CN102090904B - Rapid allergic skin test detector of Chinese medicine injection - Google Patents
Rapid allergic skin test detector of Chinese medicine injection Download PDFInfo
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- CN102090904B CN102090904B CN 201110039784 CN201110039784A CN102090904B CN 102090904 B CN102090904 B CN 102090904B CN 201110039784 CN201110039784 CN 201110039784 CN 201110039784 A CN201110039784 A CN 201110039784A CN 102090904 B CN102090904 B CN 102090904B
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Abstract
The invention relates to a rapid allergic skin test detector of a Chinese medicine injection, which comprises an electrode and a medicine liquid permeating device sleeved on the electrode, wherein the electrode is connected with an electronic impulse transmission device through a connecting wire. The rapid allergic skin test detector is characterized in that the medicine liquid permeating device comprises an electrode lantern ring and a connecting belt for fixing the electrode lantern ring, a nano sponge sheet is arranged on the electrode lantern ring, and a liposome tectorial membrane covers on the nano sponger sheet. The invention ensures that a patient can judge whether being allergic to the Chinese medicine injection by using a skin test method, thereby avoiding adverse effects of the Chinese medicine injection.
Description
Technical field
The present invention relates to a kind of Chinese medicine injection rapid allergic skin test detector.
Background technology
As a kind of novel form of Chinese medicine, Chinese medicine has been expected since eighties of last century the seventies and eighties comes out always very much, uses clinically very extensively.But, because Chinese medicine is different from Western medicine, Chinese medicine becomes branch to form by plurality of Chinese usually, and directly enter blood samples of patients, risk is larger than oral medicine, much more the untoward reaction that Chinese medicine allergy is occurred had report in nearly 2 years, even had serious adverse reaction to cause dead case.But on the other hand, brainstrust also disapprove waits untoward reaction just to keep outside the door, stop using fully because the misgivings Chinese medicine may produce allergy, because anaphylaxis only occurs in the crowd of a part of special body constitution, especially some Chinese medicine truly has the irreplaceable only road of Western medicine part.Domestic most medical experts' cognition is, no matter uses what Chinese medicine, no matter whether requires to do skin test in the package insert, all will first for the patient does skin test, to skin test anaphylaxis person be arranged, without exception without Chinese medicine with front.Although it is perfectly safe to guarantee like this, really can effectively get rid of most sensitive groups, protect as much as possible patient safety.At present, there is the multi-medicament Skin allergy test device to sell on the domestic market, but this type of drug allergy skin test instrument only limits to that the medicines such as penicillins, cephalosporins, streptomycin, refining tetanus antimycin (TAT), procaine are carried out skin test to be detected, this product structure is simple, be of limited application, can't be applied to the irritated detection of Chinese medicine.
Summary of the invention
Technical problem to be solved by this invention provides a kind of patient of making can judge whether it is irritated to Chinese medicine by the method for skin test, thus the Chinese medicine injection rapid allergic skin test detector of having avoided the Chinese medicine untoward reaction to occur.
The present invention adopts following technical scheme:
The present invention includes by connecting the electrode that wire is connected with the electronic impulse discharger and being sleeved on medicinal liquid osmosis device on the electrode, it is characterized in that described medicinal liquid osmosis device is made of the connecting band of the electrode collar and the fixed electrode collar, be provided with the nanosponges lamellar body on the described electrode collar, cover at the nanosponges lamellar body and be equipped with the liposome overlay film.
The thickness of described nanosponges lamellar body is 2.0～3.5mm.
Good effect of the present invention is as follows:
Application characteristic according to Chinese medicine, the present invention arranges (being generally four) detecting electrode and the corresponding medicinal liquid osmosis device more than three, increase the compatibility contrast kind of Chinese medicine, namely adopted respectively 10% glucose injection and normal saline solution to carry out skin test as solution and blank liquid.
The present invention adopts respectively difform skin test electrode according to the width of patient's arm.
The present invention adopts the nanosponges lamellar body as the material of absorption solution for skin test, adopt the mechanism of physical absorption, rely on the nanoscale capillary pipe opening structure in the sponge, automatically, fully adsorb various compositions in the Chinese medicine in the dropping liquid process, after slightly pushing, can discharge whole Chinese medicine compositions that it adsorbs.
