CN102091137B

CN102091137B - Chinese herbal preparation for treating ankylosing spondylitis

Info

Publication number: CN102091137B
Application number: CN2011100085932A
Authority: CN
Inventors: 王殿玲
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-01-09
Filing date: 2011-01-09
Publication date: 2012-07-04
Anticipated expiration: 2031-01-09
Also published as: CN102091137A

Abstract

The invention relates to a Chinese herbal preparation for treating ankylosing spondylitis, which comprises the following Chinese medicinal herbs by weight: 10g of rhizoma cibotii, 15g of pilose antler, 10g of himalayan teasel root, 5g of scorpio, 15g of kudzu vine root, 12g of chuanxiong rhizome, 5g of caulis spatholobi, 15g of white paeony root, 15g of common peony root, 10g of safflower carthamus, 15g of medicinal cyathula root and 10g of white mustard seed. The Chinese herbal preparation is prepared by using the steps of: weighing the Chinese medicinal herbs in the formula, adding 1500ml of water, decocting with slow fire to ensure that medicine liquid is concentrated to 250ml, filtering dregs of a decoction and preparing a decoction. During the treatment, the decoction is taken orally, each dosage is taken every day, and one treatment course includes 90 days. The Chinese herbal preparation is used for treating the ankylosing spondylitis through improving immunity and micro circulation and eliminating blood micro coagulation. The Chinese herbal preparation has the functions of inhabiting fibrosis and ossification, inhibiting or repairing bone destruction and the like, and achieves the purposes of releasing symptoms and inhibiting the disease progressing from multiple aspects and multiple links. The Chinese herbal preparation has the advantages of low cost and no toxic and side effects.

Description

A kind of Chinese medicine preparation of treating ankylosing spondylitis

Technical field

The present invention relates to a kind of Chinese medicine preparation of treating ankylosing spondylitis, belong to technical field of Chinese medicines.

Background technology

Ankylosing spondylitis (ankylosingspondylitis is hereinafter to be referred as AS) is that axis joint chronic inflammatory disease is main, and agnogenic general connective tissue disease is claimed seronegativity arthritis again, is more common in teenager.This disease onset concealment, the course of disease is long, and touching difficulty heals, and disability rate is high.In recent years, this sickness rate is on the rise, therefore; AS is the hot issue of domestic and international medical worker's research, but never has a more perfect Therapeutic Method, and the western medical treatment curative effect is fast; But because this characteristic of disease matter decision, the treatment required time is longer, so side effect is bigger; Treat and to cause new injury to patient body, leave sequela easily.

Summary of the invention

The present invention is intended to explore a new thinking and method for the Chinese traditional treatment of AS, and the new method of a Chinese traditional treatment is provided, and makes every effort to AS patient's sclerotin is made moderate progress, the process that delays or block bone destruction, deformity, disable.

Technical scheme of the present invention: a kind of Chinese medicine preparation of treating ankylosing spondylitis, process by the crude drug of following weight: Rhizoma Cibotii 10g, Cornu Cervi Pantotrichum 15g, Radix Dipsaci 10g, Scorpio 5g; Radix Puerariae 15g, Rhizoma Chuanxiong 12g, Caulis Spatholobi 5g, Radix Paeoniae Alba 15g; Radix Paeoniae Rubra 15g, Flos Carthami 10g, Radix Cyathulae 15g, Semen Sinapis Albae 10g.

During treatment, take by weighing the crude drug in the prescription, add 1500ml water, slow fire boiling makes medicinal liquid be concentrated into 250ml, and the elimination medicinal residues are processed decoction.Oral, every day potion, 90 days courses of treatment.

The pharmacological effect of each crude drug is following in the present invention's prescription:

