CN102113504B - 含多抗霉素和咪鲜胺的杀菌组合物 - Google Patents
含多抗霉素和咪鲜胺的杀菌组合物 Download PDFInfo
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- CN102113504B CN102113504B CN 201010003848 CN201010003848A CN102113504B CN 102113504 B CN102113504 B CN 102113504B CN 201010003848 CN201010003848 CN 201010003848 CN 201010003848 A CN201010003848 A CN 201010003848A CN 102113504 B CN102113504 B CN 102113504B
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
本发明公开了含多抗霉素和咪鲜胺的杀菌组合物，其中包含多抗霉素和咪鲜胺两种活性成分，所述咪鲜胺为锰盐、锌盐或铜盐，所述多抗霉素和咪鲜胺的重量比为80∶1～1∶80。所述多抗霉素和咪鲜胺的重量比为1∶45～3∶1。所述多抗霉素和咪鲜胺的累积重量百分比占重量的3％～60％。所述含多抗霉素和咪鲜胺的杀菌组合物可制成不同的应用剂型，包括微乳剂、水乳剂、悬浮剂、可湿性粉剂或水分散粒剂。本发明含多抗霉素和咪鲜胺的杀菌组合物复配增效很好、延缓抗药性、增效作用明显、扩大杀菌谱、降低使用成本、安全性好。
Description
技术领域
本发明涉及的农药杀菌剂组合物，尤其是涉及含有多抗霉素和咪鲜胺两种活性成份，防治农林业生产上多种作物发生病害的杀菌组合物。
背景技术
多抗霉素，又称多氧霉素，是属于广谱性、内吸性、高效、低毒的生物制剂。对子囊菌、担子菌、半知菌类中许多病原真菌具有较高的活性。1965年由日本最早发现，是金色链霉菌所产生的代谢产物，是具有肽嘧啶核苷酸类结构的抗生素。其作用原理主要是干扰病原菌细胞壁几丁质的生物合成，芽孢和菌丝体接触药剂后局部膨大、破裂，溢出细胞内含物，导致死亡。该药剂还有抑制病原产孢和病斑扩大的作用。市场价格较低，单独使用，防效较慢。
咪鲜胺是咪唑类杀菌剂和水果保鲜剂，有保护和治疗作用，它对由子囊菌和半知菌所引起的多种病害具特效。咪鲜胺用于谷类作物防治假尾孢属、核腔菌属、喙孢属及壳针孢属真菌，对早期的眼点病、叶斑病和白粉病有效。用于油籽、葡萄可防治链格孢属、葡萄孢属、假尾孢属、埋核盘菌属、核盘菌属真菌。用于豆科植物可防治壳二孢属、葡萄孢属和甜菜上的生尾孢属和白粉菌属，用于种子处理可防治禾谷类作物上的旋孢腔菌属、镰孢属、核腔菌属、壳针孢属真菌引起的病害。对于水果、蔬菜在收获前期喷施或收获后浸渍可预防储存期腐烂。也可防治花椰菜叶斑病、水稻稻瘟病和辣椒、荔枝、香蕉等水果的炭疽病。一种高效、杀菌谱广，但成本高，作用位点单一，通过抑制麦角甾醇的生物合成而起作用，使病菌细胞膜失去正常功能，病菌易产生抗药性。
含有单一成份的杀菌剂因连续使用，病原菌容易产生抗药性。不同品种的成份复配，是防治病原菌产生抗药性和扩大防治谱常采用的方法。复配增效很好的配方，由于明显提高了防效，减少了用药量和施药次数，降低使用成本，对延缓抗药性的产生有显著的作用，复配是病害防治的重要手段。目前未见多抗霉素和咪鲜胺的杀菌组合物的报道。
发明内容
本发明的目的在于：提供一种为了满足农业生产的需要，充分利用两种组份混配产生的增效作用和扩大杀菌谱，提高防效，降低防治成本的含多抗霉素和咪鲜胺的杀菌组合物。
为了实现上述目的，本发明的技术方案为：提供一种含多抗霉素和咪鲜胺的杀菌组合物，包含多抗霉素和咪鲜胺两种活性成分，所述咪鲜胺为锰盐、锌盐或铜盐，所述多抗霉素和咪鲜胺的重量比为1∶80～80∶1。
