CN102106473A - Feed containing mixture of N-carbamylglutamic acid and sodium salt thereof for boars, preparation and application thereof - Google Patents
Feed containing mixture of N-carbamylglutamic acid and sodium salt thereof for boars, preparation and application thereof Download PDFInfo
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- CN102106473A CN102106473A CN2010105765853A CN201010576585A CN102106473A CN 102106473 A CN102106473 A CN 102106473A CN 2010105765853 A CN2010105765853 A CN 2010105765853A CN 201010576585 A CN201010576585 A CN 201010576585A CN 102106473 A CN102106473 A CN 102106473A
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- feed
- carbamylglutamic acid
- sodium salt
- carbamylglutamic
- acid
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- LCQLHJZYVOQKHU-VKHMYHEASA-N carglumic acid Chemical compound NC(=O)N[C@H](C(O)=O)CCC(O)=O LCQLHJZYVOQKHU-VKHMYHEASA-N 0.000 title claims abstract description 99
- 239000000203 mixture Substances 0.000 title claims abstract description 58
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 241000282887 Suidae Species 0.000 title claims abstract description 11
- 159000000000 sodium salts Chemical class 0.000 title claims description 29
- 239000000463 material Substances 0.000 claims abstract description 70
- ZEPSCFSVKCOUHE-QTNFYWBSSA-L disodium (2S)-2-(carbamoylamino)pentanedioate Chemical compound [Na+].C(N)(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Na+] ZEPSCFSVKCOUHE-QTNFYWBSSA-L 0.000 claims abstract description 56
- 244000144980 herd Species 0.000 claims description 82
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 42
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 34
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 28
- BGNXCDMCOKJUMV-UHFFFAOYSA-N Tert-Butylhydroquinone Chemical compound CC(C)(C)C1=CC(O)=CC=C1O BGNXCDMCOKJUMV-UHFFFAOYSA-N 0.000 claims description 28
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 28
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 claims description 26
- 240000007594 Oryza sativa Species 0.000 claims description 23
- 235000007164 Oryza sativa Nutrition 0.000 claims description 23
- 235000009566 rice Nutrition 0.000 claims description 23
- NIQCNGHVCWTJSM-UHFFFAOYSA-N Dimethyl phthalate Chemical compound COC(=O)C1=CC=CC=C1C(=O)OC NIQCNGHVCWTJSM-UHFFFAOYSA-N 0.000 claims description 22
- 240000008042 Zea mays Species 0.000 claims description 22
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- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 14
- 229930003427 Vitamin E Natural products 0.000 claims description 14
- 235000015165 citric acid Nutrition 0.000 claims description 14
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 14
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- 229940036811 bone meal Drugs 0.000 claims description 12
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- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims description 12
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- FBSAITBEAPNWJG-UHFFFAOYSA-N dimethyl phthalate Natural products CC(=O)OC1=CC=CC=C1OC(C)=O FBSAITBEAPNWJG-UHFFFAOYSA-N 0.000 claims description 11
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 11
- 235000015099 wheat brans Nutrition 0.000 claims description 11
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- 239000003112 inhibitor Substances 0.000 claims description 10
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- 244000020551 Helianthus annuus Species 0.000 claims 1
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- 239000004475 Arginine Substances 0.000 abstract description 12
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract description 12
- 229920000768 polyamine Polymers 0.000 abstract description 7
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- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 229910002091 carbon monoxide Inorganic materials 0.000 abstract 1
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 38
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- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
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Abstract
The invention relates to a feed containing N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt for boars, preparation and application thereof. The feed is characterized by being prepared from the following components in percentage by weight: 0.10 to 0.25 percent of mixture of the N-carbamylglutamic acid and the N-carbamylglutamic acid sodium salt and auxiliary materials. The feed can promote the synthesis of source arginine in the bodies of boars, enhance the synthesis of carbon monoxide (NO) and polyamine, ensure that the boars exert the genetic potential more effectively, improve the utilization age limit and the health level of the boars and improve the economic benefit of raising the boars.
Description
Technical field
The present invention relates to animal feed, specifically, relate to a kind of pig's feed that can improve the herd boar reproductive performance, preparation and uses thereof.