The present invention adopts the flexible lipidosome overlay film at the nanosponges lamellar body, Liposomal formulation can improve medicine to the permeability of skin, the characteristics that Chinese medicine exists multicomponent to consist of, complicated component, the permeability of the skin of each component is different, the present invention can fully absorb various compositions like this, and each component can be penetrated to the skin in the tissue fully.The liposome overlay film has significant short saturating effect as the carrier of percutaneous dosing, especially to peptide and protein class macromolecular drug, flexible lipidosome has superpower crimp ability, can penetrate complete skin, even under lower dosage, also can reach active drug concentration, skin can fully be absorbed Chinese medicine to be measured.
The present invention adopts difform and the matching used medicinal liquid osmosis device of skin test electrode, uses according to the width difference of the different arm of tester.
The present invention adopts the nanosponges lamellar body as the material of absorption solution for skin test, can fully adsorb and discharge whole Chinese medicine compositions that it adsorbs.
The present invention adopts the flexible lipidosome film coating technique, even also can reach active drug concentration under lower dosage, skin can fully be absorbed Chinese medicine to be measured.
Description of drawings
Fig. 1 is structural representation of the present invention;
Fig. 2 is the A section enlarged drawing of accompanying drawing 1;
Fig. 3 is that the present invention adopts 4 electrode collars to be square sketch map is set;
Fig. 4 is that the present invention adopts 4 electrode collars to be in-line sketch map is set.
In the accompanying drawings: 1 electrode, 2 connects wire, the 3 electrode collars, 4 nanosponges lamellar bodies, 5 liposome overlay films, 6 connecting bands.
The specific embodiment
Shown in accompanying drawing 1,2, the present invention includes by connecting the electrode 1 that wire 2 is connected with the electronic impulse discharger and being sleeved on medicinal liquid osmosis device on the electrode 1, described impulse ejection device can be the DC pulse discharger, also can be ultrasonic transmission device.Described medicinal liquid osmosis device is made of the connecting band 6 of the electrode collar 3 and the fixed electrode collar 3, is provided with nanosponges lamellar body 4 on the described electrode collar 3, covers at nanosponges lamellar body 4 to be equipped with liposome overlay film 5.The present invention adopts the outer surface of nanosponges lamellar body 4 to soak in liquid lipidosome and forms liposome overlay film 5.As shown in Figure 3, be one embodiment of the present of invention, adopt the setting that is square of 4 electrode collars.As shown in Figure 4, be an alternative embodiment of the invention, adopt 4 electrode collars to be the in-line setting.The diameter of the fixed electrode collar of the present invention is 0.8～1.2mm, highly is 4.5～5.5 mm, and wherein the thickness of nanosponges lamellar body 4 is 2.0～3.5mm, and the thickness of liposome overlay film 5 is 0.1～0.5mm.Application characteristic according to Chinese medicine, the present invention arranges detecting electrode and the corresponding medicinal liquid osmosis device that (is generally four) more than three, increase the compatibility contrast kind of Chinese medicine, namely adopted respectively 10% glucose injection (or 5% glucose injection) and normal saline solution to carry out skin test as solution and blank liquid.
The present invention adopts respectively difform and the matching used medicinal liquid osmosis device of skin test electrode according to the width of patient's arm.
The present invention adopts nanosponges lamellar body 4 as the material of absorption solution for skin test, adopt the mechanism of physical absorption, rely on the nanoscale capillary pipe opening structure in the sponge, automatically, fully adsorb various compositions in the Chinese medicine in the dropping liquid process, after slightly pushing, can discharge whole Chinese medicine compositions that it adsorbs.
The present invention adopts flexible lipidosome overlay film 5, Liposomal formulation can improve medicine to the permeability of skin, the characteristics that Chinese medicine exists multicomponent to consist of, complicated component, the permeability of the skin of each component is different, so fully absorb various compositions, each component can be penetrated to the skin in the tissue fully.Liposome overlay film 5 has significant short saturating effect as the carrier of percutaneous dosing, especially to peptide and protein class macromolecular drug, flexible lipidosome has superpower crimp ability, can penetrate complete skin, even under lower dosage, also can reach active drug concentration, skin can fully be absorbed Chinese medicine to be measured.