较佳地，所述多抗霉素和咪鲜胺的重量比为1∶45～3∶1。
较佳地，所述多抗霉素和咪鲜胺的累积重量百分比占重量的3％～60％。
较佳地，所述含多抗霉素和咪鲜胺的杀菌组合物可制成不同的应用剂型，包括微乳剂、水乳剂、悬浮剂、可湿性粉剂或水分散粒剂。所述的制剂按常规的制备方法，即在多抗霉素和咪鲜胺中添加已知的溶剂和/或载体、乳化剂、分散剂，制成所需的剂型。选择剂型根据使用目的来决定。
本发明具有如下优点：
延缓抗药性：多抗霉素其作用原理主要是干扰病原菌细胞壁几丁质的生物合成，咪鲜胺通过抑制麦角甾醇的生物合成而起作用。复配剂双重作用机制，病菌不易产生抗药性；
增效作用明显：田间试验结果表明，多抗霉素和咪鲜胺按一定比例复配对瓜类枯萎病、草莓白粉病、大蒜紫斑病、芒果炭疽病、水稻纹枯病等都具有明显增效作用；
扩大杀菌谱：多抗霉素和咪鲜胺复配可防治农业生产上的多种病害；
降低使用成本：因复配具有增效作用，减少了使用次数，降低了使用成本；
安全性好：多抗霉素、咪鲜胺均属低毒农药，二者的复配制剂，高效低毒，对作物和环境安全。
本发明含多抗霉素和咪鲜胺的杀菌组合物可防治因卵菌、子囊菌、担子菌、半知菌等病原真菌引起的多种植物病害。如水稻、玉米、小麦、草莓、芒果、瓜类、大蒜、橡胶、柑橘、葡萄、草坪和花卉等上的白粉病、纹枯病、炭疽病、枯萎病、灰霉病等多种病害。
具体实施方式
下面结合优选实施例对本发明作进一步说明，但本发明决不限于下述实施例。以下实施例中各组分百分含量均以重量比计。
实施例一
22％多抗霉素·咪鲜胺，即两者重量比为1∶10的微乳剂防治瓜类枯萎病常规工艺制成，按多抗霉素2％、咪鲜胺20％、DMF5％、二甲苯10％、苯乙基酚聚氧乙烯醚10％、农乳500#5％，水补足至100％，配制成22％多抗霉素.咪鲜胺微乳剂。另外，配制2％多抗霉素微乳剂和20％咪鲜胺微乳剂做药剂对照。稀释2000倍苗期灌根和喷雾，复配剂对瓜类枯萎病10d的田间防效为92.8％，优于2％多抗霉素89.0％的防效和20％咪鲜胺91.2％的防效。所述咪鲜胺为锰盐、锌盐或铜盐。所述多抗霉素和咪鲜胺的累积重量百分比占重量的22％。所述含多抗霉素和咪鲜胺的杀菌组合物可制成不同的应用剂型，包括微乳剂、水乳剂、悬浮剂、可湿性粉剂或水分散粒剂。
实施例二
25％多抗霉素·咪鲜胺，即两者重量比为1∶11.5的水乳剂防治草莓白粉病常规工艺制成，按多抗霉素2％、咪鲜胺23％、DMF10％、二甲苯10％、异丙醇10％、乙二醇5％、苯乙基酚聚氧乙烯醚5％、十二烷基苯磺酸钙2％、水补足至100％，配制成22％多抗霉素·咪鲜胺水乳剂。另外，配制2％多抗霉素微乳剂和20％咪鲜胺水乳剂做药剂对照。稀释2000倍喷雾，复配剂对草莓白粉病10d的田间防效为93.5％，优于2％多抗霉素86.6％的防效和23％咪鲜胺84.7％的防效。所述咪鲜胺为锰盐、锌盐或铜盐。所述多抗霉素和咪鲜胺的累积重量百分比占重量的25％。所述含多抗霉素和咪鲜胺的杀菌组合物可制成不同的应用剂型，包括微乳剂、水乳剂、悬浮剂、可湿性粉剂或水分散粒剂。
实施例三
32％多抗霉素·咪鲜胺，即两者重量比为1∶15的悬浮剂防治大蒜紫斑病常规工艺制成，按多抗霉素2％、咪鲜胺30％、木质素磺酸钠3％、茶枯粉5％、膨润土5％、硅酸铝镁2％、乙二醇10％、水补足至100％，配制成40％多抗霉素·咪鲜胺悬浮剂。另外，配制10％多抗霉素悬浮剂和30％咪鲜胺悬浮剂做药剂对照。稀释2000倍喷雾，复配剂对大蒜紫斑病10d的田间防效为94.6％，优于10％多抗霉素76.5％的防效和30％咪鲜胺85.8％的防效。所述咪鲜胺为锰盐、锌盐或铜盐。所述多抗霉素和咪鲜胺的累积重量百分比占重量的32％。所述含多抗霉素和咪鲜胺的杀菌组合物可制成不同的应用剂型，包括微乳剂、水乳剂、悬浮剂、可湿性粉剂或水分散粒剂。
实施例四