Background technology
For the consideration of economic angle, the buck recoverable amount during the industrialization animal produces is considerably less, and people just utilize its sperm that excellent genes is continued.With the Swine Production is example, and the ratio of sow and boar is controlled at more than 80: 1 usually in the pig farm of employing technology of artificial insemination.Because quantity is few, control difficulty, the nutritional need of these bucks is enough paid attention to, and corresponding experimental study is also fewer.But have only necessary special physiological active material of the herd boar of satisfying and seminal fluid to generate material, could guarantee that they can provide the seminal fluid of high-quality capacity.Otherwise, may cause oligospermia and rare, sperm development is incomplete, and conception rate descends, even the forfeiture breeding capacity; The phenomenon that also can cause miscarriage, weak tire and stillborn foetus to increase simultaneously, and then reduce the production economic benefit.
Arginine is one of important nutrient that improves the herd boar fertility, and arginine can endogenous generation nitric oxide (NO).Nitric oxide (NO) is the bio signal molecule of different physiological roles such as a kind of second messenger of having concurrently, neurotransmitter and effector molecule, is bringing into play crucial physiological action in vivo.The generation of NO be unable to do without nitricoxide synthase (NOS), and NOS is distributed widely in each organ of male reproductive system, and the regulating action of reproduction is had dual nature.NO is a kind of vascular relaxing factor, has following effect for arrenotoky: can regulate the testis blood microcirculation, thereby influence the blood supply of testis, regulate the animal penile erectile function; Nitric oxide and nitric oxide synthetase be by the adjusting that participates in hypothalamic pituitary gonadal axis, the regulation of secretion that participates in testosterone, waits to regulate with androgen interaction in the body and wait androgen to secrete; Nitric oxide and nitric oxide synthetase also participate in the generation and the transportation of sperm, regulate sperm motility, influence the peroxidization of sperm membrane lipid etc., and mechanism is very complicated.
In a word, nitric oxide influences the secretion of male sex hormone, and is all playing a significant role aspect generation, maturation, activity and the fertility of sperm participating in regulating the reproductive system blood circulation.Although arginine is the NO source of using always, its character instability changes in the storage process easily, even stable in properties, addition arrives at 1% o'clock and just has remarkable result, and it is too high to add cost like this.Arginine dipeptides stability better can also discharge NO, but it is equally too high to add cost.
In addition, arginine adds daily ration to by meeting and lysine and tryptophan generation antagonism in the animal absorption process, influences the utilization of these essential amino acids.All these has limited the application of NO source biology in animal feed of arginine class, therefore needs a kind of material that can promote that arginine synthesizes in the animal body, strengthens the synthetic of NO and polyamines, thereby improves the reproductive performance of herd boar.NCG is N-acetylglutamat (being a NAG) analog, can play a role as NAG in animal body and participate in the body urea cycle, long half time, metabolic stability, can be used as the activation of metabolic activation agent participation dihydropyrrol-5-carboxylic acid synzyme (P5CS) and carbamyl phosphate synthetase I (CPS-I), promote the synthetic citrulling of glutamine or proline, and then promote arginic endogenous generation, to keeping arginine-level and body normal physiological function is very important.Nitric oxide is a cell message transmitter very important in vascular endothelial cell, the generation of catalysis cGMP, and cause loosening of blood vessel endothelium muscle, blood flow is increased.This sperm generation, maturation and discharge process to buck is all extremely important, blood flow increases, promoted that sperms such as amino acid generate the transmission of growing essential nutriment, produced simultaneously polyamines is a cation fat family amine, in cell growth, propagation and atomization, have important regulation, mainly participate in synthetic and the adjusting of stability and the adjusting of processes such as cell membrane function, enzyme function and cycli phosphate nucleoside metabolism of DNA, RNA and protein.Polyamines be present in prostate and secretion thereof and have higher concentration in refining to keeping the effect that is skillful in stability.They are to the direct activation of nuclear RNA polymerase tool, and are relevant with sperm number and dynamic role. and it is ripe that these physiological activators can promote that the sperm of buck produces, and improves sperm motility, strengthens fertility, thereby strengthen its reproductive performance.
Patent (application number: 200910062913.5) provide the N-carbamylglutamic acid to promote purposes in the pig growth, comprised as suckling pig, weanling pig, growth pig or replacement gilt and herd boar, particularly at the purposes in the newborn piglet growth, other does not see detailed applications and effect, is not applied to herd boar in order to improve its reproductive performance.
Use patent (the number of patent application: 201010227184.7) of N-carbamylglutamic acid on sow applied at this center, while is according to the mechanism of action of N-carbamylglutamic acid, carried out application test according to the using method on sow, test effect is not remarkable, and being applied to herd boar about N-carbamylglutamic acid and sodium salt mixt thereof, the purposes that improves reproductive performance does not see that patent documentation delivers.
