CN102090904A - Rapid allergic skin test detector of Chinese medicine injection - Google Patents
Rapid allergic skin test detector of Chinese medicine injection Download PDFInfo
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- CN102090904A CN102090904A CN2011100397845A CN201110039784A CN102090904A CN 102090904 A CN102090904 A CN 102090904A CN 2011100397845 A CN2011100397845 A CN 2011100397845A CN 201110039784 A CN201110039784 A CN 201110039784A CN 102090904 A CN102090904 A CN 102090904A
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- chinese medicine
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- medicine injection
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Abstract
The invention relates to a rapid allergic skin test detector of a Chinese medicine injection, which comprises an electrode and a medicine liquid permeating device sleeved on the electrode, wherein the electrode is connected with an electronic impulse transmission device through a connecting wire. The rapid allergic skin test detector is characterized in that the medicine liquid permeating device comprises an electrode lantern ring and a connecting belt for fixing the electrode lantern ring, a nano sponge sheet is arranged on the electrode lantern ring, and a liposome tectorial membrane covers on the nano sponger sheet. The invention ensures that a patient can judge whether being allergic to the Chinese medicine injection by using a skin test method, thereby avoiding adverse effects of the Chinese medicine injection.
Description
Technical field
The present invention relates to the quick irritated skin test detector of a kind of Chinese medicine.
Background technology
As a kind of novel form of Chinese medicine, Chinese medicine has been expected since eighties of last century the seventies and eighties comes out always very much, uses very extensively clinically.But, because Chinese medicine is different with Western medicine, Chinese medicine becomes branch to form by plurality of Chinese usually, and directly enter blood samples of patients, risk is bigger than oral medicine, much more the untoward reaction that Chinese medicine allergy is occurred had report in nearly 2 years, even had serious adverse reaction to cause death cases.But on the other hand, brainstrust also disapprove is just kept outside the door, is stopped using fully because of the misgivings Chinese medicine may produce untoward reaction such as allergy, because anaphylaxis only occurs in the crowd of a part of special body constitution, especially some Chinese medicine truly has the irreplaceable only road of Western medicine part.Domestic most medical experts' cognition is, no matter uses what Chinese medicine, no matter whether requires to do skin test in the package insert, with preceding all to be earlier that the patient does skin test, skin test is had anaphylaxis person, without exception without Chinese medicine.Though it is perfectly safe to guarantee like this, really can effectively get rid of most responsive crowds, protect patient safety as much as possible.At present, there is multiple drug allergy skin test instrument to sell on the domestic market, but this type of drug allergy skin test instrument only limits to that medicines such as penicillins, cephalosporins, streptomycin, refining tetanus antimycin (TAT), procaine are carried out skin test to be detected, this type of product structure is simple, be of limited application, can't be applied to the irritated detection of Chinese medicine.
Summary of the invention
Whether technical problem to be solved by this invention provides a kind of patient of making can judge it to Chinese medicine allergy by the method for skin test, thus the quick irritated skin test detector of Chinese medicine of having avoided the Chinese medicine untoward reaction to take place.
The present invention adopts following technical scheme:
The present invention includes by connecting the electrode that lead is connected with the electronic impulse discharger and being sleeved on medicinal liquid permeability apparatus on the electrode, it is characterized in that described medicinal liquid permeability apparatus is made of the connecting band of the electrode collar and the fixed electrode collar, the described electrode collar is provided with the nanosponges lamellar body, covers to be equipped with the liposome overlay film on the nanosponges lamellar body.
The thickness of described nanosponges lamellar body is 2.0～3.5mm.
Good effect of the present invention is as follows:
Application characteristic according to Chinese medicine, the present invention is provided with (being generally four) detecting electrode and the corresponding medicinal liquid permeability apparatus more than three, increased the compatibility contrast kind of Chinese medicine, promptly adopted 10% glucose injection and normal saline solution to carry out skin test respectively as solution and blank liquid.
The present invention adopts difform skin test electrode respectively according to the width of patient's arm.
The present invention adopts the material of nanosponges lamellar body as the absorption solution for skin test, adopt the mechanism of physical absorption, rely on the nanoscale capillary pipe opening structure in the sponge, automatically, fully adsorb various compositions in the Chinese medicine in the dropping liquid process, after slightly pushing, can discharge its adsorbed whole Chinese medicine compositions.
