CN102091370A - Medicament automatic lead-in system with electronic stimulating function - Google Patents
Medicament automatic lead-in system with electronic stimulating function Download PDFInfo
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- CN102091370A CN102091370A CN 201110041301 CN201110041301A CN102091370A CN 102091370 A CN102091370 A CN 102091370A CN 201110041301 CN201110041301 CN 201110041301 CN 201110041301 A CN201110041301 A CN 201110041301A CN 102091370 A CN102091370 A CN 102091370A
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Abstract
The invention relates to a medicament automatic injection lead-in system with an electronic stimulating function, which comprises a handheld shell, an injector, an automatic microinjector and a control consol, wherein the injector is arranged in the handheld shell; the automatic microinjector is connected with the injector; and the control console is electrically connected with the automatic microinjector. The medicament automatic injection lead-in system is characterized in that: an electric stimulator is arranged in the handheld shell and electrically connected with the control consol; and a singlechip with multiple interfaces is arranged in the control consol. The automatic medicament injection control and electric stimulus are combined by the singlechip, a signal is sent to trigger the electronic stimulator after the medicament is automatically injected, and the generated electric pulse signal is transmitted to a receptor tissue, so the permeability of the cell membranes of the tissue and the medicament absorption ratio of cells are improved.
Description
Technical field
The invention belongs to medical Instrument field, relate to a kind of automatic import system of medicine with electricity irritation function.
Background technology
For a long time, the mode of prevention and treatment disease has a variety of, as oral drugs, intravenous injection, intramuscular injection etc.In case mode is selected, receptor depends on physics and chemical factor with receptor autophosphorylation to a great extent to the absorption of medicine and curative effect.Studies show that in recent years, the live body electroporation technology utilizes electric impulse signal to change the permeability of cell membrane, thereby make things convenient for medicine to enter the absorbance of the raising receptor of very big degree in the cell tissue to medicine, this technology is used widely at medical domain, occurs a lot of medicines based on this technology on the market thereupon and imports instrument.This quasi-instrument utilizes the stimulating electrical signal destination organization, thereby the absorption efficiencies of macromole in histiocyte such as raising dna vaccination have the good clinical effect, are used widely.
On the other hand, traditional injection system also faces the challenge.Progress along with science and technology, the medicine injection device develops towards the direction of automatization, precise treatment, occurred a lot of automatic injecting instrument devices, automatic syringe pump, precise injection device etc. on the market, the appearance of this quasi-instrument has improved the automatization of medicine injection, has also improved the precision of little metered shot.
But in actual applications, the medicine injection generally is a proceed step by step with electricity irritation, receptor is accepted medicine injection back (being generally traditional intramuscular injection) at specific destination organization place, operator adopt medicine importing instrument that this destination organization is carried out stimulating electrical signal, accelerate the absorption of histiocyte to medicine.Because step by step, divide instrument to carry out, this kind mode causes injection and the intermediary interval of electricity irritation bigger, influence the effect that medicine imports, this mode of while operates more loaded down with trivial details, automaticity is low.
Therefore, a kind ofly gather automatic injection and electricity irritation and be forced to be essential in the medicine import system of one and ask.
Summary of the invention
The object of the present invention is to provide a kind of medicine to inject import system automatically, can realize easily specific receptor tissue is carried out medicine injection and stimulating electrical signal automatically, thereby improve the efficient that medicine imports receptor with electricity irritation function.
For achieving the above object, the present invention adopts following technical proposals: a kind of medicine with electricity irritation function is injected import system automatically, comprise by a hand-held housing, be installed in the intravital injection device of handheld housing and connect micro-automated injection device of injection device and inject import system automatically with the medicine that a control station that micro-automated injection device electrically connects constitutes, it is characterized in that also being provided with an electrical stimulation device in the described hand-held housing, this electrical stimulation device also electrically connects described control station; Be provided with the single-chip microcomputer of many interfaces in the described control station, by single-chip microcomputer medicine is injected control and electricity irritation set automatically, be implemented in medicine and send the signal triggering electrical stimulation device after the injection automatically, produce electric impulse signal and import receptor tissue into, change the permeability of the cell membrane at tissue place, improve the absorbance of cell medicine.
The structure of above-mentioned hand-held housing is: a preceding tube rear end is connected with a back seat by helicitic texture, end cap of described placket front end sliding sleeve, and this end cap inner chamber is mounted with spring, has step to slide spacing to slip lid on the slideway of this end cap and placket sliding sleeve.