Summary of the invention
Purpose of the present invention is intended to the above-mentioned defective at the prior art existence, the feed of a kind of N-of containing carbamylglutamic acid and sodium salt mixt thereof is provided, thereby this feed can either promote the synthetic of the endogenous arginine of herd boar body synthetic enhancing nitric oxide (NO) and polyamines, and then can guarantee its genetic potential of the more effective performance of herd boar, improve it and utilize the time limit and the general level of the health, and then improve the economic benefit of raising pigs.
The herd boar of a kind of N-of containing carbamylglutamic acid provided by the invention and N-carbamylglutamic acid sodium salt is used feed, and its improvements are that described feed comprises the following component of percentage meter by weight is prepared from:
The mixture and the auxiliary material of 0.10-0.25%N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt.
Provided by the invention first herd boar that preferably contains N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt is used feed, and described feed comprises the following component of percentage meter by weight is prepared from:
The mixture of 0.10-0.25%N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt and 99.75-99.90% auxiliary material.
Provided by the invention second herd boar that preferably contains N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt is used feed, and described feed comprises the following component of percentage meter by weight is prepared from: the mixture of 0.12-0.22%N-carbamylglutamic acid and sodium salt thereof and 99.78-99.88% auxiliary material.
The provided by the invention the 3rd herd boar that preferably contains N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt is used feed, and described feed comprises the following component of percentage meter by weight is prepared from: the mixture of 0.16-0.2%N-carbamylglutamic acid and sodium salt thereof and 99.84-99.8% auxiliary material.
The provided by the invention the 4th herd boar that preferably contains N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt is used feed, in the mixture of described N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt, the mass percent of N-carbamylglutamic acid is 20%-60%, and surplus is a N-carbamylglutamic acid sodium salt.
The provided by the invention the 5th herd boar that preferably contains N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt is used feed, and described auxiliary material comprises one or more the mixture that is selected from corn, Chinese sorghum, barley, wheat bran, dregs of beans, paddy, rice bran, fish meal, bone meal, the cotton benevolence dregs of rice, peanut cake, alfalfa meal, maize straw, zeolite powder, oyster shell whiting, vinasse, sunflower cake, molasses, calcium phosphate, the calcium carbonate.
The provided by the invention the 6th herd boar that preferably contains N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt is used feed, and described auxiliary material comprises one or more the mixture that is selected from mould inhibitor and the antioxidant:
Mould inhibitor: formic acid, calcium formate, sorbic acid, citric acid, horse dimethyl phthalate and allicin;
Antioxidant: TBHQ, n-propyl gallate, vitamin E.
The preparation method who contains the herd boar of N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt with feed provided by the invention comprises step:
1), with the auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize the 20-100 order;
2), N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt are weighed in described ratio;
3), auxiliary material and step 2 after the pulverizing that step 1) is obtained) the N-carbamylglutamic acid that obtains and the mixture of sodium salt thereof mix and whisk, and promptly gets finished feed through sieving.
The herd boar of the N-of containing carbamylglutamic acid provided by the invention and N-carbamylglutamic acid sodium salt and N-carbamylglutamic acid sodium salt is used feed, the application in improving the herd boar reproductive performance.
Technique scheme and design thereof:
Above-mentioned auxiliary material also can be the auxiliary material that is applied to other feeds except that enumerating.
The N-carbamylglutamic acid can promote in the herd boar body arginic endogenous synthetic, and then promote the synthetic of NO and polyamines, so feed provided by the invention, this feed has the herd boar self of raising arginine and transforms, improve the herd boar semen quality, improve the characteristics of herd boar reproductive performance.
N-carbamylglutamic acid of the present invention is according to application number: 200810187671.8 denomination of invention is the described method preparation of the patent application patent of " N-carbamylglutamic acid preparation method ".
Feed provided by the present invention can be made complete diet pellet feed, premix or concentrate feed, and the feed form can be graininess or powdery:
Premix is the abbreviation of additive premix, it is with one or more microcomponents (comprising additives such as various trace quantity mineral substance elements, various vitamin, synthesizing amino acid, some drugs) and diluent or carrier proportioning on request, the osculant compound feed products of making after evenly mixing; Premix is a kind of important component of perfect compound feed.
Concentrate feed is meant the remainder of removing energy feed in the complete feed, claims the balance mixed feed abroad, also claims protein-vitamin supplement feed; Mainly comprise protein feeds, constant mineral feed and additive premix.