The present invention adopts the flexible lipidosome overlay film on the nanosponges lamellar body, Liposomal formulation can improve the permeability of medicine to skin, the characteristics that Chinese medicine exists multicomponent to constitute, complicated component, the permeability difference of the skin of each component, the present invention can fully absorb various compositions like this, and each component can be penetrated to the skin in the tissue fully.The liposome overlay film has significant short saturating effect as the carrier of percutaneous dosing, especially to polypeptide and protein-based macromolecular drug, flexible lipidosome has superpower crimp ability, can penetrate complete skin, even under lower dosage, also can reach active drug concentration, skin can fully be absorbed to Chinese medicine to be measured.
The present invention adopts difform and the matching used medicinal liquid permeability apparatus of skin test electrode, uses according to the width difference of the different arm of tester.
The present invention adopts the material of nanosponges lamellar body as the absorption solution for skin test, can fully adsorb and discharge its adsorbed whole Chinese medicine compositions.
The present invention adopts the flexible lipidosome film coating technique, even also can reach active drug concentration under lower dosage, skin can fully be absorbed to Chinese medicine to be measured.
Description of drawings
Fig. 1 is a structural representation of the present invention;
Fig. 2 is the A portion enlarged drawing of accompanying drawing 1;
Fig. 3 is provided with sketch map for the present invention adopts 4 electrode collars to be square;
Fig. 4 is provided with sketch map for the present invention adopts 4 electrode collars to be in-line.
In the accompanying drawings: 1 electrode, 2 connects lead, the 3 electrode collars, 4 nanosponges lamellar bodies, 5 liposome overlay films, 6 connecting bands.
The specific embodiment
Shown in accompanying drawing 1,2, the present invention includes by connecting the electrode 1 that lead 2 is connected with the electronic impulse discharger and being sleeved on medicinal liquid permeability apparatus on the electrode 1, described pulse discharger can be the DC pulse discharger, also can be ultrasonic transmission device.Described medicinal liquid permeability apparatus is made of the connecting band 6 of the electrode collar 3 and the fixed electrode collar 3, and the described electrode collar 3 is provided with nanosponges lamellar body 4, covers to be equipped with liposome overlay film 5 on nanosponges lamellar body 4.The present invention adopts the outer surface of nanosponges lamellar body 4 to soak in liquid lipidosome and forms liposome overlay film 5.As shown in Figure 3, be one embodiment of the present of invention, adopt the setting that is square of 4 electrode collars.As shown in Figure 4, be an alternative embodiment of the invention, adopt 4 electrode collars to be the in-line setting.The diameter of the fixed electrode collar of the present invention is 0.8～1.2mm, highly is 4.5～5.5 mm, and wherein the thickness of nanosponges lamellar body 4 is 2.0～3.5mm, and the thickness of liposome overlay film 5 is 0.1～0.5mm.Application characteristic according to Chinese medicine, the present invention is provided with detecting electrode and the corresponding medicinal liquid permeability apparatus that (is generally four) more than three, increased the compatibility contrast kind of Chinese medicine, promptly adopted 10% glucose injection (or 5% glucose injection) and normal saline solution to carry out skin test respectively as solution and blank liquid.
The present invention adopts difform respectively and the matching used medicinal liquid permeability apparatus of skin test electrode according to the width of patient's arm.
The present invention adopts the material of nanosponges lamellar body 4 as the absorption solution for skin test, adopt the mechanism of physical absorption, rely on the nanoscale capillary pipe opening structure in the sponge, automatically, fully adsorb various compositions in the Chinese medicine in the dropping liquid process, after slightly pushing, can discharge its adsorbed whole Chinese medicine compositions.
The present invention adopts flexible lipidosome overlay film 5, Liposomal formulation can improve the permeability of medicine to skin, the characteristics that Chinese medicine exists multicomponent to constitute, complicated component, the permeability difference of the skin of each component, so fully absorb various compositions, each component can be penetrated to the skin in the tissue fully.Liposome overlay film 5 has significant short saturating effect as the carrier of percutaneous dosing, especially to polypeptide and protein-based macromolecular drug, flexible lipidosome has superpower crimp ability, can penetrate complete skin, even under lower dosage, also can reach active drug concentration, skin can fully be absorbed to Chinese medicine to be measured.