The structure of above-mentioned automated injection device is: a syringe cylinder is fixedly mounted in the described placket, and a syringe needle that is fixed in the syringe cylinder front end is in the described end cap, and a syringe piston rod stretches out from the rear end of described syringe cylinder.
The structure of above-mentioned micro-automated injection device is: fix a motor in the intracavity posterior end bottom of described back seat, fix a bevel gear on the output shaft of this motor, the back seat internal fixation is installed a rhizoid bar, fix a bevel gear on this screw mandrel rearward end, this bevel gear is meshed with described bevel gear, revolve on this screw mandrel and join slide block, a pressure transducer is installed on this slide block, the rear end of described syringe piston rod abuts against this pressure transducer.
The structure of above-mentioned electrical stimulation device is: two electrode needle of setting-in in described placket, and this electrode needle stretches in the described end cap, and needle point flushes with described syringe needle, the rear end of described two electrode needle is electrically connected with two sheet metals that are fixed on described back seat internal fixation.
The housing of above-mentioned control station is provided with display screen and input keyboard, and the circuit structure of described control station is: single-chip microcomputer connects an input and display unit, electric power system, pick off and signal processing unit, an electric impulse signal generation systems and a stepper motor transmission system respectively; Described input and display unit connect described display screen and keyboard, and described pick off and signal processing unit connect described pressure transducer, and described electric impulse signal generation systems connects described sheet metal, and described stepper motor transmission system connects described motor.
The present invention compared with prior art, have following conspicuous salience characteristics and remarkable advantage: the present invention injects control by single-chip microcomputer automatically with medicine and gathers in one with electricity irritation, has changed the existing medicine injection and the present situation of electricity irritation separate operation.The present invention can realize the precision control injection of trace drug, simultaneously can be by the receptor injection site being carried out electric pulse stimulation to improve the absorbance of receptor to medicine.
Description of drawings
Fig. 1 is a structural representation of the present invention;
Fig. 2 is the theory diagram of controller;
Fig. 3 is a placket motion sketch map in the specific embodiment of the invention.
The specific embodiment
Details are as follows in conjunction with the accompanying drawings for preferential embodiment of the present invention:
Embodiment one:
Referring to Fig. 1, originally the medicine that has the electricity irritation function is injected import system automatically, comprise by a hand-held housing, be installed in the intravital injection device of handheld housing and connect micro-automated injection device of injection device and inject import system automatically with the medicine that a control station that micro-automated injection device electrically connects constitutes, it is characterized in that also being provided with an electrical stimulation device in the described hand-held housing, this electrical stimulation device also electrically connects described control station; Be provided with the single-chip microcomputer of many interfaces in the described control station, by single-chip microcomputer medicine is injected control and electricity irritation set automatically, be implemented in medicine and send the signal triggering electrical stimulation device after the injection automatically, produce electric impulse signal and import receptor tissue into, change the permeability of the cell membrane at tissue place, improve the absorbance of cell medicine.
Embodiment two:
Referring to Fig. 1 and Fig. 2, present embodiment and embodiment one are basic identical, special feature is as follows: the structure of described hand-held housing (500) is: a placket (501) rear end is connected with a back seat (502) by helicitic texture (505), described placket (a 501) end cap of front end sliding sleeve (503), this end cap (503) inner chamber is mounted with spring (504), has step (506) to slide spacing to slip lid (503) on the slideway of this end cap (503) and placket (501) sliding sleeve.The structure of described automated injection device (400) is: a syringe cylinder (401) is fixedly mounted in the described placket (501), a syringe needle (403) that is fixed in syringe cylinder (401) front end is in the described end cap (503), and a syringe piston rod (402) stretches out from the rear end of described syringe cylinder (401).The structure of described micro-automated injection device (100) is: fix a motor (101) in the intracavity posterior end bottom of described back seat (502), fix a bevel gear (102) on the output shaft of this motor (101), back seat (502) internal fixation is installed a rhizoid bar (103), fix a bevel gear on this screw mandrel (103) rearward end, this bevel gear is meshed with described bevel gear (102), revolve on this screw mandrel (103) and join slide block (104), this slide block (104) is gone up a pressure transducer (106) is installed, and the rear end of described syringe piston rod (402) abuts against this pressure transducer (106).The structure of described electrical stimulation device (200) is: two electrode needle of setting-in (201) in described placket (501), this electrode needle (201) stretches in the described end cap (503), and needle point flushes with described syringe needle (403), and the rear end of described two electrode needle (201) is electrically connected with two sheet metals (202) that are fixed on described back seat (502) internal fixation.The housing of described control station (300) is provided with display screen (301) and input keyboard (302), and the circuit structure of described control station (300) is: a single-chip microcomputer (303) connects an input and display unit (308), an electric power system (307), pick off and signal processing unit (304), an electric impulse signal generation systems (306) and a stepper motor transmission system (305) respectively; Described input and display unit (308) connect described display screen (301) and keyboard (302), described pick off and signal processing unit (304) connect described pressure transducer (106), described electric impulse signal generation systems (306) connects described sheet metal (202), and described stepper motor transmission system (305) connects described motor (101).