Perfect compound feed also claims full-time grain mixed feed, and it can be directly used in the raising object of feeding, and can satisfy the nutritional need of the object of feeding comprehensively.Mainly comprise nutriments such as energy feed, protein feeds and mineral matter.
Compared with prior art, the herd boar of a kind of N-of containing carbamylglutamic acid provided by the invention and N-carbamylglutamic acid sodium salt has the following advantages with feed:
1, effective combination of N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt effectively improves the reproductive performance of herd boar;
2, the preparation method is simple, helps carrying out large-scale production;
3, can significantly reduce the person's of raising pigs cost, bring considerable economic interests;
4, effectively improve herd boar self arginine and transform, improve the herd boar semen quality, increase the reproductive capacity of herd boar;
Thereby 5, can promote the synthetic of the endogenous arginine of herd boar body synthetic enhancing nitric oxide (NO) and polyamines, and then can guarantee its genetic potential of the more effective performance of herd boar, improve it and utilize the time limit and the general level of the health.
Description of drawings
Fig. 1 is: the herd boar of a kind of N-of containing carbamylglutamic acid provided by the invention and N-carbamylglutamic acid sodium salt is with the influence figure of feed to the average volume of semen of herd boar;
Fig. 2 is: the herd boar of a kind of N-of containing carbamylglutamic acid provided by the invention and N-carbamylglutamic acid sodium salt is with the influence figure of feed to the herd boar sperm concentration;
Fig. 3 is: the herd boar of a kind of N-of containing carbamylglutamic acid provided by the invention and N-carbamylglutamic acid sodium salt is with the influence figure of feed to the herd boar sperm motility rate;
Fig. 4 is: the herd boar of a kind of N-of containing carbamylglutamic acid provided by the invention and N-carbamylglutamic acid sodium salt is with the influence figure of feed to the herd boar rate of teratosperm.
The specific embodiment
Below by the specific embodiment herd boar of a kind of N-of containing carbamylglutamic acid provided by the invention and N-carbamylglutamic acid sodium salt is cooked further more detailed description with feed.
Correlation test
Test 1
1.1 according to application number: 201010227184.7, the feed that denomination of invention is provided for " a kind of feed, preparation method and the purposes in improving sow reproductive performance thereof " feed respectively herd boar and sow, and be control group with the test group of feeding sow, observe the variation of the reproductive performance of herd boar and sow:
Test A feed formula: N-carbamylglutamic acid, 0.2%; Auxiliary material, 99.8%, auxiliary material is zeolite powder, cornstarch, peanut cake, rape, fish meal, rice bran, lime; Formic acid, calcium formate, sorbic acid, citric acid, horse dimethyl phthalate; TBHQ, n-propyl gallate, vitamin E, control group is for all being auxiliary material.
Test B feed formula: N-carbamylglutamic acid, 0.1%; Auxiliary material, 99.9% (auxiliary material is: the cotton benevolence dregs of rice, grass, potato, peanut cake, wheat, the stalk of sugarcane, rape, lime; Formic acid, calcium formate, sorbic acid, citric acid, horse dimethyl phthalate and allicin; TBHQ, n-propyl gallate, vitamin E).
Test C feed formula: N-carbamylglutamic acid, 0.05%; Auxiliary material, 99.95% (auxiliary material is: the stalk of zeolite powder, cornstarch, wheat bran, dregs of beans, peanut cake, wheat, sugarcane, rice bran, lime; Formic acid, calcium formate, sorbic acid, citric acid, allicin; TBHQ, n-propyl gallate, vitamin E).
Measure semen quality in the process of the test, index mainly comprises: volume of semen, sperm concentration, sperm motility rate, abnormal rate (seeing Table 1).
Table 1 N--carbamylglutamic acid is to the influence of semen quality
As can be seen from the above table, the N-carbamylglutamic acid has effect preferably to the herd boar semen quality, can obviously improve semen quality, thereby improves the fertility of herd boar.
Test 2
2.1 the preparation feed comprises the steps:
1), with 99.9% auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize 20 orders;
2), the 0.1%N-carbamylglutamic acid of the auxiliary material after the pulverizing that step 1) is obtained and described weight percent meter and N-carbamylglutamic acid sodium salt mix and whisk, and promptly gets finished feed through sieving; Wherein, N-carbamylglutamic acid mass percent is 20%.