50％多抗霉素·咪鲜胺，即两者重量比为3∶2的可湿性粉剂防治芒果炭疽病
常规工艺制成，按多抗霉素30％、咪鲜胺20％、NNO 15％、烷基苯磺酸钠5％、高岭土30％，配制成50％多抗霉素·咪鲜胺可湿性粉剂。另外，配制30％多抗霉素可湿性粉剂和20％咪鲜胺可湿性粉剂做药剂对照。稀释2000倍喷雾，复配剂对芒果炭疽病10d的田间防效为89.4％，优于30％多抗霉素82.3％的防效和20％咪鲜胺87.8％的防效。所述咪鲜胺为锰盐、锌盐或铜盐。所述多抗霉素和咪鲜胺的累积重量百分比占重量的50％。所述含多抗霉素和咪鲜胺的杀菌组合物可制成不同的应用剂型，包括微乳剂、水乳剂、悬浮剂、可湿性粉剂或水分散粒剂。
实施例五
40％多抗霉素·咪鲜胺，即两者重量比为3∶1的水分散粒剂防治水稻纹枯病
常规工艺制成，按多抗霉素30％、咪鲜胺10％、萘磺酸盐甲醛缩合物10％、烷基苯磺酸钠5％、白炭黑45％，制成40％多抗霉素·咪鲜胺水分散粒剂。另外，配制30％多抗霉素水分散粒剂和10％咪鲜胺水分散粒剂做药剂对照。稀释2000倍喷雾，复配剂对水稻纹枯病10d的田间防效为96.5％，优于30％多抗霉素82.5％的防效和10％咪鲜胺79.8％的防效。所述咪鲜胺为锰盐、锌盐或铜盐。所述多抗霉素和咪鲜胺的累积重量百分比占重量的40％。所述含多抗霉素和咪鲜胺的杀菌组合物可制成不同的应用剂型，包括微乳剂、水乳剂、悬浮剂、可湿性粉剂或水分散粒剂。
在加工成可湿性粉剂时按以下工艺进行操作：
首先把原药、助剂、填料按比例混合，并充分搅拌，然后进行粉碎，检验合格后，可湿性粉剂可进行产品包装。
制备以上各种制剂所用的助剂、表面活性剂及载体均为本领域技术人员所公知的。
本发明组合物中至少含有一种载体和一种助剂，其中至少是表面活性剂，可以是乳化剂、分散剂、润湿剂或渗透剂，可以是离子型的或非离子型的。
根据不同剂型可添加的载体为水、有机溶剂或助溶剂、填料。
必要时加入稳定剂、增稠剂、消泡剂、粘合剂等其它功能性助剂。
溶剂和助溶剂有：有芳烃、脂肪烃、醚类、酚类、酮类、醇类等，例如苯、石油醚、甲醇、二甲苯、乙醇、正丁醇、甲苯、异戊醇、乙酸乙酯、三氯甲烷、煤油、二甲亚砜、苯酚、机油等。
乳化剂有：烷基酚聚氧乙烯醚、苯乙烯基酚聚氧乙烯醚、脂肪醇聚氧乙烯基醚、苯乙烯基酚聚氧乙烯醚聚氧丙烯醚、烷基酚聚氧乙烯醚磺基琥珀酸酯、蓖麻油聚氧乙烯醚等中的一种或多种。
所述的分散剂、润湿剂、渗透剂有：木质素磺酸钠、木质素磺酸钙、十二烷基磺酸钠、甲基萘磺酸甲醛缩合物硫酸盐、烷基萘磺酸钠、聚合羧酸钠、拉开粉、茶枯粉、皂角粉等中的一种或多种。
填料有：有高岭土、活性白土、硅藻土、泥煤、轻质碳酸钙、白炭黑、叶蜡石、滑石粉、方解石等中的一种或多种。
稳定剂有：丁基缩水甘油醚、苯基缩水甘油醚、甲苯基缩水甘油醚、聚乙烯基乙二醇二缩水甘油醚、山梨醇钠中的一种或多种。
增稠剂有：阿拉伯胶、黄原胶、硅酸铝镁、硅酸、聚乙烯醇、丙烯酸钠、膨润土中的一种或多种。
消泡剂有：硅酮类、泡敌、甲醇、乙醇、磷酸酯类及酰胺等中的一种或多种。
粘合剂有：大豆卵磷脂、明胶、聚乙烯醇、聚乙二醇、大豆蛋白、糊精、松香、淀粉等中的一种或多种。
Claims (3)
1.含多抗霉素和咪鲜胺的杀菌组合物，包含多抗霉素和咪鲜胺两种活性成分，所述咪鲜胺为咪鲜胺、锰盐、锌盐或铜盐，其特征在于：所述多抗霉素和咪鲜胺的重量比为1∶15～3∶1。
2.如权利要求1所述的含多抗霉素和咪鲜胺的杀菌组合物，其特征在于：所述多抗霉素和咪鲜胺的累积重量百分比占重量的3％～60％。
3.如权利要求1所述的含多抗霉素和咪鲜胺的杀菌组合物，其特征在于：所述含多抗霉素和咪鲜胺的杀菌组合物可制成不同的应用剂型，包括微乳剂、水乳剂、悬浮剂、可湿性粉剂或水分散粒剂。
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