Rhizoma Cibotii, Gan Wen goes into the kidney channel edema caused by disorder of QI partially, be longer than tonic, can invigorating the liver and kidney, bone and muscle strengthening.The Cornu Cervi nature and flavor are salty, warm, go into the Liver and kidney warp.Function temperature compensation Liver and kidney, strong muscles and bones, promoting blood circulation and detumescence, the logical governor vessel of transferring.Radix Dipsaci is bitter, and tepor is gone into the kidney channel blood system partially, can invigorating the liver and kidney, and again can Emperor Xuantong's blood vessels and relieving rigidity of muscles and joints, symplectic bone folding.The three share and is altogether to play the effect of temperature compensation Liver and kidney by monarch drug, and kidney yang is strong contains, and helps the turbid elimination of congestion expectorant.Radix Paeoniae Rubra, hardship is slightly cold, heat clearing and blood cooling, dispelling phlegm and alleviating pain; The Radix Paeoniae Alba, picric acid is slightly cold, and is prone to battalion's yin fluid astringing, gentle muscle pain relieving, two medicines 5, one diffusing one are held back mutually, reinforcing and reducing and usefulness, promoting blood circulation to remove obstruction in the collateral, eliminating phlegm to promote tissue regeneration, muscle is rubbed in nourishing the liver, and it is the most suitable to be used for muscle arteries and veins contracture property pain.Flos Carthami, acrid in the mouth is warm in nature, goes into meridians, the stasis of dispelling, the blood coagulation of the tiny blood network of leading to is retarded by silt.Radix Cyathulae, the removing blood stasis collateral dredging, property is kind descending, and liver and kidney tonifying bone strengthening muscle is apt to control the inferior limb cold-damp flaccidity syndrome and arthralgia syndrome, sciatica, the unable person of soreness of waist and knee joint.Semen Sinapis Albae, hot wet is sharp, and property is apt to away scurry, and can change the old expectorant of cold-damp cohesion, and the power of eliminating phlegm promoting the circulation of QI is arranged, and can pass through reaches meridians thoroughly, and kind merit of searching bone joint notes expectorant between muscle is arranged.The above five tastes are ministerial drug altogether, the merit of playing the clearing away phlegm of invigorating blood circulation altogether.Caulis Spatholobi, Xin Wen, little sweet, blood circulation promoting and enriching, relaxing muscles and tendons and activating QI and blood in the collateral.Scorpio, slightly warm in nature, poisonous, go into Liver Channel.Be good at suppressing liver-wind to relieve spasm detoxifcation, it searches wind, and to pick heresy, function of promoting blood circulation to disperse blood clots very strong, to the rigid spine of AS, attack and logical it, power is quite arranged.Radix Puerariae, acrid in the mouth, fragrance can be amusing, and as the wind medicine, about the whole body that can pass through, separates at poison and controls all numbness, has expelling wind and dampness, promoting blood circulation to restore menstrual flow effect.Rhizoma Chuanxiong, Xin Wen, blood-activating and qi-promoting, wind-expelling pain-stopping for the gas medicine in the blood, can be changed stasis, opens blood stasis, the up head, assigns the sea of blood.Four is adjuvant altogether, can strengthen that invigorating blood circulation of ministerial drug is sensible searches the effect of picking, and can draw the sensible whole body joint meridians of all medicines.The all medicines in full side share, and play the kidney invigorating altogether and superintend and direct, the merit of blood stasis dispelling clearing away phlegm.

The pathomechanism of ankylosing spondylitis.The expectorant what is the pathologic product of pathogenic factor effect on human body, is again the key factor of bringing out ankylosing spondylitis.Kidney qi, kidney channel are lost empty, and the empty mistake of governor vessel is supported, congestion, the turbid invasion of taking advantage of a weak point in opponent's defence of expectorant, and multiple abscess hands over work in governor vessel in pleurodiaphragmatic in terspace, meridians, iliacus and joint, gos deep into bone joint spinal cord.Pathogenic factor from the superficial to the deep arrives heavily on the lenient side, causes rigid spine eventually, sends out to be the kyphosis.Qi-blood-body fluid stagnates, and the internal resistance of expectorant what is cut and cut down healthy energy, kidney is superintended and directed more lose, and exopathogen is taken advantage of a weak point, and causes rheumatism involving the bone eventually and shows effect repeatedly, does not touchingly heal.

Radix Puerariae contains Semen sojae atricolor pyrite and has papaverine appearance spasmolysis among the treatment Analysis on Mechanism we of ankylosing spondylitis; Microcirculation disturbance is improved significantly; And can increase the amplitude that blood capillary is moved, and improve local little blood flow, make capillary network obviously open.Chemical constituent D-cachou extract of the Radix Paeoniae Alba and progallin A are the effective ingredient of antithrombotic and anti-platelet aggregation.White peony root's total glycoside (TGP) all is dual regulation to IL-1, tumor necrosis factor (TNF) and the breeder reaction of mice bone-marrow-derived lymphocyte.The Radix Achyranthis Bidentatae decocting liquid can all have certain reduction effect to hemorheological indexes except that fibrinogen content, can prolong the external clotting time of rabbit.Inokopolyose can improve that mouse monokaryon is huge has a liking for cytophagy and NK cell killing activity.The medicine Radix Dipsaci of invigorating the kidney and strengthening the bones effect, Rhizoma Cibotii etc. can promote the growth of maturation, chondrocyte and the sclerotin of osteocyte, the reparation of cartilage destruction.The article of blood circulation promoting and blood stasis dispelling such as Radix Cyathulae, Rhizoma Chuanxiong, Caulis Spatholobi impel ossified the dissipation.