Auxiliary material: corn, dregs of beans, Chinese sorghum, fish meal, rice bran, zeolite powder; Formic acid, calcium formate, sorbic acid, citric acid, horse dimethyl phthalate; TBHQ, n-propyl gallate, vitamin E.
2.2 with the described herd boar complete diet pellet of the step 1.1 finished feed breeding season herd boar of feeding, measure semen quality in the process of the test, data see Table 2, index mainly comprises: volume of semen, sperm concentration, sperm motility rate, abnormal rate.
3.1, be used for the preparation of herd boar feed with feed of the present invention:
1), with 99.75% auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize 100 orders;
2), the 0.25%N-carbamylglutamic acid of the auxiliary material after the pulverizing that step 1) is obtained and described weight percent meter and N-carbamylglutamic acid sodium salt mix and whisk, and promptly gets finished feed through sieving; Wherein, N-carbamylglutamic acid mass percent is 60%.
Auxiliary material: corn, wheat bran, peanut cake, wheat, rice bran, oyster shell whiting; Formic acid, calcium formate, sorbic acid, citric acid, allicin; TBHQ, n-propyl gallate, vitamin E.
Feed 3.2 the feed that step 2.1 is prepared carries out herd boar, measure semen quality (data see Table 2)
4.1, be used for the preparation of herd boar feed with feed of the present invention:
1), with 99.78% auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize 70 orders;
2), the 0.22%N-carbamylglutamic acid of the auxiliary material after the pulverizing that step 1) is obtained and described weight percent meter and N-carbamylglutamic acid sodium salt mix and whisk, and promptly gets finished feed through sieving; Wherein, N-carbamylglutamic acid mass percent is 30%.
Auxiliary material: corn, Chinese sorghum, barley, wheat bran, dregs of beans, paddy, rice bran, fish meal, bone meal, the cotton benevolence dregs of rice, peanut cake, alfalfa meal, maize straw, grass meal, zeolite powder, oyster shell whiting, vinasse, sunflower cake, molasses, calcium phosphate, calcium carbonate; Formic acid, citric acid, allicin; TBHQ, vitamin E.
Feed 4.2 the feed that step 4.1 is prepared carries out herd boar, measure semen quality (data see Table 2).
Table 2 N-carbamylglutamic acid and sodium salt mixt thereof are to the influence of semen quality
The feed of the N-of the containing carbamylglutamic acid of the present invention as can be seen from Table 2 herd boar of feeding, to improving semen volume, seminal concentration improves former smart vigor significant effect, compare with data in the table 1, N-carbamylglutamic acid and sodium salt mixt thereof are to improving semen quality, and the fertility effect that improves herd boar is better.
Test 5
5.1 preparation herd boar feed comprises the steps:
1), with 99.75% auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize 20 orders; Auxiliary material: corn, Chinese sorghum, barley, paddy, fish meal, bone meal.
2), take by weighing the 0.25%N-carbamylglutamic acid of described weight percent meter and the mixture of sodium salt thereof, the percentage by weight of N-carbamylglutamic acid is 20%, 80% to be N-carbamylglutamic acid sodium salt in the described mixture.
3), with described auxiliary material of step 1) and step 2) mixture of described N-carbamylglutamic acid and sodium salt thereof mixes and whisks, and promptly gets finished feed through sieving.
5.2 with the described herd boar complete diet pellet of the step 2.1 finished feed breeding season herd boar (data are seen Fig. 1 to Fig. 4) of feeding, control group is respectively the blank group.
Test 6
6.1, be used for the preparation of herd boar feed with feed of the present invention:
1), with 99.9% auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize 100 orders; Auxiliary material: bone meal, alfalfa meal, oyster shell whiting, vinasse, sunflower cake, molasses, calcium phosphate, calcium carbonate.
2), take by weighing the 0.1%N-carbamylglutamic acid of described weight percent meter and the mixture of sodium salt thereof, the percentage by weight of N-carbamylglutamic acid is 50%, 50% to be N-carbamylglutamic acid sodium salt in the described mixture.
3), auxiliary material and step 2 after the pulverizing that step 1) is obtained) the N-carbamylglutamic acid that obtains and the mixture of sodium salt thereof mix and whisk, and promptly gets finished feed through sieving.
Feed 6.2 the feed that step 3.1 is prepared carries out herd boar, measuring semen quality (data are seen Fig. 1 to Fig. 4) control group is the blank group.