Embodiment three:
Referring to accompanying drawing 1, the medicine that originally has the electricity irritation function is injected import system automatically mainly by micro-automated injection device 100, electrical stimulation device 200, and control station 300, injection device 400, hand-held housing 500 is formed.Automated injection device 100, electrical stimulation device 200, injection device 400 is encapsulated in the hand-held housing 500.Housing 500 is divided into placket 501, back seat 502 and end cap 503, and placket 501 is connected with 502 by helicitic texture 505, by rotating separating and being connected of realization placket 501 and back seat 502.Be fixed with motor 101 in the back seat 502 and be connected with screw mandrel 103, realize injection automatically but be connected with slide block 104 pushing syringe piston rods 402 on the screw mandrel 103 by bevel gear 102.Slide block 104 is provided with pressure transducer 106 with piston rod 406 contact positions, and back seat 101 is provided with limit switch 105.Placket 501 front ends have Baltimore groove, and the top of Baltimore groove has through hole, and groove shapes matches with the syringe front end, is used for fixing syringe.The rear end of placket 501 has circular hole, and syringe cylinder 401 can insert in the placket 501 by circular hole, and syringe needle 403 stretches out by through hole, and length is about 13mm.
501 of end cap 503 and plackets are provided with slideway and step 506, end cap 503 stressed can moving along slideway, and 506 places stop to step.End cap 503 is provided with spring 504, the power that available buffer is suffered with the front end of placket 501.Placket 501 is embedded with two electrode needle 201, described electrode needle is an acupuncture needle, two pin spacings are 10mm, electrode needle one end exceeds barrel front end 13mm, consistent with syringe needle, the other end gos deep into back seat 502 and contact with the sheet metal 202 of conduction along placket, and sheet metal 202 is provided with and embeds mouth, be the increase contact area, but this end face overstriking of electrode needle.
The connection lead 203 of electrode needle, Stepping Motor Control circuit and power circuit link to each other with control station 300, are packaged with the controller of realizing injection automatically and electricity irritation in the control station 300, and the surface is provided with display screen 301 and keyboard 302.
Take off placket 501 from back seat 502, with the injection device 400 that medicine the is housed placket 501 of packing into, the placket choosing that injection device will be housed screws in back seat, and at this moment, electrode needle 201 contacts with conductive metal sheet 202, and spring 503 is in relaxed state.With outer end cap 503 contact receptors, press the on ﹠ off switch on the control station, select motor parameter, electrical stimulation pattern and electric impulse signal parameter and stimulation time.With drive end bearing bracket 503 contact receptors, and vertically firmly electrode needle and syringe needle are inserted receptor.Press automatic injection and trigger key, motor 101 rotates, drive slide block 104, when 104 touch piston rod 402, pressure transducer 106 beginning acknowledge(ment) signals, by the time medicine injection finishes, piston rod 402 is subjected to the resistance from the syringe cylinder front end, pressure transducer 106 detected pressure increase, and reach thresholding, and signal feedback is given single-chip microcomputer, 101 stop motions of control step motor, trigger electric-stimulation controller simultaneously, the electric impulse signal of generation imports recipient cell into by electrode needle 201, carries out electricity irritation.Oppositely pin is extracted receptor after electricity irritation stops, pressing the motor reset key simultaneously according to the displacement of walking before, oppositely slide block is belonged to raw bits, use convenient next time.Take off placket 501, injection device 200 is taken off, the placket of sky is loaded onto, use convenient next time.When pressure transducer 106 lost efficacy, piston rod 106 went beyond the limit of the position under the driving of motor, touch limit switch 105, the motor stop motion, thus play the effect of overload protection.
Fig. 3 has showed that syringe needle inserts receptor and extracts end cap and movement of springs process in the placket of receptor.
