Equiseti Hiemalis 3g, Herba Kalimeridis 5g, Pelvetia siliquosa Tseng et C. F. Chang 3g 、 Herba Rorippae 5g, Radix Sophorae Flavescentis 4g, Herba Artemisiae Scopariae 4g, Semen Coicis 8g, Radix Arnebiae (Radix Lithospermi) 3g after the pulverizing, add suitable adjuvant, general pill agent.
The preparation of embodiment 2 pharmaceutical composition decoctions of the present invention
Depletion Semen Fagopyri Esculenti 8g, Herba Solani Nigri 3g, Rhizoma Curcumae 2g, Herba Equiseti Hiemalis 2g, Herba Kalimeridis 3g, Pelvetia siliquosa Tseng et C. F. Chang 3g 、 Herba Rorippae 3g, Radix Sophorae Flavescentis 3g, Herba Artemisiae Scopariae 3g, Semen Coicis 3g, Radix Arnebiae (Radix Lithospermi) 3g add hydration and fry in shallow oil, and merging filtrate gets decoction of the present invention.
The preparation of embodiment 3 pharmaceutical composition granules of the present invention
Depletion Semen Fagopyri Esculenti 4g, Herba Solani Nigri 5g, Rhizoma Curcumae 5g, Herba Equiseti Hiemalis 3g, Herba Kalimeridis 5g, Pelvetia siliquosa Tseng et C. F. Chang 5g 、 Herba Rorippae 5g, Radix Sophorae Flavescentis 5g, Herba Artemisiae Scopariae 5g, Semen Coicis 8g, Radix Arnebiae (Radix Lithospermi) 5g after the pulverizing, add suitable adjuvant, general pill agent.Behind the extracting in water, filtrating concentrates respectively, adds adjuvant, processes granule respectively, promptly gets granule of the present invention.Take with preceding mixing.
The preparation of embodiment 4 medicament composition granule agent of the present invention
Depletion Semen Fagopyri Esculenti 8g, Herba Solani Nigri 5g, Rhizoma Curcumae 5g, Herba Equiseti Hiemalis 3g, Herba Kalimeridis 5g, Pelvetia siliquosa Tseng et C. F. Chang 3g 、 Herba Rorippae 5g, Radix Sophorae Flavescentis 4g, Herba Artemisiae Scopariae 4g, Semen Coicis 8g, Radix Arnebiae (Radix Lithospermi) 3g, after adding hydration and extracting, filtrating concentrates, and adds suitable adjuvant, preparation cost invention granule.
Embodiment 1-4 is to preparation of drug combination method of the present invention; Should not be construed as is the restriction to protection domain of the present invention; All based on above-mentioned technological thought, the modification, replacement, the change that utilize ordinary skill knowledge and customary means to make all belong to scope of the present invention.
Below further prove beneficial effect of the present invention through clinical practice.
Test Example 1 treatment hepatitis B clinical observation on the therapeutic effect
Accept various acute or chronic hepatitis B patient totally 75 examples for medical treatment, adopt pharmaceutical composition of the present invention (embodiment 1 makes) 40 weeks of treatment, its therapeutic effect is referring to table 1.
Above-mentioned therapeutic outcome shows; Medicine of the present invention can suppress virus replication, hepatitis B great three positive E antigen and hepatitis B virus (DNA) gene pyramiding enzyme are turned out cloudy; Effectively treat hepatitis B; And can reduce the liver function serum transaminase fast, recovering liver function has good hepatoprotective effect.
The acute and chronic hepatitis B result of table 1 medicine composite for curing of the present invention
Test Example 2 treatment posthepatitic cirrhosis clinical observation on the therapeutic effect
Accept various Patients with Cirrhosis After Hepatitis totally 45 examples for medical treatment, adopt pharmaceutical composition of the present invention (embodiment 1 makes) 40 weeks of treatment, its therapeutic effect is referring to table 2.
The result shows that pharmaceutical composition of the present invention can reduce the hepatic fibrosis level, improves liver, spleen organic disorder, and the rising serum albumin is recovered liver function, effectively treats posthepatitic cirrhosis.