7.1, be used for the preparation of herd boar feed with feed of the present invention:
1), with 98.85% auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize 70 orders; Auxiliary material: corn, Chinese sorghum, barley, paddy, fish meal, bone meal, alfalfa meal, oyster shell whiting, vinasse, sunflower cake, molasses, calcium phosphate, calcium carbonate.
2), take by weighing the 0.15%N-carbamylglutamic acid of described weight percent meter and the mixture of sodium salt thereof, the percentage by weight of N-carbamylglutamic acid is 60%, 40% to be N-carbamylglutamic acid sodium salt in the described mixture.
3), auxiliary material and step 2 after the pulverizing that step 1) is obtained) the N-carbamylglutamic acid that obtains and the mixture of sodium salt thereof mix and whisk, and promptly gets finished feed through sieving.
Feed 7.2 the feed that step 4.1 is prepared carries out herd boar, (data see that Fig. 1-Fig. 4) control group is a blank to measure semen quality.
By Fig. 1 to Fig. 4 as can be seen, the feed of the N-of containing carbamylglutamic acid of the present invention and sodium salt mixt thereof the herd boar of feeding, to improving semen volume and sperm concentration, raising sperm motility rate, reducing rate of teratosperm has significant effect, thereby can improve the reproductive performance of herd boar.
Embodiment 1
The herd boar of present embodiment is used feed, and wherein said feed comprises the following component of percentage meter by weight is prepared from:
The mixture of 0.10%N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt and 99.90% auxiliary material.
In the mixture of N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt, the mass percent of N-carbamylglutamic acid is 20%, and surplus is a N-carbamylglutamic acid sodium salt.
Auxiliary material comprises and is selected from corn, Chinese sorghum, barley, wheat bran, dregs of beans, paddy, rice bran, fish meal, bone meal, the cotton benevolence dregs of rice, peanut cake, alfalfa meal, maize straw, zeolite powder, oyster shell whiting, vinasse, sunflower cake, molasses, calcium phosphate, calcium carbonate; Mould inhibitor: formic acid, calcium formate, sorbic acid, citric acid, horse dimethyl phthalate and allicin; Antioxidant: TBHQ, n-propyl gallate, vitamin E.
Herd boar is used the preparation method of feed, comprises step:
1), with the auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize 20 orders;
2), N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt are weighed in described ratio;
3), auxiliary material and step 2 after the pulverizing that step 1) is obtained) the N-carbamylglutamic acid that obtains and the mixture of sodium salt thereof mix and whisk, and promptly gets finished feed through sieving.
Embodiment 2
The herd boar of present embodiment is used feed, it is characterized in that described feed comprises the following component of percentage meter by weight is prepared from: the mixture of 0.12%N-carbamylglutamic acid and sodium salt thereof and 99.88% auxiliary material.
In the mixture of N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt, the mass percent of N-carbamylglutamic acid is 60%, and surplus is a N-carbamylglutamic acid sodium salt.
Auxiliary material comprises and is selected from corn, Chinese sorghum, barley, wheat bran, dregs of beans, paddy, rice bran, fish meal, bone meal, the cotton benevolence dregs of rice, peanut cake, alfalfa meal, maize straw, zeolite powder, oyster shell whiting, vinasse, sunflower cake, molasses, calcium phosphate, calcium carbonate; Mould inhibitor: formic acid, calcium formate, sorbic acid, citric acid, horse dimethyl phthalate and allicin;
Antioxidant: TBHQ, n-propyl gallate, vitamin E.
Herd boar is used the preparation method of feed, comprises step:
1), with the auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize 100 orders;
2), N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt are weighed in described ratio;
3), auxiliary material and step 2 after the pulverizing that step 1) is obtained) the N-carbamylglutamic acid that obtains and the mixture of sodium salt thereof mix and whisk, and promptly gets finished feed through sieving.
The herd boar of present embodiment is used feed, it is characterized in that described feed comprises the following component of percentage meter by weight is prepared from: the mixture of 0.16%N-carbamylglutamic acid and sodium salt thereof and 99.84% auxiliary material.
In the mixture of N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt, the mass percent of N-carbamylglutamic acid is 40%, and surplus is a N-carbamylglutamic acid sodium salt.
Auxiliary material comprises and is selected from corn, Chinese sorghum, barley, wheat bran, dregs of beans, paddy, rice bran, fish meal, bone meal, the cotton benevolence dregs of rice, peanut cake, alfalfa meal, maize straw, zeolite powder, oyster shell whiting, vinasse, sunflower cake, molasses, calcium phosphate, calcium carbonate; Mould inhibitor: formic acid, calcium formate, sorbic acid, citric acid, horse dimethyl phthalate and allicin;
Antioxidant: TBHQ, n-propyl gallate, vitamin E.