The description of this invention and non-limiting, based on other embodiment of inventive concept, all among protection scope of the present invention.
Claims (6)
1. the medicine with electricity irritation function is injected import system automatically, comprise by a hand-held housing (500), be installed in a micro-automated injection device (100) of interior injection device (400) of hand-held housing (500) and connection injection device (400), and the medicine that a control station (300) that electrically connects with micro-automated injection device (100) constitutes is injected import system automatically, it is characterized in that also being provided with an electrical stimulation device (200) in the described hand-held housing (500), this electrical stimulation device (200) also electrically connects described control station (300); Be provided with the single-chip microcomputer of many interfaces in the described control station (300), by single-chip microcomputer medicine is injected control and electricity irritation set automatically, be implemented in medicine and send signal triggering electrical stimulation device (200) after the injection automatically, produce electric impulse signal and import receptor tissue into, change the permeability of the cell membrane at tissue place, improve the absorbance of cell medicine.
2. the medicine with electricity irritation function according to claim 1 is injected import system automatically, the structure that it is characterized in that described hand-held housing (500) is: a placket (501) rear end is connected with a back seat (502) by helicitic texture (505), described placket (a 501) end cap of front end sliding sleeve (503), this end cap (503) inner chamber is mounted with spring (504), has step (506) to slide spacing to slip lid (503) on the slideway of this end cap (503) and placket (501) sliding sleeve.
3. the medicine with electricity irritation function according to claim 2 is injected import system automatically, the structure that it is characterized in that described automated injection device (400) is: a syringe cylinder (401) is fixedly mounted in the described placket (501), a syringe needle (403) that is fixed in syringe cylinder (401) front end is in the described end cap (503), and a syringe piston rod (402) stretches out from the rear end of described syringe cylinder (401).
4. the medicine with electricity irritation function according to claim 3 is injected import system automatically, the structure that it is characterized in that described micro-automated injection device (100) is: fix a motor (101) in the intracavity posterior end bottom of described back seat (502), fix a bevel gear (102) on the output shaft of this motor (101), back seat (502) internal fixation is installed a rhizoid bar (103), fix a bevel gear on this screw mandrel (103) rearward end, this bevel gear is meshed with described bevel gear (102), revolve on this screw mandrel (103) and join slide block (104), this slide block (104) is gone up a pressure transducer (106) is installed, and the rear end of described syringe piston rod (402) abuts against this pressure transducer (106).
5. the medicine with electricity irritation function according to claim 2 is injected import system automatically, the structure that it is characterized in that described electrical stimulation device (200) is: two electrode needle of setting-in (201) in described placket (501), this electrode needle (201) stretches in the described end cap (503), and needle point flushes with described syringe needle (403), and the rear end of described two electrode needle (201) is electrically connected with two sheet metals (202) that are fixed on described back seat (502) internal fixation.
6. according to claim 4, or 5 described medicine with electricity irritation function inject import system automatically, the housing that it is characterized in that described control station (300) is provided with display screen (301) and input keyboard (302), and the circuit structure of described control station (300) is: a single-chip microcomputer (303) connects an input and display unit (308), an electric power system (307), pick off and signal processing unit (304), an electric impulse signal generation systems (306) and a stepper motor transmission system (305) respectively; Described input and display unit (308) connect described display screen (301) and keyboard (302), described pick off and signal processing unit (304) connect described pressure transducer (106), described electric impulse signal generation systems (306) connects described sheet metal (202), and described stepper motor transmission system (305) connects described motor (101).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110041301 CN102091370B (en) | 2011-02-21 | 2011-02-21 | Medicament automatic lead-in system with electronic stimulating function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110041301 CN102091370B (en) | 2011-02-21 | 2011-02-21 | Medicament automatic lead-in system with electronic stimulating function |