The present invention adopts the material of nanosponges as the absorption solution for skin test, can fully adsorb and discharge its adsorbed whole Chinese medicine compositions.
The present invention adopts flexible lipidosome overlay film 5, even also can reach active drug concentration under lower dosage, skin can fully be absorbed to Chinese medicine to be measured.Electronic impulse discharger of the present invention or ultrasonic transmission device are the existing electronic installation that is used for the promotion Transdermal absorption of clinical use.Use when of the present invention, clean with sterilized water for injection earlier and tried the position, medicinal liquid is added drop-wise to respectively on the liposome overlay film 5 on each electrode collar 3, then the electrode collar 3 is sleeved on the electrode 1, liposome overlay film 5 is close to tried the position, restraint in disinfectant inboard arm (injection skin test position), notice that electrode 1 should have excellent contact with skin.Buzzer automatically alarming behind the startup electronic impulse discharger 5min takes off electrode 1 this moment and can observe the positive and negative reaction.
Claims (2)
1. quick irritated skin test detector of Chinese medicine, it comprises by connecting the electrode (1) that lead (2) is connected with the electronic impulse discharger and being sleeved on medicinal liquid permeability apparatus on the electrode (1), it is characterized in that described medicinal liquid permeability apparatus is made of the connecting band (6) of the electrode collar (3) and the fixed electrode collar (3), the described electrode collar (3) is provided with nanosponges lamellar body (4), covers to be equipped with liposome overlay film (5) on nanosponges lamellar body (4).
2. the quick irritated skin test detector of Chinese medicine according to claim 1, the thickness that it is characterized in that described nanosponges lamellar body (4) is 2.0～3.5mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110039784 CN102090904B (en) | 2011-02-17 | 2011-02-17 | Rapid allergic skin test detector of Chinese medicine injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110039784 CN102090904B (en) | 2011-02-17 | 2011-02-17 | Rapid allergic skin test detector of Chinese medicine injection |
Publications (2)
| Publication Number | Publication Date |
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| CN102090904A true CN102090904A (en) | 2011-06-15 |
| CN102090904B CN102090904B (en) | 2013-04-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201110039784 Active CN102090904B (en) | 2011-02-17 | 2011-02-17 | Rapid allergic skin test detector of Chinese medicine injection |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040265354A1 (en) * | 2003-06-30 | 2004-12-30 | Mahmoud Ameri | Formulations for coated microprojections containing non-volatile counterions |
| CN2868198Y (en) * | 2005-09-20 | 2007-02-14 | 陈占会 | Electrode for quick hypersensitive skin tester |
| CN101167696A (en) * | 2007-10-24 | 2008-04-30 | 丁克祥 | Freezing-dried and non-freezing-dried hydroquinone mono-propionate beautifying effect nanometer emulsion and its preparation method |
| CN201333035Y (en) * | 2008-12-18 | 2009-10-28 | 陈远平 | Skin electrode for skin tester |
| CN201968713U (en) * | 2011-02-17 | 2011-09-14 | 中国中医科学院中医临床基础医学研究所 | Traditional Chinese medicine injection rapid allergic skin test detector |
-
2011
- 2011-02-17 CN CN 201110039784 patent/CN102090904B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040265354A1 (en) * | 2003-06-30 | 2004-12-30 | Mahmoud Ameri | Formulations for coated microprojections containing non-volatile counterions |
| CN2868198Y (en) * | 2005-09-20 | 2007-02-14 | 陈占会 | Electrode for quick hypersensitive skin tester |
| CN101167696A (en) * | 2007-10-24 | 2008-04-30 | 丁克祥 | Freezing-dried and non-freezing-dried hydroquinone mono-propionate beautifying effect nanometer emulsion and its preparation method |
| CN201333035Y (en) * | 2008-12-18 | 2009-10-28 | 陈远平 | Skin electrode for skin tester |
| CN201968713U (en) * | 2011-02-17 | 2011-09-14 | 中国中医科学院中医临床基础医学研究所 | Traditional Chinese medicine injection rapid allergic skin test detector |
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| Publication number | Publication date |
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| CN102090904B (en) | 2013-04-03 |
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