Herd boar is used the preparation method of feed, comprises step:
1), with the auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize 70 orders;
2), N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt are weighed in described ratio;
3), auxiliary material and step 2 after the pulverizing that step 1) is obtained) the N-carbamylglutamic acid that obtains and the mixture of sodium salt thereof mix and whisk, and promptly gets finished feed through sieving.
The herd boar of present embodiment is used feed, and wherein said feed comprises the following component of percentage meter by weight is prepared from:
The mixture of 0.25%N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt and 99.75% auxiliary material.
In the mixture of N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt, the mass percent of N-carbamylglutamic acid is 30%, and surplus is a N-carbamylglutamic acid sodium salt.
Auxiliary material comprises and is selected from corn, Chinese sorghum, barley, wheat bran, dregs of beans, paddy, rice bran, fish meal, bone meal, the cotton benevolence dregs of rice, peanut cake, alfalfa meal, maize straw, zeolite powder, oyster shell whiting, vinasse, sunflower cake, molasses, calcium phosphate, calcium carbonate; Mould inhibitor: formic acid, calcium formate, sorbic acid, citric acid, horse dimethyl phthalate and allicin;
Antioxidant: TBHQ, n-propyl gallate, vitamin E.
Herd boar is used the preparation method of feed, comprises step:
1), with the auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize 90 orders;
2), N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt are weighed in described ratio;
3), auxiliary material and step 2 after the pulverizing that step 1) is obtained) the N-carbamylglutamic acid that obtains and the mixture of sodium salt thereof mix and whisk, and promptly gets finished feed through sieving.
Embodiment 5
The herd boar of present embodiment is used feed, it is characterized in that described feed comprises the following component of percentage meter by weight is prepared from: the mixture of 0.22%N-carbamylglutamic acid and sodium salt thereof and 99.78% auxiliary material.
In the mixture of N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt, the mass percent of N-carbamylglutamic acid is 35%, and surplus is a N-carbamylglutamic acid sodium salt.
Auxiliary material comprises and is selected from corn, Chinese sorghum, barley, wheat bran, dregs of beans, paddy, rice bran, fish meal, bone meal, the cotton benevolence dregs of rice, peanut cake, alfalfa meal, maize straw, zeolite powder, oyster shell whiting, vinasse, sunflower cake, molasses, calcium phosphate, calcium carbonate; Mould inhibitor: formic acid, calcium formate, sorbic acid, citric acid, horse dimethyl phthalate and allicin;
Antioxidant: TBHQ, n-propyl gallate, vitamin E.
Herd boar is used the preparation method of feed, comprises step:
1), with the auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize 60 orders;
2), N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt are weighed in described ratio;
3), auxiliary material and step 2 after the pulverizing that step 1) is obtained) the N-carbamylglutamic acid that obtains and the mixture of sodium salt thereof mix and whisk, and promptly gets finished feed through sieving.
Embodiment 6
The herd boar of present embodiment is used feed, it is characterized in that described feed comprises the following component of percentage meter by weight is prepared from: the mixture of 0.2%N-carbamylglutamic acid and sodium salt thereof and 99.8% auxiliary material.
In the mixture of N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt, the mass percent of N-carbamylglutamic acid is 25%, and surplus is a N-carbamylglutamic acid sodium salt.
Auxiliary material comprises and is selected from corn, Chinese sorghum, barley, wheat bran, dregs of beans, paddy, rice bran, fish meal, bone meal, the cotton benevolence dregs of rice, peanut cake, alfalfa meal, maize straw, zeolite powder, oyster shell whiting, vinasse, sunflower cake, molasses, calcium phosphate, calcium carbonate; Mould inhibitor: formic acid, calcium formate, sorbic acid, citric acid, horse dimethyl phthalate and allicin;
Antioxidant: TBHQ, n-propyl gallate, vitamin E.
Herd boar is used the preparation method of feed, comprises step:
1), with the auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize 80 orders;
2), N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt are weighed in described ratio;
3), auxiliary material and step 2 after the pulverizing that step 1) is obtained) the N-carbamylglutamic acid that obtains and the mixture of sodium salt thereof mix and whisk, and promptly gets finished feed through sieving.