Table 2 medicine composite for curing posthepatitic cirrhosis of the present invention result
In sum, pharmaceutical composition of the present invention has the effect of stronger removing pathogenic heat from blood and toxic substance from the body, depressed liver-energy dispersing and function of gallbladder promoting, removing damp-heat, can effectively suppress virus replication; Hepatitis B great three positive E antigen and hepatitis B virus (DNA) gene pyramiding enzyme are turned out cloudy, effectively treat hepatitis B, and can reduce the hepatic fibrosis level; Improve liver, spleen organic disorder, the rising serum albumin reduces the liver function sero-enzyme fast; Recovering liver function; Have good hepatoprotective effect, can effectively treat viral hepatitis and liver cirrhosis, especially have notable therapeutic effect to hepatitis B and various posthepatitic cirrhosis.
Claims (11)
1. pharmaceutical composition of treating hepatopathy, it is characterized in that: it is the preparation that is prepared from following raw materials by weight proportions:
Rhizoma Fagopyri Dibotryis 4-8 part, Herba Solani Nigri 3-5 part, Rhizoma Curcumae 2-5 part, Herba Equiseti Hiemalis 2-3 part, Herba Kalimeridis 3-5 part, Pelvetia siliquosa Tseng et C. F. Chang 3-5 Fen 、 Herba Rorippae 3-5 part, Radix Sophorae Flavescentis 3-5 part, Herba Artemisiae Scopariae 3-5 part, Semen Coicis 3-8 part, Radix Arnebiae (Radix Lithospermi) 3-5 part.
2. pharmaceutical composition according to claim 1 is characterized in that: it is the preparation that is prepared from following raw materials by weight proportions:
8 parts of Rhizoma Fagopyri Dibotryiss, 5 parts of Herba Solani Nigris, 5 parts of Rhizoma Curcumae, 3 parts of Herba Equiseties Hiemalis, 5 parts of Herba Kalimeridis, Pelvetia siliquosa Tseng et C. F. Chang 35 parts of Fen 、 Herba Rorippae, 4 parts of Radix Sophorae Flavescentiss, 4 parts of Herba Artemisiae Scopariaes, 8 parts of Semen Coiciss, 3 parts of Radix Arnebiae (Radix Lithospermi)s.
3. pharmaceutical composition according to claim 1 and 2 is characterized in that: described preparation is oral formulations pharmaceutically commonly used.
4. pharmaceutical composition according to claim 3 is characterized in that: described oral formulations is decoction, powder, pill, granule, tablet, oral liquid.
5. pharmaceutical composition according to claim 4 is characterized in that: described oral formulations is a drop pill.
6. method for preparing any described pharmaceutical composition of claim 1-5, it is characterized in that: it is implemented as follows:
(1) get the crude drug of recipe quantity, pulverize, the powder of getting it filled is subsequent use; Or
(2) get the crude drug of recipe quantity, add water or organic solvent extraction, the active component that extracts gained is subsequent use;
(3) get the medicated powder of step (1) gained or the active component of step (2) gained, add adjuvant or complementary composition pharmaceutically commonly used, prepare through the conventional formulation method.
7. the purposes of any described pharmaceutical composition of claim 1-5 in the medicine of preparation treatment hepatitis B.
8. purposes according to claim 7 is characterized in that: described medicine is the medicine of treating acute or chronic hepatitis B.
9. the purposes of any described pharmaceutical composition of claim 1-5 in the medicine of preparation treatment liver cirrhosis.
10. purposes according to claim 9 is characterized in that: described medicine is the medicine of treatment posthepatitic cirrhosis.
11. the purposes of any described pharmaceutical composition of claim 1-5 in the medicine of preparation the liver protecting and ALT lowering.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110036505XA CN102114227B (en) | 2011-02-12 | 2011-02-12 | Pharmaceutical composition for treating hepatitis B and cirrhosis |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110036505XA CN102114227B (en) | 2011-02-12 | 2011-02-12 | Pharmaceutical composition for treating hepatitis B and cirrhosis |
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| CN102114227A CN102114227A (en) | 2011-07-06 |
| CN102114227B true CN102114227B (en) | 2012-08-22 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104474143B (en) * | 2014-11-18 | 2018-08-14 | 卢艳东 | A kind of Chinese medicine composition and preparation method thereof for treating hepatitis B |
| CN106924323A (en) * | 2015-12-30 | 2017-07-07 | 姚萍 | Application of the radix macrotomiae in the medicine for preparing treatment virus B hepatitis |
| WO2019177932A1 (en) * | 2018-03-13 | 2019-09-19 | Dst Pharma, Inc. | Fagopyrum nutraceutical compositions |
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Patent Citations (4)
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