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| Publication Number | Publication Date |
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| CN102091370A true CN102091370A (en) | 2011-06-15 |
| CN102091370B CN102091370B (en) | 2013-03-06 |
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| CN 201110041301 Expired - Fee Related CN102091370B (en) | 2011-02-21 | 2011-02-21 | Medicament automatic lead-in system with electronic stimulating function |
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Cited By (13)
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|---|---|---|---|---|
| CN102614565A (en) * | 2012-04-01 | 2012-08-01 | 上海大学 | Automatic micro-injection device |
| CN102657534A (en) * | 2012-05-17 | 2012-09-12 | 上海理工大学 | Closed opening burst pressure measuring device for biological pipeline |
| CN102887630A (en) * | 2012-10-26 | 2013-01-23 | 扬州大学 | Vacuum glass edge sealing welding flux spreading device |
| CN103300817A (en) * | 2012-03-15 | 2013-09-18 | 上海理工大学 | Blood vessel seal bursting pressure wireless measurement system |
| CN103861202A (en) * | 2014-03-18 | 2014-06-18 | 苏州文曲生物微系统有限公司 | Device for administrating medicine by use of electroporation of hollow electrode needle |
| CN106823125A (en) * | 2017-03-24 | 2017-06-13 | 长沙利星医药科技开发有限公司 | A kind of device of use amplitude modulation electric-field enhancing curative effect of medication |
| WO2018210345A1 (en) * | 2017-05-18 | 2018-11-22 | Chen Wen Shiang | Apparatus for delivery of agent |
| CN109432552A (en) * | 2018-09-28 | 2019-03-08 | 中国船舶重工集团公司第七六研究所 | The dynamic pressure detection system and method for oral anesthestia injecting systems |
| CN109937061A (en) * | 2016-11-15 | 2019-06-25 | 伊莱利利公司 | Medicine delivery device with mechanical locking system |
| CN111249614A (en) * | 2020-02-12 | 2020-06-09 | 高泰康 | Novel transducer and ultrasonic wave leading-in instrument |
| CN113274116A (en) * | 2021-05-12 | 2021-08-20 | 香港普创生物科技有限公司 | Full-automatic electric pulse perforation syringe |
| CN113307110A (en) * | 2021-06-02 | 2021-08-27 | 广州相佳数码科技有限公司 | Electric acupuncture instrument with wire winding function |
| CN114306805A (en) * | 2022-01-17 | 2022-04-12 | 中国科学院苏州生物医学工程技术研究所 | Automatic injection system |
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Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103300817A (en) * | 2012-03-15 | 2013-09-18 | 上海理工大学 | Blood vessel seal bursting pressure wireless measurement system |
| CN103300817B (en) * | 2012-03-15 | 2014-12-17 | 上海理工大学 | Blood vessel seal bursting pressure wireless measurement system |
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| CN102614565A (en) * | 2012-04-01 | 2012-08-01 | 上海大学 | Automatic micro-injection device |
| CN102657534A (en) * | 2012-05-17 | 2012-09-12 | 上海理工大学 | Closed opening burst pressure measuring device for biological pipeline |
| CN102657534B (en) * | 2012-05-17 | 2014-03-19 | 上海理工大学 | Closed opening burst pressure measuring device for biological pipeline |
| CN102887630A (en) * | 2012-10-26 | 2013-01-23 | 扬州大学 | Vacuum glass edge sealing welding flux spreading device |
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| CN109937061A (en) * | 2016-11-15 | 2019-06-25 | 伊莱利利公司 | Medicine delivery device with mechanical locking system |
| CN106823125A (en) * | 2017-03-24 | 2017-06-13 | 长沙利星医药科技开发有限公司 | A kind of device of use amplitude modulation electric-field enhancing curative effect of medication |
| WO2018210345A1 (en) * | 2017-05-18 | 2018-11-22 | Chen Wen Shiang | Apparatus for delivery of agent |
| CN109432552A (en) * | 2018-09-28 | 2019-03-08 | 中国船舶重工集团公司第七六研究所 | The dynamic pressure detection system and method for oral anesthestia injecting systems |
| CN109432552B (en) * | 2018-09-28 | 2021-04-27 | 中国船舶重工集团公司第七一六研究所 | Dynamic pressure detection system and method for oral anesthesia injection system |
| CN111249614A (en) * | 2020-02-12 | 2020-06-09 | 高泰康 | Novel transducer and ultrasonic wave leading-in instrument |
| CN113274116A (en) * | 2021-05-12 | 2021-08-20 | 香港普创生物科技有限公司 | Full-automatic electric pulse perforation syringe |
| CN113274116B (en) * | 2021-05-12 | 2024-05-14 | 普亚生物科技有限公司 | Full-automatic electroporation syringe |
| CN113307110A (en) * | 2021-06-02 | 2021-08-27 | 广州相佳数码科技有限公司 | Electric acupuncture instrument with wire winding function |
| CN114306805A (en) * | 2022-01-17 | 2022-04-12 | 中国科学院苏州生物医学工程技术研究所 | Automatic injection system |
| CN114306805B (en) * | 2022-01-17 | 2023-11-24 | 中国科学院苏州生物医学工程技术研究所 | Automatic injection system |
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