Should be noted that at last: above embodiment is only in order to illustrate that technical scheme of the present invention is not intended to limit; although the present invention is had been described in detail with reference to the foregoing description; those of ordinary skill in the field are to be understood that: the technical staff reads after the present specification still and can make amendment or be equal to replacement the specific embodiment of the present invention, but these modifications or change all do not break away within the claim protection domain that the present patent application awaits the reply.
Claims (9)
1. a herd boar that contains N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt is used feed, it is characterized in that described feed comprises the following component of percentage meter by weight is prepared from:
The mixture and the auxiliary material of 0.10-0.25%N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt.
2. herd boar according to claim 1 is used feed, it is characterized in that described feed comprises the following component of percentage meter by weight is prepared from:
The mixture of 0.10-0.25%N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt and 99.75-99.90% auxiliary material.
3. herd boar according to claim 1 is used feed, it is characterized in that described feed comprises the following component of percentage meter by weight is prepared from: the mixture of 0.12-0.22%N-carbamylglutamic acid and sodium salt thereof and 99.78-99.88% auxiliary material.
4. herd boar according to claim 1 is used feed, it is characterized in that described feed comprises the following component of percentage meter by weight is prepared from: the mixture of 0.16-0.2%N-carbamylglutamic acid and sodium salt thereof and 99.84-99.8% auxiliary material.
5. use feed according to claim 1 or 2 or 3 or 4 described herd boars, it is characterized in that in the mixture of described N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt, the mass percent of N-carbamylglutamic acid is 20%～60%, and surplus is a N-carbamylglutamic acid sodium salt.
6. use feed according to claim 1 or 2 or 3 or 4 described herd boars, it is characterized in that described auxiliary material comprises one or more the mixture that is selected from corn, Chinese sorghum, barley, wheat bran, dregs of beans, paddy, rice bran, fish meal, bone meal, the cotton benevolence dregs of rice, peanut cake, alfalfa meal, maize straw, zeolite powder, oyster shell whiting, vinasse, sunflower cake, molasses, calcium phosphate, the calcium carbonate.
7. use feed according to claim 1 or 2 or 3 or 4 described herd boars, it is characterized in that described auxiliary material comprises one or more the mixture that is selected from mould inhibitor and the antioxidant:
Mould inhibitor: formic acid, calcium formate, sorbic acid, citric acid, horse dimethyl phthalate and allicin;
Antioxidant: TBHQ, n-propyl gallate, vitamin E.
8. a herd boar according to claim 1 comprises step with the preparation method of feed:
1), with the auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize the 20-100 order;
2), N-carbamylglutamic acid and N-carbamylglutamic acid sodium salt are weighed in described ratio;
3), auxiliary material and step 2 after the pulverizing that step 1) is obtained) the N-carbamylglutamic acid that obtains and the mixture of sodium salt thereof mix and whisk, and promptly gets finished feed through sieving.
9. the feed that limits of claim 1, the application in improving the herd boar reproductive performance.
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| CN103494008A (en) * | 2013-08-27 | 2014-01-08 | 安徽省瑞森生物科技有限责任公司 | Forage for 30- to 90-day-old pigs and preparation method thereof |
| CN103829085A (en) * | 2014-01-06 | 2014-06-04 | 张勇 | Mixed feed for improving antioxidant activity of sperm of boar |
| CN103829085B (en) * | 2014-01-06 | 2015-08-26 | 张勇 | A kind of mixed feed improving boar sperm antioxidation activity |
| CN104031971A (en) * | 2014-02-28 | 2014-09-10 | 济南环亿生物科技有限公司 | Producing method of N-carbamylglutamate by free cell fermentation method, and applications of metabolites of the N-carbamylglutamate |
| CN104031971B (en) * | 2014-02-28 | 2018-04-24 | 山东环亿生物科技有限公司 | A kind of free cell fermentation method production N-carbamylglutamic acid and its method for metabolite application |
| CN104187152A (en) * | 2014-08-29 | 2014-12-10 | 广西富来康饲料有限公司 | Pig feed and preparation method thereof |
| CN104770607A (en) * | 2015-04-15 | 2015-07-15 | 唐人神集团股份有限公司 | Complete compound feed for boar and preparation method thereof |
| CN108342352A (en) * | 2018-04-20 | 2018-07-31 | 北京市农林科学院 | Application of the N- carbamylglutamic acids in pig follicle granular cell in vitro culture |
| CN108342352B (en) * | 2018-04-20 | 2021-06-22 | 北京市农林科学院 | Application of N-carbamylglutamic acid in-vitro culture of porcine follicular granulosa cells |
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