In sum, the mechanism of action of we's treatment AS is to bring out the autoimmune damage through infection, prevention; Anti-inflammatory and antalgic effectively improves symptom, and microcirculation improvement is eliminated the little attitude of coagulating of blood; Regulate immunologic function, suppress fibrosis, ossified, effects such as inhibition or reparation bone destruction are many-sided, too many levels reaches relief of symptoms, stop the purpose of disease progression.The present invention is cheap, no toxic side effect.

The specific embodiment

Below in conjunction with embodiment and clinical data the present invention is described further:

Embodiment: a kind of Chinese medicine of treating ankylosing spondylitis, formulated by the Chinese medicine of following raw materials according: Rhizoma Cibotii 10g, Cornu Cervi Pantotrichum 15g, Radix Dipsaci 10g, Scorpio 5g; Radix Puerariae 15g, Rhizoma Chuanxiong 12g, Caulis Spatholobi 5g, Radix Paeoniae Alba 15g; Radix Paeoniae Rubra 15g, Flos Carthami 10g, Radix Cyathulae 15g, Semen Sinapis Albae 10g.During treatment, take by weighing the crude drug in the prescription, add 1500ml water, slow fire boiling makes medicinal liquid be concentrated into 250ml, and the elimination medicinal residues are processed decoction.Oral, every day potion, 90 days courses of treatment.

Clinical data:

Clinical observation paralytic 62 examples, wherein, male 32 examples, women 30 examples are divided into two groups at random, treatment group and matched group, every group 31 people, wherein, male 14 examples are organized in treatment, women 17 examples; Matched group man 16 examples, women 15 examples; Two groups of patients are little from age, sex, the course of disease, state of an illness aspect difference factor, have comparability.

Therapeutic scheme:

Treatment group: endo-medicine: Rhizoma Cibotii 10g, Cornu Cervi Pantotrichum 15g, Radix Dipsaci 10g, Scorpio 5g, Radix Puerariae 15g, Rhizoma Chuanxiong 12g, Caulis Spatholobi 5g, Radix Paeoniae Alba 15g, Radix Paeoniae Rubra 15g, Flos Carthami 10g, Radix Cyathulae 15g, Semen Sinapis Albae 10g.Every day potion, decocting is processed medicament, sooner or later twice oral.90 days is 1 course of treatment.

Matched group: give methotrexate 7.5mg, weekly, the too blue or green 50mg of English, twice of every day is oral.90 days is 1 course of treatment.

Efficacy assessment standard:

The AS therapeutic evaluation factor that adopts international AS working group to establish with reference to international efficacy determination method at present, is confirmed curative effect determinate standard.

1. clinical remission: clinical symptoms disappears basically, and movable function is normal basically, and it is normal that each item observation index recovers, and the radiology performance improves or stable person.

2. produce effects: have 4 improvement to surpass 50% in 7 main curative effect index, ESR, CRP recover normal, the no significant change person of radiology performance.

3. effective: as to have 4 and ESR, CRP to improve in 7 main curative effect index and surpass 20%, the no significant change person of radiology performance.

4. invalid: as not reach the above-mentioned effective standard or the person of increasing the weight of.

Therapeutic effect:

After treating a course of treatment, treatment group clinical remission 15 examples, produce effects 9 examples, effective 5 examples, invalid 2 examples, total effective rate is 95.0%; Matched group clinical remission 12 examples, produce effects 7 examples, effective 4 examples, invalid 8 examples, total effective rate 74.2%, treatment group curative effect obviously is superior to matched group.Untoward reaction does not appear in the treatment group.

Conclusion: Chinese medicine preparation of the present invention is compared with existing Western medicine drug, and curative effect obviously is superior to the Western medicine of prior art, and has no side effect.

Claims

1. a Chinese medicine preparation of treating ankylosing spondylitis is characterized in that, is processed by the crude drug of following weight: Rhizoma Cibotii 10g, Cornu Cervi Pantotrichum 15g, Radix Dipsaci 10g; Scorpio 5g, Radix Puerariae 15g, Rhizoma Chuanxiong 12g, Caulis Spatholobi 5g, Radix Paeoniae Alba 15g; Radix Paeoniae Rubra 15g, Flos Carthami 10g, Radix Cyathulae 15g, Semen Sinapis Albae 10g; Manufacture method: take by weighing the crude drug in the prescription, after concocting, add 1500ml water, slow fire boiling makes medicinal liquid be concentrated into 250ml, and the elimination medicinal residues are processed decoction.