The present invention adopts nanosponges as the material of absorption solution for skin test, can fully adsorb and discharge whole Chinese medicine compositions that it adsorbs.
The present invention adopts flexible lipidosome overlay film 5, even also can reach active drug concentration under lower dosage, skin can fully be absorbed Chinese medicine to be measured.Electronic impulse discharger of the present invention or ultrasonic transmission device are the existing electronic installation that is used for the promotion Transdermal absorption of clinical use.Use when of the present invention, clean tested position with sterilized water for injection first, medicinal liquid is added drop-wise to respectively on the liposome overlay film 5 on each electrode collar 3, then the electrode collar 3 is sleeved on the electrode 1, liposome overlay film 5 is close to tested position, restraint the inboard arm (injection skin test position) in sterilization, notice that electrode 1 should have good contacting with skin.Buzzer automatically alarming behind the startup electronic impulse discharger 5min, taking off electrode 1 this moment is the reactions of observable positive and negative.
Claims (2)
1. Chinese medicine injection rapid allergic skin test detector, it is characterized in that it comprises four electrodes (1) that are connected with the electronic impulse discharger by connecting wire (2), be sleeved on medicinal liquid osmosis device and Chinese medicine compatibility contrast liquid on the electrode (1), namely adopt 10% glucose injection to carry out skin test as solution and blank liquid, adopt normal saline solution to carry out skin test as solution and blank liquid, described medicinal liquid osmosis device has the connecting band (6) of the electrode collar (3) and the fixed electrode collar (3) to consist of, be provided with nanosponges lamellar body (4) on the described electrode collar (3), be coated with liposome overlay film (5) at nanosponges lamellar body (4).
2. a kind of Chinese medicine injection rapid allergic skin test detector according to claim 1, the diameter that it is characterized in that the described electrode collar (3) is 0.8 ~ 1.2mm, highly be 4.5 ~ 5.5mm, the thickness of described nanosponges lamellar body (4) is 2.0 ~ 3.5mm, and the thickness of described liposome overlay film (5) is 0.1 ~ 0.5mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110039784 CN102090904B (en) | 2011-02-17 | 2011-02-17 | Rapid allergic skin test detector of Chinese medicine injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110039784 CN102090904B (en) | 2011-02-17 | 2011-02-17 | Rapid allergic skin test detector of Chinese medicine injection |
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| Publication Number | Publication Date |
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| CN102090904A CN102090904A (en) | 2011-06-15 |
| CN102090904B true CN102090904B (en) | 2013-04-03 |
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| CN 201110039784 Active CN102090904B (en) | 2011-02-17 | 2011-02-17 | Rapid allergic skin test detector of Chinese medicine injection |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2868198Y (en) * | 2005-09-20 | 2007-02-14 | 陈占会 | Electrode for quick hypersensitive skin tester |
| CN101167696A (en) * | 2007-10-24 | 2008-04-30 | 丁克祥 | Freezing-dried and non-freezing-dried hydroquinone mono-propionate beautifying effect nanometer emulsion and its preparation method |
| CN201333035Y (en) * | 2008-12-18 | 2009-10-28 | 陈远平 | Skin electrode for skin tester |
| CN201968713U (en) * | 2011-02-17 | 2011-09-14 | 中国中医科学院中医临床基础医学研究所 | Traditional Chinese medicine injection rapid allergic skin test detector |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2437565T3 (en) * | 2003-06-30 | 2014-01-13 | Alza Corporation | Formulations for coated microprojections containing non-volatile counterions |
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2011
- 2011-02-17 CN CN 201110039784 patent/CN102090904B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2868198Y (en) * | 2005-09-20 | 2007-02-14 | 陈占会 | Electrode for quick hypersensitive skin tester |
| CN101167696A (en) * | 2007-10-24 | 2008-04-30 | 丁克祥 | Freezing-dried and non-freezing-dried hydroquinone mono-propionate beautifying effect nanometer emulsion and its preparation method |
| CN201333035Y (en) * | 2008-12-18 | 2009-10-28 | 陈远平 | Skin electrode for skin tester |
| CN201968713U (en) * | 2011-02-17 | 2011-09-14 | 中国中医科学院中医临床基础医学研究所 | Traditional Chinese medicine injection rapid allergic skin test detector |
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| CN102090904A (en) | 2011-06-15 |
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